Retention kinetics of the 18F-labeled sympathetic nerve PET tracer LMI1195: Comparison with 11C-hydroxyephedrine and 123I-MIBG

Journal of Nuclear Medicine

Volumn 56, Issue 9, 2015, Pages 1429-1433

  Werner, Rudolf A ^a   Rischpler, Christoph ^b   Onthank, David ^c   Lapa, Constantin ^a   Robinson, Simon ^c   Samnick, Samuel ^a   Javadi, Mehrbod ^d   Schwaiger, Markus ^b   Nekolla, Stephan G ^b,e   Higuchi, Takahiro ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Clinical Research   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

11C hydroxyephedrine; 123Imetaiodobenzylguanidine; 18F LMI1195; Positron emission tomography; Sympathetic nerve

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 123; DESIPRAMINE; HYDROXYEPHEDRINE C 11; N [3 BROMO 4 (3 FLUOROPROPOXY)BENZYL]GUANIDINE F 18; NORADRENALIN; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; (3 IODOBENZYL)GUANIDINE; 3-HYDROXYEPHEDRINE; EPHEDRINE; FLUORINE; FLUOROBENZENE; GUANIDINE DERIVATIVE; N-(3-BROMO-4-(3-(18F)FLUORO-PROPOXY)BENZYL)GUANIDINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG RETENTION; DRUG STRUCTURE; DRUG UPTAKE; GAMMA CAMERA; HEART; IMAGE PROCESSING; INHIBITION KINETICS; MEDIASTINUM; NERVE ENDING; NEW ZEALAND WHITE (RABBIT); NONHUMAN; NORADRENALIN RELEASE; NORADRENALIN UPTAKE; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCINTIGRAPHY; SYMPATHETIC NERVE; THORAX RADIOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; ANTIBODY SPECIFICITY; AUTONOMIC NEUROPATHY; CHEMISTRY; COMPARATIVE STUDY; EVALUATION STUDY; ISOTOPE LABELING; KINETICS; METABOLIC CLEARANCE RATE; METABOLISM; PROCEDURES; RABBIT; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SYNTHESIS; TISSUE DISTRIBUTION;

3-IODOBENZYLGUANIDINE; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; EPHEDRINE; FLUORINE RADIOISOTOPES; FLUOROBENZENES; GUANIDINES; ISOTOPE LABELING; KINETICS; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; POSITRON-EMISSION TOMOGRAPHY; RABBITS; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 84940995620     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.115.158493     Document Type: Article

References (25)

1. Parati G, Esler M. The human sympathetic nervous system: its relevance in hypertension and heart failure. Eur Heart J. 2012;33:1058-1066.
2. Jacobson AF, Senior R, Cerqueira MD, et al. Myocardial iodine-123 metaiodobenzylguanidine imaging and cardiac events in heart failure: results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55: 2212-2221.
3. Fallavollita JA, Heavey BM, Luisi AJ Jr, et al. Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol. 2014;63:141-149.
4. Yu M, Bozek J, Lamoy M, et al. Evaluation of LMI1195, a novel 18F-labeled cardiac neuronal PET imaging agent, in cells and animal models. Circ Cardiovasc Imaging. 2011;4:435-443.
5. Sinusas AJ, Lazewatsky J, Brunetti J, et al. Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation. J Nucl Med. 2014;55:1445-1451.
6. Rosenspire KC, Haka MS, Van Dort ME, et al. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med. 1990;31:1328-1334.
7. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC: National Academies Press; 2011.
8. Yamane T, Park MJ, Richter D, et al. Small-animal PET imaging of isolated perfused rat heart. J Nucl Med. 2014;55:495-499.
9. Disselhorst JA, Brom M, Laverman P, et al. Image-quality assessment for several positron emitters using the NEMA NU 4-2008 standards in the Siemens Inveon small-animal PET scanner. J Nucl Med. 2010;51:610-617.
10. Loening AM, Gambhir SS. AMIDE: a free software tool for multimodality medical image analysis. Mol Imaging. 2003;2:131-137.
11. Lautamaki R, Sasano T, Higuchi T, et al. Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone. J Nucl Med. 2015;56:457-463.
12. Higuchi T, Schwaiger M. Noninvasive imaging of heart failure: neuronal dysfunction and risk stratification. Heart Fail Clin. 2006;2:193-204.
13. Higuchi T, Schwaiger M. Imaging cardiac neuronal function and dysfunction. Curr Cardiol Rep. 2006;8:131-138.
14. Foley KF, Cozzi NV. Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs. Naunyn Schmiedebergs Arch Pharmacol. 2002;365: 457-461.
15. Higuchi T, Yousefi BH, Reder S, et al. Myocardial kinetics of a novel [18F]- labeled sympathetic nerve PET tracer LMI1195 in the isolated perfused rabbit heart. JACC Cardiovasc Imaging. March 12, 2015 [Epub ahead of print].
16. Higuchi T, Yousefi BH, Kaiser F, et al. Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. J Nucl Med. 2013;54: 1142-1146.
17. Yu M, Bozek J, Kagan M, et al. Cardiac retention of PET neuronal imaging agent LMI1195 in different species: impact of norepinephrine uptake-1 and -2 transporters. Nucl Med Biol. 2013;40:682-688.
18. Iversen LL, Salt PJ, Wilson HA. Inhibition of catecholamine uptake in the isolated rat heart by haloalkylamines related to phenoxybenzamine. Br J Pharmacol. 1972;46:647-657.
19. Rischpler C, Fukushima K, Isoda T, et al. Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and metaiodobenzylguanidine (MIBG) in rat hearts. Eur J Nucl Med Mol Imaging. 2013;40:1077-1083.
20. DeGrado TR, Hutchins GD, Toorongian SA, Wieland DM, Schwaiger M. Myocardial kinetics of carbon-11-meta-hydroxyephedrine: retention mechanisms and effects of norepinephrine. J Nucl Med. 1993;34:1287-1293.
21. Jarrott B. Uptake and metabolism of catecholamines in the perfused hearts of different species. Br J Pharmacol. 1970;38:810-821.
22. Raffel DM, Wieland DM. Assessment of cardiac sympathetic nerve integrity with positron emission tomography. Nucl Med Biol. 2001;28:541-559.
23. Bengel FM. Imaging targets of the sympathetic nervous system of the heart: translational considerations. J Nucl Med. 2011;52:1167-1170.
24. Tipre DN, Fox JJ, Holt DP, et al. In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. J Nucl Med. 2008;49:1189-1195.
25. Kreusser MM, Haass M, Buss SJ, et al. Injection of nerve growth factor into stellate ganglia improves norepinephrine reuptake into failing hearts. Hypertension. 2006;47:209-215.