Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 6, 2002, Pages 457-461

  Foley, Kevin F ^a   Cozzi, Nicholas V ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Aminopropiophenone; Bupropion; Catecholamine; Cysteine; Methamphetamine; Methcathinone; Norepinephrine transporter; Uptake

Indexed keywords

3 BROMOMETHCATHINONE; 4 BROMOMETHCATHINONE; AMFEBUTAMONE; CYSTEINE; DESIPRAMINE; METHAMPHETAMINE; METHCATHINONE; N ETHYLMALEIMIDE; NORADRENALIN; NORADRENALIN TRANSPORTER; TRITIUM; UNCLASSIFIED DRUG; COTRANSPORTER; SLC6A2 PROTEIN, HUMAN; SLC6A2 PROTEIN, RAT;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; GLIA CELL; HUMAN; IC 50; MOLECULAR CLONING; NEUROTRANSMITTER UPTAKE; NONHUMAN; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GLIA; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; TRANSPORT AT THE CELLULAR LEVEL;

ANIMAL; BIOLOGICAL TRANSPORT; DESIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLMALEIMIDE; HUMAN; NEUROGLIA; NOREPINEPHRINE; PROTEIN BINDING; RATS; SYMPORTERS; ANIMALS; HUMANS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0035987111     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0532-3     Document Type: Article

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