Prognostic role of circulating tumor cells during induction chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Inhestern, Johanna ^a   Oertel, Katrin ^a   Stemmann, Viola ^a   Schmalenberg, Harald ^a   Dietz, Andreas ^b   Rotter, Nicole ^c   Veit, Johannes ^c   Görner, Martin ^d   Sudhoff, Holger ^d   Junghanb, Christian ^e   Wittekindt, Claus ^f   Pachmann, Katharina ^a,d   Guntinas Lichius, Orlando ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d Department of Otorhinolaryngology Head and Neck Surgery Ulm University Medical Center ^*  (Germany)

^e UNIVERSITY OF ROSTOCK   (Germany)

^f UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOCETAXEL; FLUOROURACIL;

ADJUVANT CHEMORADIOTHERAPY; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CELL ASSAY; CELL FUNCTION; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FOLLOW UP; HUMAN; LASER SCANNING CYTOMETRY; MALE; MIDDLE AGED; MOUTH SQUAMOUS CELL CARCINOMA; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; OROPHARYNX CARCINOMA; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RECURRENCE FREE SURVIVAL; RECURRENCE RISK; RISK ASSESSMENT; RISK FACTOR; SURVIVAL RATE; CANCER STAGING; CARCINOMA, SQUAMOUS CELL; CELL COUNT; CLINICAL TRIAL; DISEASE FREE SURVIVAL; INDUCTION CHEMOTHERAPY; KAPLAN MEIER METHOD; MOUTH NEOPLASMS; MULTIVARIATE ANALYSIS; OROPHARYNGEAL NEOPLASMS; PATHOLOGY; POSTOPERATIVE CARE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TUMOR EMBOLISM; TUMOR RECURRENCE;

CARCINOMA, SQUAMOUS CELL; CELL COUNT; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INDUCTION CHEMOTHERAPY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MOUTH NEOPLASMS; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASTIC CELLS, CIRCULATING; OROPHARYNGEAL NEOPLASMS; POSTOPERATIVE CARE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84940872156     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132901     Document Type: Article

References (36)

1. Forastiere A, Koch W, Trotti A, Sidransky D (2001) Head and neck cancer. N Engl J Med 345: 1890-1900. PMID: 11756581
2. Argiris A, Karamouzis MV, Raben D, Ferris RL (2008) Head and neck cancer. Lancet 371: 1695-1709. doi: 10.1016/S0140-6736(08)60728-X PMID: 18486742
3. Balasubramanian P, Lang JC, Jatana KR, Miller B, Ozer E, Old M, et al. (2012) Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PLoS One 7: e42048. doi: 10.1371/journal.pone.0042048 PMID: 22844540
4. Schlimok G, Funke I, Holzmann B, Göttlinger G, Schmidt G, Häuser H, et al. (1987) Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies. Proc Natl Acad Sci U S A 84: 8672-8676. PMID: 2446326
5. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351: 781-791. PMID: 15317891
6. Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, et al. (2008) Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 26: 3213-3221. doi: 10.1200/JCO.2007.15.8923 PMID: 18591556
7. Scher HI, Jia X, de Bono JS, Fleisher M, Pienta KJ, Raghavan D, et al. (2009) Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data. Lancet Oncol 10: 233-239. doi: 10.1016/S1470-2045(08)70340-1 PMID: 19213602
8. Posner M, Vermorken JB (2008) Induction therapy in the modern era of combined-modality therapy for locally advanced head and neck cancer. Semin Oncol 35: 221-228. doi: 10.1053/j.seminoncol.2008. 03.007 PMID: 18544437
9. Oertel K, Spiegel K, Schmalenberg H, Dietz A, Maschmeyer G, Kuhnt T, et al. (2012) Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1). BMC Cancer 12: 483. doi: 10.1186/1471-2407-12-483 PMID: 23083061
10. Zhong LP, Zhang CP, Ren GX, Guo W, William WN Jr, Sun J, et al. (2013) Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol 31: 744-751. doi: 10.1200/JCO.2012.43.8820 PMID: 23129742
11. Guntinas-Lichius O, Wendt TG, Kornetzky N, Buentzel J, Esser D, Böger D, et al. (2014) Trends in epidemiology and treatment and outcome for head and neck cancer: A population-based long-term analysis from 1996 to 2011 of the Thuringian cancer registry. Oral Oncol 50: 1157-1164. doi: 10.1016/j. oraloncology.2014.09.015 PMID: 25459063
12. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45: 228-247. doi: 10.1016/j.ejca.2008.10.026 PMID: 19097774
13. Glombitza F, Guntinas-Lichius O, Petersen I (2010) HPV status in head and neck tumors. Pathol Res Pract 206: 229-234. doi: 10.1016/j.prp.2009.11.007 PMID: 20138710
14. Pachmann K, Camara O, Kavallaris A, Krauspe S, Malarski N, Gajda M, et al. (2008) Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse. J Clin Oncol 26: 1208-1215. doi: 10.1200/JCO.2007.13.6523 PMID: 18323545
15. Pachmann UA, Hekimian K, Carl S, Ruediger N, Rabenstein C, Pachmann K (2011) Comparing Sequential Steps For Detection Of Circulating Tumor Cells: More Specific Or Just Less Sensitive?. WebmedCentral CANCER 2: WMC001490.
16. Pachmann K, Camara O, Kavallaris A, Schneider U, Schünemann S, Höffken K. Quantification of the response of circulating epithelial cells (CEC) to neodadjuvant treatment of breast cancer: A new tool for therapy monitoring. Breast Cancer Research 7:R975-R979. PMID: 16280045
17. Mockelmann N, Laban S, Pantel K, Knecht R (2014) Circulating tumor cells in head and neck cancer: clinical impact in diagnosis and follow-up. Eur Arch Otorhinolaryngol 271: 15-21. doi: 10.1007/s00405- 013-2391-6 PMID: 23408023
18. Hristozova T, Konschak R, Stromberger C, Fusi A, Liu Z, WeichertWet al. (2011) The presence of circulating tumor cells (CTCss) correlates with lymph node metastasis in nonresectable squamous cell carcinoma of the head and neck region (SCCHN). Ann Oncol 22: 1878-1885. doi: 10.1093/annonc/ mdr130 PMID: 21525401
19. Weller P, Nel I, Hassenkamp P, Gauler T, Schlueter A, Lang S et al. (2014) Detection of circulating tumor cell subpopulations in patients with head and neck squamous cell carcinoma (HNSCC). PLoS One 9: e113706. doi: 10.1371/journal.pone.0113706 PMID: 25479539
20. Wikner J, Grobe A, Pantel K, Riethdorf S (2014) Squamous cell carcinoma of the oral cavity and circulating tumour cells. World J Clin Oncol 5: 114-124. doi: 10.5306/wjco.v5.i2.114 PMID: 24829858
21. Gröbe A, Blessmann M, Hanken H, Friedrich RE, Schön G, Wikner J, et al. (2014) Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity. Clin Cancer Res 20: 425-433. doi: 10.1158/1078-0432. CCR-13-1101 PMID: 24218516
22. Buglione M, Grisanti S, Almici C, Mangoni M, Polli C, Consoli F, et al. (2012) Circulating tumour cells in locally advanced head and neck cancer: preliminary report about their possible role in predicting response to non-surgical treatment and survival. Eur J Cancer 48: 3019-3026. doi: 10.1016/j.ejca. 2012.05.007 PMID: 22682019
23. Nichols AC, Lowes LE, Szeto CC, Basmaji J, Dhaliwal S, Chapeskie C, et al. (2012) Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system. Head Neck 34: 1440-1444. doi: 10.1002/hed.21941 PMID: 22076949
24. Hsieh JC, Lin HC, Huang CY, Hsu HL, Wu TM, et al. (2014) Prognostic value of circulating tumor cells with podoplanin expression in patients with locally advanced or metastatic head and neck squamous cell carcinoma. Head Neck, doi: 10.1002/hed.23779. [Epub ahead of print].
25. Mirghani H, Amen F, Moreau F, Lacau St Guily J (2015) Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma? Oral Oncol; 51: 229-236. doi: 10.1016/j.oraloncology.2014.11. 011 PMID: 25488179
26. Hitt R, López-Pousa A, Martínez-Trufero J, Escrig V, Carles J, Rizo A, et al. (2005) Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol 23: 8636-8645. PMID: 16275937
27. Lorch JH, Goloubeva O, Haddad RI, Cullen K, Sarlis N, Tishler R, et al. (2011) Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial. Lancet Oncol 12: 153-159. doi: 10.1016/S1470-2045(10)70279-5 PMID: 21233014
28. Jatana KR, Balasubramanian P, Lang JC, Yang L, Jatana CA, White E, et al. (2010) Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: initial results. Arch Otolaryngol Head Neck Surg 136: 1274-1279. doi: 10.1001/archoto.2010.223 PMID: 21173379
29. Tinhofer I, Konschak R, Stromberger C, Raguse JD, Dreyer JH, Jöhrens K, et al. (2014) Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck. Ann Oncol 25: 2042-2047. doi: 10.1093/annonc/ mdu271 PMID: 25057171
30. Kusukawa J, Suefuji Y, Ryu F, Noguchi R, Iwamoto O, Kameyama T (2000) Dissemination of cancer cells into circulation occurs by incisional biopsy of oral squamous cell carcinoma. J Oral Pathol Med 29: 303-307. PMID: 10947245
31. Liu Z, Jiang M, Zhao J, Ju H (2007) Circulating tumor cells in perioperative esophageal cancer patients: quantitative assay system and potential clinical utility. Clin Cancer Res 13: 2992-2997. PMID: 17505001
32. Hashimoto M, Tanaka F, Yoneda K, Takuwa T, Matsumoto S, Okumura Y, et al. (2014) Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer. Interact Cardiovasc Thorac Surg 18: 775-783. doi: 10.1093/icvts/ivu048 PMID: 24618055
33. Nesteruk D, Rutkowski A, Fabisiewicz S, Pawlak J, Siedlecki JA, Fabisiewicz A. (2014) Evaluation of prognostic significance of circulating tumor cells detection in rectal cancer patients treated with preoperative radiotherapy: prospectively collected material data. Biomed Res Int: 712827.
34. Perrone F, Bossi P, Cortelazzi B, Locati L, Quattrone P, Pierotti MA, et al. (2010) TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma. J Clin Oncol 28: 761-766. doi: 10.1200/JCO.2009.22.4170 PMID: 20048189
35. Feng Z, Guo W, Zhang C, Xu Q, Zhang P, Sun J, et al. (2011) CCND1 as a predictive biomarker of neoadjuvant chemotherapy in patients with locally advanced head and neck squamous cell carcinoma. PLoS One 6(10): e26399. doi: 10.1371/journal.pone.0026399 PMID: 22065993
36. Zhu DW, Liu Y, Yang X, Yang CZ, Ma J, Yang X, et al. (2013) Low Annexin A1 expression predicts benefit from induction chemotherapy in oral cancer patients with moderate or poor pathologic differentiation grade. BMC Cancer 13:301. doi: 10.1186/1471-2407-13-301 PMID: 23786757