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Volumn 16, Issue 10, 2015, Pages

Management of Dermatologic Complications of Lung Cancer Therapies

Author keywords

Anaplastic kinase lymphoma inhibitor; BRAF inhibitor; Checkpoint inhibitor; Epidermal growth factor receptor inhibitor; Hair; Immunotherapy; Lung cancer; Nails; Oncodermatology; Papulopustular eruption; Paronychia; PD 1; Photosensitivity; Programmed cell death protein 1; Pruritus; Pyogenic granuloma; Rash; Skin toxicity; Vascular endothelial growth factor inhibitor; Xerosis

Indexed keywords

AFATINIB; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; B RAF KINASE INHIBITOR; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; CORTICOSTEROID; DOCETAXEL; DOXYCYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ETOPOSIDE; GEMCITABINE; IRINOTECAN; KERATOLYTIC AGENT; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; NAVELBINE; NINTEDANIB; NIVOLUMAB; PACLITAXEL; PEMETREXED; PLACEBO; PSEUDOMONIC ACID; RADIOPROTECTIVE AGENT; RAMUCIRUMAB; TAZAROTENE; TETRACYCLINE; TOPOTECAN; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 84941111889     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-015-0368-y     Document Type: Review
Times cited : (14)

References (96)
  • 1
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • PID: 24846037, This study showed that the majority of lung adenocarcinomas have an identifiable oncogenic driver and that matching targeted therapies to these drivers allowed individuals to live longe
    • Kris MG, Johnson B, Berry L, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014;311(19):1998–2006. This study showed that the majority of lung adenocarcinomas have an identifiable oncogenic driver and that matching targeted therapies to these drivers allowed individuals to live longer.
    • (2014) JAMA , vol.311 , Issue.19 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.2    Berry, L.3
  • 2
    • 84906544828 scopus 로고    scopus 로고
    • Dermatologic adverse events to chemotherapeutic agents, part 1: cytotoxics, epidermal growth factor receptors, multikinase inhibitors, and proteasome inhibitors
    • PID: 2503725
    • Kyllo RL, Anadkat MJ. Dermatologic adverse events to chemotherapeutic agents, part 1: cytotoxics, epidermal growth factor receptors, multikinase inhibitors, and proteasome inhibitors. Semin Cutan Med Surg. 2014;33(1):28–39.
    • (2014) Semin Cutan Med Surg , vol.33 , Issue.1 , pp. 28-39
    • Kyllo, R.L.1    Anadkat, M.J.2
  • 3
    • 84880865947 scopus 로고    scopus 로고
    • Impact of dermatologic adverse events on quality of life in 283 cancer patients: a questionnaire study in a dermatology referral clinic
    • PID: 23625802, Patient quality-of-life was noted to be negatively affected by the skin toxicities associated with chemotherapy. Quality-of-life scores were lower for patients on targeted therapy as compared to conventional therap
    • Rosen AC, Case EC, Dusza SW, et al. Impact of dermatologic adverse events on quality of life in 283 cancer patients: a questionnaire study in a dermatology referral clinic. Am J Clin Dermatol. 2013;14(4):327–33. Patient quality-of-life was noted to be negatively affected by the skin toxicities associated with chemotherapy. Quality-of-life scores were lower for patients on targeted therapy as compared to conventional therapy.
    • (2013) Am J Clin Dermatol , vol.14 , Issue.4 , pp. 327-333
    • Rosen, A.C.1    Case, E.C.2    Dusza, S.W.3
  • 4
    • 85044292244 scopus 로고    scopus 로고
    • Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: part II. Targeted therapy
    • Reyes-Habito CM, Roh E
    • Reyes-Habito CM, Roh EK. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: part II. Targeted therapy. J Am Acad Dermatol. 2014;71(2):217.e1–217.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.2 , pp. 1-217
  • 5
    • 77957927866 scopus 로고    scopus 로고
    • Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review
    • Makrilia N, Syrigou E, Kaklamanos I, et al. Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review. Met Based Drugs. 2010;2010.
    • (2010) Met Based Drugs , pp. 2010
    • Makrilia, N.1    Syrigou, E.2    Kaklamanos, I.3
  • 6
    • 84941118843 scopus 로고    scopus 로고
    • Litt JZ. Litt’s . Accessed 5 Apri
    • Litt JZ. Litt’s Drug Eruption and Reaction Database. http://www.drugeruptiondata.com.laneproxy.stanford.edu/. Accessed 5 April 2015.
    • (2015) Drug Eruption and Reaction Database
  • 8
    • 18844444218 scopus 로고    scopus 로고
    • Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel
    • Aydogan I, Kavak A, Parlak AH, et al. Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel. J Eur Acad Dermatol Venereol. 2005;19(3):345–7.
    • (2005) J Eur Acad Dermatol Venereol , vol.19 , Issue.3 , pp. 345-347
    • Aydogan, I.1    Kavak, A.2    Parlak, A.H.3
  • 9
    • 84941051709 scopus 로고    scopus 로고
    • Celgene
    • ABRAXANE. Celgene. Revised December 2014. http://www.abraxane.com/downloads/Abraxane_PrescribingInformation.pdf. Accessed 6 April 2015.
    • (2014) Revised
  • 10
    • 84937695885 scopus 로고    scopus 로고
    • Molecular epidemiology of lung cancer and geographic variations with special reference to EGFR mutations
    • Mitsudomi T. Molecular epidemiology of lung cancer and geographic variations with special reference to EGFR mutations. Transl Lung Cancer Res. 2014;3(4):205–11.
    • (2014) Transl Lung Cancer Res , vol.3 , Issue.4 , pp. 205-211
    • Mitsudomi, T.1
  • 11
    • 84941034972 scopus 로고    scopus 로고
    • Updated May 15 . Accessed 1 April 201
    • U.S. Food and Drug Administration. Erlotinib. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm352317.htm. Updated May 15 2013. Accessed 1 April 2015.
    • (2013) Erlotinib
  • 12
    • 84884614710 scopus 로고    scopus 로고
    • Updated July 12. Accessed 1 April 201
    • U.S. Food and Drug Administration. Afatinib. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm360574.htm. Updated July 12 2013. Accessed 1 April 2015
    • (2013) Afatinib
  • 13
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet. 2009;373(9674):1525–31.
    • (2009) Lancet , vol.373 , Issue.9674 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 14
    • 84906911022 scopus 로고    scopus 로고
    • Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations
    • Janjigian YY, Smit EF, Groen HJ, et al. Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations. Cancer Discov. 2014;4(9):1036–45.
    • (2014) Cancer Discov , vol.4 , Issue.9 , pp. 1036-1045
    • Janjigian, Y.Y.1    Smit, E.F.2    Groen, H.J.3
  • 15
    • 84911488148 scopus 로고    scopus 로고
    • A randomized, multicenter, open-label, phase III study of gemcitabine-cisplatin (GC) chemotherapy plus necitumumab (IMC-11F8/LY3012211) versus GC alone in the first-line treatment of patients (pts) with stage IV squamous non-small cell lung cancer (sq-NSCLC). 2014 ASCO Annual Meeting
    • Thatcher N, Hirsch FR, Szczesna A, et al. A randomized, multicenter, open-label, phase III study of gemcitabine-cisplatin (GC) chemotherapy plus necitumumab (IMC-11F8/LY3012211) versus GC alone in the first-line treatment of patients (pts) with stage IV squamous non-small cell lung cancer (sq-NSCLC). 2014 ASCO Annual Meeting. J Clin Oncol. 2014;32:5s (suppl; abstr 8008^).
    • (2014) J Clin Oncol , vol.5s , pp. 32
    • Thatcher, N.1    Hirsch, F.R.2    Szczesna, A.3
  • 16
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture ME. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer. 2006;6(10):803–12.
    • (2006) Nat Rev Cancer , vol.6 , Issue.10 , pp. 803-812
    • Lacouture, M.E.1
  • 17
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361(10):958–67.
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 18
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012;13(5):528–38.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 19
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
    • Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012;13(5):539–48.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 539-548
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 20
    • 84921892043 scopus 로고    scopus 로고
    • Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials
    • Yang JC, Wu YL, Schuler M, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol. 2015;16(2):141–51.
    • (2015) Lancet Oncol , vol.16 , Issue.2 , pp. 141-151
    • Yang, J.C.1    Wu, Y.L.2    Schuler, M.3
  • 21
    • 84928746232 scopus 로고    scopus 로고
    • Rociletinib in EGFR-mutated non-small-cell lung cancer
    • Sequist LV, Soria JC, Goldman JW, et al. Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2015;372(18):1700–9.
    • (2015) N Engl J Med , vol.372 , Issue.18 , pp. 1700-1709
    • Sequist, L.V.1    Soria, J.C.2    Goldman, J.W.3
  • 22
    • 84928739294 scopus 로고    scopus 로고
    • AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
    • Janne PA, Yang JC, Kim DW, et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med. 2015;372(18):1689–99.
    • (2015) N Engl J Med , vol.372 , Issue.18 , pp. 1689-1699
    • Janne, P.A.1    Yang, J.C.2    Kim, D.W.3
  • 24
    • 84984568870 scopus 로고    scopus 로고
    • Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities
    • Lacouture ME, Anadkat MJ, Bensadoun RJ, et al. Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. Support Care Cancer. 2011;19(8):1079–95.
    • (2011) Support Care Cancer , vol.19 , Issue.8 , pp. 1079-1095
    • Lacouture, M.E.1    Anadkat, M.J.2    Bensadoun, R.J.3
  • 25
    • 16644369733 scopus 로고    scopus 로고
    • Practical management of patients with non-small-cell lung cancer treated with gefitinib
    • Shah NT, Kris MG, Pao W, et al. Practical management of patients with non-small-cell lung cancer treated with gefitinib. J Clin Oncol. 2005;23(1):165–74.
    • (2005) J Clin Oncol , vol.23 , Issue.1 , pp. 165-174
    • Shah, N.T.1    Kris, M.G.2    Pao, W.3
  • 26
    • 84922176642 scopus 로고    scopus 로고
    • Changes in sebum levels and the development of acneiform rash in patients with non-small cell lung cancer after treatment with EGFR inhibitors
    • Nakahara T, Moroi Y, Takayama K, et al. Changes in sebum levels and the development of acneiform rash in patients with non-small cell lung cancer after treatment with EGFR inhibitors. Onco Targets Ther. 2015;8:259–63.
    • (2015) Onco Targets Ther , vol.8 , pp. 259-263
    • Nakahara, T.1    Moroi, Y.2    Takayama, K.3
  • 27
    • 84860287213 scopus 로고    scopus 로고
    • Folliculitis induced by EGFR inhibitors, preventive and curative efficacy of tetracyclines in the management and incidence rates according to the type of EGFR inhibitor administered: a systematic literature review
    • Bachet JB, Peuvrel L, Bachmeyer C, et al. . A thorough literature review investigating the use of tetracyclines for prophylactic and curative treatment of EGFR inhibitor papulopustular eruption. This study concluded that prophylactic tetracycline therapy should be routinely prescribed to all patient
    • Bachet JB, Peuvrel L, Bachmeyer C, et al. Folliculitis induced by EGFR inhibitors, preventive and curative efficacy of tetracyclines in the management and incidence rates according to the type of EGFR inhibitor administered: a systematic literature review. Oncologist. 2012;17(4):555–68. A thorough literature review investigating the use of tetracyclines for prophylactic and curative treatment of EGFR inhibitor papulopustular eruption. This study concluded that prophylactic tetracycline therapy should be routinely prescribed to all patients.
    • (2012) Oncologist , vol.17 , pp. 68-555
  • 28
    • 77950495095 scopus 로고    scopus 로고
    • Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer
    • Lacouture ME, Mitchel EP, Piperdi B, et al. Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol. 2010;28(8):1351–7.
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1351-1357
    • Lacouture, M.E.1    Mitchel, E.P.2    Piperdi, B.3
  • 29
    • 50249101750 scopus 로고    scopus 로고
    • Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB)
    • Jatoi A, Rowland K, Sloan JA, et al. Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB). Cancer. 2008;113(4):847–53.
    • (2008) Cancer , vol.113 , Issue.4 , pp. 847-853
    • Jatoi, A.1    Rowland, K.2    Sloan, J.A.3
  • 30
    • 78049394045 scopus 로고    scopus 로고
    • CYTAR: a randomized clinical trial evaluating the preventive effect of doxycycline on erlotinib-induced folliculitis in non-small cell lung cancer patients. 2010 ASCO Annual Meeting
    • Deplanque G, Chavaillon J, Vergnenegre A, et al. CYTAR: a randomized clinical trial evaluating the preventive effect of doxycycline on erlotinib-induced folliculitis in non-small cell lung cancer patients. 2010 ASCO Annual Meeting. J Clin Oncol. 2010;28:15s (suppl; abstr 9019).
    • (2010) J Clin Oncol , vol.15s , pp. 28
    • Deplanque, G.1    Chavaillon, J.2    Vergnenegre, A.3
  • 31
    • 36849093857 scopus 로고    scopus 로고
    • Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption
    • Scope A, Agero AL, Dusza SW, et al. Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption. J Clin Oncol. 2007;25(34):5390–6.
    • (2007) J Clin Oncol , vol.25 , Issue.34 , pp. 5390-5396
    • Scope, A.1    Agero, A.L.2    Dusza, S.W.3
  • 32
    • 84873870877 scopus 로고    scopus 로고
    • Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis
    • Liu H, Wu Y, Lv TF, et al. . A review of clinic trials concluding that patients who developed a rash during EGFR inhibitor treatment had longer progression-free survival and overall survival than the control grou
    • Liu H, Wu Y, Lv TF, et al. Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis. PLoS One. 2013;8(1):e55128. A review of clinic trials concluding that patients who developed a rash during EGFR inhibitor treatment had longer progression-free survival and overall survival than the control group.
    • (2013) PLoS One , vol.8 , Issue.1 , pp. 55128
  • 33
    • 84941052594 scopus 로고    scopus 로고
    • Pan-Canadian rash trial with EGFR inhibitors. 2014 ASCO Annual Meeting
    • Melosky BL, Anderson H, Burkes RL. Pan-Canadian rash trial with EGFR inhibitors. 2014 ASCO Annual Meeting. J Clin Oncol. 2014;32:5s (suppl; abstr 8013).
    • (2014) J Clin Oncol , vol.5s , pp. 32
  • 34
    • 84922516101 scopus 로고    scopus 로고
    • Cutaneous adverse effects of targeted therapies
    • Macdonald JB, Macdonald B, Golitz LE, et al. Cutaneous adverse effects of targeted therapies. J Am Acad Dermatol. 2015;72(2):203–18.
    • (2015) J Am Acad Dermatol , vol.72 , Issue.2 , pp. 203-218
    • Macdonald, J.B.1    Macdonald, B.2    Golitz, L.E.3
  • 35
    • 84879347673 scopus 로고    scopus 로고
    • Dermatologic adverse events associated with afatinib: an oral ErbB family blocker
    • Lacouture ME, Schadendorf D, Chu CY, et al. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):721–8.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 721-728
    • Lacouture, M.E.1    Schadendorf, D.2    Chu, C.Y.3
  • 36
    • 84884294797 scopus 로고    scopus 로고
    • Isotretinoin for high-grade or refractory epidermal growth factor receptor inhibitor-related acneiform papulopustular eruptions
    • Chiang HC, Anadkat MJ. Isotretinoin for high-grade or refractory epidermal growth factor receptor inhibitor-related acneiform papulopustular eruptions. J Am Acad Dermatol. 2013;69(4):657–8.
    • (2013) J Am Acad Dermatol , vol.69 , Issue.4 , pp. 657-658
    • Chiang, H.C.1    Anadkat, M.J.2
  • 38
    • 84895074194 scopus 로고    scopus 로고
    • Pilot clinical trial on the efficacy of prophylactic use of vitamin K1-based cream (Vigorskin) to prevent cetuximab-induced skin rash in patients with metastatic colorectal cancer
    • Pinta F, Ponzetti A, Spadi R, et al.. This trial studied the use of topical vitamin K1 as preventive treatment to avoid cetuximab-induced papulopustular rash in colorectal cancer patients. Patients were noted to have a lower incidence of grades 2–3 rashes as compared to the literatur
    • Pinta F, Ponzetti A, Spadi R, et al. Pilot clinical trial on the efficacy of prophylactic use of vitamin K1-based cream (Vigorskin) to prevent cetuximab-induced skin rash in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2014;13(1):62–7. This trial studied the use of topical vitamin K1 as preventive treatment to avoid cetuximab-induced papulopustular rash in colorectal cancer patients. Patients were noted to have a lower incidence of grades 2–3 rashes as compared to the literature.
    • (2014) Clin Colorectal Cancer , vol.13 , Issue.1 , pp. 7-62
  • 39
    • 77957805725 scopus 로고    scopus 로고
    • Staphylococcus coagulase-positive skin inflammation associated with epidermal growth factor receptor-targeted therapy: an early and a late phase of papulopustular eruptions
    • Amitay-Laish I, David M, Stemmer SM. Staphylococcus coagulase-positive skin inflammation associated with epidermal growth factor receptor-targeted therapy: an early and a late phase of papulopustular eruptions. Oncologist. 2010;15(9):1002–8.
    • (2010) Oncologist , vol.15 , Issue.9 , pp. 1002-1008
    • Amitay-Laish, I.1    David, M.2    Stemmer, S.M.3
  • 40
    • 74049120784 scopus 로고    scopus 로고
    • Dermatologic infections in cancer patients treated with epidermal growth factor receptor inhibitor therapy
    • Eilers RE, Gandhi M, Patel JD, et al. Dermatologic infections in cancer patients treated with epidermal growth factor receptor inhibitor therapy. J Natl Cancer Inst. 2010;102(1):47–53.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.1 , pp. 47-53
    • Eilers, R.E.1    Gandhi, M.2    Patel, J.D.3
  • 41
    • 84884209653 scopus 로고    scopus 로고
    • Dermatologic adverse events to targeted therapies in lower GI cancers: clinical presentation and management
    • Belum VR, Cercek A, Sanz-Motilva V, et al. Dermatologic adverse events to targeted therapies in lower GI cancers: clinical presentation and management. Curr Treat Options Oncol. 2013;14(3):389–404.
    • (2013) Curr Treat Options Oncol , vol.14 , Issue.3 , pp. 389-404
    • Belum, V.R.1    Cercek, A.2    Sanz-Motilva, V.3
  • 42
    • 84858332195 scopus 로고    scopus 로고
    • MRSA eradication in dermatologic outpatients—theory and practice
    • Meyer V, Kerk N, Mellmann A, et al. MRSA eradication in dermatologic outpatients—theory and practice. J Dtsch Dermatol Ges. 2012;10(3):186–96.
    • (2012) J Dtsch Dermatol Ges , vol.10 , Issue.3 , pp. 186-196
    • Meyer, V.1    Kerk, N.2    Mellmann, A.3
  • 43
    • 77957818555 scopus 로고    scopus 로고
    • Does sunscreen prevent epidermal growth factor receptor (EGFR) inhibitor-induced rash? Results of a placebo-controlled trial from the North Central Cancer Treatment Group (N05C4)
    • Jatoi A, Thrower A, Sloan JA, et al. Does sunscreen prevent epidermal growth factor receptor (EGFR) inhibitor-induced rash? Results of a placebo-controlled trial from the North Central Cancer Treatment Group (N05C4). Oncologist. 2010;15(9):1016–22.
    • (2010) Oncologist , vol.15 , Issue.9 , pp. 1016-1022
    • Jatoi, A.1    Thrower, A.2    Sloan, J.A.3
  • 44
    • 84929516117 scopus 로고    scopus 로고
    • Valentine J, Belum VR, Duran J, et al. Incidence and risk of xerosis with targeted anticancer therapies. . . Xerosis is an important side effect of targeted therapy that can significantly reduce quality of life and interrupt treatmen
    • Valentine J, Belum VR, Duran J, et al. Incidence and risk of xerosis with targeted anticancer therapies. J Am Acad Dermatol. 2015;72(4):656–67. Xerosis is an important side effect of targeted therapy that can significantly reduce quality of life and interrupt treatment.
    • (2015) J Am Acad Dermatol , vol.72 , Issue.4 , pp. 67-656
  • 45
    • 33846245846 scopus 로고    scopus 로고
    • Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management
    • Hu JC, Sadeghi P, Pinter-Brown LC, et al. Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management. J Am Acad Dermatol. 2007;56(2):317–26.
    • (2007) J Am Acad Dermatol , vol.56 , Issue.2 , pp. 317-326
    • Hu, J.C.1    Sadeghi, P.2    Pinter-Brown, L.C.3
  • 46
    • 0035724536 scopus 로고    scopus 로고
    • Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
    • Busam KJ, Capodieci P, Motzer R, et al. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol. 2001;144(6):1169–76.
    • (2001) Br J Dermatol , vol.144 , Issue.6 , pp. 1169-1176
    • Busam, K.J.1    Capodieci, P.2    Motzer, R.3
  • 47
    • 84885623104 scopus 로고    scopus 로고
    • Pruritus in patients treated with targeted cancer therapies: systematic review and meta-analysis
    • Ensslin CJ, Rosen AC, Wu S, et al. . Pruritus is a common and important side effect of anticancer therapy that can significantly reduce quality of life and interrupt treatmen
    • Ensslin CJ, Rosen AC, Wu S, et al. Pruritus in patients treated with targeted cancer therapies: systematic review and meta-analysis. J Am Acad Dermatol. 2013;69(5):708–20. Pruritus is a common and important side effect of anticancer therapy that can significantly reduce quality of life and interrupt treatment.
    • (2013) J Am Acad Dermatol , vol.69 , Issue.5 , pp. 20-708
  • 48
    • 84866904056 scopus 로고    scopus 로고
    • Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study
    • Santini D, Vincenzi B, Guida FM, et al. .. Prospective study of aprepitant in treating pruritus induced by biological cancer treatment in 45 patients with metastatic solid tumors. Aprepitant effectively decreased severe pruritus with no reported adverse event
    • Santini D, Vincenzi B, Guida FM, et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. Lancet Oncol. 2012;13(10):1020–4. Prospective study of aprepitant in treating pruritus induced by biological cancer treatment in 45 patients with metastatic solid tumors. Aprepitant effectively decreased severe pruritus with no reported adverse events.
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 4
  • 49
    • 79954602846 scopus 로고    scopus 로고
    • Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib
    • Hepper DM, Wu P, Anadkat MJ. Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib. J Am Acad Dermatol. 2011;64(5):996–8.
    • (2011) J Am Acad Dermatol , vol.64 , Issue.5 , pp. 996-998
    • Hepper, D.M.1    Wu, P.2    Anadkat, M.J.3
  • 51
    • 84867745226 scopus 로고    scopus 로고
    • Erosive pustular dermatosis of the scalp-like eruption due to gefitinib: case report and review of the literature of alopecia associated with EGFR inhibitors
    • Toda N, Fujimoto N, Kato T, et al. Erosive pustular dermatosis of the scalp-like eruption due to gefitinib: case report and review of the literature of alopecia associated with EGFR inhibitors. Dermatology. 2012;225(1):18–21.
    • (2012) Dermatology , vol.225 , Issue.1 , pp. 18-21
    • Toda, N.1    Fujimoto, N.2    Kato, T.3
  • 52
    • 84941116772 scopus 로고    scopus 로고
    • The spectrum of oculocutaneous disease
    • Day A, Abramson AK, Patel M, et al. :82
    • Day A, Abramson AK, Patel M, et al. The spectrum of oculocutaneous disease. J Am Acad Dermatol. 2014;70(5):821.e1–19.
    • (2014) J Am Acad Dermatol , vol.70 , Issue.5 , pp. 1-19
  • 53
    • 80052761828 scopus 로고    scopus 로고
    • Successful treatment of epidermal growth factor receptor inhibitor-induced periungual inflammation with adapalene
    • Hachisuka J, Doi K, Moroi Y, et al. Successful treatment of epidermal growth factor receptor inhibitor-induced periungual inflammation with adapalene. Case Rep Dermatol. 2011;3(2):130–6.
    • (2011) Case Rep Dermatol , vol.3 , Issue.2 , pp. 130-136
    • Hachisuka, J.1    Doi, K.2    Moroi, Y.3
  • 54
    • 85015497707 scopus 로고    scopus 로고
    • Clinical advances in the development of novel VEGFR2 inhibitors
    • Fontanella C, Ongaro E, Bolzonello S, et al. Clinical advances in the development of novel VEGFR2 inhibitors. Ann Transl Med. 2014;2(12):123.
    • (2014) Ann Transl Med , vol.2 , Issue.12 , pp. 123
    • Fontanella, C.1    Ongaro, E.2    Bolzonello, S.3
  • 55
    • 84871469122 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. . Updated December 7 2014. Accessed 20 April 201
    • U.S. Food and Drug Administration. Bevacizumab. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm279177.htm. Updated December 7 2014. Accessed 20 April 2015.
    • (2014) Bevacizumab
  • 56
    • 84930542973 scopus 로고    scopus 로고
    • Nintedanib: a review of its use as second-line treatment in adults with advanced non-small cell lung cancer of adenocarcinoma histology
    • Dhillon S. Nintedanib: a review of its use as second-line treatment in adults with advanced non-small cell lung cancer of adenocarcinoma histology. Target Oncol. 2015;10(2):303–10.
    • (2015) Target Oncol , vol.10 , Issue.2 , pp. 303-310
    • Dhillon, S.1
  • 57
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355(24):2542–50.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 58
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
    • Garon EB, Ciuleanu TE, Arrieta O, et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet. 2014;384(9944):665–73.
    • (2014) Lancet , vol.384 , Issue.9944 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3
  • 59
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial
    • Reck M, Kaiser R, Mellemgaard A, et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol. 2014;15(2):143–55.
    • (2014) Lancet Oncol , vol.15 , Issue.2 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 60
    • 42049112958 scopus 로고    scopus 로고
    • Correlation between rash and a positive drug response associated with bevacizumab in a patient with advanced colorectal cancer
    • Saif MW, Longo WL, Israel G. Correlation between rash and a positive drug response associated with bevacizumab in a patient with advanced colorectal cancer. Clin Colorectal Cancer. 2008;7(2):144–8.
    • (2008) Clin Colorectal Cancer , vol.7 , Issue.2 , pp. 144-148
    • Saif, M.W.1    Longo, W.L.2    Israel, G.3
  • 61
    • 33750558062 scopus 로고    scopus 로고
    • Skin rash secondary to bevacizumab in a patient with advanced colorectal cancer and relation to response
    • Gotli V, Khaled S, Lapko I, et al. Skin rash secondary to bevacizumab in a patient with advanced colorectal cancer and relation to response. Anticancer Drugs. 2006;17(10):1227–9.
    • (2006) Anticancer Drugs , vol.17 , Issue.10 , pp. 1227-1229
    • Gotli, V.1    Khaled, S.2    Lapko, I.3
  • 63
    • 84875064064 scopus 로고    scopus 로고
    • Acute and severe acne in a patient treated with bevacizumab
    • Molina-Ruiz AM, Domine M, Requena L. Acute and severe acne in a patient treated with bevacizumab. Int J Dermatol. 2013;52:486–90.
    • (2013) Int J Dermatol , vol.52 , pp. 486-490
    • Molina-Ruiz, A.M.1    Domine, M.2    Requena, L.3
  • 64
    • 84881669674 scopus 로고    scopus 로고
    • The contribution of targeted therapy to the neoadjuvant chemoradiation of rectal cancer
    • Torino F, Sarmiento R, Gasparini G. The contribution of targeted therapy to the neoadjuvant chemoradiation of rectal cancer. Crit Rev Oncol Hematol. 2013;87(3):283–305.
    • (2013) Crit Rev Oncol Hematol , vol.87 , Issue.3 , pp. 283-305
    • Torino, F.1    Sarmiento, R.2    Gasparini, G.3
  • 65
    • 79957925927 scopus 로고    scopus 로고
    • Inc, Revise
    • AVASTIN (Bevacizumab) [package insert]. Genentech, Inc. Revised May 2009. http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/125085s0169lbl.pdf. Accessed 20 April 2015.
    • (2009) Genentech
  • 66
    • 80054748832 scopus 로고    scopus 로고
    • Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy
    • Fourcade S, Gaudy-Marqueste C, Tasei AM, et al. Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy. Arch Dermatol. 2011;147:1227–8.
    • (2011) Arch Dermatol , vol.147 , pp. 1227-1228
    • Fourcade, S.1    Gaudy-Marqueste, C.2    Tasei, A.M.3
  • 67
    • 84858741266 scopus 로고    scopus 로고
    • Ulceration of abdominal striae distensae (stretch marks) in a cancer patient
    • Dosal J, Handler MZ, Ricotti CA, et al. Ulceration of abdominal striae distensae (stretch marks) in a cancer patient. Arch Dermatol. 2012;148:385–90.
    • (2012) Arch Dermatol , vol.148 , pp. 385-390
    • Dosal, J.1    Handler, M.Z.2    Ricotti, C.A.3
  • 68
    • 84916917512 scopus 로고    scopus 로고
    • Ulcerations within striae distensae associated with bevacizumab therapy
    • Farber SA, Samimi S, Rosenbach M. Case report describing the development of ulcerations within striae secondary to bevacizumab therapy, reviewing potential pathophysiology and recommending treatment
    • Farber SA, Samimi S, Rosenbach M. Ulcerations within striae distensae associated with bevacizumab therapy. J Am Acad Dermatol. 2015;72:e33–5. Case report describing the development of ulcerations within striae secondary to bevacizumab therapy, reviewing potential pathophysiology and recommending treatment.
    • (2015) J Am Acad Dermatol , vol.72 , pp. 5-33
  • 69
    • 78651276029 scopus 로고    scopus 로고
    • Ulceration of striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy
    • Peters KB, Coyle TE, Vredenburgh JJ, et al. Ulceration of striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy. J Neurooncol. 2011;101:155–9.
    • (2011) J Neurooncol , vol.101 , pp. 155-159
    • Peters, K.B.1    Coyle, T.E.2    Vredenburgh, J.J.3
  • 70
    • 84924362694 scopus 로고    scopus 로고
    • Clinicopathological characteristics of patients with non-small-cell lung cancer who harbor EML4-ALK fusion gene: a meta-analysis
    • Zhao F, Xu M, Lei H, et al. (2):e011733
    • Zhao F, Xu M, Lei H, et al. Clinicopathological characteristics of patients with non-small-cell lung cancer who harbor EML4-ALK fusion gene: a meta-analysis. PLoS One. 2015;10(2):e0117333.
    • (2015) PLoS One , vol.10
  • 71
    • 65249095599 scopus 로고    scopus 로고
    • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • Wong DW, Leung EL, So KK, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. 2009;115(8):1723–33.
    • (2009) Cancer , vol.115 , Issue.8 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    So, K.K.3
  • 72
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385–94.
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 73
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • Shaw AT, Kim DW, Mehra R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014;370(13):1189–97.
    • (2014) N Engl J Med , vol.370 , Issue.13 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.W.2    Mehra, R.3
  • 74
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
    • Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol. 2012;13(10):1011–9.
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 75
    • 84941034020 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals
    • ZYKADIA (Ceritinib). Novartis Pharmaceuticals. Revised April 2014. http://www.pharma.us.novartis.com/product/pi/pdf/zykadia.pdf. Accessed 20 April 2015.
    • (2014) Revised
  • 76
    • 84908569219 scopus 로고    scopus 로고
    • Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study
    • Gadgeel SM, Gandhi L, Riely GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol. 2014;15(10):1119–28.
    • (2014) Lancet Oncol , vol.15 , Issue.10 , pp. 1119-1128
    • Gadgeel, S.M.1    Gandhi, L.2    Riely, G.J.3
  • 77
    • 84902457475 scopus 로고    scopus 로고
    • A severe photosensitivity dermatitis caused by crizotinib
    • Oser MG, Pasi AJ. A severe photosensitivity dermatitis caused by crizotinib. J Thorac Oncol. 2014;9(7):e51–3.
    • (2014) J Thorac Oncol , vol.9 , Issue.7 , pp. e51-e53
    • Oser, M.G.1    Pasi, A.J.2
  • 78
    • 84918804764 scopus 로고    scopus 로고
    • First-line crizotinib versus chemotherapy in ALK-positive lung cancer
    • Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–77.
    • (2014) N Engl J Med , vol.371 , Issue.23 , pp. 2167-2177
    • Solomon, B.J.1    Mok, T.2    Kim, D.W.3
  • 79
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol. 2011;29:2046–51.
    • (2011) J Clin Oncol , vol.29 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3
  • 80
    • 84906538234 scopus 로고    scopus 로고
    • BRAF inhibitors, MEK inhibitors, and ipilimumab
    • Choi JN. Dermatologic adverse events to chemotherapeutic agents, part 2: BRAF inhibitors, MEK inhibitors, and ipilimumab. Semin Cutan Med Surg. 2014;33(1):40–8
    • (2014) Semin Cutan Med Surg , vol.33 , Issue.1 , pp. 40-48
  • 81
    • 84941097635 scopus 로고    scopus 로고
    • Dabrafenib in patients with BRAF V600E-mutant advanced non-small cell lung cancer: a multicenter, open-label phase II trial (BRF113928). ESMO Congress. Abstract LBA38_PR
    • Planchard D, Kim TM, Mazieres J, et al. Dabrafenib in patients with BRAF V600E-mutant advanced non-small cell lung cancer: a multicenter, open-label phase II trial (BRF113928). ESMO Congress. Abstract LBA38_PR. Presented September 29, 2014.
    • (2014) Presented September , pp. 29
    • Planchard, D.1    Kim, T.M.2    Mazieres, J.3
  • 82
    • 84875037998 scopus 로고    scopus 로고
    • RASopathic skin eruptions during vemurafenib therapy
    • Rinderknecht JD, Goldinger SM, Rozati S, et al. RASopathic skin eruptions during vemurafenib therapy. PLoS One. 2013;8(3):e58721.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e58721
    • Rinderknecht, J.D.1    Goldinger, S.M.2    Rozati, S.3
  • 83
    • 84889064077 scopus 로고    scopus 로고
    • Systemic retinoids for the chemoprevention of cutaneous squamous cell carcinoma and verrucal keratosis in a cohort of patients on BRAF inhibitors
    • Anforth R, Blumetti TC, Clements A, et al. Systemic retinoids for the chemoprevention of cutaneous squamous cell carcinoma and verrucal keratosis in a cohort of patients on BRAF inhibitors. Br J Dermatol. 2013;169(6):1310–3.
    • (2013) Br J Dermatol , vol.169 , Issue.6 , pp. 1310-1313
    • Anforth, R.1    Blumetti, T.C.2    Clements, A.3
  • 84
    • 84856582443 scopus 로고    scopus 로고
    • Ultraviolet A and photosensitivity during vemurafenib therapy
    • Dummer R, Rinderknecht J, Goldinger SM. Ultraviolet A and photosensitivity during vemurafenib therapy. N Engl J Med. 2012;366(5):480–1.
    • (2012) N Engl J Med , vol.366 , Issue.5 , pp. 480-481
    • Dummer, R.1    Rinderknecht, J.2    Goldinger, S.M.3
  • 85
    • 84938083571 scopus 로고    scopus 로고
    • Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients
    • Hecht M, Zimmer L, Loquai C, et al. Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients. Ann Oncol. 2015;26(6):1238–44.
    • (2015) Ann Oncol , vol.26 , Issue.6 , pp. 1238-1244
    • Hecht, M.1    Zimmer, L.2    Loquai, C.3
  • 86
    • 84940439534 scopus 로고    scopus 로고
    • Erythema nodosum-like lesions during BRAF inhibitor therapy: report on 16 new cases and review of the literature
    • Mossner R, Zimmer L, Berking C, et al. Erythema nodosum-like lesions during BRAF inhibitor therapy: report on 16 new cases and review of the literature. J Eur Acad Dermatol Venerol. 2015.
    • (2015) J Eur Acad Dermatol Venerol
    • Mossner, R.1    Zimmer, L.2    Berking, C.3
  • 87
    • 84938207532 scopus 로고    scopus 로고
    • Comparative profile of cutaneous adverse events: BRAF/MEK inhibitor combination therapy versus BRAF monotherapy in melanoma
    • Sanlorenzo M, Choudhry A, Vujic I, et a
    • Sanlorenzo M, Choudhry A, Vujic I, et al. Comparative profile of cutaneous adverse events: BRAF/MEK inhibitor combination therapy versus BRAF monotherapy in melanoma. J Am Acad Dermatol. 2014;71(6):1102–1109.e1.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 1102-1109
  • 88
    • 84910115731 scopus 로고    scopus 로고
    • Involution of eruptive melanocytic nevi on combination BRAF and MEK inhibitor therapy
    • Chen FW, Tseng D, Reddy S, et al. Involution of eruptive melanocytic nevi on combination BRAF and MEK inhibitor therapy. JAMA Dermatol. 2014;150(11):1209–12.
    • (2014) JAMA Dermatol , vol.150 , Issue.11 , pp. 1209-1212
    • Chen, F.W.1    Tseng, D.2    Reddy, S.3
  • 89
    • 84941102850 scopus 로고    scopus 로고
    • Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538)
    • Grosso J, Horak CE, Inzunza D, et al. . 2013 ASCO Annual Meeting.. 2013;31(suppl):abstract 301
    • Grosso J, Horak CE, Inzunza D, et al. Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538). 2013 ASCO Annual Meeting. J Clin Oncol. 2013;31(suppl):abstract 3016.
    • (2013) J Clin Oncol
  • 90
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 91
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
    • Rizvi NA, Mazières J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16(3):257–65.
    • (2015) Lancet Oncol , vol.16 , Issue.3 , pp. 257-265
    • Rizvi, N.A.1    Mazières, J.2    Planchard, D.3
  • 92
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372(21):2018–28.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 93
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–65.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 94
    • 84907532904 scopus 로고    scopus 로고
    • A phase 1 study of MEDI4736, an anti-PD-L1 antibody, in patients with advanced solid tumors. 2014 ASCO Annual Meeting
    • Lutzky J, Antonia SJ, Blake-Haskins A. A phase 1 study of MEDI4736, an anti-PD-L1 antibody, in patients with advanced solid tumors. 2014 ASCO Annual Meeting. J Clin Oncol. 2014;32:5s (suppl; abstr 3001^).
    • (2014) J Clin Oncol , vol.5s , pp. 32
    • Lutzky, J.1    Antonia, S.J.2    Blake-Haskins, A.3
  • 95
    • 84907521154 scopus 로고    scopus 로고
    • Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody. 2014 ASCO Annual Meeting
    • Segal NH, Antonia SJ, Brahmer JR, et al. Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody. 2014 ASCO Annual Meeting. J Clin Oncol. 2014;32:5s (suppl; abstr 3002^).
    • (2014) J Clin Oncol , vol.5s , pp. 32
    • Segal, N.H.1    Antonia, S.J.2    Brahmer, J.R.3
  • 96
    • 84939470051 scopus 로고    scopus 로고
    • Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy
    • Joseph RW, Cappel M, Goedjen B. Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy. Cancer Immunol Res. 2015;3(1):18–22.
    • (2015) Cancer Immunol Res , vol.3 , Issue.1 , pp. 18-22
    • Joseph, R.W.1    Cappel, M.2    Goedjen, B.3


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