메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOSACCHARIDE; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

EID: 84940970609     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13517     Document Type: Article
Times cited : (152)

References (54)
  • 1
    • 84886848268 scopus 로고    scopus 로고
    • The human milk metabolome reveals diverse oligosaccharide profiles
    • Smilowitz, J. T. et al. The human milk metabolome reveals diverse oligosaccharide profiles. J Nutr 143, 1709-18 (2013).
    • (2013) J Nutr , vol.143 , pp. 1709-1718
    • Smilowitz, J.T.1
  • 2
    • 23944482922 scopus 로고    scopus 로고
    • Human milk glycans protect infants against enteric pathogens
    • Newburg, D. S., Ruiz-Palacios, G. M. & Morrow, A. L. Human milk glycans protect infants against enteric pathogens. Annu Rev Nutr 25, 37-58 (2005).
    • (2005) Annu Rev Nutr , vol.25 , pp. 37-58
    • Newburg, D.S.1    Ruiz-Palacios, G.M.2    Morrow, A.L.3
  • 3
    • 84896884079 scopus 로고    scopus 로고
    • Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression
    • Rogier, E. W. et al. Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression. Proc Natl Acad Sci USA 111, 3074-9 (2014).
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 3074-3079
    • Rogier, E.W.1
  • 4
    • 78650496817 scopus 로고    scopus 로고
    • Development: Mother's milk: A rich opportunity
    • Petherick, A. Development: Mother's milk: A rich opportunity. Nature 468, S5-7 (2010).
    • (2010) Nature , vol.468 , pp. S5-7
    • Petherick, A.1
  • 5
    • 77955462811 scopus 로고    scopus 로고
    • Development of an annotated library of neutral human milk oligosaccharides
    • Wu, S., Tao, N., German, J. B., Grimm, R. & Lebrilla, C. B. Development of an annotated library of neutral human milk oligosaccharides. J Proteome Res 9, 4138-51 (2010).
    • (2010) J Proteome Res , vol.9 , pp. 4138-4151
    • Wu, S.1    Tao, N.2    German, J.B.3    Grimm, R.4    Lebrilla, C.B.5
  • 6
    • 79953709953 scopus 로고    scopus 로고
    • Annotation and structural analysis of sialylated human milk oligosaccharides
    • Wu, S., Grimm, R., German, J. B. & Lebrilla, C. B. Annotation and structural analysis of sialylated human milk oligosaccharides. J Proteome Res 10, 856-68 (2011).
    • (2011) J Proteome Res , vol.10 , pp. 856-868
    • Wu, S.1    Grimm, R.2    German, J.B.3    Lebrilla, C.B.4
  • 7
    • 0034083133 scopus 로고    scopus 로고
    • Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract
    • Engfer, M. B., Stahl, B., Finke, B., Sawatzki, G. & Daniel, H. Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract. Am J Clin Nutr 71, 1589-96 (2000).
    • (2000) Am J Clin Nutr , vol.71 , pp. 1589-1596
    • Engfer, M.B.1    Stahl, B.2    Finke, B.3    Sawatzki, G.4    Daniel, H.5
  • 8
    • 84875740598 scopus 로고    scopus 로고
    • Consumption of human milk glycoconjugates by infant-associated bifidobacteria: Mechanisms and implications
    • Garrido, D., Dallas, D. C. & Mills, D. A. Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications. Microbiology 159, 649-64 (2013).
    • (2013) Microbiology , vol.159 , pp. 649-664
    • Garrido, D.1    Dallas, D.C.2    Mills, D.A.3
  • 9
    • 12844251441 scopus 로고    scopus 로고
    • Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR
    • Penders, J. et al. Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR. FEMS Microbiol Lett 243, 141-7 (2005).
    • (2005) FEMS Microbiol Lett , vol.243 , pp. 141-147
    • Penders, J.1
  • 10
    • 33748415364 scopus 로고    scopus 로고
    • Factors influencing the composition of the intestinal microbiota in early infancy
    • Penders, J. et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118, 511-21 (2006).
    • (2006) Pediatrics , vol.118 , pp. 511-521
    • Penders, J.1
  • 11
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko, T. et al. Human gut microbiome viewed across age and geography. Nature 486, 222-7 (2012).
    • (2012) Nature , vol.486 , pp. 222-227
    • Yatsunenko, T.1
  • 12
    • 78049502664 scopus 로고    scopus 로고
    • Longitudinal investigation of the faecal microbiota of healthy full-term infants using fluorescence in situ hybridization and denaturing gradient gel electrophoresis
    • Roger, L. C. & McCartney, A. L. Longitudinal investigation of the faecal microbiota of healthy full-term infants using fluorescence in situ hybridization and denaturing gradient gel electrophoresis. Microbiology 156, 3317-28 (2010).
    • (2010) Microbiology , vol.156 , pp. 3317-3328
    • Roger, L.C.1    McCartney, A.L.2
  • 13
    • 38949216694 scopus 로고    scopus 로고
    • Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells
    • Kuntz, S., Rudloff, S. & Kunz, C. Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells. Br J Nutr 99, 462-71 (2008).
    • (2008) Br J Nutr , vol.99 , pp. 462-471
    • Kuntz, S.1    Rudloff, S.2    Kunz, C.3
  • 14
    • 84875150368 scopus 로고    scopus 로고
    • Gut microbiota of healthy Canadian infants: Profiles by mode of delivery and infant diet at 4 months
    • Azad, M. B. et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ 185, 385-94 (2013).
    • (2013) CMAJ , vol.185 , pp. 385-394
    • Azad, M.B.1
  • 15
    • 13444288243 scopus 로고    scopus 로고
    • Glycoprofiling with micro-arrays of glycoconjugates and lectins
    • Angeloni, S. et al. Glycoprofiling with micro-arrays of glycoconjugates and lectins. Glycobiology 15, 31-41 (2005).
    • (2005) Glycobiology , vol.15 , pp. 31-41
    • Angeloni, S.1
  • 16
    • 84861011960 scopus 로고    scopus 로고
    • Diversity of bifidobacteria within the infant gut microbiota
    • Turroni, F. et al. Diversity of bifidobacteria within the infant gut microbiota. PLoS One 7, e36957 (2012).
    • (2012) PLoS One , vol.7
    • Turroni, F.1
  • 17
    • 84898646785 scopus 로고    scopus 로고
    • Establishment of Intestinal Microbiota during Early Life: A Longitudinal, Explorative Study of a Large Cohort of Danish Infants
    • Bergstrom, A. et al. Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants. Appl Environ Microbiol 80, 2889-900 (2014).
    • (2014) Appl Environ Microbiol , vol.80 , pp. 2889-2900
    • Bergstrom, A.1
  • 18
    • 33745142549 scopus 로고    scopus 로고
    • In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri
    • Ward, R. E., Ninonuevo, M., Mills, D. A., Lebrilla, C. B. & German, J. B. In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri. Appl Environ Microbiol 72, 4497-9 (2006).
    • (2006) Appl Environ Microbiol , vol.72 , pp. 4497-4499
    • Ward, R.E.1    Ninonuevo, M.2    Mills, D.A.3    Lebrilla, C.B.4    German, J.B.5
  • 19
    • 36148991870 scopus 로고    scopus 로고
    • Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation
    • LoCascio, R. G. et al. Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation. J Agric Food Chem 55, 8914-9 (2007).
    • (2007) J Agric Food Chem , vol.55 , pp. 8914-8919
    • LoCascio, R.G.1
  • 20
    • 78650609691 scopus 로고    scopus 로고
    • Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging
    • Turroni, F. et al. Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad Sci USA 107, 19514-9 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19514-19519
    • Turroni, F.1
  • 21
    • 84884189488 scopus 로고    scopus 로고
    • Variation in consumption of human milk oligosaccharides by infant gut-associated strains of Bifidobacterium breve
    • Ruiz-Moyano, S. et al. Variation in consumption of human milk oligosaccharides by infant gut-associated strains of Bifidobacterium breve. Appl Environ Microbiol 79, 6040-9 (2013).
    • (2013) Appl Environ Microbiol , vol.79 , pp. 6040-6049
    • Ruiz-Moyano, S.1
  • 22
    • 57749113201 scopus 로고    scopus 로고
    • The genome sequence of Bifidobacterium longum subsp. Infantis reveals adaptations for milk utilization within the infant microbiome
    • Sela, D. A. et al. The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proc Natl Acad Sci USA 105, 18964-9 (2008).
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18964-18969
    • Sela, D.A.1
  • 23
    • 79952636140 scopus 로고    scopus 로고
    • Oligosaccharide binding proteins from Bifidobacterium longum subsp. Infantis reveal a preference for host glycans
    • Garrido, D., Kim, J. H., German, J. B., Raybould, H. E. & Mills, D. A. Oligosaccharide binding proteins from Bifidobacterium longum subsp. infantis reveal a preference for host glycans. PLoS One 6, e17315 (2011).
    • (2011) PLoS One , vol.6
    • Garrido, D.1    Kim, J.H.2    German, J.B.3    Raybould, H.E.4    Mills, D.A.5
  • 24
    • 77954142215 scopus 로고    scopus 로고
    • Nursing our microbiota: Molecular linkages between bifidobacteria and milk oligosaccharides
    • Sela, D. A. & Mills, D. A. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends Microbiol 18, 298-307 (2010).
    • (2010) Trends Microbiol , vol.18 , pp. 298-307
    • Sela, D.A.1    Mills, D.A.2
  • 25
    • 84864358611 scopus 로고    scopus 로고
    • A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract
    • Garrido, D., Barile, D. & Mills, D. A. A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract. Adv Nutr 3, 415S-21S (2012).
    • (2012) Adv Nutr , vol.3 , pp. 415S-421S
    • Garrido, D.1    Barile, D.2    Mills, D.A.3
  • 26
    • 84866789452 scopus 로고    scopus 로고
    • Bifidobacterial enzymes involved in the metabolism of human milk oligosaccharides
    • Kitaoka, M. Bifidobacterial Enzymes Involved in the Metabolism of Human Milk Oligosaccharides. Advances in Nutrition: An International Review Journal 3, 422S-429S (2012).
    • (2012) Advances in Nutrition: An International Review Journal , vol.3 , pp. 422S-429S
    • Kitaoka, M.1
  • 27
    • 77949917258 scopus 로고    scopus 로고
    • Species delineation and clonal diversity in four Bifidobacterium species as revealed by multilocus sequencing
    • Deletoile, A. et al. Species delineation and clonal diversity in four Bifidobacterium species as revealed by multilocus sequencing. Res Microbiol 161, 82-90 (2010).
    • (2010) Res Microbiol , vol.161 , pp. 82-90
    • Deletoile, A.1
  • 28
    • 78649698242 scopus 로고    scopus 로고
    • Broad conservation of milk utilization genes in Bifidobacterium longum subsp. Infantis as revealed by comparative genomic hybridization
    • LoCascio, R. G., Desai, P., Sela, D. A., Weimer, B. & Mills, D. A. Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization. Appl Environ Microbiol 76, 7373-81 (2010).
    • (2010) Appl Environ Microbiol , vol.76 , pp. 7373-7381
    • LoCascio, R.G.1    Desai, P.2    Sela, D.A.3    Weimer, B.4    Mills, D.A.5
  • 29
    • 84880958392 scopus 로고    scopus 로고
    • A refined palate: Bacterial consumption of host glycans in the gut
    • Marcobal, A., Southwick, A. M., Earle, K. A. & Sonnenburg, J. L. A refined palate: Bacterial consumption of host glycans in the gut. Glycobiology 23, 1038-1046 (2013).
    • (2013) Glycobiology , vol.23 , pp. 1038-1046
    • Marcobal, A.1    Southwick, A.M.2    Earle, K.A.3    Sonnenburg, J.L.4
  • 30
    • 84874786947 scopus 로고    scopus 로고
    • Proteomic analysis of Bifidobacterium longum subsp. Infantis reveals the metabolic insight on consumption of prebiotics and host glycans
    • Kim, J. H. et al. Proteomic analysis of Bifidobacterium longum subsp. infantis reveals the metabolic insight on consumption of prebiotics and host glycans. PLoS One 8, e57535 (2013).
    • (2013) PLoS One , vol.8
    • Kim, J.H.1
  • 31
    • 80053393387 scopus 로고    scopus 로고
    • Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria
    • Asakuma, S. et al. Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria. J Biol Chem 286, 34583-92 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 34583-34592
    • Asakuma, S.1
  • 32
    • 84871599142 scopus 로고    scopus 로고
    • How deep is deep enough for RNA-Seq profiling of bacterial transcriptomes?
    • Haas, B. J., Chin, M., Nusbaum, C., Birren, B. W. & Livny, J. How deep is deep enough for RNA-Seq profiling of bacterial transcriptomes? BMC Genomics 13, 734 (2012).
    • (2012) BMC Genomics , vol.13 , pp. 734
    • Haas, B.J.1    Chin, M.2    Nusbaum, C.3    Birren, B.W.4    Livny, J.5
  • 33
    • 84858990515 scopus 로고    scopus 로고
    • Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes
    • Giannoukos, G. et al. Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes. Genome Biol 13, R23 (2012).
    • (2012) Genome Biol , vol.13 , pp. R23
    • Giannoukos, G.1
  • 34
    • 33748863131 scopus 로고    scopus 로고
    • Bacterial RNase P: A new view of an ancient enzyme
    • Kazantsev, A. V. & Pace, N. R. Bacterial RNase P: a new view of an ancient enzyme. Nat Rev Microbiol 4, 729-40 (2006).
    • (2006) Nat Rev Microbiol , vol.4 , pp. 729-740
    • Kazantsev, A.V.1    Pace, N.R.2
  • 36
    • 84863393342 scopus 로고    scopus 로고
    • Bifidobacterium longum subsp. Infantis uses two different beta-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides
    • Yoshida, E. et al. Bifidobacterium longum subsp. infantis uses two different beta-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides. Glycobiology 22, 361-8 (2012).
    • (2012) Glycobiology , vol.22 , pp. 361-368
    • Yoshida, E.1
  • 37
    • 84862907640 scopus 로고    scopus 로고
    • Bifidobacterium longum subsp. Infantis ATCC 15697 alpha-fucosidases are active on fucosylated human milk oligosaccharides
    • Sela, D. A. et al. Bifidobacterium longum subsp. infantis ATCC 15697 alpha-fucosidases are active on fucosylated human milk oligosaccharides. Appl Environ Microbiol 78, 795-803 (2012).
    • (2012) Appl Environ Microbiol , vol.78 , pp. 795-803
    • Sela, D.A.1
  • 38
    • 35448959649 scopus 로고    scopus 로고
    • Identification of N-Acetylhexosamine 1-Kinase in the Complete Lacto-N-Biose I/Galacto-N-Biose Metabolic Pathway in Bifidobacterium longum
    • Nishimoto, M. & Kitaoka, M. Identification of N-Acetylhexosamine 1-Kinase in the Complete Lacto-N-Biose I/Galacto-N-Biose Metabolic Pathway in Bifidobacterium longum. Applied and Environmental Microbiology 73, 6444-6449 (2007).
    • (2007) Applied and Environmental Microbiology , vol.73 , pp. 6444-6449
    • Nishimoto, M.1    Kitaoka, M.2
  • 39
    • 0030778298 scopus 로고    scopus 로고
    • Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides
    • Thurl, S., Henker, J., Siegel, M., Tovar, K. & Sawatzki, G. Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides. Glycoconj J 14, 795-9 (1997).
    • (1997) Glycoconj J , vol.14 , pp. 795-799
    • Thurl, S.1    Henker, J.2    Siegel, M.3    Tovar, K.4    Sawatzki, G.5
  • 40
    • 78149471642 scopus 로고    scopus 로고
    • Variation of human milk oligosaccharides in relation to milk groups and lactational periods
    • Thurl, S. et al. Variation of human milk oligosaccharides in relation to milk groups and lactational periods. Br J Nutr 104, 1261-71 (2010).
    • (2010) Br J Nutr , vol.104 , pp. 1261-1271
    • Thurl, S.1
  • 41
    • 79956257405 scopus 로고    scopus 로고
    • Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine
    • Wacklin, P. et al. Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine. PLoS ONE 6, e20113 (2011).
    • (2011) PLoS ONE , vol.6
    • Wacklin, P.1
  • 42
    • 0032929297 scopus 로고    scopus 로고
    • Convergent Pathways for Utilization of the Amino Sugars N-Acetylglucosamine,N-Acetylmannosamine, and N-Acetylneuraminic Acid by Escherichia coli
    • Plumbridge, J. & Vimr, E. Convergent Pathways for Utilization of the Amino Sugars N-Acetylglucosamine,N-Acetylmannosamine, and N-Acetylneuraminic Acid by Escherichia coli. Journal of Bacteriology 181, 47-54 (1999).
    • (1999) Journal of Bacteriology , vol.181 , pp. 47-54
    • Plumbridge, J.1    Vimr, E.2
  • 44
    • 84926468863 scopus 로고    scopus 로고
    • Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium
    • Egan, M. et al. Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium. BMC Microbiol 14, 282 (2014).
    • (2014) BMC Microbiol , vol.14 , pp. 282
    • Egan, M.1
  • 45
    • 84876841275 scopus 로고    scopus 로고
    • Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model
    • Van den Abbeele, P. et al. Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model. ISME J 7, 949-61 (2013).
    • (2013) ISME J , vol.7 , pp. 949-961
    • Van Den Abbeele, P.1
  • 46
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson, J. D., Higgins, D. G. & Gibson, T. J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22, 4673-80 (1994).
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 47
    • 34547892713 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of Lactobacillus casei strains isolated from different ecological niches suggests frequent recombination and niche specificity
    • Cai, H., Rodriguez, B. T., Zhang, W., Broadbent, J. R. & Steele, J. L. Genotypic and phenotypic characterization of Lactobacillus casei strains isolated from different ecological niches suggests frequent recombination and niche specificity. Microbiology 153, 2655-65 (2007).
    • (2007) Microbiology , vol.153 , pp. 2655-2665
    • Cai, H.1    Rodriguez, B.T.2    Zhang, W.3    Broadbent, J.R.4    Steele, J.L.5
  • 48
    • 84891820094 scopus 로고    scopus 로고
    • IMG 4 version of the integrated microbial genomes comparative analysis system
    • Markowitz, V. M. et al. IMG 4 version of the integrated microbial genomes comparative analysis system. Nucleic Acids Res 42, D560-7 (2014).
    • (2014) Nucleic Acids Res , vol.42 , pp. D560-D567
    • Markowitz, V.M.1
  • 50
    • 0043009767 scopus 로고    scopus 로고
    • Differential expression in SAGE: Accounting for normal between-library variation
    • Baggerly, K. A., Deng, L., Morris, J. S. & Aldaz, C. M. Differential expression in SAGE: accounting for normal between-library variation. Bioinformatics 19, 1477-83 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 1477-1483
    • Baggerly, K.A.1    Deng, L.2    Morris, J.S.3    Aldaz, C.M.4
  • 51
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol 11, R106 (2010).
    • (2010) Genome Biol , vol.11 , pp. R106
    • Anders, S.1    Huber, W.2
  • 52
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545-50 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 53
    • 24644503098 scopus 로고    scopus 로고
    • Blast2GO: A universal tool for annotation, visualization and analysis in functional genomics research
    • Conesa, A. et al. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21, 3674-6 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 3674-3676
    • Conesa, A.1
  • 54
    • 75849133666 scopus 로고    scopus 로고
    • Pathway Tools version 13.0: Integrated software for pathway/genome informatics and systems biology
    • Karp, P. D. et al. Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology. Brief Bioinform 11, 40-79 (2010).
    • (2010) Brief Bioinform , vol.11 , pp. 40-79
    • Karp, P.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.