A pro-nerve growth factor (proNGF) and NGF binding protein, α2-macroglobulin, differentially regulates p75 and TrkA receptors and is relevant to neurodegeneration ex vivo and in vivo

Molecular and Cellular Biology

Volumn 35, Issue 19, 2015, Pages 3396-3408

  Barcelona, Pablo F ^a,b   Saragovi, H Uri ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; FURIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR BINDING PROTEIN; NEUROTROPHIN; NEUROTROPHIN RECEPTOR P75; PRO NERVE GROWTH FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NERVE GROWTH FACTOR RECEPTOR; NERVE PROTEIN; NGFR PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN PRECURSOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CELL SURFACE; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; DIMERIZATION; ENZYME ACTIVATION; ENZYME MECHANISM; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIMIT OF QUANTITATION; MALE; MOUSE; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STOICHIOMETRY; UPREGULATION; WESTERN BLOTTING; ANIMAL; DEGENERATIVE DISEASE; METABOLISM; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; PROTEIN STABILITY;

ALPHA-MACROGLOBULINS; ANIMALS; HUMANS; MICE; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN PRECURSORS; PROTEIN STABILITY; PROTEOLYSIS; RATS; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR;

EID: 84941066690     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00544-15     Document Type: Article

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