Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone

Journal of Nuclear Medicine

Volumn 56, Issue 3, 2015, Pages 457-463

  Lautamaki, Riikka ^a   Sasano, Tetsuo ^a   Higuchi, Takahiro ^a   Nekolla, Stephan G ^b   Lardo, Albert C ^a   Holt, Daniel P ^a   Dannals, Robert F ^a   Abraham, M Roselle ^a   Bengel, Frank M ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Magnetic resonance imaging; Myocardial infarction; Positron emission tomography; Sympathetic innervation

Indexed keywords

AMMONIA N 13; CATECHOLAMINE; EPINEPHRINE C 11; HYDROXYEPHEDRINE C 11; PHENYLEPHRINE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; ADRENALIN; AMMONIA; CARBON; EPHEDRINE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE METABOLISM; CONTROLLED STUDY; DENERVATION; HEART ELECTROPHYSIOLOGY; HEART INFARCTION; HEART INFARCTION SIZE; HEART PERFUSION; HEART VENTRICLE TACHYCARDIA; HISTOPATHOLOGY; IMAGE ANALYSIS; MOLECULAR IMAGING; MULTIPARAMETRIC MOLECULAR IMAGING; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SWINE; SYMPATHETIC INNERVATION IMPAIRMENT; ADRENERGIC SYSTEM; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DISEASE MODEL; HEART; HEART ARRHYTHMIA; IMAGE PROCESSING; INNERVATION; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PERFUSION; PIG; PROCEDURES; SCINTISCANNING; TACHYCARDIA; TIME;

AMMONIA; ANIMALS; ARRHYTHMIAS, CARDIAC; CARBON RADIOISOTOPES; CATECHOLAMINES; DISEASE MODELS, ANIMAL; EPHEDRINE; EPINEPHRINE; HEART; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MOLECULAR IMAGING; MYOCARDIAL INFARCTION; NEURONS; PERFUSION; PHENYLEPHRINE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SWINE; SYMPATHETIC NERVOUS SYSTEM; TACHYCARDIA; TIME FACTORS;

EID: 84928169649     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.114.149971     Document Type: Article

References (36)

1. Bengel FM, Barthel P, Matsunari I, Schmidt G, Schwaiger M. Kinetics of I-123-metaiodobenzylguanidine after acute myocardial infarction and reperfusion therapy. J Nucl Med. 1999;40:904-910.
2. McGhie AI, Corbett JR, Akers MS, et al. Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction. Am J Cardiol. 1991;67:236-242.
3. Simões MV, Barthel P, Matsunari I, et al. Presence of sympathetically denervated but viable myocardium and its electrophysiologic correlates after early revascularised, acute myocardial infarction. Eur Heart J. 2004;25:551-557.
4. Matsunari I, Schricke U, Bengel FM, et al. Extent of cardiac sympathetic neuronal damage is determined by the area of ischemia in patients with acute coronary syndromes. Circulation. 2000;101:2579-2585.
5. Arora R, Ferrick KJ, Nakata T, et al. I-123 MIBG imaging and heart rate variability analysis to predict the need for an implantable cardioverter defibrillator. J Nucl Cardiol. 2003;10:121-131.
6. Kramer CM, Nicol PD, Rogers WJ, et al. Reduced sympathetic innervation underlies adjacent noninfarcted region dysfunction during left ventricular remodeling. J Am Coll Cardiol. 1997;30:1079-1085.
7. Sakata K, Mochizuki M, Yoshida H, et al. Cardiac sympathetic dysfunction contributes to left ventricular remodeling after acute myocardial infarction. Eur J Nucl Med. 2000;27:1641-1649.
8. Bengel FM. Imaging targets of the sympathetic nervous system of the heart: translational considerations. J Nucl Med. 2011;52:1167-1170.
9. Tipre DN, Fox JJ, Holt DP, et al. In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. J Nucl Med. 2008;49:1189-1195.
10. Nguyen NT, DeGrado TR, Chakraborty P, Wieland DM, Schwaiger M. Myocardial kinetics of carbon-11-epinephrine in the isolated working rat heart. J Nucl Med. 1997;38:780-785.
11. 11C-meta-hydroxyephedrine retention on norepinephrine transporter density. J Nucl Med. 2006;47:1490-1496.
12. 11C]phenylephrine kinetics: studies in isolated rat heart. J Nucl Med. 1999;40:323-330.
13. Sasano T, Abraham MR, Chang KC, et al. Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2008;51:2266-2275.
14. Sasano T, McDonald AD, Kikuchi K, Donahue JK. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med. 2006;12:1256-1258.
15. 11C]epinephrine for routine PET studies in humans. Nucl Med Biol. 1993;20:939-944.
16. 11C]-(-)-phenylephrine as a functional heart neuronal PET agent. Nucl Med Biol. 1996;23:611-616.
17. Schwaiger M, Guibourg H, Rosenspire K, et al. Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol. J Nucl Med. 1990;31:1352-1357.
18. 11C]hydroxyephedrine and positron emission tomography. Circulation. 2000;101:516-523.
19. Nekolla SG, Miethaner C, Nguyen N, Ziegler SI, Schwaiger M. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography. Eur J Nucl Med. 1998;25:1313-1321.
20. Bengel FM, Permanetter B, Ungerer M, Nekolla SG, Schwaiger M. Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart: a non-invasive study using positron emission tomography. Eur Heart J. 2001;22:1594-1600.
21. Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M. Myocardial efficiency and sympathetic reinnervation after orthotopic heart transplantation: a noninvasive study with positron emission tomography. Circulation. 2001;103:1881-1886.
22. 11C]phenylephrine kinetics to monoamine oxidase activity in normal human heart. J Nucl Med. 1999;40:232-238.
23. Delbeke D, Lorenz CH, Votaw JR, et al. Estimation of left ventricular mass and infarct size from nitrogen-13-ammonia PET images based on pathological examination of explanted human hearts. J Nucl Med. 1993;34:826-833.
24. Ryf S, Kissinger KV, Spiegel MA, et al. Spiral MR myocardial tagging. Magn Reson Med. 2004;51:237-242.
25. Osman NF, Kerwin WS, McVeigh ER, Prince JL. Cardiac motion tracking using CINE harmonic phase (HARP) magnetic resonance imaging. Magn Reson Med. 1999;42:1048-1060.
26. Liu YB, Wu CC, Lu LS, et al. Sympathetic nerve sprouting, electrical remodeling, and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits. Circ Res. 2003;92:1145-1152.
27. Cao JM, Fishbein MC, Han JB, et al. Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation. 2000;101:1960-1969.
28. Chen P-S, Chen LS, Cao J-M, Sharifi B, Karagueuzian HS, Fishbein MC. Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res. 2001;50:409-416.
29. Allman KC, Wieland DM, Muzik O, Degrado TR, Wolfe ER Jr, Schwaiger M. Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. J Am Coll Cardiol. 1993;22:368-375.
30. Fallavollita JA, Heavey BM, Luisi AJ Jr, et al. Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol. 2014;63:141-149.
31. Carr EA Jr, Carroll M, Counsell RE, Tyson JW. Studies of uptake of the bretylium analogue, iodobenzyltrimethylammonium iodide, by non-primate, monkey and human hearts. Br J Clin Pharmacol. 1979;8:425-432.
32. Callingham BA. Comparative aspects of monoamine oxidase. Vet Res Commun. 1983;7:325-330.
33. 123I-MIBG uptake. Eur J Nucl Med Mol Imaging. 2006;33:871-878.
34. Tanaka S, Tsuchida H, Namba H, Namiki A. Clonidine and lidocaine inhibition of isoflurane-induced tachycardia in humans. Anesthesiology. 1994;81:1341-1349.
35. Jacobson AF, Senior R, Cerqueira MD, et al. Myocardial iodine-123 metaiodobenzylguanidine imaging and cardiac events in heart failure: results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212-2221.
36. 18F-labeled cardiac neuronal PET imaging agent, in cells and animal models. Circ Cardiovasc Imaging. 2011;4:435-443.