Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation

Molecular Vision

Volumn 21, Issue , 2015, Pages 1036-1050

  Zanon, Caroline de Freitas ^a   Sonehara, Nathália Martins ^a   Girol, Ana Paula ^a,b   Gil, Cristiane Damas ^c   Oliani, Sonia Maria ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b Integrated College Padre Albino Foundation (FIPA)   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYCLOOXYGENASE 2; DEXAMETHASONE; GALECTIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; CCL2 PROTEIN, RAT; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENDOTOXIN-INDUCED UVEITIS; EYE INFLAMMATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PIGMENT EPITHELIUM; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; RETINAL PIGMENT EPITHELIUM; SUBCUTANEOUS DRUG ADMINISTRATION; UVEITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CHEMOKINE CCL2; CYCLOOXYGENASE 2; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GALECTIN 1; GENE EXPRESSION REGULATION; HUMANS; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NEUTROPHIL INFILTRATION; RATS; RECOMBINANT PROTEINS; RETINAL PIGMENT EPITHELIUM; UVEITIS;

EID: 84940854868     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR. Endotoxin-induced uveitis in rats as a model for human disease. Nature 1980; 286:611-3. [PMID: 7402339]
2. Chang JH, McCluskey P, Missotten T, Ferrante P, Jalaludin B, Lightman S. Use of ocular hypotensive prostaglandin analogues in patients with uveitis: does their use increase anterior uveitis and cystoid macular oedema? Br J Ophthalmol 2008; 92:916-21. [PMID: 18460537]
3. Girol AP, Mimura KK, Drewes CC, Bolonheis SM, Solito E, Farsky SH, Gil CD, Oliani SM. Anti-Inflammatory Mechanisms of the Annexin A1 Protein and Its Mimetic Peptide Ac2-26 in Models of Ocular Inflammation In Vivo and In Vitro. J Immunol 2013; 190:5689-701. [PMID: 23645879]
4. Ruiz-Moreno JM, Thillaye B, de Kozak Y. Retino-choroidal changes in endotoxin-induced uveitis in the rat. Ophthalmic Res 1992; 24:162-8. [PMID: 1407958]
5. Altan-Yaycioglu R, Akova YA, Akca S, Yilmaz G. Inflammation of the posterior uvea: findings on fundus fluorescein and indocyanine green angiography. Ocul Immunol Inflamm 2006; 14:171-9. [PMID: 16766401]
6. da Silva PS, Girol AP, Oliani SM. Mast cells modulate the inflammatory process in endotoxin-induced uveitis. Mol Vis 2011; 17:1310-9. [PMID: 21633711]
7. Chang JH, McCluskey PJ, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. Br J Ophthalmol 2006; 90:103-8. [PMID: 16361678]
8. Goureau O, Bellot J, Thillaye B, Courtois Y, de Kozak Y. Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase. J Immunol 1995; 154:6518-23. [PMID: 7539024]
9. Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S. Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats. Mol Vis 2012; 18:2586-97. [PMID: 23112571]
10. Medeiros R, Rodrigues GB, Figueiredo CP, Rodrigues EB, Grumman A, Menezes-de-Lima O, Passos GF, Calixto JB. Molecular mechanisms of topical anti-inflammatory effects of lipoxin A(4) in endotoxin-induced uveitis. Mol Pharmacol 2008; 74:154-61. [PMID: 18413658]
11. Li S, Lu H, Hu X, Chen W, Xu Y, Wang J. Expression of TLR4MyD88 and NF-κB in the iris during endotoxin-induced uveitis. Mediators Inflamm 2010; xxx:748218
12. Kalariya NM, Reddy AB, Ansari NH, VanKuijk FJ, Ramana KV. Preventive effects of ethyl pyruvate on endotoxininduced uveitis in rats. Invest Ophthalmol Vis Sci 2011; 52:5144-52. [PMID: 21551413]
13. Touchard E, Omri S, Naud MC, Berdugo M, Deloche C, Abadie C, Jonet L, Jeanny JC, Crisanti P, de Kozak Y, Combette JM, Behar-Cohen F. A peptide inhibitor of c-Jun N-terminal kinase for the treatment of endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 2010; 51:4683-93. [PMID: 20393119]
14. Srivastava A, Rajappa M, Kaur J. Uveitis: Mechanisms and recent advances in therapy. Clin Chim Acta 2010; 411:116571. [PMID: 20416287]
15. Larson T, Nussenblatt RB, Sen HN. Emerging drugs for uveitis. Expert Opin Emerg Drugs 2011; 16:309-22.[PMID: 21210752]
16. Rosenbaum JT. Future for biological therapy for uveitis. Curr Opin Ophthalmol 2010; 21:473-7. [PMID: 20829688]
17. Perillo NL, Marcus ME, Baum LG. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med (Berl) 1998; 76:402-12. [PMID: 9625297]
18. Rabinovich GA, Ariel A, Hershkoviz R, Hirabayashi J, Kasai KI, Lider O. Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 1999; 97:100-6. [PMID: 10447720]
19. Santucci L, Fiorucci S, Cammilleri F, Servillo G, Federici B, Morelli A. Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatology 2000; 31:399-406. [PMID: 10655263]
20. Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M, Rabinovich GA. Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate. Methods Enzymol 2010; 480:199-244. [PMID: 20816212]
21. Cooper D, Iqbal AJ, Gittens BR, Cervone C, Perretti M. The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? Ann N Y Acad Sci 2012; [PMID: 22256855]
22. Cooper DN, Barondes SH. God must love galectins; he made so many of them. Glycobiology 1999; 9:979-84. [PMID: 10521533]
23. Liu FT, Rabinovich GA. Galectins: regulators of acute and chronic inflammation. Ann N Y Acad Sci 2010; 1183:15882. [PMID: 20146714]
24. Offner H, Celnik B, Bringman TS, Casentini-Borocz D, Nedwin GE, Vandenbark AA. Recombinant human betagalactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol 1990; 28:177-84. [PMID: 1694534]
25. Rabinovich GA, Daly G, Dreja H, Tailor H, Riera CM, Hirabayashi J, Chernajovsky Y. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 1999; 190:385-98.[PMID: 10430627]
26. Toscano MA, Commodaro AG, Ilarregui JM, Bianco GA, Liberman A, Serra HM, Hirabayashi J, Rizzo LV, Rabinovich GA. Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2and T regulatory-mediated anti-inflammatory responses. J Immunol 2006; 176:6323-32. [PMID: 16670344]
27. Perone MJ, Bertera S, Tawadrous ZS, Shufesky WJ, Piganelli JD, Baum LG, Trucco M, Morelli AE. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 2006; 177:5278-89. [PMID: 17015713]
28. Barondes SH, Cooper DN, Gitt MA, Leffler H. Galectins. Structure and function of a large family of animal lectins. J Biol Chem 1994; 269:20807-10. [PMID: 8063692]
29. Rabinovich GA, Sotomayor CE, Riera CM, Bianco I, Correa SG. Evidence of a role for galectin-1 in acute inflammation. Eur J Immunol 2000; 30:1331-9. [PMID: 10820379]
30. La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasai K, Oliani SM, Chernajovsky Y, Perretti M. A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol 2003; 163:1505-15. [PMID: 14507657]
31. Gil CD, Gullo CE, Oliani SM. Effect of exogenous galectin-1 on leukocyte migration: modulation of cytokine levels and adhesion molecules. Int J Clin Exp Pathol 2010; 4:74-84. [PMID: 21228929]
32. Iqbal AJ, Sampaio AL, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D. Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. Am J Pathol 2011; 178:1201-9. [PMID: 21356371]
33. Seropian IM, Cerliani JP, Toldo S, Van Tassell BW, Ilarregui JM, González GE, Matoso M, Salloum FN, Melchior R, Gelpi RJ, Stupirski JC, Benatar A, Gómez KA, Morales C, Abbate A, Rabinovich GA. Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction. Am J Pathol 2013; 182:29-40. [PMID: 23142379]
34. Gil CD, Cooper D, Rosignoli G, Perretti M, Oliani SM. Inflammation-induced modulation of cellular galectin-1 and −3 expression in a model of rat peritonitis. Inflamm Res 2006; 55:99-107. [PMID: 16673152]
35. Oliani SM, Perretti M. Cell localization of the anti-inflammatory protein annexin 1 during experimental inflammatory response. Ital J Anat Embryol 2001; 106:Suppl 169-77. [PMID: 11729999]
36. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 1996; 62:155-69. [PMID: 8698076]
37. Chang SW, Chou SF, Yu SY. Dexamethasone reduces mitomycin C-related inflammatory cytokine expression without inducing further cell death in corneal fibroblasts. Wound Repair Regen 2010; 18:59-69. [PMID: 20002897]
38. Leung KW, Barnstable CJ, Tombran-Tink J. Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol 2009; 46:1374-86. [PMID: 19157552]
39. Mochizuki M, Sugita S, Kamoi K. Immunological homeostasis of the eye. Prog Retin Eye Res 2013; 33:10-27. [PMID: 23108335]
40. Zheng C, Lei C, Chen Z, Zheng S, Yang H, Qiu Y, Lei B. Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis. Mol Vis 2015; 21:403-11. [PMID: 25883526]
41. Yang S, Lu H, Wang J, Qi X, Liu X, Zhang X. The effect of toll-like receptor 4 on macrophage cytokines during endotoxin induced uveitis. Int J Mol Sci 2012; 13:7508-20. [PMID: 22837708]
42. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J 1990; 4:2860-7. [PMID: 2199284]
43. McMenamin PG, Crewe J. Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol Vis Sci 1995; 36:1949-59. [PMID: 7657537]
44. Srivastava SK, Ramana KV. Focus on molecules: nuclear factor-kappaB. Exp Eye Res 2009; 88:2-3. [PMID: 18472097]
45. Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001; 107:7-11. [PMID: 11134171]
46. Malik RK, Ghurye RR, Lawrence-Watt DJ, Stewart HJ. Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. Glycobiology 2009; 19:1402-7. [PMID: 19561030]
47. Fulcher JA, Hashimi ST, Levroney EL, Pang M, Gurney KB, Baum LG, Lee B. Galectin-1-matured human monocytederived dendritic cells have enhanced migration through extracellular matrix. J Immunol 2006; 177:216-26. [PMID: 16785517]
48. Cooper D, Norling LV, Perretti M. Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol 2008; 83:1459-66. [PMID: 18372340]
49. Auvynet C, Moreno S, Melchy E, Coronado-Martínez I, Montiel JL, Aguilar-Delfin I, Rosenstein Y. Galectin-1 promotes human neutrophil migration. Glycobiology 2013; 23:32-42. [PMID: 22942212]
50. Fautsch MP, Silva AO, Johnson DH. Carbohydrate binding proteins galectin-1 and galectin-3 in human trabecular meshwork. Exp Eye Res 2003; 77:11-6. [PMID: 12823983]
51. Gil CD, La M, Perretti M, Oliani SM. Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int 2006; 30:338-44. [PMID: 16530434]
52. Uehara F, Ohba N, Ozawa M. Isolation and characterization of galectins in the mammalian retina. Invest Ophthalmol Vis Sci 2001; 42:2164-72. [PMID: 11527926]
53. Romero MD, Muiño JC, Bianco GA, Ferrero M, Juarez CP, Luna JD, Rabinovich GA. Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis. Invest Ophthalmol Vis Sci 2006; 47:1550-6. [PMID: 16565391]
54. Paimela T, Ryhänen T, Mannermaa E, Ojala J, Kalesnykas G, Salminen A, Kaarniranta K. The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Immunol Lett 2007; 110:139-44. [PMID: 17532054]
55. Alge CS, Priglinger SG, Kook D, Schmid H, Haritoglou C, Welge-Lussen U, Kampik A. Galectin-1 influences migration of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2006; 47:415-26. [PMID: 16384992]
56. Delbrouck C, Doyen I, Belot N, Decaestecker C, Ghanooni R, de Lavareille A, Kaltner H, Choufani G, Danguy A, Vandenhoven G, Gabius HJ, Hassid S, Kiss R. Galectin-1 is overexpressed in nasal polyps under budesonide and inhibits eosinophil migration. Lab Invest 2002; 82:147-58. [PMID: 11850528]
57. Sena AA, Provazzi PJ, Fernandes AM, Cury PM, Rahal P, Oliani SM. Spatial expression of two anti-inflammatory mediators, annexin 1 and galectin-1, in nasal polyposis. Clin Exp Allergy 2006; 36:1260-7. [PMID: 17014434]
58. Fernandes AM, Babeto E, Rahal P, Provazzi PJ, Hidalgo CA, Anselmo-Lima WT. Expression of genes that encode the annexin-1 and galectin-1 proteins in nasal polyposis and their modulation by glucocorticoid. Braz J Otorhinolaryngol 2010; 76:213-8. [PMID: 20549082].