Intrabronchial Microdialysis: Effects of Probe Localization on Tissue Trauma and Drug Penetration into the Pulmonary Epithelial Lining Fluid

Basic and Clinical Pharmacology and Toxicology

Volumn 117, Issue 4, 2015, Pages 242-250

  Rottbøll, Lisa Amanda Holm ^a   Skovgaard, Kerstin ^b   Barington, Kristiane ^a   Jensen, Henrik Elvang ^a   Friis, Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID A PROTEIN; FLORFENICOL; INTERLEUKIN 1BETA; INTERLEUKIN 6; INULIN; AUTACOID; INSULIN; SERUM AMYLOID A; THIAMPHENICOL;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG PENETRATION; EPITHELIAL LINING FLUID; GENE EXPRESSION; HISTOPATHOLOGY; LUNG ALVEOLUS EPITHELIUM; MICRODIALYSIS; NONHUMAN; PERMEABILITY; PIG; PRIORITY JOURNAL; TISSUE INJURY; UPREGULATION; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL MODEL; BLOOD; BRONCHUS; DEVICES; FEMALE; GENETICS; INJURIES; INTRAVENOUS DRUG ADMINISTRATION; LUNG INJURY; METABOLISM; RESPIRATORY FUNCTION; RESPIRATORY TRACT MUCOSA;

ADMINISTRATION, INTRAVENOUS; ANIMALS; BRONCHI; FEMALE; INFLAMMATION MEDIATORS; INSULIN; INTERLEUKIN-1BETA; INTERLEUKIN-6; LUNG INJURY; MICRODIALYSIS; MODELS, ANIMAL; PERMEABILITY; RESPIRATORY MUCOSA; RESPIRATORY TRACT ABSORPTION; SERUM AMYLOID A PROTEIN; SWINE; THIAMPHENICOL;

EID: 84940898973     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12403     Document Type: Article

References (41)

1. Theuretzbacher U. Tissue penetration of antibacterial agents: how should this be incorporated into pharmacodynamic analyses? Curr Opin Pharmacol 2007;7:498-504.
2. Bosquillon C. Drug transporters in the lung-do they play a role in the biopharmaceutics of inhaled drugs? J Pharm Sci 2010;99:2240-55.
3. Chandra T, Miller I, Yeates D. A pore transport model for pulmonary alveolar epithelium. Ann Biomed Eng 1992;20:481-94.
4. Rodvold KA, Yoo L, George JM. Penetration of anti-infective agents into pulmonary epithelial lining fluid. Clin Pharmacokinet 2011;50:689-704.
5. de Lange E, Danhof M, de Boer AG, Breimer DD. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Res Rev 1997;25:27-49.
6. Chaurasia CS, Muller M, Bashaw ED, Benfeldt E, Bolinder J, Bullock R et al. AAPS-FDA workshop white paper: microdialysis principles, application, and regulatory perspectives. J Clin Pharmacol 2007;47:589-603.
7. Westergren I, Nyström B, Hamberger A, Johansson BB. Intracerebral dialysis and the blood-brain barrier. J Neurochem 1995;64:229-34.
8. Davies M, Lunte C. Microdialysis sampling for hepatic-metabolism studies - impact of microdialysis probe design and implantation technique on liver-tissue. Drug Metab Dispos 1995;23:1072-9.
9. Stenken JA, Church MK, Gill CA, Clough GF. How minimally invasive is microdialysis sampling? A cautionary note for cytokine collection in human skin and other clinical studies. AAPS J 2010;12:73-8.
10. Eisenberg EJ, Conzentino P, Eickhoff WM, Cundy KC. Pharmacokinetic measurement of drugs in lung epithelial lining fluid by microdialysis - aminoglycoside antibiotics in rat bronchi. J Pharmacol Toxicol Methods 1993;29:93-8.
11. Aoki M, Iguchi M, Hayashi H, Suzuki H, Shibasaki S, Kurosawa T et al. Proposal of membrane transport mechanism of protein-unbound ulifloxacin into epithelial lining fluid determined by improved microdialysis. Biol Pharm Bull 2008;31:1773-7.
12. Rottboll LAH, Friis C. Microdialysis as a tool for drug quantification in the bronchioles of anaesthetized pigs. Basic Clin Pharmacol Toxicol 2014;114:226-32.
13. Tyvold SS, Solligard E, Lyng O, Steinshamn SL, Gunnes S, Aadahl P. Continuous monitoring of the bronchial epithelial lining fluid by microdialysis. Respir Res 2007;8:78.
14. Tyvold SS, Solligard E, Gunnes S, Lyng O, Johannisson A, Gronbech JE et al. Bronchial microdialysis of cytokines in the epithelial lining fluid in experimental intestinal ischemia and reperfusion before onset of manifest lung injury. Shock 2010;34:517-24.
15. Normand ICS, Olver RE, Reynolds EOR, Strang LB. Permeabilty of lung capillaries and alveoli to non-electrolytes in the foetal lamb. J Physiol 1971;219:303-30.
16. Restrick L, Sampson A, Piper P, Costello J. Inulin as a marker of dilution of bronchoalveolar lavage in asthmatic and normal subjects. Am J Respir Crit Care Med 1995;151:1211-7.
17. Bouw M, Hammarlund-Udenaes M. Methodological aspects of the use of a calibrator in in vivo microdialysis - further development of the retrodialysis method. Pharm Res 1998;15:1673-9.
18. Schmidt F. Die enzymatische bestimmung von glucose und fructose nebeneinander. Klin Wochenschr 1961;39:1244-7.
19. Liu J, Fung K, Chen Z, Zeng Z, Zhang J. Pharmacokinetics of florfenicol in healthy pigs and in pigs experimentally infected with actinobacillus pleuropneumoniae. Antimicrob Agents Chemother 2003;47:820-3.
20. Skovgaard K, Cirera S, Vasby D, Podolska A, Breum SO, Durrwald R et al. Expression of innate immune genes, proteins and microRNAs in lung tissue of pigs infected experimentally with influenza virus (H1N2). Innate Immun 2013;19:531-44.
21. Untergasser A, Cutcutache I, Koressaar T, Ye J, Faircloth BC, Remm M, et al. Primer3- new capabilities and interfaces. Nucleic Acids Res. 2012;40:e115.
22. Skovgaard K, Mortensen S, Boye M, Hedegaard J, Heegaard PM. Hepatic gene expression changes in pigs experimentally infected with the lung pathogen actinobacillus pleuropneumoniae as analysed with an innate immunity focused microarray. Innate Immun 2010;16:343-53.
23. Gibaldi M, Perrier D. Multicompartment models. In: Gibaldi M, Perrier D (eds). Pharmacokinetics. Marcel Dekker, New York, 1982;45-111.
24. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;18:3.
25. Andersen CL, Jensen JL, Orntoft TF. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 2004;64:5245-50.
26. Vareille M, Kieninger E, Edwards MR, Regamey N. The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev 2011;24:210-29.
27. García-Delgado M, Navarrete-Sánchez I, Colmenero M, Touma-Fernández Á, López-Cuervo JE, Hassan-Montero L et al. Intermittent alveolar overdistension for 30 or 240 minutes does not produce acute lung injury in normal pig lung. J Surg Res 2006;131:233-40.
28. Mols G, Priebe HJ, Guttmann J. Alveolar recruitment in acute lung injury. Br J Anaesth 2006;96:156-66.
29. Mathias NR, Yamashita F, Lee VHL. Respiratory epithelial cell culture models for evaluation of ion and drug transport. Adv Drug Deliv Rev 1996;22:215-49.
30. Middleton E. Molecular-configuration of inulin - implications for ultrafiltration theory and glomerular permeability. J Membr Biol 1977;34:93-101.
31. Hermans C, Bernard A. Lung epithelium-specific proteins - characteristics and potential applications as markers. Am J Respir Crit Care Med 1999;159:646-78.
32. Kendrick KM. Use of microdialysis in neuroendocrinology. Methods Enzymol 1989;168:182-205.
33. Ao X, Stenken JA. Microdialysis sampling of cytokines. Methods 2006;38:331-41.
34. Bengtsson J, Boström E, Hammarlund-Udenaes M. The use of a deuterated calibrator for in vivo recovery estimations in microdialysis studies. J Pharm Sci 2008;97:3433-41.
35. Friis C. Penetration of danofloxacin into the respiratory tract tissues and secretions in calves. Am J Vet Res 1993;54:1122-7.
36. Schrickx JA, Fink-Gremmels J. Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters. Br J Pharmacol 2007;150:463-9.
37. Schrickx J, Fink-Gremmels J. P-glycoprotein-mediated transport of oxytetracycline in the caco-2 cell model. J Vet Pharmacol Ther 2007;30:25-31.
38. Bergogne-Berezin E. Penetration of antibiotics into the respiratory tree. J Antimicrob Chemother 1981;8:171-4.
39. Joukhadar C, Stass H, Muller-Zellenberg U, Lackner E, Kovar F, Minar E et al. Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans. Antimicrob Agents Chemother 2003;47:3099-103.
40. Bertilsson PM, Olsson P, Magnusson K. Cytokines influence mRNA expression of cytochrome P450 3A4 and MDRI in intestinal cells. J Pharm Sci 2001;90:638-46.
41. Clough G, Boutsiouki P, Church M, Michel C. Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin. J Pharmacol Exp Ther 2002;302:681-6.