Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells

Journal of Pathology

Volumn 237, Issue 2, 2015, Pages 238-248

  Lo, Angela Kwok Fung ^a   Dawson, Christopher W ^b   Young, Lawrence S ^c   Ko, Chuen Wai ^a   Hau, Pok Man ^a   Lo, Kwok Wai ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Epstein Barr virus; FGFR1; glycolysis; LMP1; nasopharyngeal carcinoma

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUTAMINE; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; LACTIC ACID; LATENT MEMBRANE PROTEIN 1; PYRUVATE DEHYDROGENASE KINASE 1; PYRUVATE KINASE; PYRUVATE KINASE M2; PYRUVIC ACID; UNCLASSIFIED DRUG; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 2; MATRIX PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANGIOGENESIS; ARTICLE; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; ENERGY METABOLISM; ENZYME ACTIVITY; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NASOPHARYNX CARCINOMA; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG EFFECTS; EPITHELIUM CELL; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; NASOPHARYNX; NASOPHARYNX TUMOR; PATHOGENICITY; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE; VIROLOGY; VIRUS CELL TRANSFORMATION;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, VIRAL; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HERPESVIRUS 4, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; NASOPHARYNGEAL NEOPLASMS; NASOPHARYNX; NEOPLASM INVASIVENESS; PHOSPHORYLATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION; TIME FACTORS; VIRAL MATRIX PROTEINS;

EID: 84940897675     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4575     Document Type: Article

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