Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels

Histochemistry and Cell Biology

Volumn 143, Issue 1, 2015, Pages 83-94

  Cretoiu, Sanda Maria ^a,b   Radu, Beatrice Mihaela ^c,d   Banciu, Adela ^d   Banciu, Daniel Dumitru ^b,d   Cretoiu, Dragos ^a,b   Ceafalan, Laura Cristina ^a,b   Popescu, Laurentiu Mircea ^a,b  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

^c UNIVERSITY OF VERONA   (Italy)

^d UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

CainfV inf3.1; CainfV inf3.2; Human myometrium; T type calcium channels; Telocytes

Indexed keywords

CALCIUM CHANNEL CAV3.1; CALCIUM CHANNEL CAV3.2; CALCIUM CHANNEL T TYPE; CD34 ANTIGEN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG;

ARTICLE; CELL BODY; CELL FUNCTION; ELECTROPHYSIOLOGY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MYOMETRIUM; PROTEIN EXPRESSION; TELOCYTE; UTERUS; CELL SEPARATION; CYTOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; STROMA CELL;

CALCIUM CHANNELS, T-TYPE; CELL SEPARATION; ELECTROPHYSIOLOGY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; STROMAL CELLS; UTERUS;

EID: 84940822465     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-014-1268-0     Document Type: Article

References (65)

1. Aguilar HN, Mitchell BF (2010) Physiological pathways and molecular mechanisms regulating uterine contractility. Hum Reprod Update 16:725–744
2. Baruscotti M, DiFrancesco D, Robinson RB (2000) Na(+) current contribution to the diastolic depolarization in newborn rabbit SA node cells. Am J Physiol Heart Circ Physiol 279:H2303–H2309
3. Bassotti G, Villanacci V, Creţoiu D, Creţoiu SM, Becheanu G (2013) Cellular and molecular basis of chronic constipation: taking the functional/idiopathic label out. World J Gastroenterol 19:4099–4105
4. Blanks AM, Zhao ZH, Shmygol A, Bru-Mercier G, Astle S, Thornton S (2007) Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium. J Physiol 581:915–926
5. Burgess A, Vigneron S, Brioudes E, Labbé J-C, Lorca T, Castro A (2010) Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Proc Natl Acad Sci USA 107:12564–12569
6. Campeanu RA, Radu BM, Cretoiu SM, Banciu DD, Banciu A, Cretoiu D, Popescu LM (2014) Near infrared low-level laser stimulation of telocytes from human myometrium. Lasers Med Sci. doi:10.1007/s10103-014-1589-1
7. Ceafalan L, Gherghiceanu M, Popescu LM, Simionescu O (2012) Telocytes in human skin - are they involved in skin regeneration? J Cell Mol Med 16:1405–1420
8. Chen X, Zheng Y, Manole CG, Wang X, Wang Q (2013) Telocytes in human oesophagus. J Cell Mol Med 17:1506–1512
9. Ciontea SM, Radu E, Regalia T, Ceafalan L, Cretoiu D, Gherghiceanu M, Braga RI, Malincenco M, Zagrean L, Hinescu ME, Popescu LM (2005) c-kit immunopositive interstitial cells (Cajal-type) in human myometrium. J Cell Mol Med 9:407–420
10. Clozel JP, Ertel SI, Ertel EA (1997) Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens 15:S17–S25
11. Comunanza V, Carbone E, Marcantoni A, Sher E, Ursu D (2011) Calcium-dependent inhibition of T-type calcium channels by TRPV1 activation in rat sensory neurons. Pflug Arch Eur J Physiol 462:709–722
12. Corradi LS, Jesus MM, Fochi RA, Vilamaior PS, Justulin LA Jr, Góes RM, Felisbino SL, Taboga SR (2013) Structural and ultrastructural evidence for telocytes in prostate stroma. J Cell Mol Med 17:398–406
13. Cretoiu D, Ciontea SM, Popescu LM, Ceafalan L, Ardeleanu C (2006) Interstitial Cajal-like cells (ICLC) as steroid hormone sensors in human myometrium: immunocytochemical approach. J Cell Mol Med 10:789–795
14. Cretoiu SM, Cretoiu D, Suciu L, Popescu LM (2009) Interstitial Cajal-like cells of human Fallopian tube express estrogen and progesterone receptors. J Mol Histol 40:387–394
15. Cretoiu SM, Simionescu AA, Caravia L, Curici A, Cretoiu D, Popescu LM (2011) Complex effects of imatinib on spontaneous and oxytocin-induced contractions in human non-pregnant myometrium. Acta Physiol Hung 98:329–338
16. Cretoiu D, Cretoiu SM, Simionescu AA, Popescu LM (2012a) Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum. Histol Histopathol 27:1067–1078
17. Cretoiu SM, Cretoiu D, Popescu LM (2012b) Human myometrium—the ultrastructural 3D network of telocytes. J Cell Mol Med 16:2844–2849
18. Cretoiu SM, Cretoiu D, Marin A, Radu BM, Popescu LM (2013) Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium. Reproduction 145:357–370
19. Deguchi S, Ohashi T, Sato M (2006) Tensile properties of single stress fibers isolated from cultured vascular smooth muscle cells. J Biomech 39:2603–2610
20. Díaz-Flores L, Gutiérrez R, Sáez FJ, Díaz-Flores L Jr, Madrid JF (2013) Telocytes in neuromuscular spindles. J Cell Mol Med 17:457–465
21. Duquette RA, Shmygol A, Vaillant C, Mobasheri A, Pope M, Burdyga T, Wray S (2005) Vimentin-positive, c-kit-negative interstitial cells in human and rat uterus: a role in pacemaking? Biol Reprod 72:276–283
22. Edelstein L, Smythies J (2014) The role of telocytes in morphogenetic bioelectrical signaling: once more unto the breach. Front Mol Neurosci 7:41
23. Galiger C, Kostin S, Golec A, Ahlbrecht K, Becker S, Gherghiceanu M, Popescu LM, Morty R, Seeger W, Voswinckell R (2014) Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung. J Cell Mol Med. doi:10.1111/jcmm.12295
24. Gherghiceanu M, Popescu LM (2011) Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions. J Cell Mol Med 15:1005–1011
25. Gherghiceanu M, Popescu LM (2012) Cardiac telocytes - their junctions and functional implications. Cell Tissue Research 348:265–279
26. Hutchings G, Williams O, Cretoiu D, Ciontea SM (2009) Myometrial interstitial cells and the coordination of myometrial contractility. J Cell Mol Med 13:4268–4282
27. Kuo IY, Howitt L, Sandow SL, McFarlane A, Hansen PB, Hill CE (2014) Role of T-type channels in vasomotor function: team player or chameleon? Pflüg Archiv Eur J Physiol 466:767–779
28. Leoni P, Carli F, Halliday D (1990) Intermediate filaments in smooth muscle from pregnant and non-pregnant human uterus. Biochem J 269:31–34
29. Leung CL, Green KJ, Liem RK (2002) Plakins: a family of versatile cytolinker proteins. Trends Cell Biol 12:37–45
30. Leuranguer V, Mangoni ME, Nargeot J, Richard S (2001) Inhibition of T-type and L-type calcium channels by mibefradil: physiologic and pharmacologic bases of cardiovascular effects. J Cardiovasc Pharmacol 37:649–661
31. Luesma MJ, Gherghiceanu M, Popescu LM (2013) Telocytes and stem cells in limbus and uvea of mouse eye. J Cell Mol Med 17:1016–1024
32. Matsumoto T, Nagayama K (2012) Tensile properties of vascular smooth muscle cells: bridging vascular and cellular biomechanics. J Biomech 45:745–755
33. Matyja A, Gil K, Pasternak A, Sztefko K, Gajda M, Tomaszewski KA, Matyja M, Walocha JA, Kulig J, Thor P (2013) Telocytes: new insight into the pathogenesis of gallstone disease. J Cell Mol Med 17:734–742
34. McKay BE, McRory JE, Molineux ML, Hamid J, Snutch TP, Zamponi GW, Turner RW (2006) Ca(V)3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci 24:2581–2594
35. Milia AF, Ruffo M, Manetti M, Rosa I, Conte D, Fazi M, Messerini L, Ibba-Manneschi L (2013) Telocytes in Crohn’s disease. J Cell Mol Med 17:1525–1536
36. Mosher AA, Rainey KJ, Bolstad SS, Lye SJ, Mitchell BF, Olson DM, Wood SL, Slater DM (2013) Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC Pregnancy Childbirth Suppl 1(S1):S7
37. Mou Y, Wang Y, Li J, Lü S, Duan C, Du Z, Yang G, Chen W, Zhao S, Zhou J, Wang C (2013) Immunohistochemical characterization and functional identification of mammary gland telocytes in the self-assembly of reconstituted breast cancer tissue in vitro. J Cell Mol Med 17:65–75
38. Nilius B, Carbone E (2014) Amazing T-type calcium channels: updating functional properties in health and disease. Pflug Arch 466:623–626
39. Ohkubo T, Inoue Y, Kawarabayashi T, Kitamura K (2005) Identification and electrophysiological characteristics of isoforms of T-type calcium channel Ca(v)3.2 expressed in pregnant human uterus. Cell Physiol Biochem 16:245–254
40. Popescu LM, Faussone-Pellegrini MS (2010) TELOCYTES—a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES. J Cell Mol Med 14:729–740
41. Popescu LM, Nicolescu MI (2013) Telocytes and stem cells. In: dos Santos Goldenberg RC, Campos de Carvalho AC (eds) Resident stem cells and regenerative therapy. Academic Press, Oxford, pp 205–231
42. Popescu LM, Gherghiceanu M, Cretoiu D, Radu E (2005) The connective connection: interstitial cells of Cajal (ICC) and ICC-like cells establish synapses with immunoreactive cells. Electron microscope study in situ. J Cell Mol Med 9:714–730
43. Popescu LM, Gherghiceanu M, Hinescu ME, Cretoiu D, Ceafalan L, Regalia T, Popescu AC, Ardeleanu C, Mandache E (2006a) Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC). J Cell Mol Med 10:429–458
44. Popescu LM, Vidulescu C, Curici A, Caravia L, Simionescu AA, Ciontea SM, Simion S (2006b) Imatinib inhibits spontaneous rhythmic contractions of human uterus and intestine. Eur J Pharmacol 546:177–181
45. Popescu LM, Ciontea SM, Cretoiu D (2007) Interstitial Cajal-like cells in human uterus and fallopian tube. Ann N Y Acad Sci 1101:139–165
46. Qi G, Lin M, Xu M, Manole CG, Wang X, Zhu T (2012) Telocytes in the human kidney cortex. J Cell Mol Med 16:3116–3122
47. Radu BM, Dumitrescu DI, Marin A, Banciu DD, Iancu AD, Selescu T, Radu M (2014) Advanced type 1 diabetes is associated with ASIC alterations in mouse lower thoracic dorsal root ganglia neurons. Cell Biochem Biophys 68:9–23
48. Rodman DM, Reese K, Harral J, Fouty B, Wu S, West J, Hoedt-Miller M, Tada Y, Li KX, Cool C, Fagan K, Cribbs L (2005) Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res 96:864–872
49. Rosenbaum ST, Svalø J, Nielsen K, Larsen T, Jørgensen JC, Bouchelouche P (2012) Immunolocalization and expression of small-conductance calcium-activated potassium channels in human myometrium. J Cell Mol Med 16:3001–3008
50. Senadheera S, Bertrand PP, Grayson TH, Leader L, Tare M, Murphy TV, Sandow SL (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Am J Physiol Regul Integr Compar Physiol 305:R917–R926
51. Sheng J, Shim W, Lu J, Lim SY, Ong BH, Lim TS, Liew R, Chua YL, Wong P (2014) Electrophysiology of human cardiac atrial and ventricular telocytes. J Cell Mol Med 18:355–362
52. Sun X, Zheng M, Zhang M, Qian M, Zheng Y, Li M, Cretoiu D, Chen C, Chen L, Popescu LM, Wang X (2014) Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes. J Cell Mol Med 18:801–810
53. Taylor JT, Zeng XB, Pottle JE, Lee K, Wang AR, Yi SG, Scruggs JA, Sikka SS, Li M (2008) Calcium signaling and T-type calcium channels in cancer cell cycling. World J Gastroenterol 14:4984–4991
54. Tufan H, Zhang XH, Haghshenas N, Sussman MA, Cleemann L, Morad M (2012) Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes. J Mol Cell Cardiol 53:695–706
55. Vannucchi MG, Traini C, Manetti M, Ibba-Manneschi L, Faussone-Pellegrini MS (2013) Telocytes express PDGFRα in the human gastrointestinal tract. J Cell Mol Med 17:1099–1108
56. Wang N, Stamenovic D (2002) Mechanics of vimentin intermediate filaments. J Muscle Res Cell Motil 23:535–540
57. Wang F, Gao H, Kubo H, Fan X, Zhang H, Berretta R, Chen X, Sharp T, Starosta T, Makarewich C, Li Y, Molkentin JD, Houser SR (2013) T-type Casup2+/supchannels regulate the exit of cardiac myocytes from the cell cycle after birth. J Mol Cell Cardiol 62:122–130
58. Xiao J, Wang F, Liu Z, Yang C (2013) Telocytes in liver: electron microscopic and immunofluorescent evidence. J Cell Mol Med 17:1537–1542
59. Young RC, Zhang P (2005) Inhibition of in vitro contractions of human myometrium by mibefradil, a T-type calcium channel blocker: support for a model using excitation-contraction coupling, and autocrine and paracrine signaling mechanisms. J Soc Gynecol Investig 12:e7–e12
60. Young RC, Smith LH, McLaren MD (1993) T-type and L-type calcium currents in freshly dispersed human uterine smooth muscle cells. Am J Obstet Gynecol 169:785–792
61. Zheng Y, Bai C, Wang X (2012) Telocyte morphologies and potential roles in diseases. J Cell Physiol 227:2311–2317
62. Zheng Y, Zhang M, Qian M, Wang L, Cismasiu VB, Bai C, Popescu LM, Wang X (2013) Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts. J Cell Mol Med 174:567–577
63. Zheng Y, Cretoiu D, Yan GQ, Cretoiu SM, Popescu LM, Wang X (2014a) Comparative proteomic analysis of human lung telocytes with fibroblasts. J Cell Mol Med 18:568–589
64. Zheng Y, Cretoiu D, Yan G, Cretoiu SM, Popescu LM, Fang H, Wang X (2014b) Protein profiling of human lung telocytes and microvascular endothelial cells using iTRAQ quantitative proteomics. J Cell Mol Med 18:1035–1059
65. Zong L, Lu C, Zhao Y, Li Q, Han D, Yang W, Shen Y, Zheng Q, Wang Q (2012) Clue to a new deafness gene: a large Chinese nonsyndromic hearing loss family linked to DFNA4. J Genet Genomics 39:653–657