Long-Term Effects of Neonatal Morphine Infusion on Pain Sensitivity: Follow-Up of a Randomized Controlled Trial

Journal of Pain

Volumn 16, Issue 9, 2015, Pages 926-933

  Valkenburg, Abraham J ^a   Van Den Bosch, Gerbrich E ^a   De Graaf, Joke ^a   Van Lingen, Richard A ^b   Weisglas Kuperus, Nynke ^a   Van Rosmalen, Joost ^c   Groot Jebbink, Liesbeth J M ^b   Tibboel, Dick ^a   Van Dijk, Monique ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ISALA HOSPITAL   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

follow up; Morphine; neonatal intensive care; quantitative sensory testing; randomized controlled trial

Indexed keywords

MORPHINE; PLACEBO; NARCOTIC ANALGESIC AGENT;

ABDOMINAL PAIN; ARTICLE; ARTIFICIAL VENTILATION; CHILD; CHRONIC PAIN; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; HEADACHE; HUMAN; INCIDENCE; LOADING DRUG DOSE; MALE; MULTICENTER STUDY (TOPIC); NEUROLOGIC EXAMINATION; NEWBORN; NOCICEPTION; PAIN THRESHOLD; RANDOMIZED CONTROLLED TRIAL (TOPIC); SENSORY ANALYSIS; CHEMICALLY INDUCED; DEVELOPMENTAL DISORDER; DRUG EFFECTS; INFANT; LONGITUDINAL STUDY; NEUROPSYCHOLOGICAL TEST; NEWBORN INTENSIVE CARE; PAIN; PAIN MEASUREMENT; PATHOPHYSIOLOGY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; REGRESSION ANALYSIS; RETROSPECTIVE STUDY;

ANALGESICS, OPIOID; CHILD; DEVELOPMENTAL DISABILITIES; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE, NEONATAL; LONGITUDINAL STUDIES; MALE; MORPHINE; NEUROPSYCHOLOGICAL TESTS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SURVEYS AND QUESTIONNAIRES;

EID: 84940790404     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2015.06.007     Document Type: Article

References (28)

1. K.J. Anand, R.W. Hall, N. Desai, B. Shephard, L.L. Bergqvist, T.E. Young, E.M. Boyle, R. Carbajal, V.K. Bhutani, M.B. Moore, S.S. Kronsberg, and B.A. Barton Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial Lancet 363 2004 1673 1682
2. S. Atici, L. Cinel, I. Cinel, N. Doruk, M. Aktekin, A. Akca, H. Camdeviren, and U. Oral Opioid neurotoxicity: comparison of morphine and tramadol in an experimental rat model Int J Neurosci 114 2004 1001 1011
3. D. Bajic, and H.K. Proudfit Projections from the rat cuneiform nucleus to the A7, A6 (locus coeruleus), and A5 pontine noradrenergic cell groups J Chem Neuroanat 50-51 2013 11 20
4. R. Bellu', K. Dewaal, and R. Zanini Opioids for neonates receiving mechanical ventilation. a systematic review and meta-analysis Arch Dis Child-Fetal 95 2009 241 251
5. R. Carbajal, R. Lenclen, M. Jugie, A. Paupe, B.A. Barton, and K.J.S. Anand Morphine does not provide adequate analgesia for acute procedural pain among preterm neonates Pediatrics 115 2005 1494 1500
6. J. de Graaf, A.J. Valkenburg, D. Tibboel, and M. van Dijk Thermal detection thresholds in 5-year-old preterm born children Early Hum Dev 88 2012 487 491
7. J. de Graaf, R.A. van Lingen, S.H.P. Simons, K.J.S. Anand, H.J. Duivenvoorden, N. Weisglas-Kuperus, D.W.E. Roofthooft, L.J.M.G. Jebbink, R.R. Veenstra, D. Tibboel, and M. van Dijk Long-term effects of routine morphine infusion in mechanically ventilated neonates on children's functioning: five-year follow-up of a randomized controlled trial Pain 152 2011 1391 1397
8. J. de Graaf, R.A. van Lingen, A.J. Valkenburg, N. Weisglas-Kuperus, L. Groot Jebbink, B. Wijnberg-Williams, K.J. Anand, D. Tibboel, and M. van Dijk Does neonatal morphine use affect neuropsychological outcomes at 8 to 9 years of age? Pain 154 2013 449 458
9. S.A. Ferguson, W.L. Ward, M.G. Paule, R.W. Hall, and K.J. Anand A pilot study of preemptive morphine analgesia in preterm neonates: effects on head circumference, social behavior, and response latencies in early childhood Neurotoxicol Teratol 34 2012 47 55
10. AM. Fredriks, S. van Buuren, J.M. Wit, and S.P. Verloove-Vanhorick Body index measurements in 1996-7 compared with 1980 Arch Dis Child 82 2000 107 112
11. K.F. Hauser, J.A. Gurwell, and C.S. Turbek Morphine inhibits Purkinje cell survival and dendritic differentiation in organotypic cultures of the mouse cerebellum Exp Neurol 130 1994 95 105
12. C. Hermann, J. Hohmeister, S. Demirakça, K. Zohsel, and H. Flor Long-term alteration of pain sensitivity in school-aged children with early pain experiences Pain 125 2006 278 285
13. C.C. Johnston, A.M. Fernandes, and M. Campbell-Yeo Pain in neonates is different Pain 152 2011 S65 S73
14. S.E. Juul, R.P. Beyer, T.K. Bammler, F.M. Farin, and C.A. Gleason Effects of neonatal stress and morphine on murine hippocampal gene expression Pediatr Res 69 2010 285 292
15. H.K. Kikkert, C. De Jong, and M. Hadders-Algra Minor neurological dysfunction and IQ in 9-year-old children born at term Dev Disabil Res Rev 53 2011 e16 25
16. W. Kort, M. Schittekatte, P.H. Dekker, P. Verhaeghe, E.L. Compaan, M. Bosmans, and G. Vermeir WISC-III NL Wechsler Intelligence Scale for Children Editie N.L. Derde, Handleiding en Verantwoording 2005 Harcourt Test Publishers/Nederlands Instituut voor Psychologen Amsterdam
17. M.U. Manto, and P. Jissendi Cerebellum: links between development, developmental disorders and motor learning Front Neuroanat 6 2012 1 10
18. C.W. Perquin, A.A. Hazebroek-Kampschreur, J.A. Hunfeld, A.M. Bohnen, L.W. van Suijlekom-Smit, J. Passchier, and J.C. van der Wouden Pain in children and adolescents: a common experience Pain 87 2000 51 58
19. B.M. Schmelzle-Lubiecki, K.A. Campbell, R.H. Howard, L. Franck, and M. Fitzgerald Long-term consequences of early infant injury and trauma upon somatosensory processing Eur J Pain 11 2007 799 809
20. S.H. Simons, M. van Dijk, R.A. van Lingen, D. Roofthooft, H.J. Duivenvoorden, N. Jongeneel, C. Bunkers, E. Smink, K.J.S. Anand, J.N. van den Anker, and D. Tibboel Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial JAMA 290 2003 2419 2427
21. W.F. Sternberg, L. Scorr, L.D. Smith, C.G. Ridgway, and M. Stout Long-term effects of neonatal surgery on adulthood pain behavior Pain 113 2005 347 353
22. A. Taddio, V. Shah, E. Atenafu, and J. Katz Influence of repeated painful procedures and sucrose analgesia on the development of hyperalgesia in newborn infants Pain 144 2009 43 48
23. D. Tibboel, K.J.S. Anand, and J.N. van den Anker The pharmacological treatment of neonatal pain Semin Fetal Neonat Med 10 2005 195 205
24. G.E. van den Bosch, T. White, D. Tibboel, and M. van Dijk Functional MRI pain studies in children? Yes, we (s)can! Pediatr Radiol 43 2013 1235 1236
25. T.N. Vien, C.A. Gleason, S.L. Hays, R.J. McPherson, C. Chavkin, and S.E. Juul Effects of neonatal stress and morphine on kappa opioid receptor signaling Neonatology 96 2009 235 243
26. S.M. Walker, L.S. Franck, M. Fitzgerald, J. Myles, J. Stocks, and N. Marlow Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm Pain 141 2009 79 87
27. A.A. Wright, B. Zhang, A. Ray, J.W. Mack, E. Trice, T. Balboni, S.L. Mitchell, V.A. Jackson, S.D. Block, P.K. Maciejewski, and H.G. Prigerson Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment JAMA 300 2008 1665 1673
28. V.J. Yohai, and R.H. Zamar Optimal locally robust M-estimates of regression J Stat Plan Inference 64 1997 309 323