Impact of fetal chromosomal disorders on maternal blood metabolome: Toward new biomarkers?

American Journal of Obstetrics and Gynecology

Volumn 213, Issue 6, 2015, Pages 841.e1-841.e15

  Pinto, Joana ^a   Almeida, Lara Monteiro ^a   Martins, Ana Sofia ^a   Duarte, Daniela ^a   Domingues, Maria Rosário Marques ^b   Barros, António Sousa ^b   Galhano, Eulália ^c   Pita, Cristina ^c   Do Céu Almeida, Maria ^c   Carreira, Isabel Marques ^d   Gil, Ana Maria ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

chromosomal disorders; lipid extracts; maternal plasma; nuclear magnetic resonance metabolomics; pregnancy; trisomy 21

Indexed keywords

ACETIC ACID; ALBUMIN; BIOLOGICAL MARKER; CITRIC ACID; FATTY ACID; HIGH DENSITY LIPOPROTEIN; LIPID; LOW DENSITY LIPOPROTEIN; METHANOL; PROLINE; PYRUVIC ACID; SUGAR; VERY LOW DENSITY LIPOPROTEIN; ACETIC ACID DERIVATIVE; CREATININE; GLUCOSE BLOOD LEVEL; KETONE BODY; SERUM ALBUMIN; UREA;

ADULT; ARTICLE; CHEMOMETRICS; CHROMOSOME DISORDER; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; HUMAN; INTESTINE FLORA; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MATERNAL BLOOD; METABOLOME; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA; PREGNANT WOMAN; PRIORITY JOURNAL; SECOND TRIMESTER PREGNANCY; TRISOMY 21; UREA BLOOD LEVEL; URINALYSIS; BLOOD; CASE CONTROL STUDY; DOWN SYNDROME; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; PREGNANCY; YOUNG ADULT;

ACETATES; ADULT; BIOMARKERS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHROMOSOME DISORDERS; CITRIC ACID; CREATININE; DOWN SYNDROME; FATTY ACIDS; FEMALE; HUMANS; KETONE BODIES; LIPID METABOLISM; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; METHANOL; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY TRIMESTER, SECOND; PROLINE; PYRUVIC ACID; SERUM ALBUMIN; UREA; YOUNG ADULT;

EID: 84940831397     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2015.07.032     Document Type: Article

References (45)

1. 1H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations J Proteome Res 8 2009 4144 4150
2. G. Graça, I.F. Duarte, A.S. Barros, and et al. Impact of prenatal disorders on the metabolic profile of second trimester amniotic fluid: a nuclear magnetic resonance metabonomic study J Proteome Res 9 2010 6016 6024
3. R. Romero, S. Mazaki-Tovi, E. Vaisbuch, and et al. Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery J Matern Fetal Neonatal Med 23 2010 1344 1359
4. G. Graça, S.O. Diaz, J. Pinto, and et al. Can biofluids metabolic profiling help to improve healthcare during pregnancy? Spectrosc Int J 27 2012 515 523
5. G. Graça, B.J. Goodfellow, A.S. Barros, and et al. UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers Mol Biosyst 8 2012 1243 1254
6. R.P. Horgan, D.I. Broadhurst, W.B. Dunn, and et al. Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies Placenta 31 2010 893 901
7. W.B. Dunn, M. Brown, S.A. Worton, and et al. The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy Metabolomics 8 2012 579 597
8. R.P. Horgan, D.I. Broadhurst, S.K. Walsh, and et al. Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy J Proteome Res 10 2011 3660 3673
9. 1H-NMR-based metabolic profiling of maternal and umbilical cord blood indicates altered materno-foetal nutrient exchange in preterm infants PLoS One 7 2012 e29947
10. M.-C. Alexandre-Gouabau, F. Courant, T. Moyon, and et al. Maternal and cord blood LC-HRMS metabolomics reveal alterations in energy and polyamine metabolism, and oxidative stress in very-low birth weight infants J Proteome Res 12 2013 2764 2778
11. S.O. Diaz, J. Pinto, G. Graça, and et al. Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma J Proteome Res 10 2011 3732 3742
12. D. Sachse, L. Sletner, K. Mørkrid, and et al. Metabolic changes in urine during and after pregnancy in a large, multiethnic population-based cohort study of gestational diabetes PLoS One 7 2012 e52399
13. S.O. Diaz, A.S. Barros, B.J. Goodfellow, and et al. Following healthy pregnancy by nuclear magnetic resonance (NMR) metabolic profiling of human urine J Proteome Res 12 2013 969 979
14. S.O. Diaz, A.S. Barros, B.J. Goodfellow, and et al. Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes J Proteome Res 12 2013 2946 2957
15. D.K. Trivedi, and R.K. Iles Shotgun metabolomic profiles in maternal urine identify potential mass spectral markers of abnormal fetal biochemistry - dihydrouracil and progesterone in the metabolism of Down syndrome Biomed Chromatogr 29 2015 1173 1183
16. L.C. Kenny, D.I. Broadhurst, W. Dunn, and et al. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers Hypertension 56 2010 741 749
17. R.O. Bahado-Singh, R. Akolekar, R. Mandal, and et al. Metabolomics and first-trimester prediction of early-onset preeclampsia J Matern Fetal Neonatal Med 25 2012 1840 1847
18. R.O. Bahado-Singh, R. Akolekar, R. Mandal, and et al. Metabolomic analysis for first-trimester Down syndrome prediction Am J Obstet Gynecol 208 2013 371.e1 371.e8
19. R.O. Bahado-Singh, R. Akolekar, A. Chelliah, and et al. Metabolomic analysis for first-trimester trisomy 18 detection Am J Obstet Gynecol 209 2013 65.e1 65.e9
20. S. Kuc, M.P.H. Koster, J.L.A. Pennings, and et al. Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia PLoS One 9 2014 e98540
21. J. Pinto, E. Maciel, T.S. Melo, and et al. Maternal plasma phospholipids are altered in trisomy 21 cases and prior to preeclampsia and preterm outcomes Rapid Commun Mass Spectrom 28 2014 1635 1638
22. J. Pinto, A.S. Barros, M.R.M. Domingues, and et al. Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine J Proteome Res 14 2014 1263 1274
23. H. Luan, N. Meng, P. Liu, and et al. Pregnancy-induced metabolic phenotype variations in maternal plasma J Proteome Res 13 2014 1527 1536
24. X. Zheng, M. Su, L. Pei, and et al. Metabolic signature of pregnant women with neural tube defects in offspring J Proteome Res 10 2011 4845 4854
25. R.O. Bahado-Singh, R. Ertl, R. Mandal, and et al. Metabolomic prediction of fetal congenital heart defect in the first trimester Am J Obstet Gynecol 211 2014 240.e1 240.e14
26. C. Auray-Blais, E. Raiche, R. Gagnon, M. Berthiaume, and J.-C. Pasquier Metabolomics and preterm birth: What biomarkers in cervicovaginal secretions are predictive of high-risk pregnant women? Int J Mass Spectrom 307 2011 33 38
27. A.M. Amorini, C. Giorlandino, S. Longo, and et al. Metabolic profile of amniotic fluid as a biochemical tool to screen for inborn errors of metabolism and fetal anomalies Mol Cell Biochem 359 2012 205 216
28. A. Tabor, and Z. Alfirevic Update on procedure-related risks for prenatal diagnosis techniques Fetal Diagn Ther 27 2010 1 7
29. K.H. Nicolaides Screening for fetal aneuploidies at 11 to 13 weeks Prenat Diagn 31 2011 7 15
30. J.M.E. Walsh, and J.D. Goldberg Fetal aneuploidy detection by maternal plasma DNA sequencing: a technology assessment Prenat Diagn 33 2013 514 520
31. J. Pinto, M.R.M. Domingues, E. Galhano, and et al. Human plasma stability during handling and storage: impact on NMR metabolomics Analyst 139 2014 1168 1177
32. V. Matyash, G. Liebisch, T.V. Kurzchalia, A. Shevchenko, and D. Schwudke Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics J Lipid Res 49 2008 1137 1146
33. B.R. Seavey, E.A. Farr, W.M. Westler, and J.L. Markley A relational database for sequence-specific protein NMR data J Biomol NMR 1 1991 217 236
34. D.S. Wishart, D. Tzur, C. Knox, and et al. HMDB: the Human Metabolome Database Nucleic Acids Res 35 Database issue 2007 D521 D526
35. K.A. Veselkov, J.C. Lindon, T.M.D. Ebbels, and et al. Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery Anal Chem 81 2009 56 66
36. 1H NMR metabonomics Anal Chem 78 2006 4281 4290
37. T. Jolliffe Principal component analysis, 2nd ed 2002 Springer-Verlag New York
38. M. Barker, and W. Rayens Partial least squares for discrimination J Chemom 17 2003 166 173
39. S. Wiklund, D. Nilsson, L. Eriksson, M. Sjöström, S. Wold, and K. Faber A randomization test for PLS component selection J Chemom 21 2007 427 439
40. J.A. Westerhuis, H.C.J. Hoefsloot, S. Smit, and et al. Assessment of PLSDA cross validation Metabolomics 4 2008 81 89
41. R. D. C. Team. Language and environment for statistical computing 2010 R Foundation for Statistical Computing Vienna, Austria
42. L. Berben, S.M. Sereika, and S. Engberg Effect size estimation: methods and examples Int J Nurs Stud 49 2012 1039 1047
43. 1H NMR data sets Anal Chem 77 2005 1282 1289
44. R.K. Creasy, R. Resnik, and J.D. Iams Creasy and Resnik's maternal-fetal medicine: principles and practice 6th ed. 2009 Saunders Elsevier Philadelphia
45. R. Wall, R.P. Ross, G.F. Fitzgerald, and C. Stanton Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids Nutr Rev 68 2010 280 289