Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κB signaling

Food and Function

Volumn 6, Issue 9, 2015, Pages 2984-2995

  Medicherla, Kanakaraju ^a   Sahu, Bidya Dhar ^b   Kuncha, Madhusudana ^b   Kumar, Jerald Mahesh ^c   Sudhakar, Godi ^a   Sistla, Ramakrishna ^b  

^a ANDHRA UNIVERSITY   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; BLOOD; DAMAGE DETECTION; DISEASES; ENZYMES; MAMMALS; SULFUR COMPOUNDS; TISSUE;

ANTIOXIDATIVE PROPERTY; COMPLEMENTARY AND ALTERNATIVE MEDICINES; INFLAMMATORY BOWEL DISEASE; NUCLEAR TRANSLOCATIONS; PRO-INFLAMMATORY CYTOKINES; SUPEROXIDE DISMUTASE ACTIVITIES; THERAPEUTIC POTENTIALS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

MONOTERPENES;

CYTOKINE; GERANIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TERPENE;

ANIMAL; BAGG ALBINO MOUSE; COLITIS, ULCERATIVE; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; INTESTINE MUCOSA; MALE; MOUSE; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; COLITIS, ULCERATIVE; CYTOKINES; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; TERPENES;

EID: 84940887071     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c5fo00405e     Document Type: Article

References (34)

1. F. Borrelli B. Romano S. Petrosino E. Pagano R. Capasso D. Coppola G. Battista P. Orlando V. Di Marzo A. A. Izzo Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent Br. J. Pharmacol. 2014 170 1122 1133
2. Z. Ju S. S. Chavan D. J. Antoine M. Dancho T. Tsaava J. Li B. Lu Y. A. Levine A. Stiegler Y. Tamari Y. Al-Abed J. Roth K. J. Tracey H. Yang Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis PLoS One 2014 9 8 e103992
3. S. B. Weisser L. K. Kozicky H. K. Brugger E. N. Ngoh B. Cheung R. Jen S. C. Menzies A. Samarakoon P. J. Murray C. J. Lim P. Johnson J. L. Boucher N. van Rooijen L. M. Sly Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate-induced intestinal inflammation Eur. J. Immunol. 2014 44 3353 3367
4. S. Sanchez-Fidalgo I. Villegas M. A. Rosillo M. A. Soto C. A. D. L. Lastra Dietary squalene supplementation improves DSS-induced acute colitis by down regulating p38 MAPK and NF-kB signaling pathways Mol. Nutr. Food Res. 2015 59 284 292
5. G. Rogler Chronic ulcerative colitis and colorectal cancer Cancer Lett. 2014 345 235 241
6. C. Du P. Wang Y. Yu F. Chen J. Liu Y. Li Gadolinium chloride improves the course of TNBS and DSS-induced colitis through protecting against colonic mucosal inflammation Sci. Rep. 2014 4 6096
7. F. Seibold N. Fournier C. Beglinger C. Mottet V. Pittet G. Rogler Swiss IBD cohort study group, Topical therapy is underused in patients with ulcerative colitis J. Crohns Colitis 2014 8 56 63
8. M. Sałaga U. Lewandowska D. Sosnowska P. K. Zakrzewski A. I. Cygankiewicz A. Piechota-Polańczyk M. Sobczak P. Mosinska C. Chen W. M. Krajewska J. Fichna Polyphenol extract from evening primrose pomace alleviates experimental colitis after intracolonic and oral administration in mice Naunyn-Schmiedeberg's Arch. Pharmacol. 2014 387 1069 1078
9. K. M. Kim Y. S. Kim J. Y. Lim S. J. Min J. H. Shin H. C. Ko S. J. Kim Y. Lim Y. Kim Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium-induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation Nutr. Res. 2014 34 894 905
10. J. R. Guzman J. S. Koo J. R. Goldsmith M. Muhlbauer A. Narula C. Jobin Oxymatrine Prevents NF-kB Nuclear Translocation And Ameliorates Acute Intestinal Inflammation Sci. Rep. 2013 3 1629
11. K. I. D. Carvalho F. Bonamin R. C. Doa Santos L. L. Périco F. P. Beserra D. P. D. Sousa J. M. Filho L. R. da Rocha C. A. Hiruma-Lima Geraniol - a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa Naunyn-Schmiedeberg's Arch. Pharmacol. 2014 387 355 365
12. S. N. Prasad Muralidhara Protective Effects of Geraniol (a Monoterpene) in a Diabetic Neuropathy Rat Model, Attenuation of Behavioral Impairments and Biochemical Perturbations J. Neurosci. Res. 2014 92 1205 1216
13. S. C. Chaudhary M. S. Siddiqui M. Athar M. S. Alam Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis J. Appl. Toxicol. 2012 33 828 837
14. K. R. Rekha G. P. Selvakumar Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease Chem. Biol. Int. 2014 217 57 66
15. Y. W. Su S. H. Chao M. H. Lee T. Y. Ou Y. C. Tsai Inhibitory Effects of Citronellol and Geraniol on Nitric Oxide and Prostaglandin E2 Production in Macrophages Planta Med. 2010 76 1666 1671
16. W. Dou J. Zhang G. Ren L. Ding A. Sun C. Deng X. Wu X. Wei S. Mani Z. Wang Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation Int. Immunopharmacol. 2014 23 170 178
17. R. C. Schwanke R. Marcon F. C. Meotti A. F. Bento R. C. Dutra M. G. Pizzollatti J. B. Calixto Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3 K/Akt signaling pathway Mol. Nutr. Food Res. 2013 57 1938 1949
18. K. R. Rekha G. P. Selvakumar S. Sethupathy K. Santha R. I. Sivakamasundari Geraniol Ameliorates the Motor Behavior and Neurotrophic Factors Inadequacy in MPTP-Induced Mice Model of Parkinson's Disease J. Mol. Neurosci. 2013 51 851 862
19. B. S. Thippeswamy S. Mahendran M. I. Biradar P. Raj K. Srivastava S. Badami V. P. Veerapur Protective effect of embelin against acetic acid induced ulcerative colitis in rats Eur. J. Pharmacol. 2011 654 100 105
20. L. C. Green D. A. Wagner J. Glagowski P. L. Skipper J. S. Wishnok S. R. Tannenbaum Analysis of nitrate, nitrite and [15N] nitrate in biological fluids Anal. Biochem. 1982 126 131 138
21. G. L. Ellman Tissue sulfhydryl groups Arch. Biochem. Biophys. 1959 82 70 77
22. H. Ohkawa N. Ohishi K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 1979 95 351 358
23. B. D. Sahu A. K. Kalvala M. Koneru J. Mahesh Kumar M. Kuncha S. S. Rachamalla R. Sistla Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-kB Activation and Antioxidant Defence PLoS One 2014 9 9 e105070
24. J. Zhang L. Ding B. Wang G. Ren A. Sun C. Deng X. Wei S. Mani Z. Wang W. Dou Notoginsenoside R1 Attenuates Experimental Inflammatory Bowel Disease via Pregnane X Receptor Activation J. Pharmacol. Exp. Ther. 2015 352 315 324
25. G. Samak K. K. Chaudhry R. Gangwar D. Narayanan J. H. Jaggar R. K. Rao Calcium-Ask1-MKK7-JNK2-c-Src Signaling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium Biochem. J. 2015 465 503 515
26. M. P. Utrilla M. J. Peinado R. Ruiz A. R. Nogales F. Algieri M. E. R. Cabezas A. Clemente J. Galvez L. A. Rubio Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis Mol. Nutr. Food Res. 2015 59 807 819
27. J. Yao L. Zhao Q. Zhao Y. Zhao Y. Sun Y. Zhang NF-kB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis Cell Death Dis. 2014 5 e1283
28. X. Xiao J. Kim Q. Sun D. Kim C. S. Park T. S. Lu Y. Park Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice Food Chem. 2015 167 438 446
29. Y. Lin L. Lin Q. Wang Y. Jin Y. Zhang Y. Cao C. Zheng Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in mice Clin. Exp. Pharmacol. Physiol. 2015 42 76 86
30. K. M. Sakthivel C. Guruvayoorappan Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis Int. Immunopharmacol. 2013 17 907 916
31. H. M. M. Arafa R. A. Hemeida A. I. M. El-Bahrawy F. M. A. Hamada Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model Food Chem. Toxicol. 2009 47 1311 1317
32. M. Marín R. M. Giner J. L. Ríos M. D. C. Recio Protective Effect of Apocynin in a Mouse Model of Chemically-Induced Colitis Planta Med. 2013 79 1392 1400
33. P. P. Trivedi G. B. Jena Mechanistic insight into beta-carotene-mediated protection against ulcerative colitis-associated local and systemic damage in mice Eur. J. Nutr. 2015 54 639 652
34. B. Khor A. Gardet R. J. Xavier Genetics and pathogenesis of inflammatory bowel disease Nature 2011 474 307 317