Formulation and evaluation of Itraconazole nanoemulsion for enhanced oral bioavailability

Journal of Microencapsulation

Volumn 32, Issue 6, 2015, Pages 559-569

  Thakkar, Hetal P ^a   Khunt, Amit ^a   Dhande, Rahul D ^a   Patel, Arpita A ^a  

^a Shri GH Patel Pharmacy Building   (India)

Author keywords

Antimycotic; Nanosize; Poorly soluble; Surfactant

Indexed keywords

COSURFACTANT; CREMOPHORE EL; EMULSIFYING AGENT; ITRACONAZOLE; OCTANOIN; PLACEBO; POLOXAMER; SURFACTANT; UNCLASSIFIED DRUG; ACYLGLYCEROL; ANTIFUNGAL AGENT; CAPMUL MCM C8; CREMOPHOR; EMULSION; EXCIPIENT; GLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG MARKETING; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; EVALUATION STUDY; EX VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; MALE; NANOEMULSION; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; RAT; ULTRASOUND; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CHEMISTRY; CONFOCAL MICROSCOPY; DIFFUSION; EMULSION; KINETICS; NANOMEDICINE; ORAL DRUG ADMINISTRATION; PERMEABILITY; PROCEDURES; SPRAGUE DAWLEY RAT; TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; ANTIFUNGAL AGENTS; BIOLOGICAL AVAILABILITY; DIFFUSION; EMULSIONS; EXCIPIENTS; GLYCERIDES; GLYCEROL; ITRACONAZOLE; KINETICS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; PARTICLE SIZE; PERMEABILITY; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; SURFACE-ACTIVE AGENTS; TEMPERATURE;

EID: 84940961879     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2015.1065917     Document Type: Article

References (42)

1. Abdelbary G, Fahmy RH. Diazepam-loaded solid lipid nanoparticles: Design and characterization. AAPS PharmSciTech, 2009; 10 (1): 211-19
2. Aungst BJ, Nguyen NH, Rogers NJ, Rowe SM, Hussain MA, White SJ, Shum L. Amphiphilic vehicles improve the oral bioavailability of a poorly soluble HIV protease inhibitor at high doses. Int J Pharm, 1997; 156: 79-88
3. Barrett AM, Dehghani F, Foster NR. Increasing the dissolution rate of itraconazole processed by gas antisolvent techniques using polyethylene glycol as a carrier. Pharm Res, 2008; 25 (6): 1274-89
4. Beule KD, Gestel JV. Pharmacology of Itraconazole. Drugs, 2001; 61 (1): 27-37
5. Beule KD. Itraconazole: Pharmacology, clinical experience and future development. Int J Antimicrob Ageing, 1996; 6: 175-81
6. Bouchemal K, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimisation. Int J Pharm, 2004; 280 (1-2): 241-51
7. Burcham DL, Maurin MB, Hausner EA, Huang SM. Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions. Biopharm Drug Dispos, 1997; 18 (8): 737-42
8. Chen H, Khemtong C, Yang X, Chang X, Gao J. Nanonization strategies for poorly water-soluble drugs. Drug Discov Today, 2011; 16 (7-8): 354-60
9. Craig DQM, Lievens HSR, Pitt KG, Storey DE. An investigation into the physico-chemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. Int J Pharm, 1993; 96: 147-55
10. Fernandez-Campos F, Clares Naveros B, Lopez Serrano O, Alonso Merino C, Calpena Campmany AC. Evaluation of novel nystatin nanoemulsion for skin candidosis infections. Mycoses, 2013; 56 (1): 70-81
11. Fryd MM, Mason TG. Advanced nanoemulsions. Annu Rev Phys Chem, 2012; 63: 493-518
12. Gelderblom H, Verweij J, Nooter K, Sparreboom A. Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer, 2001; 37: 1590-8
13. Hong JY, Kim JK, Song YK, Park JS, Kim CK. A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption. J Control Release, 2006; 110 (2): 332-8
14. Hu J, Johnston KP, Williams RO III. Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs. Drug Dev Ind Pharm, 2004; 30 (3): 233-45
15. Jung JY, Yoo SD, Lee SH, Kim KH, Yoon DS, Lee KH. Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique. Int J Pharm, 1999; 1987: 209-18
16. Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm, 2004; 274 (1-2): 65-73
17. Kim JK, Park JS, Kim CK. Development of a binary lipid nanoparticles formulation of itraconazole for parenteral administration and controlled release. Int J Pharm, 2010; 383 (1-2): 209-15
18. Koteswari P, Krishna SR, Reddy VP, Narasu LM. Formulation and preparation of felodipine nanoemulsions. Asian J Pharm Clin Res, 2011; 4: 116-17
19. Kotta S, Khan AW, Pramod K, Ansari SH, Sharma RK, Ali J. Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv, 2012; 9 (5): 585-98
20. Miyake K, Irie T, Arima H, Hirayama F, Uekama K, Hiramo M, Okamoto Y. Characterization of itraconazole/2-hydroxypropyl-β-cyclodextrin inclusion complex in aqueous propylene glycol solution. Int J Pharm, 1999; 179: 237-45
21. Momoh AO, Oladunmoye MK, Adebolu TT. Evaluation of the antimicrobial and phytochemical properties of oil from castor seeds (Ricinus communis Linn). Bull Environ Pharmacol Life Sci, 2012; 1 (10): 21-7
22. Murakami A, Fukada K, Yamano Y, Gohtani S. Effects of sugars on the D phase emulsification of triglyceride using polyoxyethylene sorbitan fatty acid ester. J Oleo Sci, 2005; 54 (12): 633-9
23. Muskett H, Shahin J, Eyres G, Harvey S, Rowan K, Harrison D. Risk factors for invasive fungal disease in critically ill adult patients: A systematic review. Crit Care, 2011; 15 (6): R287
24. Myers RA, Stella VJ. Systemic bioavailability of penclomedine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats. Int J Pharm, 1992; 78: 217-26
25. Narkhede RS, Gujar KN, Gambhire VM. Design and evaluation of self-nanoemulsifying drug delivery systems for nebivolol hydrochloride. Asian J Pharm, 2014; 8 (3): 200-9
26. Palin KJ, Phillips AJ, Ning A. The oral absorption of cefoxitin from oil and emulsion vehicles in rats. Int J Pharm, 1986; 33: 99-104
27. Rangel-Yagui CO, Pessoa-Jr A, Tavare LC. Micellar solubilization of drugs. J Pharm Pharma Sci 2005; 8 (2): 147-63
28. Rasenack N, Müller BW. Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharm Res, 2002; 19 (12): 1894-900
29. Ravi TPU, Padma T. Nanoemulsions for drug delivery through different routes. Res Biotechnol, 2011; 2 (3): 1-13
30. Rigter IM, Schipper HG, Koopmans RP, Van Kan HJM, Frijlink HW, Kager PA, Guchelaar HJ. Relatively bioavailability of three newly developed albendazole formulations: A randomized cross over study with healthy volunteers. Antimicrob Agents Chemother, 2004; 48: 1051-4
31. Saag MS, Dismukes WE. Azole antifungal agents: Emphasis on new triazoles. Antimicrob Agents Chemother, 1988; 32 (1): 1-8
32. Serajuddin ATM, Sheen PC, Mufson D, Bernstein DF, Augusti MA. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions. J Pharm Sci, 1988; 77 (5): 414-17
33. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm, 1994; 106: 15-23
34. Singh N. Trends in the epidemiology of opportunistic fungal infections: Predisposing factors and the impact of antimicrobial use practices. Clin Infect Dis, 2001; 33: 1692-6
35. Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm Res, 2004; 21 (2): 201-30
36. Tang SY, Shridharan P, Sivakumar M. Impact of process parameters in the generation of novel aspirin nanoemulsions-Comparative studies between ultrasound cavitation and microfluidizer. Ultrason Sonochem, 2013; 20 (1): 485-97
37. Tao T, Zhao Y, Wu J, Zhou B. Preparation and evaluation of itraconazole dihydrochloride for the solubility and dissolution rate enhancement. Int J Pharm, 2009; 367 (1-2): 109-14
38. Uchegbu IF, Schatzlein AG, Cheng WP, Lalatsa A. 2013. Fundamentals of pharmaceutical science. New York: Springer Publications
39. Wakerly MG, Pouton CW, Meakin BJ, Morton FS. Self-emulsification of vegetable oil-nonionic surfactant mixtures. ACS Symp Ser, 1986; 311: 242-55
40. Walsh TJ, Dixon DM. 1996. Spectrum of mycoses. In: Baron S, ed. Medical microbiology. NCBI Bookshelf. Bethesda, MD: A Service of the National Library of Medicine, National Institutes of Health. [Online] Available at: http://www.ncbi.nlm.nih.gov/books/NBK7902/?report=printable
41. Wisplinghoff H, Bischoff T, Edmond MB, Tallent SM, Seifert H, Wenzel RP. Nosocomial bloodstream infections in US Hospitals: Analysis of 24,179 cases from a Prospective Nationwide Surveillance Study. Clin Infect Dis, 2004; 39: 309-17
42. Woo JS, Song YK, Hong JY, Lim SJ, Kim CK. Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci, 2008; 33 (2): 159-65