Nanodrug Formed by Coassembly of Dual Anticancer Drugs to Inhibit Cancer Cell Drug Resistance

ACS Applied Materials and Interfaces

Volumn 7, Issue 34, 2015, Pages 19295-19305

  Zhao, Yuanyuan ^a   Chen, Fei ^a,b   Pan, Yuanming ^a   Li, Zhipeng ^a   Xue, Xiangdong ^a,b   Okeke, Chukwunweike Ikechukwu ^a,b   Wang, Yifeng ^a,b   Li, Chan ^a   Peng, Ling ^c   Wang, Paul C ^d   Ma, Xiaowei ^a   Liang, Xing Jie ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c AIX MARSEILLE UNIVERSITÉ   (France)

^d HOWARD UNIVERSITY   (United States)

Author keywords

assemble; carrier free; drug resistance; insoluble drugs; pure nanodrug

Indexed keywords

CELL PROLIFERATION; CHEMICAL BONDS; CYTOLOGY; DISEASES; DRUG THERAPY; MOLECULAR DYNAMICS; MOLECULES; NANOPARTICLES; REACTION KINETICS; SELF ASSEMBLY; SOLUBILITY;

ASSEMBLE; CARRIER-FREE; DRUG RESISTANCE; INSOLUBLE DRUG; PURE NANODRUG;

CELLS;

10-HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DOXORUBICIN; NANOPARTICLE; NANOSPHERE; NANOTUBE;

ANALOGS AND DERIVATIVES; CELL COUNT; CELL DEATH; CFU COUNTING; CHEMISTRY; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; FLOW CYTOMETRY; HUMAN; MOLECULAR DYNAMICS; SPECTROFLUOROMETRY; TUMOR CELL LINE; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL COUNT; CELL DEATH; CELL LINE, TUMOR; COLONY-FORMING UNITS ASSAY; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; MOLECULAR DYNAMICS SIMULATION; NANOPARTICLES; NANOSPHERES; NANOTUBES; SPECTROMETRY, FLUORESCENCE;

EID: 84940874165     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b05347     Document Type: Article

References (42)

1. Montenegro, J. M.; Grazu, V.; Sukhanova, A.; Agarwal, S.; de la Fuente, J. M.; Nabiev, I.; Greiner, A.; Parak, W. J. Controlled antibody/(bio-) Conjugation of Inorganic Nanoparticles for Targeted Delivery Adv. Drug Delivery Rev. 2013, 65, 677-688 10.1016/j.addr.2012.12.003
2. Bhirde, A. A.; Chikkaveeraiah, B. V.; Srivatsan, A.; Niu, G.; Jin, A. J.; Kapoor, A.; Wang, Z.; Patel, S.; Patel, V.; Gorbach, A. M.; Leapman, R. D.; Gutkind, J. S.; Hight Walker, A. R.; Chen, X. Targeted Therapeutic Nanotubes Influence the Viscoelasticity of Cancer Cells to Overcome Drug Resistance ACS Nano 2014, 8, 4177-4189 10.1021/nn501223q
3. Zhen, Z.; Tang, W.; Chen, H.; Lin, X.; Todd, T.; Wang, G.; Cowger, T.; Chen, X.; Xie, J. RGD-modified Apoferritin Nanoparticles for Efficient Drug Delivery to Tumors ACS Nano 2013, 7, 4830-4837 10.1021/nn305791q
4. Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A Review of Stimuli-responsive Nanocarriers for Drug and Gene Delivery J. Controlled Release 2008, 126, 187-204 10.1016/j.jconrel.2007.12.017
5. Junghanns, J. U.; Muller, R. H. Nanocrystal Technology, Drug Delivery and Clinical Applications Int. J. Nanomed. 2008, 3, 295-309 10.2147/IJN.S595
6. Fang, R. H.; Hu, C. M.; Luk, B. T.; Gao, W.; Copp, J. A.; Tai, Y.; O'Connor, D. E.; Zhang, L. Cancer Cell Membrane-coated Nanoparticles for Anticancer Vaccination and Drug Delivery Nano Lett. 2014, 14, 2181-2188 10.1021/nl500618u
7. Xu, X. Y.; Xie, K.; Zhang, X. Q.; Pridgen, E. M.; Park, G. Y.; Cui, D. S.; Shi, J. J.; Wu, J.; Kantoff, P. W.; Lippard, S. J.; Langer, R.; Walker, G. C.; Farokhzad, O. C. Enhancing Tumor Cell Response to Chemotherapy through Nanoparticle-mediated Codelivery of siRNA and Cisplatin Prodrug Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 18638-18643 10.1073/pnas.1303958110
8. Wei, T.; Liu, J.; Ma, H.; Cheng, Q.; Huang, Y.; Zhao, J.; Huo, S.; Xue, X.; Liang, Z.; Liang, X. J. Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in vitro and in vivo Nano Lett. 2013, 13, 2528-2534 10.1021/nl400586t
9. Pelaz, B.; Jaber, S.; de Aberasturi, D. J.; Wulf, V.; Aida, T.; de la Fuente, J. M.; Feldmann, J.; Gaub, H. E.; Josephson, L.; Kagan, C. R.; Kotov, N. A.; Liz-Marzan, L. M.; Mattoussi, H.; Mulvaney, P.; Murray, C. B.; Rogach, A. L.; Weiss, P. S.; Willner, I.; Parak, W. J. The State of Nanoparticle-Based Nanoscience and Biotechnology: Progress, Promises, and Challenges ACS Nano 2012, 6, 8468-8483 10.1021/nn303929a
10. Gao, Z.; Lukyanov, A. N.; Singhal, A.; Torchilin, V. P. Diacyllipid-Polymer Micelles as Nanocarriers for Poorly Soluble Anticancer Drugs Nano Lett. 2002, 2, 979-982 10.1021/nl025604a
11. Stylianopoulos, T. EPR-effect: Utilizing Size-dependent Nanoparticle Delivery to Solid Tumors Ther. Delivery 2013, 4, 421-433 10.4155/tde.13.8
12. Maeda, H.; Nakamura, H.; Fang, J. The EPR Effect for Macromolecular Drug Delivery to Solid Tumors: Improvement of Tumor Uptake, Lowering of Systemic Toxicity, and Distinct Tumor Imaging in vivo Adv. Drug Delivery Rev. 2013, 65, 71-79 10.1016/j.addr.2012.10.002
13. Liu, G.; Gao, J.; Ai, H.; Chen, X. Applications and Potential Toxicity of Magnetic Iron Oxide Nanoparticles Small 2013, 9, 1533-1545 10.1002/smll.201201531
14. Jia, L.; Zhao, Y. L.; Liang, X. J. Fast Evolving Nanotechnology and Relevant Programs and Entities in China Nano Today 2011, 6, 6-11 10.1016/j.nantod.2010.11.003
15. Huhn, D.; Kantner, K.; Geidel, C.; Brandholt, S.; De Cock, I.; Soenen, S. J.; Rivera Gil, P.; Montenegro, J. M.; Braeckmans, K.; Mullen, K.; Nienhaus, G. U.; Klapper, M.; Parak, W. J. Polymer-coated Nanoparticles Interacting with Proteins and Cells: Focusing on the Sign of the Net Charge ACS Nano 2013, 7, 3253-3263 10.1021/nn3059295
16. Kasai, H.; Murakami, T.; Ikuta, Y.; Koseki, Y.; Baba, K.; Oikawa, H.; Nakanishi, H.; Okada, M.; Shoji, M.; Ueda, M.; Imahori, H.; Hashida, M. Creation of Pure Nanodrugs and Their Anticancer Properties Angew. Chem., Int. Ed. 2012, 51, 10315-10318 10.1002/anie.201204596
17. Zhang, J.; Li, Y.; An, F. F.; Zhang, X.; Chen, X.; Lee, C. S. Preparation and Size Control of Sub-100 nm Pure Nanodrugs Nano Lett. 2015, 15, 313-318 10.1021/nl503598u
18. Zhang, L. Y.; Yang, M.; Wang, Q.; Li, Y.; Guo, R.; Jiang, X. Q.; Yang, C. Z.; Liu, B. R. 10-Hydroxycamptothecin Loaded Nanoparticles: Preparation and Antitumor Activity in Mice J. Controlled Release 2007, 119, 153-162 10.1016/j.jconrel.2007.02.013
19. Niu, G.; Zhu, L.; Ho, D. N.; Zhang, F.; Gao, H.; Quan, Q.; Hida, N.; Ozawa, T.; Liu, G.; Chen, X. Longitudinal Bioluminescence Imaging of the Dynamics of Doxorubicin Induced Apoptosis Theranostics 2013, 3, 190-200 10.7150/thno.5825
20. Zhou, M.; Zhang, X.; Yang, Y.; Liu, Z.; Tian, B.; Jie, J.; Zhang, X. Carrier-free Functionalized Multidrug Nanorods for Synergistic Cancer Therapy Biomaterials 2013, 34, 8960-8967 10.1016/j.biomaterials.2013.07.080
21. Zolotarskaya, O. Y.; Wagner, A. F.; Beckta, J. M.; Valerie, K.; Wynne, K. J.; Yang, H. Synthesis of Water-Soluble Camptothecin-Polyoxetane Conjugates via Click Chemistry Mol. Pharmaceutics 2012, 9, 3403-3408 10.1021/mp3005066
22. Liu, Z.; Robinson, J. T.; Sun, X. M.; Dai, H. J. PEGylated Nanographene Oxide for Delivery of Water-insoluble Cancer Drugs J. Am. Chem. Soc. 2008, 130, 10876-10877 10.1021/ja803688x
23. Discovery Studio Modeling Environment, Release 4.0. Accelrys Software Inc.: San Diego, 2013.
24. Frederick, C. A.; Williams, L. D.; Ughetto, G.; van der Marel, G. A.; van Boom, J. H.; Rich, A.; Wang, A. H. Structural Comparison of Anticancer Drug-DNA Complexes: Adriamycin and Daunomycin Biochemistry 1990, 29, 2538-2549 10.1021/bi00462a016
25. Lebwohl, D. E.; Canetta, R. New Developments in Chemotherapy of Advanced Breast Cancer Ann. Oncol. 1999, 10, 139-146 10.1023/A:1008318725670
26. Xue, X.; Zhao, Y.; Dai, L.; Zhang, X.; Hao, X.; Zhang, C.; Huo, S.; Liu, J.; Liu, C.; Kumar, A.; Chen, W. Q.; Zou, G.; Liang, X. J. Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-induced Emission Adv. Mater. 2014, 26, 712-717 10.1002/adma.201302365
27. Solntsev, K. M.; Sullivan, E. N.; Tolbert, L. M.; Ashkenazi, S.; Leiderman, P.; Huppert, D. Excited-state Proton Transfer Reactions of 10-hydroxycamptothecin J. Am. Chem. Soc. 2004, 126, 12701-12708 10.1021/ja047821e
28. Morgan, M. T.; Nakanishi, Y.; Kroll, D. J.; Griset, A. P.; Carnahan, M. A.; Wathier, M.; Oberlies, N. H.; Manikumar, G.; Wani, M. C.; Grinstaff, M. W. Dendrimer-encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity in vitro Cancer Res. 2006, 66, 11913-11921 10.1158/0008-5472.CAN-06-2066
29. Kong, X.; Yu, K.; Yu, M.; Feng, Y.; Wang, J.; Li, M.; Chen, Z.; He, M.; Guo, R.; Tian, R.; Li, Y.; Wu, W.; Hong, Z. A Novel Multifunctional Poly(amidoamine) Dendrimeric Delivery System with Superior Encapsulation Capacity for Targeted Delivery of the Chemotherapy Drug 10-hydroxycamptothecin Int. J. Pharm. 2014, 465, 378-387 10.1016/j.ijpharm.2014.02.022
30. Schmidt, M. Chemotherapy in Early Breast Cancer: When, How and Which One? Breast Care 2014, 9, 154-160 10.1159/000363755
31. Sinclair, S.; Swain, S. M. Primary Systemic Chemotherapy for Inflammatory Breast Cancer Cancer 2010, 116, 2821-2828 10.1002/cncr.25166
32. Endo, M.; Miwa, M.; Ura, M.; Tanimura, H.; Taniguchi, K.; Miyazaki, Y.; Ohwada, J.; Tsukazaki, M.; Niizuma, S.; Murata, T.; Ozawa, S.; Suda, H.; Ogawa, K.; Nanba, E.; Nagao, S.; Shimma, N.; Yamada-Okabe, H. A Water Soluble Prodrug of a Novel Camptothecin Analog is Efficacious Against Breast Cancer Resistance Protein-expressing Tumor Xenografts Cancer Chemother. Pharmacol. 2010, 65, 363-371 10.1007/s00280-009-1042-5
33. Nogi, H.; Kobayashi, T.; Tabei, I.; Kawase, K.; Toriumi, Y.; Suzuki, M.; Morikawa, T.; Uchida, K. The Predictive Value of PgR and HER-2 for Response to Primary Systemic Chemotherapy in Inflammatory Breast Cancer Int. J. Clin. Oncol. 2008, 13, 340-344 10.1007/s10147-008-0760-8
34. Riganti, C.; Voena, C.; Kopecka, J.; Corsetto, P. A.; Montorfano, G.; Enrico, E.; Costamagna, C.; Rizzo, A. M.; Ghigo, D.; Bosia, A. Liposome-Encapsulated Doxorubicin Reverses Drug Resistance by Inhibiting P-Glycoprotein in Human Cancer Cells Mol. Pharmaceutics 2011, 8, 683-700 10.1021/mp2001389
35. Komarova, N. L.; Wodarz, D. Drug Resistance in Cancer: Principles of Emergence and Prevention Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 9714-9719 10.1073/pnas.0501870102
36. Xu, X.; Li, R. B.; Ma, M.; Wang, X.; Wang, Y. H.; Zou, H. F. Multidrug Resistance Protein P-glycoprotein Does Not Recognize Nanoparticle C-60: Experiment and Modeling Soft Matter 2012, 8, 2915-2923 10.1039/c2sm06811g
37. Yusa, K.; Tsuruo, T. Reversal Mechanism Of Multidrug Resistance by Verapamil-Direct Binding Of Verapamil To P-Glycoprotein on Specific Sites And Transport Of Verapamil Outward across the Plasma-Membrane Of K562 Adm Cells Cancer Res. 1989, 49, 5002-5006
38. Park, H. W.; Park, H.; Semple, I. A.; Jang, I.; Ro, S. H.; Kim, M.; Cazares, V. A.; Stuenkel, E. L.; Kim, J. J.; Kim, J. S.; Lee, J. H. Pharmacological Correction of Obesity-induced Autophagy Arrest Using Calcium Channel Blockers Nat. Commun. 2014, 5, 4834-4858 10.1038/ncomms5834
39. Kaufmann, S. H. Antagonism between Camptothecin and Topoisomerase II-directed Chemotherapeutic Agents in a Human Leukemia Cell Line Cancer Res. 1991, 51, 1129-1136
40. Gracz, A. D.; Johnston, M. J.; Wang, F. C.; Williamson, I. A.; Wang, Y. L.; Balowski, J.; Sims, C.; Li, L. H.; Allbritton, N.; Magness, S. T. An in vitro Assay for Clonogenic, High-throughput Analysis of Intestinal Stem Cells FASEB. J. 2012, 26, 340-349
41. Tan, K. B.; Mattern, M. R.; Eng, W. K.; Mccabe, F. L.; Johnson, R. K. Nonproductive Rearrangement of DNA Topoisomerase-I and Topoisomerase-Ii Genes-Correlation with Resistance to Topoisomerase Inhibitors J. Natl. Cancer Inst. 1989, 81, 1732-1735 10.1093/jnci/81.22.1732
42. Sugimoto, Y.; Tsukahara, S.; Ohhara, T.; Liu, L. F.; Tsuruo, T. Elevated Expression of DNA Topoisomerase-Ii in Camptothecin-Resistant Human Tumor-Cell Lines Cancer Res. 1990, 50, 7962-7965