JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

Cell Death and Differentiation

Volumn 22, Issue 10, 2015, Pages 1630-1640

  Zhao, L ^a   Zhang, Y ^a   Gao, Y ^a   Geng, P ^a   Lu, Y ^a   Liu, X ^a   Yao, R ^a   Hou, P ^a   Liu, D ^b   Lu, J ^a   Huang, B ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEMETHYLASE; JUMONJI DOMAIN CONTAINING 3; LYSINE; METHYLTRANSFERASE; NONHISTONE PROTEIN; RETINOBLASTOMA PROTEIN; SERINE; UNCLASSIFIED DRUG; HETEROCHROMATIN; KDM6B PROTEIN, HUMAN;

ARTICLE; CELL AGING; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOPLASM; DEMETHYLATION; GENE EXPRESSION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI; UPREGULATION; CELL LINE; FIBROBLAST; HETEROCHROMATIN; HUMAN; METABOLISM; METHYLATION; PHOSPHORYLATION; PHYSIOLOGY;

CELL AGING; CELL LINE; FIBROBLASTS; HETEROCHROMATIN; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; METHYLATION; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN;

EID: 84941179933     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.6     Document Type: Article

References (41)

1. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8: 729-740.
2. Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev 2014; 28: 99-114.
3. Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005; 37: 961-976.
4. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-602.
5. Hemann MT, Narita M. Oncogenes and senescence: breaking down in the fast lane. Genes Dev 2007; 21: 1-5.
6. Longhese MP. DNA damage response at functional and dysfunctional telomeres. Genes Dev 2008; 22: 125-140.
7. Narita M, Nuñez S, Heard E, Narita M, Lin AW, Hearn SA et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003; 113: 703-716.
8. Schulz L, Tyler J. Heterochromatin focuses on senescence. Mol Cell 2005; 17: 168-170.
9. Narita M, Narita M, Krizhanovsky V, Nunez S, Chicas A, Hearn SA et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 2006; 126: 503-514.
10. Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 2005; 8: 19-30.
11. Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 2007; 27: 2343-2358.
12. Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell 2012; 47: 203-214.
13. Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR et al. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev 2013; 27: 1800-1808.
14. Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K et al. Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev 2013; 27: 1787-1799.
15. Zhang R, Adams PD. Heterochromatin and its relationship to cell senescence and cancer therapy. Cell Cycle 2007; 6: 784-789.
16. Gonzalo S, Garcia-Cao M, Fraga MF, Schotta G, Peters AH, Cotter SE et al. Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol 2005; 7: 420-428.
17. Kaelin WG Jr. Functions of the retinoblastoma protein. BioEssays 1999; 21: 950-958.
18. Uchida C. The retinoblastoma protein: functions beyond the G1-S regulator. Curr Drug Targets 2012; 13: 1622-1632.
19. Dick FA, Dyson N. pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol Cell 2003; 12: 639-649.
20. Burke JR, Hura GL, Rubin SM. Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev 2012; 26: 1156-1166.
21. Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P et al. Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol 2007; 27: 2452-2465.
22. Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D et al. Rb targets histone H3 methylation and HP1 to promoters. Nature 2001; 412: 561-565.
23. Zhang Y, Gao Y, Zhao L, Han L, Lu Y, Hou P et al. Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells. FEBS J 2013; 280: 4625-4639.
24. Longworth MS, Dyson NJ. pRb a local chromatin organizer with global possibilities. Chromosoma 2010; 119: 1-11.
25. Munro S, Carr SM, La Thangue NB. Diversity within the pRb pathway: is there a code of conduct? Oncogene 2012; 31: 4343-4352.
26. Munro S, Khaire N, Inche A, Carr S, La Thangue NB. Lysine methylation regulates the pRb tumour suppressor protein. Oncogene 2010; 29: 2357-2367.
27. Saddic LA, West LE, Aslanian A, Yates JR, Rubin SM, Gozani O et al. Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem 2010; 285: 37733-37740.
28. Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB. Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J 2011; 30: 317-327.
29. Cho HS, Hayami S, Toyokawa G, Maejima K, Yamane Y, Suzuki T et al. RB1 methyl by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation1. Neoplasia 2012; 14: 476-486.
30. Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007; 449: 731-734.
31. Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev 2009; 23: 1177-1182.
32. Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J et al. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev 2009; 23: 1171-1176.
33. Ene CI, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S et al. Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS One 2012; 7: e51407.
34. Sola S, Xavier JM, Santos DM, Aranha MM, Morgado AL, Jepsen K et al. p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation. PLoS One 2011; 6: e18421.
35. Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci USA 2008; 105: 1907-1912.
36. Xiang Y, Zhu ZQ, Han G, Lin HQ, Xu LY, Chen CD. JMJD3 is a histone H3K27 demethylase. Cell Res 2007; 17: 850-857.
37. Zhou ZW, Sun XT, Zou ZH, Sun LT, Zhang T, Guo SS et al. PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130. Cell Res 2010; 20: 1023-1033.
38. Schaal C, Pillai S, Chellappan SP. The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis. Adv Cancer Res 2014; 121: 147-182.
39. Sun Y, Lou XM, Yang M, Yuan CF, Ma L, Xie BK et al. Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G(2)/M phases of the cell cycle. Cell Cycle 2013; 12: 3512-3525.
40. Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M et al. p53 is regulated by the lysine demethylase LSD1. Nature 2007; 449: 105-U180.
41. Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M et al. Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res 2011; 71: 655-660.