Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and metaiodobenzylguanidine (MIBG) in rat hearts

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 40, Issue 7, 2013, Pages 1077-1083

  Rischpler, Christoph ^a,b   Fukushima, Kenji ^a   Isoda, Takuro ^a   Javadi, Mehrbod S ^a   Dannals, Robert F ^a   Abraham, Roselle ^a   Wahl, Richard ^a   Bengel, Frank M ^a,c   Higuchi, Takahiro ^a,d,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

11C Hydroxyephedrine; 123I 131I Metaiodobenzylguanidine; Rat hearts

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 123; (3 IODOBENZYL)GUANIDINE I 131; DESIPRAMINE; HYDROXYEPHEDRINE C 11; HYDROXYPHEDRINE; NORADRENALIN DERIVATIVE; PHENOXYBENZAMINE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CORONARY ARTERY BLOOD FLOW; DRUG DISTRIBUTION; DRUG UPTAKE; ENDOCARDIUM; EPICARDIUM; HEART; HEART INFARCTION; HEART MUSCLE; HISTOLOGY; MALE; NONHUMAN; RAT;

3-IODOBENZYLGUANIDINE; ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL TRANSPORT; CORONARY OCCLUSION; EPHEDRINE; ISOTOPE LABELING; MALE; MYOCARDIAL REPERFUSION; MYOCARDIUM; NOREPINEPHRINE; RATS; RATS, WISTAR;

EID: 84879497730     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-013-2393-z     Document Type: Article

References (30)

1. Hartikainen J, Mustonen J, Kuikka J, Vanninen E, Kettunen R. Cardiac sympathetic denervation in patients with coronary artery disease without previous myocardial infarction. Am J Cardiol 1997;80:273-7.
2. Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol 2010;55:2212-21. doi: 10.1016/j.jacc.2010.01.014.
3. Watson AM, Hood SG, May CN. Mechanisms of sympathetic activation in heart failure. Clin Exp Pharmacol Physiol 2006;33:1269-74. doi: 10.1111/j.1440-1681. 2006.04523.x.
4. Verberne HJ, Brewster LM, Somsen GA, van Eck-Smit BL. Prognostic value of myocardial 123I-metaiodobenzylguanidine (MIBG) parameters in patients with heart failure: a systematic review. Eur Heart J 2008;29:1147-59.
5. Pietilä M, Malminiemi K, Ukkonen H, Saraste M, Någren K, Lehikoinen P, et al. Reduced myocardial carbon-11 hydroxyephedrine retention is associated with poor prognosis in chronic heart failure. Eur J Nucl Med 2001;28:373-6.
6. Hartmann F, Ziegler S, Nekolla S, Hadamitzky M, Seyfarth M, Richardt G, et al. Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography. Heart 1999;81:262-70.
7. Higuchi T, Bengel FM, Seidl S, Watzlowik P, Kessler H, Hegenloh R, et al. Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography. Cardiovasc Res 2008;78:395-403.
8. Higuchi T, Fukushima K, Xia J, Mathews WB, Lautamäki R, Bravo PE, et al. Radionuclide imaging of angiotensin II type 1 receptor upregulation after myocardial ischemia-reperfusion injury. J Nucl Med 2010;51:1956-61. doi: 10.2967/jnumed.110.079855.
9. Higuchi T, Anton M, Saraste A, Dumler K, Pelisek J, Nekolla SG, et al. Reporter gene PET for monitoring survival of transplanted endothelial progenitor cells in the rat heart after pretreatment with VEGF and atorvastatin. J Nucl Med 2009;50:1881-6.
10. Higuchi T, Bengel FM. Cardiovascular nuclear imaging: from perfusion to molecular function: non-invasive imaging. Heart 2008;94:809-16.
11. Higuchi T, Nekolla SG, Jankaukas A, Weber AW, Huisman MC, Reder S, et al. Characterization of normal and infarcted rat myocardium using a combination of small-animal PET and clinical MRI. J Nucl Med 2007;48:288-94.
12. Gallagher AM, Bahnson TD, Yu H, Kim NN, Printz MP. Species variability in angiotensin receptor expression by cultured cardiac fibroblasts and the infarcted heart. Am J Physiol 1998;274:H801-9.
13. Rosenspire KC, Haka MS, Van Dort ME, Jewett DM, Gildersleeve DL, Schwaiger M, et al. Synthesis and preliminary evaluation of carbon-11-meta- hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med 1990;31:1328-34.
14. Guide for the care and use of laboratory animals. 8th edition Washington, DC: National Academies Press (US); 2011.
15. Higuchi T, Taki J, Nakajima K, Kinuya S, Namura M, Tonami N. Time course of discordant BMIPP and thallium uptake after ischemia and reperfusion in a rat model. J Nucl Med 2005;46:172-5.
16. Taki J, Higuchi T, Kawashima A, Tait JF, Kinuya S, Muramori A, et al. Detection of cardiomyocyte death in a rat model of ischemia and reperfusion using 99mTc-labeled annexin V. J Nucl Med 2004;45:1536-41.
17. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012;9:671-5.
18. Matsunari I, Schricke U, Bengel FM, Haase HU, Barthel P, Schmidt G, et al. Extent of cardiac sympathetic neuronal damage is determined by the area of ischemia in patients with acute coronary syndromes. Circulation 2000;101:2579-85.
19. Tipre DN, Fox JJ, Holt DP, Green G, Yu J, Pomper M, et al. In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. J Nucl Med 2008;49:1189-95.
20. Iversen LL. Catecholamine uptake processes. Br Med Bull 1973;29:130-5.
21. Malizia AL, Melichar JK, Rhodes CG, Haida A, Reynolds AH, Jones T, et al. Desipramine binding to noradrenaline reuptake sites in cardiac sympathetic neurons in man in vivo. Eur J Pharmacol 2000;391:263-7.
22. DeGrado TR, Hutchins GD, Toorongian SA, Wieland DM, Schwaiger M. Myocardial kinetics of carbon-11-meta-hydroxyephedrine: retention mechanisms and effects of norepinephrine. J Nucl Med 1993;34:1287-93.
23. Iversen LL, Salt PJ, Wilson HA. Inhibition of catecholamine uptake in the isolated rat heart by haloalkylamines related to phenoxybenzamine. Br J Pharmacol 1972;46:647-57.
24. Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, et al. Sema3a maintains normal heart rhythm through sympathetic innervation patterning. Nat Med 2007;13:604-12.
25. Raffel DM, Chen W, Jung YW, Jang KS, Gu G, Cozzi NV. Radiotracers for cardiac sympathetic innervation: transport kinetics and binding affinities for the human norepinephrine transporter. Nucl Med Biol 2013;40:331-37.
26. Raffel DM, Chen W. Binding of [3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies. Naunyn Schmiedebergs Arch Pharmacol 2004;370:9-16.
27. Sisson JC, Wieland DM, Sherman P, Mangner TJ, Tobes MC, Jacques Jr S. Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function. J Nucl Med 1987;28:1620-4.
28. Tobes MC, Jaques Jr S, Wieland DM, Sisson JC. Effect of uptake-one inhibitors on the uptake of norepinephrine and metaiodobenzylguanidine. J Nucl Med 1985;26:897-907.
29. Yu M, Bozek J, Lamoy M, Guaraldi M, Silva P, Kagan M, et al. Evaluation of LMI1195, a novel 18F-labeled cardiac neuronal PET imaging agent, in cells and animal models. Circ Cardiovasc Imaging 2011;4:435-43.
30. Estorch M, Campreciós M, Flotats A, Marí C, Bernà L, Catafau AM, et al. Sympathetic reinnervation of cardiac allografts evaluated by 123I-MIBG imaging. J Nucl Med 1999;40:911-6.