Relative Bioavailability of Three Newly Developed Albendazole Formulations: A Randomized Crossover Study with Healthy Volunteers

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 3, 2004, Pages 1051-1054

  Rigter, I M ^a   Schipper, H G ^a   Koopmans, R P ^a   Van Kan, H J M ^a   Frijlink, H W ^b   Kager, P A ^a   Guchelaarl, H J ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALBENDAZOLE; ALBENDAZOLE SULFOXIDE; ARACHIS OIL; EXCIPIENT; MACROGOL; POLYSORBATE 80; SUPPOSITORY BASE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG SOLUTION; FEMALE; FOOD DRUG INTERACTION; HUMAN; LIPID DIET; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUSPENSION; TABLET;

ADOLESCENT; ADULT; ALBENDAZOLE; ANTHELMINTICS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; FEMALE; HALF-LIFE; HUMANS; MALE; SPECTROPHOTOMETRY, ULTRAVIOLET; TABLETS;

EID: 1442275593     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.3.1051-1054.2004     Document Type: Article

References (19)

1. Awadzi, K., M. Hero, N. O. Opoku, D. W. Büttner, P. A. Coventry, M. A. Prime, M. L. E. Orme, and G. Edwards. 1994. The chemotherapy of onchocerciasis XVII. A clinical evaluation of albendazole in patients with onchocerciasis; effects of food and pretreatment with ivermectin on drug response and pharmacokinetics. Trop. Med. Parasitol. 45:203-208.
2. Davis, A., H. Dixon, and Z. S. Pawlowski. 1989. Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). Bull. W. H. O. 67:503-508.
3. del Estal, J. L., A. I. Alvarez, C. Villaverde, P. Coronel, S. Fabra, and J. G. Prieto. 1991. Effect of surfactants on albendazole absorption. J. Pharm. Biomed. Anal. 9:1161-1164.
4. del Estal, J. L., A. I. Alvarez, C. Villaverde, A. Justel, and J. G. Prieto. 1994. Increased systemic bioavailability of albendazol when administered with surfactants in rats. Int. J. Pharm. 102:257-260.
5. del Estal, J. L., A. I. Alvarez, C. Villaverde, and J. G. Prieto. 1993. Comparative effects of anionic, natural bile acid surfactants and mixed micelles on the intestinal absorption of the anthelmintic albendazole. Int. J. Pharm. 91:105-109.
6. Evrard, B., P. Chiap, P. DeTullio, F. Ghalmi, G. Piel, T. van Hees, J. Crommen, B. Losson, and L. DaLattre. 2002. Oral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-beta-cyclodextrin. J. Control. Release 85:45-50.
7. Homeida, M., W. Leahy, S. Copeland, M. M. Ali, and D. W. Harron. 1994. Pharmacokinetic interaction between praziquantel and albendazole in Sudanese men. Ann. Trop. Med. Parasitol. 88:551-559.
8. Horton, R. J. 1997. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop. 64:79-93.
9. Jung, H., L. Medina, L. Garcia, I. Fuentes, and R. Moreno-Esparza. 1998. Absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide. J. Pharm. Pharmacol. 50:43-48.
10. Kitzman, D., K. J. Cheng, and L. Fleckenstein. 2002. HPLC assay for albendazole and metabolites in human plasma for clinical pharmacokinetic studies. J. Pharm. Biomed. Anal. 30:801-813.
11. Kohri, N., Y. Yamayoshi, H. Xin, K. Iseki, N. Sato, S. Todo, and K. Miyazaki. 1999. Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique. J. Pharm. Pharmacol. 51:159-164.
12. Lange, H., R. Eggers, and J. Bircher. 1988. Increased systemic availability of albendazole when taken with a fatty meal. Eur. J. Clin. Pharmacol. 34:315-317.
13. Lund, W. 1994. The pharmaceutical codex: principles and practice of pharmaceutics, 12th ed. The Pharmaceutical Press, London, United Kingdom.
14. Mingjie, W., X. Shuhua, C. Junjie, L. Bin, F. Cheng, S. Weixia, and P. Hotez. 2002. Albendazole-soybean oil emulsion for the treatment of human cystic echinococcosis: evaluation of bioavailability and bioequivalence. Acta Trop. 83:177-181.
15. Nagy, J., H. G. Schipper, R. P. Koopmans, J. J. Butter, C. J. van Boxtel, and P. A. Kager. 2002. Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability. Am. J. Trop. Med. Hyg. 66:260-263.
16. Piel, G., B. Evrard, T. Van Hees, G. Llabres, and L. Delattre. 1999. Development of a parenteral and of an oral formulation of albendazole with cyclodextrins. Stp. Pharma. Sci. 9:257-260.
17. Schipper, H. G., R. P. Koopmans, J. Nagy, J. J. Butter, P. A. Kager, and C. J. van Boxtel. 2000. Effect of dose increase or cimetidine co-administration on albendazole bioavailability. Am. J. Trop. Med. Hyg. 63:270-273.
18. Torrado, S., M. L. Lopez, G. Torrado, F. Bolas, G. Torrado, and R. A. Cadorniga. 1997. Novel formulation of albendazole solution: oral bioavailability and efficacy evaluation. Int. J. Pharm. 156:181-187.
19. Wen, H., R. R. C. New, M. Muhmut, J. H. Wang, Y. H. Wang, J. H. Zhang, Y. M. Shao, and P. S. Craig. 1996. Pharmacology and efficacy of liposomeentrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine. Parasitology 13:111-121.