A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist

Biochimica et Biophysica Acta - General Subjects

Volumn 1800, Issue 9, 2010, Pages 1018-1026

  Brahimi, Fouad ^a   Liu, Jing ^b   Malakhov, Andrey ^b   Chowdhury, Shafinaz ^a   Purisima, Enrico O ^c   Ivanisevic, Ljubica ^a   Caron, Antoine ^a   Burgess, Kevin ^b   Saragovi, H Uri ^a  

^a MCGILL UNIVERSITY   (Canada)

^b TEXAS A AND M UNIVERSITY   (United States)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Agonist; Antagonist; Ligand; Linker; Neurotrophin; Tyrosine kinase receptor

Indexed keywords

HOMODIMER; NERVE GROWTH FACTOR RECEPTOR; PEPTIDOMIMETIC AGENT; PROTEIN TYROSINE KINASE A; TYROSINE KINASE RECEPTOR; NERVE GROWTH FACTOR; NGF PROTEIN, HUMAN; OLIGOPEPTIDE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; 3T3 CELL LINE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; PROTEIN MULTIMERIZATION;

ANIMALS; HUMANS; MICE; NERVE GROWTH FACTOR; NIH 3T3 CELLS; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN MULTIMERIZATION; RECEPTOR, TRKA;

EID: 77955282196     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2010.06.007     Document Type: Article

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