Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Kramer, M Gabriela ^a   Masner, Martín ^a   Casales, Erkuden ^b,c   Moreno, María ^a   Smerdou, Cristian ^b,c   Chabalgoity, José A ^a  

^a Universidad de la Republica Instituto de Higiene   (Uruguay)

^b UNIVERSITY OF NAVARRA   (Spain)

^c IdiSNA Navarra Institute for Health Research   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; PROBIOTIC AGENT; SEMLIKI FOREST VIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS VECTOR; INTERFERON GAMMA (1-39); PEPTIDE FRAGMENT;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CANCER GENE THERAPY; CANCER INHIBITION; CANCER MORTALITY; CANCER SURVIVAL; CANCER TRANSPLANTATION; CONTROLLED STUDY; DISTANT METASTASIS; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; GENE EXPRESSION; GRANULOCYTE; IL 12 GENE; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE MIGRATION; LUNG METASTASIS; METASTASIS INHIBITION; METASTASIS POTENTIAL; MONOTHERAPY; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SURVIVAL RATE; SURVIVAL TIME; TUMOR INVASION; VIRAL GENE DELIVERY SYSTEM; VIRUS PARTICLE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BREAST NEOPLASMS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE THERAPY; GENE VECTOR; GENETICS; LUNG NEOPLASMS; MULTIMODALITY CANCER THERAPY; NEOADJUVANT THERAPY; PATHOLOGY; PHYSIOLOGY; SECONDARY; SEMLIKI FOREST VIRUS; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; GENETIC THERAPY; GENETIC VECTORS; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-12; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; NEOADJUVANT THERAPY; NEOPLASM TRANSPLANTATION; PEPTIDE FRAGMENTS; SALMONELLA TYPHIMURIUM; SEMLIKI FOREST VIRUS; SURVIVAL RATE;

EID: 84940829635     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1618-x     Document Type: Article

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