메뉴 건너뛰기




Volumn 72, Issue 4, 2015, Pages 656-667

Incidence and risk of xerosis with targeted anticancer therapies

Author keywords

CD20; CD52; dry skin; EGFR; HDAC; HER2; incidence; Key words Bcr Abl; MEK; mTOR; Raf; risk; VEGFR; xerosis

Indexed keywords

AFATINIB; ALEMTUZUMAB; ALITRETINOIN; ANASTROZOLE; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; BEXAROTENE; BORTEZOMIB; BOSUTINIB; BRENTUXIMAB VEDOTIN; CABOZANTINIB; CARFILZOMIB; CERITINIB; CETUXIMAB; CRIZOTINIB; DABRAFENIB; DACLIZUMAB; DASATINIB; DENILEUKIN DIFTITOX; DENOSUMAB; ERLOTINIB; EVEROLIMUS; EXEMESTANE; FULVESTRANT; GEFITINIB; IBRITUMOMAB TIUXETAN; IBRUTINIB; TRASTUZUMAB EMTANSINE; UNINDEXED DRUG; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; ENZYME INHIBITOR; HORMONE ANTAGONIST; MONOCLONAL ANTIBODY; TUMOR PROTEIN;

EID: 84929516117     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2014.12.010     Document Type: Article
Times cited : (36)

References (166)
  • 1
    • 1642442499 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors: A new prospective in the treatment of lung cancer
    • M. Tiseo, M. Loprevite, and A. Ardizzoni Epidermal growth factor receptor inhibitors: a new prospective in the treatment of lung cancer Curr Med Chem Anticancer Agents 4 2004 139 148
    • (2004) Curr Med Chem Anticancer Agents , vol.4 , pp. 139-148
    • Tiseo, M.1    Loprevite, M.2    Ardizzoni, A.3
  • 2
    • 84859241733 scopus 로고    scopus 로고
    • Advances in the understanding and treatment of colorectal cancer
    • K. Soreide, M. Berg, B.S. Skudal, and B.S. Nedreboe Advances in the understanding and treatment of colorectal cancer Discov Med 12 2011 393 404
    • (2011) Discov Med , vol.12 , pp. 393-404
    • Soreide, K.1    Berg, M.2    Skudal, B.S.3    Nedreboe, B.S.4
  • 3
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • N.E. Hynes, and H.A. Lane ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 5 2005 341 354
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 4
    • 77956131018 scopus 로고    scopus 로고
    • Dermatologic toxicities of targeted anticancer therapies
    • Y. Balagula, M.E. Lacouture, and J.A. Cotliar Dermatologic toxicities of targeted anticancer therapies J Support Oncol 8 2010 149 161
    • (2010) J Support Oncol , vol.8 , pp. 149-161
    • Balagula, Y.1    Lacouture, M.E.2    Cotliar, J.A.3
  • 5
    • 0036051312 scopus 로고    scopus 로고
    • Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor
    • R. Van Doorn, G. Kirtschig, E. Scheffer, T.J. Stoof, and G. Giaccone Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor Br J Dermatol 147 2002 598 601
    • (2002) Br J Dermatol , vol.147 , pp. 598-601
    • Van Doorn, R.1    Kirtschig, G.2    Scheffer, E.3    Stoof, T.J.4    Giaccone, G.5
  • 6
    • 40649091391 scopus 로고    scopus 로고
    • Chemotherapeutic agents and the skin: An update
    • N. Heidary, H. Naik, and S. Burgin Chemotherapeutic agents and the skin: an update J Am Acad Dermatol 58 2008 545 570
    • (2008) J Am Acad Dermatol , vol.58 , pp. 545-570
    • Heidary, N.1    Naik, H.2    Burgin, S.3
  • 7
    • 77956802819 scopus 로고    scopus 로고
    • Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life
    • A. Joshi, S. Ortiz, and J. Witherspoon Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life Cancer 116 2010 3916 3923
    • (2010) Cancer , vol.116 , pp. 3916-3923
    • Joshi, A.1    Ortiz, S.2    Witherspoon, J.3
  • 9
    • 33748466742 scopus 로고    scopus 로고
    • The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome
    • M.E. Lacouture, and S. Lai The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome Br J Dermatol 155 2006 852 854
    • (2006) Br J Dermatol , vol.155 , pp. 852-854
    • Lacouture, M.E.1    Lai, S.2
  • 10
    • 69149096621 scopus 로고    scopus 로고
    • Cutaneous side effects in patients on long-term treatment with epidermal growth factor receptor inhibitors
    • A. Osio, C. Mateus, and J.C. Soria Cutaneous side effects in patients on long-term treatment with epidermal growth factor receptor inhibitors Br J Dermatol 161 2009 515 521
    • (2009) Br J Dermatol , vol.161 , pp. 515-521
    • Osio, A.1    Mateus, C.2    Soria, J.C.3
  • 11
    • 84880865947 scopus 로고    scopus 로고
    • Impact of dermatologic adverse events on quality of life in 283 cancer patients: A questionnaire study in a dermatology referral clinic
    • A.C. Rosen, E.C. Case, and S.W. Dusza Impact of dermatologic adverse events on quality of life in 283 cancer patients: a questionnaire study in a dermatology referral clinic Am J Clin Dermatol 14 2013 327 333
    • (2013) Am J Clin Dermatol , vol.14 , pp. 327-333
    • Rosen, A.C.1    Case, E.C.2    Dusza, S.W.3
  • 12
    • 84885623104 scopus 로고    scopus 로고
    • Pruritus in patients treated with targeted cancer therapies: Systemic review and meta-analysis
    • C. Ensslin, A. Rosen, S. Wu, and M.E. Lacouture Pruritus in patients treated with targeted cancer therapies: systemic review and meta-analysis J Am Acad Dermatol 69 2013 708 720
    • (2013) J Am Acad Dermatol , vol.69 , pp. 708-720
    • Ensslin, C.1    Rosen, A.2    Wu, S.3    Lacouture, M.E.4
  • 13
    • 79951686643 scopus 로고    scopus 로고
    • Unanticipated toxicities from anticancer therapies: Survivors' perspectives
    • M. Gandhi, K. Oishi, B. Zubal, and M.E. Lacouture Unanticipated toxicities from anticancer therapies: survivors' perspectives Support Care Cancer 18 2010 1461 1468
    • (2010) Support Care Cancer , vol.18 , pp. 1461-1468
    • Gandhi, M.1    Oishi, K.2    Zubal, B.3    Lacouture, M.E.4
  • 14
    • 10744228140 scopus 로고    scopus 로고
    • CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment
    • A. Trotti, A.D. Colevas, and A. Setser CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 2003 176 181
    • (2003) Semin Radiat Oncol , vol.13 , pp. 176-181
    • Trotti, A.1    Colevas, A.D.2    Setser, A.3
  • 15
    • 84872679025 scopus 로고    scopus 로고
    • Grading of dermatologic adverse events of cancer treatments: The common terminology criteria for adverse events version 4.0
    • A.P. Chen, A. Setser, and M.J. Anadkat Grading of dermatologic adverse events of cancer treatments: the common terminology criteria for adverse events version 4.0 J Am Acad Dermatol 67 2012 1025 1039
    • (2012) J Am Acad Dermatol , vol.67 , pp. 1025-1039
    • Chen, A.P.1    Setser, A.2    Anadkat, M.J.3
  • 18
    • 0030693603 scopus 로고    scopus 로고
    • Quantitative synthesis in systematic reviews
    • J. Lau, J.P. Ioannidis, and C.H. Schmid Quantitative synthesis in systematic reviews Ann Intern Med 127 1997 820 826
    • (1997) Ann Intern Med , vol.127 , pp. 820-826
    • Lau, J.1    Ioannidis, J.P.2    Schmid, C.H.3
  • 19
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • L.V. Sequist, J.C. Yang, and N. Yamamoto Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations J Clin Oncol 3 2013 3327 3334
    • (2013) J Clin Oncol , vol.3 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 20
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • J.C. Yang, J.Y. Shih, and W.C. Su Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial Lancet Oncol 13 2012 539 548
    • (2012) Lancet Oncol , vol.13 , pp. 539-548
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 21
    • 72949118893 scopus 로고    scopus 로고
    • Alemtuzumab for relapsed and refractory erythrodermic cutaneous T-cell lymphoma: A single institution experience from the Robert H. Lurie Comprehensive Cancer Center
    • C. Querfeld, N. Mehta, and S.T. Rosen Alemtuzumab for relapsed and refractory erythrodermic cutaneous T-cell lymphoma: a single institution experience from the Robert H. Lurie Comprehensive Cancer Center Leuk Lymphoma 50 2009 1969 1976
    • (2009) Leuk Lymphoma , vol.50 , pp. 1969-1976
    • Querfeld, C.1    Mehta, N.2    Rosen, S.T.3
  • 22
    • 34548537574 scopus 로고    scopus 로고
    • A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
    • I.E. Smith, G. Walsh, and A. Skene A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer J Clin Oncol 25 2007 3816 3822
    • (2007) J Clin Oncol , vol.25 , pp. 3816-3822
    • Smith, I.E.1    Walsh, G.2    Skene, A.3
  • 23
    • 70349388719 scopus 로고    scopus 로고
    • Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
    • B.I. Rini, G. Wilding, and G. Hudes Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma J Clin Oncol 27 2009 4462 4468
    • (2009) J Clin Oncol , vol.27 , pp. 4462-4468
    • Rini, B.I.1    Wilding, G.2    Hudes, G.3
  • 24
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
    • O. Rixe, R.M. Bukowski, and M.D. Michaelson Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study Lancet Oncol 8 2007 975 984
    • (2007) Lancet Oncol , vol.8 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 25
    • 33750609546 scopus 로고    scopus 로고
    • Phase II trial of bexarotene capsules in patients with advanced non-small-cell lung cancer after failure of two or more previous therapies
    • R. Govindan, J. Crowley, and L. Schwartzberg Phase II trial of bexarotene capsules in patients with advanced non-small-cell lung cancer after failure of two or more previous therapies J Clin Oncol 24 2006 4848 4854
    • (2006) J Clin Oncol , vol.24 , pp. 4848-4854
    • Govindan, R.1    Crowley, J.2    Schwartzberg, L.3
  • 26
    • 3042823306 scopus 로고    scopus 로고
    • Comparison of selective retinoic acid receptor- and retinoic X receptor-mediated efficacy, tolerance, and survival in cutaneous t-cell lymphoma
    • C. Querfeld, S.T. Rosen, and J. Guitart Comparison of selective retinoic acid receptor- and retinoic X receptor-mediated efficacy, tolerance, and survival in cutaneous t-cell lymphoma J Am Acad Dermatol 51 2004 25 32
    • (2004) J Am Acad Dermatol , vol.51 , pp. 25-32
    • Querfeld, C.1    Rosen, S.T.2    Guitart, J.3
  • 27
    • 84890571003 scopus 로고    scopus 로고
    • Cabozantinib in progressive medullary thyroid cancer
    • R. Elisei, M.J. Schlumberger, and S.P. Müller Cabozantinib in progressive medullary thyroid cancer J Clin Oncol 31 2013 3639 3646
    • (2013) J Clin Oncol , vol.31 , pp. 3639-3646
    • Elisei, R.1    Schlumberger, M.J.2    Müller, S.P.3
  • 28
    • 79955612113 scopus 로고    scopus 로고
    • Cetuximab for the treatment of advanced bronchioloalveolar carcinoma (BAC): An Eastern Cooperative Oncology Group phase II study (ECOG 1504)
    • S.S. Ramalingam, J.W. Lee, and C.P. Belani Cetuximab for the treatment of advanced bronchioloalveolar carcinoma (BAC): an Eastern Cooperative Oncology Group phase II study (ECOG 1504) J Clin Oncol 29 2011 3419 3426
    • (2011) J Clin Oncol , vol.29 , pp. 3419-3426
    • Ramalingam, S.S.1    Lee, J.W.2    Belani, C.P.3
  • 29
    • 79957834501 scopus 로고    scopus 로고
    • A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma
    • J.A. Chan, L.S. Blaszkowsky, and P.C. Enzinger A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma Ann Oncol 22 2011 1367 1373
    • (2011) Ann Oncol , vol.22 , pp. 1367-1373
    • Chan, J.A.1    Blaszkowsky, L.S.2    Enzinger, P.C.3
  • 30
    • 78149426819 scopus 로고    scopus 로고
    • Cetuximab monotherapy in patients with advanced non-small cell lung cancer after prior epidermal growth factor receptor tyrosine kinase inhibitor therapy
    • J.W. Neal, R.S. Heist, and P. Fidias Cetuximab monotherapy in patients with advanced non-small cell lung cancer after prior epidermal growth factor receptor tyrosine kinase inhibitor therapy J Thorac Oncol 5 2010 1855 1858
    • (2010) J Thorac Oncol , vol.5 , pp. 1855-1858
    • Neal, J.W.1    Heist, R.S.2    Fidias, P.3
  • 31
    • 67449087686 scopus 로고    scopus 로고
    • Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study
    • L.D. Locati, P. Bossi, and F. Perrone Cetuximab in recurrent and/or metastatic salivary gland carcinomas: a phase II study Oral Oncol 45 2009 574 578
    • (2009) Oral Oncol , vol.45 , pp. 574-578
    • Locati, L.D.1    Bossi, P.2    Perrone, F.3
  • 32
    • 41549104310 scopus 로고    scopus 로고
    • First-line single-agent cetuximab in patients with advanced colorectal cancer
    • A. Pessino, S. Artale, and S. Sciallero First-line single-agent cetuximab in patients with advanced colorectal cancer Ann Oncol 19 2008 711 716
    • (2008) Ann Oncol , vol.19 , pp. 711-716
    • Pessino, A.1    Artale, S.2    Sciallero, S.3
  • 33
    • 34547102484 scopus 로고    scopus 로고
    • Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
    • A.X. Zhu, K. Stuart, and L.S. Blaszkowsky Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma Cancer 110 2007 581 589
    • (2007) Cancer , vol.110 , pp. 581-589
    • Zhu, A.X.1    Stuart, K.2    Blaszkowsky, L.S.3
  • 34
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • J.B. Vermorken, J. Trigo, and R. Hitt Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy J Clin Oncol 25 2007 2171 2177
    • (2007) J Clin Oncol , vol.25 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3
  • 35
    • 12444251187 scopus 로고    scopus 로고
    • Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
    • R.J. Motzer, R. Amato, and M. Todd Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma Invest New Drugs 21 2003 99 101
    • (2003) Invest New Drugs , vol.21 , pp. 99-101
    • Motzer, R.J.1    Amato, R.2    Todd, M.3
  • 36
    • 79151473575 scopus 로고    scopus 로고
    • A phase II, multicenter study of cetuximab monotherapy in patients with refractory metastatic colorectal carcinoma with absent epidermal growth factor receptor immunostaining
    • R. Wierzbicki, D.J. Jonker, and M.J. Moore A phase II, multicenter study of cetuximab monotherapy in patients with refractory metastatic colorectal carcinoma with absent epidermal growth factor receptor immunostaining Invest New Drugs 29 2011 167 174
    • (2011) Invest New Drugs , vol.29 , pp. 167-174
    • Wierzbicki, R.1    Jonker, D.J.2    Moore, M.J.3
  • 37
    • 73149115110 scopus 로고    scopus 로고
    • Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer
    • E.Y. Yu, G. Wilding, and E. Posadas Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer Clin Cancer Res 15 2009 7421 7428
    • (2009) Clin Cancer Res , vol.15 , pp. 7421-7428
    • Yu, E.Y.1    Wilding, G.2    Posadas, E.3
  • 38
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • J.C. Yao, M.H. Shah, and T. Ito Everolimus for advanced pancreatic neuroendocrine tumors N Engl J Med 364 2011 514 523
    • (2011) N Engl J Med , vol.364 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 39
    • 77956227464 scopus 로고    scopus 로고
    • Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
    • R.J. Motzer, B. Escudier, and S. Oudard Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors Cancer 116 2010 4256 4265
    • (2010) Cancer , vol.116 , pp. 4256-4265
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 40
    • 73949088959 scopus 로고    scopus 로고
    • Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II trial
    • J.C. Yao, C. Lombard-Bohas, and E. Baudin Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial J Clin Oncol 28 2010 69 76
    • (2010) J Clin Oncol , vol.28 , pp. 69-76
    • Yao, J.C.1    Lombard-Bohas, C.2    Baudin, E.3
  • 41
    • 84880781405 scopus 로고    scopus 로고
    • Phase II study of everolimus in metastatic urothelial cancer
    • M.I. Milowsky, G. Iyer, and A.M. Regazzi Phase II study of everolimus in metastatic urothelial cancer BJU Int 112 2013 462 470
    • (2013) BJU Int , vol.112 , pp. 462-470
    • Milowsky, M.I.1    Iyer, G.2    Regazzi, A.M.3
  • 42
    • 84883050535 scopus 로고    scopus 로고
    • Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): A composite, multicentre, phase 3 randomised trial
    • S.R. Johnston, L.S. Kilburn, and P. Ellis Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trial Lancet Oncol 14 2013 989 998
    • (2013) Lancet Oncol , vol.14 , pp. 989-998
    • Johnston, S.R.1    Kilburn, L.S.2    Ellis, P.3
  • 43
    • 84884411444 scopus 로고    scopus 로고
    • A prospective, phase II, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC)
    • K. Goto, M. Nishio, and N. Yamamoto A prospective, phase II, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC) Lung Cancer 82 2013 109 114
    • (2013) Lung Cancer , vol.82 , pp. 109-114
    • Goto, K.1    Nishio, M.2    Yamamoto, N.3
  • 44
    • 84883360843 scopus 로고    scopus 로고
    • A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC)
    • H.J. Groen, M.A. Socinski, and F. Grossi A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC) Ann Oncol 24 2013 2382 2389
    • (2013) Ann Oncol , vol.24 , pp. 2382-2389
    • Groen, H.J.1    Socinski, M.A.2    Grossi, F.3
  • 45
    • 84878660120 scopus 로고    scopus 로고
    • Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell lung cancer harboring EGFR mutations: Results of Lung Oncology Group in Kyushu (LOGiK0803)
    • K. Yamada, K. Takayama, and S. Kawakami Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell lung cancer harboring EGFR mutations: results of Lung Oncology Group in Kyushu (LOGiK0803) Jpn J Clin Oncol 43 2013 629 635
    • (2013) Jpn J Clin Oncol , vol.43 , pp. 629-635
    • Yamada, K.1    Takayama, K.2    Kawakami, S.3
  • 46
    • 84866255620 scopus 로고    scopus 로고
    • Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer
    • S.S. Ramalingam, F. Blackhall, and M. Krzakowski Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer J Clin Oncol 30 2012 3337 3344
    • (2012) J Clin Oncol , vol.30 , pp. 3337-3344
    • Ramalingam, S.S.1    Blackhall, F.2    Krzakowski, M.3
  • 47
    • 84864540328 scopus 로고    scopus 로고
    • Tumor response and toxicity of neoadjuvant erlotinib in patients with early-stage non-small-cell lung cancer
    • E.E. Schaake, I. Kappers, and H.E. Codrington Tumor response and toxicity of neoadjuvant erlotinib in patients with early-stage non-small-cell lung cancer J Clin Oncol 30 2012 2731 2738
    • (2012) J Clin Oncol , vol.30 , pp. 2731-2738
    • Schaake, E.E.1    Kappers, I.2    Codrington, H.E.3
  • 48
    • 84863936062 scopus 로고    scopus 로고
    • Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: A phase III trial
    • G.V. Scagliotti, M. Krzakowski, and A. Szczesna Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: a phase III trial J Clin Oncol 30 2012 2070 2078
    • (2012) J Clin Oncol , vol.30 , pp. 2070-2078
    • Scagliotti, G.V.1    Krzakowski, M.2    Szczesna, A.3
  • 49
    • 84863780354 scopus 로고    scopus 로고
    • Efficacy and safety of maintenance erlotinib in Asian patients with advanced non-small-cell lung cancer: A subanalysis of the phase III, randomized SATURN study
    • Y.L. Wu, J.H. Kim, K. Park, A. Zaatar, G. Klingelschmitt, and C. Ng Efficacy and safety of maintenance erlotinib in Asian patients with advanced non-small-cell lung cancer: a subanalysis of the phase III, randomized SATURN study Lung Cancer 77 2012 339 345
    • (2012) Lung Cancer , vol.77 , pp. 339-345
    • Wu, Y.L.1    Kim, J.H.2    Park, K.3    Zaatar, A.4    Klingelschmitt, G.5    Ng, C.6
  • 50
    • 84857501696 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study
    • T. Ciuleanu, L. Stelmakh, and S. Cicenas Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study Lancet Oncol 13 2012 300 308
    • (2012) Lancet Oncol , vol.13 , pp. 300-308
    • Ciuleanu, T.1    Stelmakh, L.2    Cicenas, S.3
  • 51
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • L.V. Sequist, J. von Pawel, and E.G. Garmey Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer J Clin Oncol 29 2011 3307 3315
    • (2011) J Clin Oncol , vol.29 , pp. 3307-3315
    • Sequist, L.V.1    Von Pawel, J.2    Garmey, E.G.3
  • 52
    • 83555166254 scopus 로고    scopus 로고
    • Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy
    • S.T. Kim, J.E. Uhm, and J. Lee Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy Lung Cancer 75 2012 82 88
    • (2012) Lung Cancer , vol.75 , pp. 82-88
    • Kim, S.T.1    Uhm, J.E.2    Lee, J.3
  • 53
    • 84857098148 scopus 로고    scopus 로고
    • Safety of erlotinib treatment in outpatients with previously treated non-small-cell lung cancer in Japan
    • H. Nagai, S. Tanaka, and M. Niimi Safety of erlotinib treatment in outpatients with previously treated non-small-cell lung cancer in Japan Int J Clin Oncol 16 2011 560 567
    • (2011) Int J Clin Oncol , vol.16 , pp. 560-567
    • Nagai, H.1    Tanaka, S.2    Niimi, M.3
  • 54
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • R.B. Natale, S. Thongprasert, and F.A. Greco Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer J Clin Oncol 29 2011 1059 1066
    • (2011) J Clin Oncol , vol.29 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 55
    • 77953434938 scopus 로고    scopus 로고
    • A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: Clinical and pathological results
    • R.S. Pruthi, M. Nielsen, and S. Heathcote A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: clinical and pathological results BJU Int 106 2010 349 354
    • (2010) BJU Int , vol.106 , pp. 349-354
    • Pruthi, R.S.1    Nielsen, M.2    Heathcote, S.3
  • 56
    • 65649085659 scopus 로고    scopus 로고
    • A phase II study of erlotinib as initial treatment for patients with stage IIIB-IV non-small cell lung cancer
    • W. Akerley, K.M. Boucher, J.S. Bentz, K. Arbogast, and T. Walters A phase II study of erlotinib as initial treatment for patients with stage IIIB-IV non-small cell lung cancer J Thorac Oncol 4 2009 214 219
    • (2009) J Thorac Oncol , vol.4 , pp. 214-219
    • Akerley, W.1    Boucher, K.M.2    Bentz, J.S.3    Arbogast, K.4    Walters, T.5
  • 57
    • 61449374843 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: A phase II study
    • K. Kubota, Y. Nishiwaki, and T. Tamura Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study J Thorac Oncol 3 2008 1439 1445
    • (2008) J Thorac Oncol , vol.3 , pp. 1439-1445
    • Kubota, K.1    Nishiwaki, Y.2    Tamura, T.3
  • 58
    • 52049125733 scopus 로고    scopus 로고
    • Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148
    • A.M. Oza, E.A. Eisenhauer, and L. Elit Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148 J Clin Oncol 26 2008 4319 4325
    • (2008) J Clin Oncol , vol.26 , pp. 4319-4325
    • Oza, A.M.1    Eisenhauer, E.A.2    Elit, L.3
  • 59
    • 67349087409 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer
    • M.N. Dickler, M.A. Cobleigh, K.D. Miller, P.M. Klein, and E.P. Winer Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer Breast Cancer Res Treat 115 2009 115 121
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 115-121
    • Dickler, M.N.1    Cobleigh, M.A.2    Miller, K.D.3    Klein, P.M.4    Winer, E.P.5
  • 60
    • 34548150925 scopus 로고    scopus 로고
    • Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    • M.B. Thomas, R. Chadha, and K. Glover Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma Cancer 110 2007 1059 1067
    • (2007) Cancer , vol.110 , pp. 1059-1067
    • Thomas, M.B.1    Chadha, R.2    Glover, K.3
  • 61
    • 34347273808 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with malignant pleural mesothelioma: A Southwest Oncology Group Study
    • L.L. Garland, C. Rankin, and D.R. Gandara Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study J Clin Oncol 25 2007 2406 2413
    • (2007) J Clin Oncol , vol.25 , pp. 2406-2413
    • Garland, L.L.1    Rankin, C.2    Gandara, D.R.3
  • 62
    • 33947504732 scopus 로고    scopus 로고
    • Phase II clinical trial of chemotherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer
    • D.M. Jackman, B.Y. Yeap, and N.I. Lindeman Phase II clinical trial of chemotherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer J Clin Oncol 25 2007 760 766
    • (2007) J Clin Oncol , vol.25 , pp. 760-766
    • Jackman, D.M.1    Yeap, B.Y.2    Lindeman, N.I.3
  • 63
    • 33745970752 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with advanced biliary cancer
    • P.A. Philip, M.R. Mahoney, and C. Allmer Phase II study of erlotinib in patients with advanced biliary cancer J Clin Oncol 24 2006 3069 3074
    • (2006) J Clin Oncol , vol.24 , pp. 3069-3074
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 64
    • 28944439741 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: Results from a phase II multicenter study
    • A.N. Gordon, N. Finkler, and R.P. Edwards Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study Int J Gynecol Cancer 15 2005 785 792
    • (2005) Int J Gynecol Cancer , vol.15 , pp. 785-792
    • Gordon, A.N.1    Finkler, N.2    Edwards, R.P.3
  • 65
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • P.A. Philip, M.R. Mahoney, and C. Allmer Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer J Clin Oncol 23 2005 6657 6663
    • (2005) J Clin Oncol , vol.23 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 66
    • 79951769461 scopus 로고    scopus 로고
    • A multicenter phase II trial of adjuvant erlotinib in patients with resected non-small cell lung cancer (NSCLC) and mutations in the epidermal growth factor receptor (EGFR): Toxicity evaluation
    • [abstr 7078]
    • J.W. Neal, N.A. Pennell, and B.W. Goodgame A multicenter phase II trial of adjuvant erlotinib in patients with resected non-small cell lung cancer (NSCLC) and mutations in the epidermal growth factor receptor (EGFR): toxicity evaluation J Clin Oncol 28 2010 15s [abstr 7078]
    • (2010) J Clin Oncol , vol.28 , pp. 15s
    • Neal, J.W.1    Pennell, N.A.2    Goodgame, B.W.3
  • 67
    • 84860479704 scopus 로고    scopus 로고
    • Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): A multicentre, double-blind randomised phase 3 trial
    • L. Zhang, S. Ma, and X. Song Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial Lancet Oncol 13 2012 466 475
    • (2012) Lancet Oncol , vol.13 , pp. 466-475
    • Zhang, L.1    Ma, S.2    Song, X.3
  • 68
    • 84863793250 scopus 로고    scopus 로고
    • The administration of gefitinib in patients with advanced non-small-cell lung cancer after the failure of erlotinib
    • F. Grossi, E. Rijavec, and M.G. Dal Bello The administration of gefitinib in patients with advanced non-small-cell lung cancer after the failure of erlotinib Cancer Chemother Pharmacol 69 2012 1407 1412
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 1407-1412
    • Grossi, F.1    Rijavec, E.2    Dal Bello, M.G.3
  • 69
    • 83455262219 scopus 로고    scopus 로고
    • A phase II trial of gefitinib in patients with rising PSA following radical prostatectomy or radiotherapy
    • G. Joensuu, T. Joensuu, and N. Nupponen A phase II trial of gefitinib in patients with rising PSA following radical prostatectomy or radiotherapy Acta Oncol 51 2012 130 133
    • (2012) Acta Oncol , vol.51 , pp. 130-133
    • Joensuu, G.1    Joensuu, T.2    Nupponen, N.3
  • 70
    • 80155135291 scopus 로고    scopus 로고
    • Gefitinib as first-line treatment in elderly epidermal growth factor receptor-mutated patients with advanced lung adenocarcinoma: Results of a Nagano Lung Cancer Research Group study
    • K. Asami, T. Koizumi, and K. Hirai Gefitinib as first-line treatment in elderly epidermal growth factor receptor-mutated patients with advanced lung adenocarcinoma: results of a Nagano Lung Cancer Research Group study Clin Lung Cancer 12 2011 387 392
    • (2011) Clin Lung Cancer , vol.12 , pp. 387-392
    • Asami, K.1    Koizumi, T.2    Hirai, K.3
  • 71
    • 79952714380 scopus 로고    scopus 로고
    • A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer
    • J.Y. Han, S.H. Lee, and N.J. Yoo A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer Clin Cancer Res 17 2011 1553 1560
    • (2011) Clin Cancer Res , vol.17 , pp. 1553-1560
    • Han, J.Y.1    Lee, S.H.2    Yoo, N.J.3
  • 72
    • 78650189256 scopus 로고    scopus 로고
    • A multicenter phase II study to evaluate the efficacy and safety of gefitinib as first-line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations
    • D.W. Kim, S.H. Lee, and J.S. Lee A multicenter phase II study to evaluate the efficacy and safety of gefitinib as first-line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations Lung Cancer 71 2011 65 69
    • (2011) Lung Cancer , vol.71 , pp. 65-69
    • Kim, D.W.1    Lee, S.H.2    Lee, J.S.3
  • 73
    • 76749154617 scopus 로고    scopus 로고
    • Randomized phase III trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy
    • D.H. Lee, K. Park, and J.H. Kim Randomized phase III trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy Clin Cancer Res 16 2010 1307 1314
    • (2010) Clin Cancer Res , vol.16 , pp. 1307-1314
    • Lee, D.H.1    Park, K.2    Kim, J.H.3
  • 74
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • T. Mitsudomi, S. Morita, and Y. Yatabe Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial Lancet Oncol 11 2010 121 128
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 75
    • 74949129970 scopus 로고    scopus 로고
    • Phase II study of preoperative gefitinib in clinical stage i non-small-cell lung cancer
    • H. Lara-Guerra, T.K. Waddell, and M.A. Salvarrey Phase II study of preoperative gefitinib in clinical stage I non-small-cell lung cancer J Clin Oncol 27 2009 6229 6236
    • (2009) J Clin Oncol , vol.27 , pp. 6229-6236
    • Lara-Guerra, H.1    Waddell, T.K.2    Salvarrey, M.A.3
  • 76
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • T.S. Mok, Y.L. Wu, and S. Thongprasert Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 2009 947 957
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 77
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized phase II study
    • R.B. Natale, D. Bodkin, and R. Govindan Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase II study J Clin Oncol 27 2009 2523 2529
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 78
    • 64649097892 scopus 로고    scopus 로고
    • Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected]
    • J.S. Stewart, E.E. Cohen, and L. Licitra Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected] J Clin Oncol 27 2009 1864 1871
    • (2009) J Clin Oncol , vol.27 , pp. 1864-1871
    • Stewart, J.S.1    Cohen, E.E.2    Licitra, L.3
  • 79
    • 65549154268 scopus 로고    scopus 로고
    • Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status
    • G. Goss, D. Ferry, and R. Wierzbicki Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status J Clin Oncol 27 2009 2253 2260
    • (2009) J Clin Oncol , vol.27 , pp. 2253-2260
    • Goss, G.1    Ferry, D.2    Wierzbicki, R.3
  • 80
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • E.S. Kim, V. Hirsh, and T. Mok Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial Lancet 372 2008 1809 1818
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3
  • 81
    • 52049096854 scopus 로고    scopus 로고
    • Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): A randomized, phase II study
    • L. Crinò, F. Cappuzzo, and P. Zatloukal Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study J Clin Oncol 26 2008 4253 4260
    • (2008) J Clin Oncol , vol.26 , pp. 4253-4260
    • Crinò, L.1    Cappuzzo, F.2    Zatloukal, P.3
  • 82
    • 52049125250 scopus 로고    scopus 로고
    • Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer
    • R. Maruyama, Y. Nishiwaki, and T. Tamura Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer J Clin Oncol 26 2008 4244 4252
    • (2008) J Clin Oncol , vol.26 , pp. 4244-4252
    • Maruyama, R.1    Nishiwaki, Y.2    Tamura, T.3
  • 83
    • 40349111048 scopus 로고    scopus 로고
    • Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: Results of the West Japan Thoracic Oncology Group trial (WJTOG0403)
    • K. Tamura, I. Okamoto, and T. Kashii Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403) Br J Cancer 98 2008 907 914
    • (2008) Br J Cancer , vol.98 , pp. 907-914
    • Tamura, K.1    Okamoto, I.2    Kashii, T.3
  • 84
    • 45749107871 scopus 로고    scopus 로고
    • Phase II study of nedaplatin and irinotecan followed by gefitinib for elderly patients with unresectable non-small cell lung cancer
    • F. Oshita, K. Yamada, H. Saito, and K. Noda Phase II study of nedaplatin and irinotecan followed by gefitinib for elderly patients with unresectable non-small cell lung cancer Cancer Chemother Pharmacol 62 2008 465 470
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 465-470
    • Oshita, F.1    Yamada, K.2    Saito, H.3    Noda, K.4
  • 85
    • 34247599684 scopus 로고    scopus 로고
    • Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy
    • Y.M. Chen, J.M. Liu, T.Y. Chou, R.P. Perng, C.M. Tsai, and J. Whang-Peng Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy Cancer 109 2007 1821 1828
    • (2007) Cancer , vol.109 , pp. 1821-1828
    • Chen, Y.M.1    Liu, J.M.2    Chou, T.Y.3    Perng, R.P.4    Tsai, C.M.5    Whang-Peng, J.6
  • 86
    • 33750205340 scopus 로고    scopus 로고
    • A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    • H. Asahina, K. Yamazaki, and I. Kinoshita A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations Br J Cancer 95 2006 998 1004
    • (2006) Br J Cancer , vol.95 , pp. 998-1004
    • Asahina, H.1    Yamazaki, K.2    Kinoshita, I.3
  • 87
    • 33644845421 scopus 로고    scopus 로고
    • First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: A phase II study
    • S. Niho, K. Kubota, and K. Goto First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study J Clin Oncol 24 2006 64 69
    • (2006) J Clin Oncol , vol.24 , pp. 64-69
    • Niho, S.1    Kubota, K.2    Goto, K.3
  • 88
    • 33644822287 scopus 로고    scopus 로고
    • Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
    • M.L. Rothenberg, B. LaFleur, and D.E. Levy Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma J Clin Oncol 23 2005 9265 9274
    • (2005) J Clin Oncol , vol.23 , pp. 9265-9274
    • Rothenberg, M.L.1    Lafleur, B.2    Levy, D.E.3
  • 89
    • 27644484102 scopus 로고    scopus 로고
    • Gefitinib in the adjuvant setting: Safety results from a phase III study in patients with completely resected non-small cell lung cancer
    • M. Tsuboi, H. Kato, and K. Nagai Gefitinib in the adjuvant setting: safety results from a phase III study in patients with completely resected non-small cell lung cancer Anticancer Drugs 16 2005 1123 1128
    • (2005) Anticancer Drugs , vol.16 , pp. 1123-1128
    • Tsuboi, M.1    Kato, H.2    Nagai, K.3
  • 90
    • 19944408390 scopus 로고    scopus 로고
    • Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: A double-blind placebo-controlled phase II randomised trial
    • A. Polychronis, H.D. Sinnett, and D. Hadjiminas Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial Lancet Oncol 6 2005 383 391
    • (2005) Lancet Oncol , vol.6 , pp. 383-391
    • Polychronis, A.1    Sinnett, H.D.2    Hadjiminas, D.3
  • 91
    • 17144385106 scopus 로고    scopus 로고
    • Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers
    • D.H. Lee, J.Y. Han, and H.G. Lee Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers Clin Cancer Res 11 2005 3032 3037
    • (2005) Clin Cancer Res , vol.11 , pp. 3032-3037
    • Lee, D.H.1    Han, J.Y.2    Lee, H.G.3
  • 92
    • 20044372705 scopus 로고    scopus 로고
    • Randomized phase II study of two doses of gefitinib in hormone-refractory prostate cancer: A trial of the National Cancer Institute of Canada-Clinical Trials Group
    • C.M. Canil, M.J. Moore, and E. Winquist Randomized phase II study of two doses of gefitinib in hormone-refractory prostate cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group J Clin Oncol 23 2005 455 460
    • (2005) J Clin Oncol , vol.23 , pp. 455-460
    • Canil, C.M.1    Moore, M.J.2    Winquist, E.3
  • 93
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    • M. Fukuoka, S. Yano, and G. Giaccone Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected] J Clin Oncol 21 2003 2237 2246
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 94
    • 12144287534 scopus 로고    scopus 로고
    • United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets
    • M.H. Cohen, G.A. Williams, and R. Sridhara United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets Clin Cancer Res 10 2004 1212 1218
    • (2004) Clin Cancer Res , vol.10 , pp. 1212-1218
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3
  • 95
    • 62849096370 scopus 로고    scopus 로고
    • Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial
    • R.P. Dematteo, K.V. Ballman, and C.R. Antonescu Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial Lancet 373 2009 1097 1104
    • (2009) Lancet , vol.373 , pp. 1097-1104
    • Dematteo, R.P.1    Ballman, K.V.2    Antonescu, C.R.3
  • 96
    • 84859187987 scopus 로고    scopus 로고
    • One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial
    • H. Joensuu, M. Eriksson, and K. Sundby Hall One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial JAMA 307 2012 1265 1272
    • (2012) JAMA , vol.307 , pp. 1265-1272
    • Joensuu, H.1    Eriksson, M.2    Sundby Hall, K.3
  • 97
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • R.D. Carvajal, C.R. Antonescu, and J.D. Wolchok KIT as a therapeutic target in metastatic melanoma JAMA 305 2011 2327 2334
    • (2011) JAMA , vol.305 , pp. 2327-2334
    • Carvajal, R.D.1    Antonescu, C.R.2    Wolchok, J.D.3
  • 98
    • 79957625763 scopus 로고    scopus 로고
    • Activity and side effects of imatinib in patients with gastrointestinal stromal tumors: Data from a German multicenter trial
    • M. Schlemmer, S. Bauer, and R. Schütte Activity and side effects of imatinib in patients with gastrointestinal stromal tumors: data from a German multicenter trial Eur J Med Res 16 2011 206 212
    • (2011) Eur J Med Res , vol.16 , pp. 206-212
    • Schlemmer, M.1    Bauer, S.2    Schütte, R.3
  • 99
    • 19944426270 scopus 로고    scopus 로고
    • A phase II trial of imatinib mesylate in patients with prostate specific antigen progression after local therapy for prostate cancer
    • K. Rao, S. Goodin, and M.J. Levitt A phase II trial of imatinib mesylate in patients with prostate specific antigen progression after local therapy for prostate cancer Prostate 62 2005 115 122
    • (2005) Prostate , vol.62 , pp. 115-122
    • Rao, K.1    Goodin, S.2    Levitt, M.J.3
  • 100
    • 34548533134 scopus 로고    scopus 로고
    • Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands
    • M. Agulnik, E.W. Cohen, and R.B. Cohen Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands J Clin Oncol 25 2007 3978 3984
    • (2007) J Clin Oncol , vol.25 , pp. 3978-3984
    • Agulnik, M.1    Cohen, E.W.2    Cohen, R.B.3
  • 101
    • 84875608696 scopus 로고    scopus 로고
    • An open-label study of lapatinib in women with HER-2-negative early breast cancer: The lapatinib pre-surgical study (LPS study)
    • R.C. Coombes, T. Tat, and M.L. Miller An open-label study of lapatinib in women with HER-2-negative early breast cancer: the lapatinib pre-surgical study (LPS study) Ann Oncol 24 2013 924 930
    • (2013) Ann Oncol , vol.24 , pp. 924-930
    • Coombes, R.C.1    Tat, T.2    Miller, M.L.3
  • 102
    • 84871712684 scopus 로고    scopus 로고
    • Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial
    • P.E. Goss, I.E. Smith, and J. O'Shaughnessy Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial Lancet Oncol 14 2013 88 96
    • (2013) Lancet Oncol , vol.14 , pp. 88-96
    • Goss, P.E.1    Smith, I.E.2    O'Shaughnessy, J.3
  • 103
    • 70449517339 scopus 로고    scopus 로고
    • Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: Efficacy, safety, and biomarker results from Japanese patients phase II studies
    • M. Toi, H. Iwata, and Y. Fujiwara Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies Br J Cancer 101 2009 1676 1682
    • (2009) Br J Cancer , vol.101 , pp. 1676-1682
    • Toi, M.1    Iwata, H.2    Fujiwara, Y.3
  • 104
    • 78650006394 scopus 로고    scopus 로고
    • A multicenter phase II clinical trial of lapatinib (GW572016) in hormonally untreated advanced prostate cancer
    • S.S. Sridhar, S.J. Hotte, and J.L. Chin A multicenter phase II clinical trial of lapatinib (GW572016) in hormonally untreated advanced prostate cancer Am J Clin Oncol 33 2010 609 613
    • (2010) Am J Clin Oncol , vol.33 , pp. 609-613
    • Sridhar, S.S.1    Hotte, S.J.2    Chin, J.L.3
  • 105
    • 77949694139 scopus 로고    scopus 로고
    • Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer
    • H.J. Ross, G.R. Blumenschein Jr., and J. Aisner Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer Clin Cancer Res 16 2010 1938 1949
    • (2010) Clin Cancer Res , vol.16 , pp. 1938-1949
    • Ross, H.J.1    Blumenschein, Jr.G.R.2    Aisner, J.3
  • 106
    • 84873988267 scopus 로고    scopus 로고
    • A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer
    • Y.E. Whang, A.J. Armstrong, and W.K. Rathmell A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer Urol Oncol 31 2013 82 86
    • (2013) Urol Oncol , vol.31 , pp. 82-86
    • Whang, Y.E.1    Armstrong, A.J.2    Rathmell, W.K.3
  • 107
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • S. Johnston, J. Pippen, and X. Pivot Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer J Clin Oncol 27 2009 5538 5546
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen, J.2    Pivot, X.3
  • 108
    • 84856239290 scopus 로고    scopus 로고
    • Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab
    • R.C. Wadlow, A.F. Hezel, and T.A. Abrams Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab Oncologist 17 2012 14
    • (2012) Oncologist , vol.17 , pp. 14
    • Wadlow, R.C.1    Hezel, A.F.2    Abrams, T.A.3
  • 109
    • 65549128100 scopus 로고    scopus 로고
    • A phase 2 clinical trial of panitumumab monotherapy in Japanese patients with metastatic colorectal cancer
    • K. Muro, T. Yoshino, and T. Doi A phase 2 clinical trial of panitumumab monotherapy in Japanese patients with metastatic colorectal cancer Jpn J Clin Oncol 39 2009 321 326
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 321-326
    • Muro, K.1    Yoshino, T.2    Doi, T.3
  • 110
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • E. Van Cutsem, M. Peeters, and S. Siena Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer J Clin Oncol 25 2007 1658 1664
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 111
    • 77957359933 scopus 로고    scopus 로고
    • Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: Results of a phase 2 consortium study
    • K.C. Bible, V.J. Suman, and J.R. Molina Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study Lancet Oncol 11 2010 962 972
    • (2010) Lancet Oncol , vol.11 , pp. 962-972
    • Bible, K.C.1    Suman, V.J.2    Molina, J.R.3
  • 112
    • 78149492402 scopus 로고    scopus 로고
    • Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)
    • F.M. Iwamoto, K.R. Lamborn, and H.I. Robins Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02) Neuro Oncol 12 2010 855 861
    • (2010) Neuro Oncol , vol.12 , pp. 855-861
    • Iwamoto, F.M.1    Lamborn, K.R.2    Robins, H.I.3
  • 113
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
    • A. Grothey, E. Van Cutsem, and A. Sobrero Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial Lancet 381 2013 303 312
    • (2013) Lancet , vol.381 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 114
    • 84876974877 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial
    • R.J. Motzer, B. Escudier, and P. Tomczak Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial Lancet Oncol 14 2013 552 562
    • (2013) Lancet Oncol , vol.14 , pp. 552-562
    • Motzer, R.J.1    Escudier, B.2    Tomczak, P.3
  • 115
    • 84879112772 scopus 로고    scopus 로고
    • A randomized phase II trial of maintenance therapy with Sorafenib in front-line ovarian carcinoma
    • T.J. Herzog, G. Scambia, and B.G. Kim A randomized phase II trial of maintenance therapy with Sorafenib in front-line ovarian carcinoma Gynecol Oncol 130 2013 25 30
    • (2013) Gynecol Oncol , vol.130 , pp. 25-30
    • Herzog, T.J.1    Scambia, G.2    Kim, B.G.3
  • 116
    • 84873354408 scopus 로고    scopus 로고
    • A phase II study of sorafenib in patients with platinum-pretreated, advanced (stage IIIb or IV) non-small cell lung cancer with a KRAS mutation
    • A.M. Dingemans, W.W. Mellema, and H.J. Groen A phase II study of sorafenib in patients with platinum-pretreated, advanced (stage IIIb or IV) non-small cell lung cancer with a KRAS mutation Clin Cancer Res 19 2013 743 751
    • (2013) Clin Cancer Res , vol.19 , pp. 743-751
    • Dingemans, A.M.1    Mellema, W.W.2    Groen, H.J.3
  • 117
    • 84866625336 scopus 로고    scopus 로고
    • A double-blind randomized discontinuation phase-II study of sorafenib (BAY 43-9006) in previously treated non-small-cell lung cancer patients: Eastern cooperative oncology group study E2501
    • H.A. Wakelee, J.W. Lee, N.H. Hanna, A.M. Traynor, D.P. Carbone, and J.H. Schiller A double-blind randomized discontinuation phase-II study of sorafenib (BAY 43-9006) in previously treated non-small-cell lung cancer patients: eastern cooperative oncology group study E2501 J Thorac Oncol 7 2012 1574 1582
    • (2012) J Thorac Oncol , vol.7 , pp. 1574-1582
    • Wakelee, H.A.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5    Schiller, J.H.6
  • 118
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • E.T. Lam, M.D. Ringel, and R.T. Kloos Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer J Clin Oncol 28 2010 2323 2330
    • (2010) J Clin Oncol , vol.28 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 119
    • 79955627111 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a phase II randomized discontinuation trial
    • S. Pacey, M.J. Ratain, and K.T. Flaherty Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a phase II randomized discontinuation trial Invest New Drugs 29 2011 481 488
    • (2011) Invest New Drugs , vol.29 , pp. 481-488
    • Pacey, S.1    Ratain, M.J.2    Flaherty, K.T.3
  • 120
    • 70149087258 scopus 로고    scopus 로고
    • Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer
    • G. Bianchi, S. Loibl, and C. Zamagni Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer Anticancer Drugs 20 2009 616 624
    • (2009) Anticancer Drugs , vol.20 , pp. 616-624
    • Bianchi, G.1    Loibl, S.2    Zamagni, C.3
  • 121
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • G.R. Blumenschein Jr., U. Gatzemeier, and F. Fossella Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer J Clin Oncol 27 2009 4274 4280
    • (2009) J Clin Oncol , vol.27 , pp. 4274-4280
    • Blumenschein, Jr.G.R.1    Gatzemeier, U.2    Fossella, F.3
  • 122
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • B. Escudier, T. Eisen, and W.M. Stadler Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial J Clin Oncol 27 2009 3312 3318
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 123
    • 63849265332 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in metastatic thyroid cancer
    • R.T. Kloos, M.D. Ringel, and M.V. Knopp Phase II trial of sorafenib in metastatic thyroid cancer J Clin Oncol 27 2009 1675 1684
    • (2009) J Clin Oncol , vol.27 , pp. 1675-1684
    • Kloos, R.T.1    Ringel, M.D.2    Knopp, M.V.3
  • 124
    • 62449186539 scopus 로고    scopus 로고
    • Randomized phase II trial of first-line treatment with sorafenib versus interferon alfa-2a in patients with metastatic renal cell carcinoma
    • B. Escudier, C. Szczylik, and T.E. Hutson Randomized phase II trial of first-line treatment with sorafenib versus interferon alfa-2a in patients with metastatic renal cell carcinoma J Clin Oncol 27 2009 1280 1289
    • (2009) J Clin Oncol , vol.27 , pp. 1280-1289
    • Escudier, B.1    Szczylik, C.2    Hutson, T.E.3
  • 125
    • 58149335533 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336
    • A. Moreno-Aspitia, R.F. Morton, and D.W. Hillman Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336 J Clin Oncol 27 2009 11 15
    • (2009) J Clin Oncol , vol.27 , pp. 11-15
    • Moreno-Aspitia, A.1    Morton, R.F.2    Hillman, D.W.3
  • 126
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • J.M. Llovet, S. Ricci, and V. Mazzaferro Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 127
    • 40749122148 scopus 로고    scopus 로고
    • A phase II clinical trial of sorafenib in androgen-independent prostate cancer
    • W.L. Dahut, C. Scripture, and E. Posadas A phase II clinical trial of sorafenib in androgen-independent prostate cancer Clin Cancer Res 14 2008 209 214
    • (2008) Clin Cancer Res , vol.14 , pp. 209-214
    • Dahut, W.L.1    Scripture, C.2    Posadas, E.3
  • 128
    • 41549144309 scopus 로고    scopus 로고
    • A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer
    • K.N. Chi, S.L. Ellard, and S.J. Hotte A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer Ann Oncol 19 2008 746 751
    • (2008) Ann Oncol , vol.19 , pp. 746-751
    • Chi, K.N.1    Ellard, S.L.2    Hotte, S.J.3
  • 129
    • 34548504810 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma
    • C. Elser, L.L. Siu, and E. Winquist Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma J Clin Oncol 25 2007 3766 3773
    • (2007) J Clin Oncol , vol.25 , pp. 3766-3773
    • Elser, C.1    Siu, L.L.2    Winquist, E.3
  • 130
    • 33846260566 scopus 로고    scopus 로고
    • Sorafenib for the treatment of advanced renal cell carcinoma
    • R.C. Kane, A.T. Farrell, and H. Saber Sorafenib for the treatment of advanced renal cell carcinoma Clin Cancer Res 12 2006 7271 7278
    • (2006) Clin Cancer Res , vol.12 , pp. 7271-7278
    • Kane, R.C.1    Farrell, A.T.2    Saber, H.3
  • 131
    • 84865573372 scopus 로고    scopus 로고
    • A phase II clinical trial of sunitinib following hepatic transarterial embolization for metastatic neuroendocrine tumors
    • J.R. Strosberg, J.M. Weber, and J. Choi A phase II clinical trial of sunitinib following hepatic transarterial embolization for metastatic neuroendocrine tumors Ann Oncol 23 2012 2335 2341
    • (2012) Ann Oncol , vol.23 , pp. 2335-2341
    • Strosberg, J.R.1    Weber, J.M.2    Choi, J.3
  • 132
    • 84861747033 scopus 로고    scopus 로고
    • A phase II study of sunitinib in recurrent and/or metastatic adenoid cystic carcinoma (ACC) of the salivary glands: Current progress and challenges in evaluating molecularly targeted agents in ACC
    • N.G. Chau, S.J. Hotte, and E.X. Chen A phase II study of sunitinib in recurrent and/or metastatic adenoid cystic carcinoma (ACC) of the salivary glands: current progress and challenges in evaluating molecularly targeted agents in ACC Ann Oncol 23 2012 1562 1570
    • (2012) Ann Oncol , vol.23 , pp. 1562-1570
    • Chau, N.G.1    Hotte, S.J.2    Chen, E.X.3
  • 133
    • 70249084594 scopus 로고    scopus 로고
    • Phase II study of sunitinib administered in a continuous once-daily dosing regimen in patients with cytokine-refractory metastatic renal cell carcinoma
    • B. Escudier, J. Roigas, and S. Gillessen Phase II study of sunitinib administered in a continuous once-daily dosing regimen in patients with cytokine-refractory metastatic renal cell carcinoma J Clin Oncol 27 2009 4068 4075
    • (2009) J Clin Oncol , vol.27 , pp. 4068-4075
    • Escudier, B.1    Roigas, J.2    Gillessen, S.3
  • 134
    • 67651165187 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, phase II study
    • S. Faivre, E. Raymond, and E. Boucher Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study Lancet Oncol 10 2009 794 800
    • (2009) Lancet Oncol , vol.10 , pp. 794-800
    • Faivre, S.1    Raymond, E.2    Boucher, E.3
  • 135
    • 67649946279 scopus 로고    scopus 로고
    • Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
    • A.X. Zhu, D.V. Sahani, and D.G. Duda Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study J Clin Oncol 27 2009 3027 3035
    • (2009) J Clin Oncol , vol.27 , pp. 3027-3035
    • Zhu, A.X.1    Sahani, D.V.2    Duda, D.G.3
  • 136
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
    • M.A. Socinski, S. Novello, and J.R. Brahmer Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer J Clin Oncol 26 2008 650 656
    • (2008) J Clin Oncol , vol.26 , pp. 650-656
    • Socinski, M.A.1    Novello, S.2    Brahmer, J.R.3
  • 137
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • R.J. Motzer, T.E. Hutson, and P. Tomczak Sunitinib versus interferon alfa in metastatic renal-cell carcinoma N Engl J Med 356 2007 115 124
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 138
    • 77951729433 scopus 로고    scopus 로고
    • FDA approval summary: Temsirolimus as treatment for advanced renal cell carcinoma
    • V.E. Kwitkowski, T.M. Prowell, and A. Ibrahim FDA approval summary: temsirolimus as treatment for advanced renal cell carcinoma Oncologist 15 2010 428 435
    • (2010) Oncologist , vol.15 , pp. 428-435
    • Kwitkowski, V.E.1    Prowell, T.M.2    Ibrahim, A.3
  • 139
    • 33750510023 scopus 로고    scopus 로고
    • A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
    • I. Duran, J. Kortmansky, and D. Singh A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas Br J Cancer 95 2006 1148 1154
    • (2006) Br J Cancer , vol.95 , pp. 1148-1154
    • Duran, I.1    Kortmansky, J.2    Singh, D.3
  • 140
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • A.M. Oza, L. Elit, and M.S. Tsao Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group J Clin Oncol 29 2011 3278 3285
    • (2011) J Clin Oncol , vol.29 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3
  • 141
    • 84874777853 scopus 로고    scopus 로고
    • Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
    • K.B. Kim, R. Kefford, and A.C. Pavlick Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor J Clin Oncol 31 2013 482 489
    • (2013) J Clin Oncol , vol.31 , pp. 482-489
    • Kim, K.B.1    Kefford, R.2    Pavlick, A.C.3
  • 142
    • 84887617202 scopus 로고    scopus 로고
    • A randomized, phase II study of vandetanib maintenance for advanced or metastatic non-small-cell lung cancer following first-line platinum-doublet chemotherapy
    • J.S. Ahn, K.H. Lee, and J.M. Sun A randomized, phase II study of vandetanib maintenance for advanced or metastatic non-small-cell lung cancer following first-line platinum-doublet chemotherapy Lung Cancer 82 2013 455 460
    • (2013) Lung Cancer , vol.82 , pp. 455-460
    • Ahn, J.S.1    Lee, K.H.2    Sun, J.M.3
  • 143
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • S.A. Wells Jr., B.G. Robinson, and R.F. Gagel Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial J Clin Oncol 30 2012 134 141
    • (2012) J Clin Oncol , vol.30 , pp. 134-141
    • Wells, Jr.S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 144
    • 41749097667 scopus 로고    scopus 로고
    • A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
    • K. Kiura, K. Nakagawa, and T. Shinkai A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer J Thorac Oncol 3 2008 386 393
    • (2008) J Thorac Oncol , vol.3 , pp. 386-393
    • Kiura, K.1    Nakagawa, K.2    Shinkai, T.3
  • 145
    • 79952773321 scopus 로고    scopus 로고
    • Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma
    • M. Kirschbaum, P. Frankel, and L. Popplewell Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma J Clin Oncol 29 2011 1198 1203
    • (2011) J Clin Oncol , vol.29 , pp. 1198-1203
    • Kirschbaum, M.1    Frankel, P.2    Popplewell, L.3
  • 147
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • J.Y. Douillard, S. Siena, and J. Cassidy Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study J Clin Oncol 28 2010 4697 4705
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 148
    • 84866646369 scopus 로고    scopus 로고
    • Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study
    • J. Thaler, M. Karthaus, and L. Mineur Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study BMC Cancer 12 2012 438
    • (2012) BMC Cancer , vol.12 , pp. 438
    • Thaler, J.1    Karthaus, M.2    Mineur, L.3
  • 149
    • 84910131661 scopus 로고    scopus 로고
    • Managing skin toxicities related to panitumumab
    • H. Bergman, T. Walton, and R. Del Bel Managing skin toxicities related to panitumumab J Am Acad Dermatol 71 2014 754 759
    • (2014) J Am Acad Dermatol , vol.71 , pp. 754-759
    • Bergman, H.1    Walton, T.2    Del Bel, R.3
  • 150
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • M.E. Lacouture Mechanisms of cutaneous toxicities to EGFR inhibitors Nat Rev Cancer 6 2006 803 812
    • (2006) Nat Rev Cancer , vol.6 , pp. 803-812
    • Lacouture, M.E.1
  • 151
    • 0036139727 scopus 로고    scopus 로고
    • Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
    • J. Albanell, F. Rojo, and S. Averbuch Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition J Clin Oncol 20 2002 110 124
    • (2002) J Clin Oncol , vol.20 , pp. 110-124
    • Albanell, J.1    Rojo, F.2    Averbuch, S.3
  • 152
    • 84883890133 scopus 로고    scopus 로고
    • Epidermal EGFR controls cutaneous host defense an prevents inflammation
    • B.M. Lichtenberger, P.A. Gerber, and M. Holcmann Epidermal EGFR controls cutaneous host defense an prevents inflammation Sci Transl Med 5 2013 199ra111
    • (2013) Sci Transl Med , vol.5 , pp. 199ra111
    • Lichtenberger, B.M.1    Gerber, P.A.2    Holcmann, M.3
  • 153
    • 84875808184 scopus 로고    scopus 로고
    • Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice
    • T. Sugawara, N. Iwamoto, and M. Akashi Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice J Dermatol Sci 70 2013 12 18
    • (2013) J Dermatol Sci , vol.70 , pp. 12-18
    • Sugawara, T.1    Iwamoto, N.2    Akashi, M.3
  • 154
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • K.T. Flaherty, C. Robert, and P. Hersey Improved survival with MEK inhibition in BRAF-mutated melanoma N Engl J Med 367 2012 107 114
    • (2012) N Engl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 155
    • 84911438827 scopus 로고    scopus 로고
    • Acneiform eruptions: A common cutaneous toxicity of the MEK inhibitor trametinib
    • R. Anforth, M. Liu, and B. Nguyen Acneiform eruptions: a common cutaneous toxicity of the MEK inhibitor trametinib Australas J Dermatol 55 2014 250 254
    • (2014) Australas J Dermatol , vol.55 , pp. 250-254
    • Anforth, R.1    Liu, M.2    Nguyen, B.3
  • 156
    • 35548969264 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: An evolving paradigm in clinical management
    • T. Lynch, E. Kim, B. Eaby, J. Garey, D. West, and M.E. Lacouture Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management Oncologist 12 2007 610 621
    • (2007) Oncologist , vol.12 , pp. 610-621
    • Lynch, T.1    Kim, E.2    Eaby, B.3    Garey, J.4    West, D.5    Lacouture, M.E.6
  • 157
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogen activated protein kinase cascade for the treatment of cancer
    • P.J. Roberts, and C.J. Der Targeting the Raf-MEK-ERK mitogen activated protein kinase cascade for the treatment of cancer Oncogene 26 2007 3291 3310
    • (2007) Oncogene , vol.26 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 158
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • J. Folkman Role of angiogenesis in tumor growth and metastasis Semin Oncol 29 2002 15 18
    • (2002) Semin Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 159
    • 0026756163 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing
    • L.F. Brown, K.T. Yeo, and B. Berse Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing J Exp Med 176 1992 1375 1379
    • (1992) J Exp Med , vol.176 , pp. 1375-1379
    • Brown, L.F.1    Yeo, K.T.2    Berse, B.3
  • 160
    • 84865253075 scopus 로고    scopus 로고
    • Concise drug review: Pazopanib and axitinib
    • R.M. Van Geel, J.H. Beijnen, and J.H. Schellens Concise drug review: pazopanib and axitinib Oncologist 17 2012 1081 1089
    • (2012) Oncologist , vol.17 , pp. 1081-1089
    • Van Geel, R.M.1    Beijnen, J.H.2    Schellens, J.H.3
  • 161
    • 74049120784 scopus 로고    scopus 로고
    • Dermatologic infections in cancer patients treated with epidermal growth factor receptor inhibitor therapy
    • R. Eilers, M. Gandhi, and J. Patel Dermatologic infections in cancer patients treated with epidermal growth factor receptor inhibitor therapy J Natl Cancer Inst 102 2010 47 53
    • (2010) J Natl Cancer Inst , vol.102 , pp. 47-53
    • Eilers, R.1    Gandhi, M.2    Patel, J.3
  • 162
    • 79955960147 scopus 로고    scopus 로고
    • Meta-analysis of dermatological toxicities associated with sorafenib
    • L. Zhang, Q. Zhou, L. Ma, Z. Wu, and Y. Wang Meta-analysis of dermatological toxicities associated with sorafenib Clin Exp Dermatol 36 2011 344 350
    • (2011) Clin Exp Dermatol , vol.36 , pp. 344-350
    • Zhang, L.1    Zhou, Q.2    Ma, L.3    Wu, Z.4    Wang, Y.5
  • 163
    • 84896079154 scopus 로고    scopus 로고
    • Other topical medications
    • J.L. Bolognia, J.L. Jorizzo, R.P. Rapini, 1st ed. Elsevier Limited Philadelphia (PA)
    • D. Lipster, K. Kragballe, and J.H. Saurat Other topical medications J.L. Bolognia, J.L. Jorizzo, R.P. Rapini, Dermatology 1st ed. 2003 Elsevier Limited Philadelphia (PA) 2062
    • (2003) Dermatology , pp. 2062
    • Lipster, D.1    Kragballe, K.2    Saurat, J.H.3
  • 164
    • 8944227498 scopus 로고    scopus 로고
    • Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function
    • A.V. Rawlings, A. Davies, and M. Carlomusto Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function Arch Dermatol Res 288 1996 383 390
    • (1996) Arch Dermatol Res , vol.288 , pp. 383-390
    • Rawlings, A.V.1    Davies, A.2    Carlomusto, M.3
  • 165
    • 0021688510 scopus 로고
    • Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids
    • E.J. Van Scott, and R.J. Yu Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids J Am Acad Dermatol 11 1984 867 879
    • (1984) J Am Acad Dermatol , vol.11 , pp. 867-879
    • Van Scott, E.J.1    Yu, R.J.2
  • 166
    • 84882889101 scopus 로고    scopus 로고
    • Erlotinib-related skin toxicities: Treatment strategies in patients with metastatic non-small cell lung cancer
    • Y. Kiyohara, N. Yamazaki, and A. Kishi Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer J Am Acad Dermatol 69 2013 463 472
    • (2013) J Am Acad Dermatol , vol.69 , pp. 463-472
    • Kiyohara, Y.1    Yamazaki, N.2    Kishi, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.