FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages

Cellular and Molecular Immunology

Volumn 12, Issue 5, 2015, Pages 615-624

  Wang, Wenyan ^a   Li, Ting ^a   Wang, Xiaolin ^a   Yuan, Wanxiong ^a   Cheng, Yingying ^a   Zhang, Heyu ^a   Xu, Enquan ^a   Zhang, Yingmei ^a   Shi, Shuang ^a   Ma, Dalong ^a   Han, Wenling ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

cytokine; FAM19A4; FPR1; macrophages; phagocytosis

Indexed keywords

FORMYLPEPTIDE RECEPTOR; LIGAND; LIPOPOLYSACCHARIDE; PROTEIN FAM19A4; PROTEIN FPR1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SECRETORY PROTEIN; UNCLASSIFIED DRUG; ZYMOSAN; CYTOKINE; TAFA4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; RECEPTOR BINDING ASSAY; RECEPTOR BLOCKING; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL LINE; CELL MOTION; CHEMISTRY; CHEMOTAXIS; CYTOLOGY; MACROPHAGE; METABOLISM; MOLECULAR GENETICS; MONOCYTE; PATHOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MOVEMENT; CHEMOTAXIS; CYTOKINES; ENZYME ACTIVATION; HUMANS; INFLAMMATION; LIGANDS; MACROPHAGES; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MONOCYTES; PHAGOCYTOSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, FORMYL PEPTIDE; UP-REGULATION;

EID: 84941139515     PISSN: 16727681     EISSN: 20420226     Source Type: Journal    
DOI: 10.1038/cmi.2014.61     Document Type: Article

References (39)

1. Bezbradica JS, Medzhitov R. Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol 2009; 10: 333-339.
2. Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 2008; 8: 279-289.
3. Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 2014; 40: 274-288.
4. Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TB et al. Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. Cell Host Microbe 2014; 15: 494-505.
5. Munder M, Mallo M, Eichmann K, Modolell M. Murine macrophages secrete interferongammaupon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J Exp Med 1998; 187: 2103-2108.
6. Rothfuchs AG, Gigliotti D, Palmblad K, Andersson U, Wigzell H, Rottenberg ME. IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 2001; 167: 6453-6461.
7. Le Y, Murphy PM, Wang JM. Formyl-peptide receptors revisited. Trends Immunol 2002; 23: 541-548.
8. Liu M, Chen K, Yoshimura T, Liu Y, Gong W, Wang A et al. Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes. Sci Rep 2012; 2: 786.
9. Leoni G, Alam A, Neumann PA, Lambeth JD, Cheng G, McCoy J et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 2013; 123: 443-454.
10. Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev 2013; 65: 967-986.
11. Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M et al. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev 2009; 61: 119-161.
12. Galluzzi L, Kepp O, Kroemer G. Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol 2012; 13: 780-788.
13. Liu M, Zhao J, Chen K, Bian X, Wang C, Shi Y et al. G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma. Int Immunopharmacol 2012; 14: 283-288.
14. Brenner C, Galluzzi L, Kepp O, Kroemer G. Decoding cell death signals in liver inflammation. J Hepatol 2013; 59: 583-594.
15. Tom TY, Emtage P, Funk WD, Hu T, Arterburn M, Park EE et al. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Genomics 2004; 83: 727-734.
16. Guo X, Zhang Y, Wang P, Li T, Fu W, Mo X et al. VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells. Cell Immunol 2012; 278: 136-142.
17. Pei X, Sun Q, Zhang Y, Wang P, Peng X, Guo C et al. PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. J Immunol 2014; 192: 1878-1886.
18. Locati M, Mantovani A, Sica A. Macrophage activation and polarization as an adaptive component of innate immunity. Adv Immunol 2013; 120: 163-184.
19. Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 2011; 12: 1035-1044.
20. Flannagan RS, Jaumouille V, Grinstein S. The cell biology of phagocytosis. Annu Rev Pathol 2012; 7: 61-98.
21. Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R et al. Inhibitor hijacking of Akt activation. Nat Chem Biol 2009; 5: 484-493.
22. Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest SJ, Loretz C et al. Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages. PLoS One 2012; 7: e50195.
23. Yousefi S, Cooper PR, Potter SL, Mueck B, Jarai G. Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes. J Leukoc Biol 2001; 69: 1045-1052.
24. Stenfeldt AL, Karlsson J, Wenneras C, Bylund J, Fu H, Dahlgren C. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 2007; 30: 224-229.
25. Partida-Sanchez S, Iribarren P, Moreno-Garcia ME, Gao JL, Murphy PM, Oppenheimer N et al. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose. J Immunol 2004; 172: 1896-906.
26. John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M et al. Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. FASEB J 2007; 21: 1037-1046.
27. Fay SP, Posner RG, Swann WN, Sklar LA. Real-time analysis of the assembly of ligand, receptor, and G protein by quantitative fluorescence flow cytometry. Biochemistry 1991; 30: 5066-5075.
28. Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ et al. Endogenous lipid-and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med 2002; 8: 1296-1302.
29. Hauser CJ, Sursal T, Rodriguez EK, Appleton PT, Zhang Q, Itagaki K. Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase. J Orthop Trauma 2010; 24: 534-538.
30. Raoof M, Zhang Q, Itagaki K, Hauser CJ. Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1. J Trauma 2010; 68: 1328-1332, 1332-1334.
31. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104-107.
32. Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U. An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J Immunol 2004; 172: 7669-7676.
33. Schepetkin IA, Khlebnikov AI, Giovannoni MP, Kirpotina LN, Cilibrizzi A, Quinn MT. Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition. Curr Med Chem 2014; 21: 1478-1504.
34. Molloy MJ, Grainger JR, Bouladoux N, Hand TW, Koo LY, Naik S et al. Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis. Cell Host Microbe 2013; 14: 318-328.
35. Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel alarmin? PLoS One 2008; 3: e3331.
36. Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR et al. Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc Natl Acad Sci USA 2010; 107: 2574-2579.
37. Barbier M, Faille D, Loriod B, Textoris J, Camus C, Puthier D et al. Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria. PLoS One 2011; 6: e19651.
38. DelfiniMC, Mantilleri A, Gaillard S, Hao J, Reynders A,Malapert P et al. TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity inmice. Cell Rep 2013; 5: 378-388.
39. Becker EL, Forouhar FA, Grunnet ML, Boulay F, Tardif M, Bormann BJ et al. Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues, and cells. Cell Tissue Res 1998; 292: 129-135.