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Volumn 89, Issue 19, 2015, Pages 9998-10009

Protection from severe influenza virus infections in mice carrying the Mx1 influenza virus resistance gene strongly depends on genetic background

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE FUNCTION; GENETIC SUSCEPTIBILITY; INFECTION PREVENTION; INFECTION RESISTANCE; INFECTION SENSITIVITY; INFLUENZA; INFLUENZA A (H1N1); INFLUENZA A VIRUS (H1N1); MOUSE; MX1 GENE; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION; WILD TYPE; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CONGENIC STRAIN; DBA MOUSE; GENETIC PREDISPOSITION; GENETICS; HOST RANGE; HUMAN; IMMUNOLOGY; INFLUENZA A VIRUS (H3N2); KNOCKOUT MOUSE; METABOLISM; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; PATHOGENICITY; PHYSIOLOGY; VIROLOGY;

EID: 84941002975     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01305-15     Document Type: Article
Times cited : (44)

References (63)
  • 1
    • 33750365541 scopus 로고    scopus 로고
    • Seasonal and pandemic influenza preparedness: science and countermeasures
    • Fauci AS. 2006. Seasonal and pandemic influenza preparedness: science and countermeasures. J Infect Dis 194(Suppl 2):S73-S76. http://dx.doi.org/10.1086/507550.
    • (2006) J Infect Dis , vol.194 , pp. S73-S76
    • Fauci, A.S.1
  • 2
    • 79951543585 scopus 로고    scopus 로고
    • Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: lessons from the 2009 pandemic
    • Klenk HD, Garten W, Matrosovich M. 2011. Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: lessons from the 2009 pandemic. Bioessays 33:180-188. http://dx.doi.org/10.1002/bies.201000118.
    • (2011) Bioessays , vol.33 , pp. 180-188
    • Klenk, H.D.1    Garten, W.2    Matrosovich, M.3
  • 3
    • 31344448218 scopus 로고    scopus 로고
    • Influenza pandemics of the 20th century
    • Kilbourne ED. 2006. Influenza pandemics of the 20th century. Emerg Infect Dis 12:9-14. http://dx.doi.org/10.3201/eid1201.051254.
    • (2006) Emerg Infect Dis , vol.12 , pp. 9-14
    • Kilbourne, E.D.1
  • 4
    • 27544484489 scopus 로고    scopus 로고
    • The genesis of a pandemic influenza virus
    • Russell CJ, Webster RG. 2005. The genesis of a pandemic influenza virus. Cell 123:368-371. http://dx.doi.org/10.1016/j.cell.2005.10.019.
    • (2005) Cell , vol.123 , pp. 368-371
    • Russell, C.J.1    Webster, R.G.2
  • 5
    • 0036514779 scopus 로고    scopus 로고
    • Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic
    • Johnson NP, Mueller J. 2002. Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic. Bull Hist Med 76:105-115. http://dx.doi.org/10.1353/bhm.2002.0022.
    • (2002) Bull Hist Med , vol.76 , pp. 105-115
    • Johnson, N.P.1    Mueller, J.2
  • 8
    • 67649297821 scopus 로고    scopus 로고
    • Emergence and pandemic potential of swine-origin H1N1 influenza virus
    • Neumann G, Noda T, Kawaoka Y. 2009. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459:931-939. http://dx.doi.org/10.1038/nature08157.
    • (2009) Nature , vol.459 , pp. 931-939
    • Neumann, G.1    Noda, T.2    Kawaoka, Y.3
  • 12
    • 66449099742 scopus 로고    scopus 로고
    • Unraveling the mystery of swine influenza virus
    • Wang TT, Palese P. 2009. Unraveling the mystery of swine influenza virus. Cell 137:983-985. http://dx.doi.org/10.1016/j.cell.2009.05.032.
    • (2009) Cell , vol.137 , pp. 983-985
    • Wang, T.T.1    Palese, P.2
  • 13
    • 42949111564 scopus 로고    scopus 로고
    • Human infection with highly pathogenic H5N1 influenza virus
    • Gambotto A, Barratt-Boyes SM, de Jong MD, Neumann G, Kawaoka Y. 2008. Human infection with highly pathogenic H5N1 influenza virus. Lancet 371:1464-1475. http://dx.doi.org/10.1016/S0140-6736(08)60627-3.
    • (2008) Lancet , vol.371 , pp. 1464-1475
    • Gambotto, A.1    Barratt-Boyes, S.M.2    de Jong, M.D.3    Neumann, G.4    Kawaoka, Y.5
  • 14
    • 33645069136 scopus 로고    scopus 로고
    • Virology. Clues to the virulence of H5N1 viruses in humans
    • Krug RM. 2006. Virology. Clues to the virulence of H5N1 viruses in humans. Science 311:1562-1563.
    • (2006) Science , vol.311 , pp. 1562-1563
    • Krug, R.M.1
  • 16
    • 84883362875 scopus 로고    scopus 로고
    • H7N9 avian influenza A virus and the perpetual challenge of potential human pandemicity
    • Morens DM, Taubenberger JK, Fauci AS. 2013. H7N9 avian influenza A virus and the perpetual challenge of potential human pandemicity. mBio 4(4):e00445-13. http://dx.doi.org/10.1128/mBio.00445-13.
    • (2013) mBio , vol.4 , Issue.4
    • Morens, D.M.1    Taubenberger, J.K.2    Fauci, A.S.3
  • 21
    • 77955169025 scopus 로고    scopus 로고
    • Influenza A/H1N1v in pregnancy: an investigation of the characteristics and management of affected women and the relationship to pregnancy outcomes for mother and infant
    • Yates L, Pierce M, Stephens S, Mill A, Spark P, Kurinczuk J, Valappil M, Brocklehurst P, Thomas S, Knight M. 2010. Influenza A/H1N1v in pregnancy: an investigation of the characteristics and management of affected women and the relationship to pregnancy outcomes for mother and infant. Health Technol Assess 14:109-182. http://dx.doi.org/10.3310/hta14340-02.
    • (2010) Health Technol Assess , vol.14 , pp. 109-182
    • Yates, L.1    Pierce, M.2    Stephens, S.3    Mill, A.4    Spark, P.5    Kurinczuk, J.6    Valappil, M.7    Brocklehurst, P.8    Thomas, S.9    Knight, M.10
  • 25
    • 84880510658 scopus 로고    scopus 로고
    • Obesity and respiratory infections: does excess adiposity weigh down host defense?
    • Mancuso P. 2013. Obesity and respiratory infections: does excess adiposity weigh down host defense? Pulm Pharmacol Ther 26:412-419. http://dx.doi.org/10.1016/j.pupt.2012.04.006.
    • (2013) Pulm Pharmacol Ther , vol.26 , pp. 412-419
    • Mancuso, P.1
  • 26
    • 84867720208 scopus 로고    scopus 로고
    • Review on the impact of pregnancy and obesity on influenza virus infection
    • Karlsson EA, Marcelin G, Webby RJ, Schultz-Cherry S. 2012. Review on the impact of pregnancy and obesity on influenza virus infection. Influenza Other Respir Viruses 6:449-460. http://dx.doi.org/10.1111/j.1750-2659.2012.00342.x.
    • (2012) Influenza Other Respir Viruses , vol.6 , pp. 449-460
    • Karlsson, E.A.1    Marcelin, G.2    Webby, R.J.3    Schultz-Cherry, S.4
  • 29
    • 84869487923 scopus 로고    scopus 로고
    • The mouse as model system to study hostpathogen interactions in influenza A infections
    • Wilk E, Schughart K. 2012. The mouse as model system to study hostpathogen interactions in influenza A infections. Curr Protoc Mouse Biol 2:177-205. http://dx.doi.org/10.1002/9780470942390.mo110173.
    • (2012) Curr Protoc Mouse Biol , vol.2 , pp. 177-205
    • Wilk, E.1    Schughart, K.2
  • 31
    • 46949084427 scopus 로고    scopus 로고
    • Genetic susceptibility and resistance to influenza infection and disease in humans and mice
    • Trammell RA, Toth LA. 2008. Genetic susceptibility and resistance to influenza infection and disease in humans and mice. Expert Rev Mol Diagn 8:515-529. http://dx.doi.org/10.1586/14737159.8.4.515.
    • (2008) Expert Rev Mol Diagn , vol.8 , pp. 515-529
    • Trammell, R.A.1    Toth, L.A.2
  • 32
    • 40349084265 scopus 로고    scopus 로고
    • Gene expression in lung and basal forebrain during influenza infection in mice
    • Ding M, Lu L, Toth LA. 2008. Gene expression in lung and basal forebrain during influenza infection in mice. Genes Brain Behav 7:173-183. http://dx.doi.org/10.1111/j.1601-183X.2007.00335.x.
    • (2008) Genes Brain Behav , vol.7 , pp. 173-183
    • Ding, M.1    Lu, L.2    Toth, L.A.3
  • 34
    • 77954476468 scopus 로고    scopus 로고
    • Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 influenza mouse model
    • Boon AC, Debeauchamp J, Krauss S, Rubrum A, Webb AD, Webster RG, McElhaney J, Webby RJ. 2010. Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 influenza mouse model. J Virol 84:7662-7667. http://dx.doi.org/10.1128/JVI.02444-09.
    • (2010) J Virol , vol.84 , pp. 7662-7667
    • Boon, A.C.1    Debeauchamp, J.2    Krauss, S.3    Rubrum, A.4    Webb, A.D.5    Webster, R.G.6    McElhaney, J.7    Webby, R.J.8
  • 35
    • 80052515768 scopus 로고    scopus 로고
    • Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models
    • Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G. 2011. Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models. Am J Pathol 179:230-239. http://dx.doi.org/10.1016/j.ajpath.2011.03.041.
    • (2011) Am J Pathol , vol.179 , pp. 230-239
    • Otte, A.1    Sauter, M.2    Alleva, L.3    Baumgarte, S.4    Klingel, K.5    Gabriel, G.6
  • 36
    • 80455168605 scopus 로고    scopus 로고
    • H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load
    • Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ. 2011. H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. mBio 2(5):e00171-11. http://dx.doi.org/10.1128/mBio.00171-11.
    • (2011) mBio , vol.2 , Issue.5
    • Boon, A.C.1    Finkelstein, D.2    Zheng, M.3    Liao, G.4    Allard, J.5    Klumpp, K.6    Webster, R.7    Peltz, G.8    Webby, R.J.9
  • 37
    • 84355162158 scopus 로고    scopus 로고
    • Host genetic background and the innate inflammatory response of lung to influenza virus
    • Trammell RA, Liberati TA, Toth LA. 2012. Host genetic background and the innate inflammatory response of lung to influenza virus. Microbes Infect 14:50-58. http://dx.doi.org/10.1016/j.micinf.2011.08.008.
    • (2012) Microbes Infect , vol.14 , pp. 50-58
    • Trammell, R.A.1    Liberati, T.A.2    Toth, L.A.3
  • 38
    • 81255179897 scopus 로고    scopus 로고
    • The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses
    • Pica N, Iyer A, Ramos I, Bouvier NM, Fernandez-Sesma A, Garcia-Sastre A, Lowen AC, Palese P, Steel J. 2011. The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses. J Virol 85:12825-12829. http://dx.doi.org/10.1128/JVI.05930-11.
    • (2011) J Virol , vol.85 , pp. 12825-12829
    • Pica, N.1    Iyer, A.2    Ramos, I.3    Bouvier, N.M.4    Fernandez-Sesma, A.5    Garcia-Sastre, A.6    Lowen, A.C.7    Palese, P.8    Steel, J.9
  • 39
    • 34347268783 scopus 로고    scopus 로고
    • Interferon-induced Mx proteins in antiviral host defense
    • Haller O, Staeheli P, Kochs G. 2007. Interferon-induced Mx proteins in antiviral host defense. Biochimie 89:812-818. http://dx.doi.org/10.1016/j.biochi.2007.04.015.
    • (2007) Biochimie , vol.89 , pp. 812-818
    • Haller, O.1    Staeheli, P.2    Kochs, G.3
  • 40
    • 68149098653 scopus 로고    scopus 로고
    • Protective role of interferoninduced Mx GTPases against influenza viruses
    • Haller O, Staeheli P, Kochs G. 2009. Protective role of interferoninduced Mx GTPases against influenza viruses. Rev Sci Tech 28:219-231.
    • (2009) Rev Sci Tech , vol.28 , pp. 219-231
    • Haller, O.1    Staeheli, P.2    Kochs, G.3
  • 41
    • 0019751240 scopus 로고
    • Inborn resistance of mice to orthomyxoviruses
    • Haller O. 1981. Inborn resistance of mice to orthomyxoviruses. Curr Top Microbiol Immunol 92:25-52.
    • (1981) Curr Top Microbiol Immunol , vol.92 , pp. 25-52
    • Haller, O.1
  • 43
    • 80755153638 scopus 로고    scopus 로고
    • Structure of myxovirus resistance protein a reveals intra-and intermolecular domain interactions required for the antiviral function
    • Gao S, von der Malsburg A, Dick A, Faelber K, Schroder GF, Haller O, Kochs G, Daumke O. 2011. Structure of myxovirus resistance protein a reveals intra-and intermolecular domain interactions required for the antiviral function. Immunity 35:514-525. http://dx.doi.org/10.1016/j.immuni.2011.07.012.
    • (2011) Immunity , vol.35 , pp. 514-525
    • Gao, S.1    von der Malsburg, A.2    Dick, A.3    Faelber, K.4    Schroder, G.F.5    Haller, O.6    Kochs, G.7    Daumke, O.8
  • 44
    • 84896877632 scopus 로고    scopus 로고
    • Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influ-enza A virus
    • Patzina C, Haller O, Kochs G. 2014. Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influ-enza A virus. J Biol Chem 289:6020-6027. http://dx.doi.org/10.1074/jbc. M113.543892.
    • (2014) J Biol Chem , vol.289 , pp. 6020-6027
    • Patzina, C.1    Haller, O.2    Kochs, G.3
  • 45
    • 80052285645 scopus 로고    scopus 로고
    • The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection
    • Wisskirchen C, Ludersdorfer TH, Muller DA, Moritz E, Pavlovic J. 2011. The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection. J Virol 85:8646-8655. http://dx.doi.org/10.1128/JVI.02559-10.
    • (2011) J Virol , vol.85 , pp. 8646-8655
    • Wisskirchen, C.1    Ludersdorfer, T.H.2    Muller, D.A.3    Moritz, E.4    Pavlovic, J.5
  • 46
    • 80053422068 scopus 로고    scopus 로고
    • Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49
    • Wisskirchen C, Ludersdorfer TH, Muller DA, Moritz E, Pavlovic J. 2011. Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49. J Biol Chem 286:34743-34751. http://dx.doi.org/10.1074/jbc. M111.251843.
    • (2011) J Biol Chem , vol.286 , pp. 34743-34751
    • Wisskirchen, C.1    Ludersdorfer, T.H.2    Muller, D.A.3    Moritz, E.4    Pavlovic, J.5
  • 47
    • 0000964244 scopus 로고
    • The resistance of A2G mice to myxoviruses
    • Lindenmann J, Lance CA, Hobson D. 1963. The resistance of A2G mice to myxoviruses. J Immunol 90:942.
    • (1963) J Immunol , vol.90 , pp. 942
    • Lindenmann, J.1    Lance, C.A.2    Hobson, D.3
  • 48
    • 0023791475 scopus 로고
    • Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation
    • Staeheli P, Grob R, Meier E, Sutcliffe JG, Haller O. 1988. Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol 8:4518-4523.
    • (1988) Mol Cell Biol , vol.8 , pp. 4518-4523
    • Staeheli, P.1    Grob, R.2    Meier, E.3    Sutcliffe, J.G.4    Haller, O.5
  • 50
    • 6544232711 scopus 로고    scopus 로고
    • Characterization and expression of the Mx1 gene in wild mouse species
    • Jin HK, Yamashita T, Ochiai K, Haller O, Watanabe T. 1998. Characterization and expression of the Mx1 gene in wild mouse species. Biochem Genet 36:311-322. http://dx.doi.org/10.1023/A:1018741312058.
    • (1998) Biochem Genet , vol.36 , pp. 311-322
    • Jin, H.K.1    Yamashita, T.2    Ochiai, K.3    Haller, O.4    Watanabe, T.5
  • 51
    • 84857848700 scopus 로고    scopus 로고
    • Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival
    • Cilloniz C, Pantin-Jackwood MJ, Ni C, Carter VS, Korth MJ, Swayne DE, Tumpey TM, Katze MG. 2012. Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. J Virol 86:2437-2446. http://dx.doi.org/10.1128/JVI.06156-11.
    • (2012) J Virol , vol.86 , pp. 2437-2446
    • Cilloniz, C.1    Pantin-Jackwood, M.J.2    Ni, C.3    Carter, V.S.4    Korth, M.J.5    Swayne, D.E.6    Tumpey, T.M.7    Katze, M.G.8
  • 52
    • 81355161360 scopus 로고    scopus 로고
    • Influenza virus pathophysiology and brain invasion in mice with functional and dysfunctional Mx1 genes
    • Hodgson NR, Bohnet SG, Majde JA, Krueger JM. 2012. Influenza virus pathophysiology and brain invasion in mice with functional and dysfunctional Mx1 genes. Brain Behav Immun 26:83-89. http://dx.doi.org/10.1016/j.bbi.2011.07.238.
    • (2012) Brain Behav Immun , vol.26 , pp. 83-89
    • Hodgson, N.R.1    Bohnet, S.G.2    Majde, J.A.3    Krueger, J.M.4
  • 53
    • 70350399459 scopus 로고    scopus 로고
    • Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J
    • Moritoh K, Yamauchi H, Asano A, Yoshii K, Kariwa H, Takashima I, Isoda N, Sakoda Y, Kida H, Sasaki N, Agui T. 2009. Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J. Jpn J Vet Res 57:89-99.
    • (2009) Jpn J Vet Res , vol.57 , pp. 89-99
    • Moritoh, K.1    Yamauchi, H.2    Asano, A.3    Yoshii, K.4    Kariwa, H.5    Takashima, I.6    Isoda, N.7    Sakoda, Y.8    Kida, H.9    Sasaki, N.10    Agui, T.11
  • 54
    • 34648833226 scopus 로고    scopus 로고
    • The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses
    • Tumpey TM, Szretter KJ, Van Hoeven N, Katz JM, Kochs G, Haller O, Garcia-Sastre A, Staeheli P. 2007. The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. J Virol 81:10818-10821. http://dx.doi.org/10.1128/JVI.01116-07.
    • (2007) J Virol , vol.81 , pp. 10818-10821
    • Tumpey, T.M.1    Szretter, K.J.2    Van Hoeven, N.3    Katz, J.M.4    Kochs, G.5    Haller, O.6    Garcia-Sastre, A.7    Staeheli, P.8
  • 56
    • 33846796382 scopus 로고    scopus 로고
    • Protective role of beta interferon in host defense against influenza A virus
    • Koerner I, Kochs G, Kalinke U, Weiss S, Staeheli P. 2007. Protective role of beta interferon in host defense against influenza A virus. J Virol 81: 2025-2030. http://dx.doi.org/10.1128/JVI.01718-06.
    • (2007) J Virol , vol.81 , pp. 2025-2030
    • Koerner, I.1    Kochs, G.2    Kalinke, U.3    Weiss, S.4    Staeheli, P.5
  • 57
    • 41149123801 scopus 로고    scopus 로고
    • Mx1 causes resistance against influenza A viruses in the Mus spretus-derived inbred mouse strain SPRET/Ei
    • Vanlaere I, Vanderrijst A, Guenet JL, De Filette M, Libert C. 2008. Mx1 causes resistance against influenza A viruses in the Mus spretus-derived inbred mouse strain SPRET/Ei. Cytokine 42:62-70. http://dx.doi.org/10.1016/j.cyto.2008.01.013.
    • (2008) Cytokine , vol.42 , pp. 62-70
    • Vanlaere, I.1    Vanderrijst, A.2    Guenet, J.L.3    De Filette, M.4    Libert, C.5
  • 58
    • 84863115856 scopus 로고    scopus 로고
    • The genome architecture of the Collaborative Cross mouse genetic reference population
    • Collaborative Cross Consortium. 2012. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics 190: 389-401. http://dx.doi.org/10.1534/genetics.111.132639.
    • (2012) Genetics , vol.190 , pp. 389-401
  • 59
    • 79952537278 scopus 로고    scopus 로고
    • Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors
    • Blazejewska P, Koscinski L, Viegas N, Anhlan D, Ludwig S, Schughart K. 2011. Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors. Virology 412:36-45. http://dx.doi.org/10.1016/j.virol.2010.12.047.
    • (2011) Virology , vol.412 , pp. 36-45
    • Blazejewska, P.1    Koscinski, L.2    Viegas, N.3    Anhlan, D.4    Ludwig, S.5    Schughart, K.6
  • 60
    • 84893281225 scopus 로고    scopus 로고
    • New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant
    • Liedmann S, Hrincius ER, Anhlan D, McCullers JA, Ludwig S, Ehrhardt C. 2014. New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant. J Infect Dis 209:532-541. http://dx.doi.org/10.1093/infdis/jit463.
    • (2014) J Infect Dis , vol.209 , pp. 532-541
    • Liedmann, S.1    Hrincius, E.R.2    Anhlan, D.3    McCullers, J.A.4    Ludwig, S.5    Ehrhardt, C.6
  • 61
    • 84884942143 scopus 로고    scopus 로고
    • The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model
    • Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T. 2013. The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model. J Immunol 191:4740-4747. http://dx.doi.org/10.4049/jimmunol.1301744.
    • (2013) J Immunol , vol.191 , pp. 4740-4747
    • Takaki, H.1    Takeda, M.2    Tahara, M.3    Shingai, M.4    Oshiumi, H.5    Matsumoto, M.6    Seya, T.7
  • 62
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408. http://dx.doi.org/10.1006/meth.2001.1262.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 63
    • 84858235640 scopus 로고    scopus 로고
    • The role of host genetics in susceptibility to influenza: a systematic review
    • Horby P, Nguyen NY, Dunstan SJ, Baillie JK. 2012. The role of host genetics in susceptibility to influenza: a systematic review. PLoS One 7:e33180. http://dx.doi.org/10.1371/journal.pone.0033180.
    • (2012) PLoS One , vol.7
    • Horby, P.1    Nguyen, N.Y.2    Dunstan, S.J.3    Baillie, J.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.