Long-term effects of routine morphine infusion in mechanically ventilated neonates on children's functioning: Five-year follow-up of a randomized controlled trial

Pain

Volumn 152, Issue 6, 2011, Pages 1391-1397

  De Graaf, Joke ^a   Van Lingen, Richard A ^b   Simons, Sinno H P ^c   Anand, Kanwaljeet J S ^d   Duivenvoorden, Hugo J ^a   Weisglas Kuperus, Nynke ^a   Roofthooft, Daniella W E ^a   Groot Jebbink, Liesbeth J M ^b   Veenstra, Ravian R ^b   Tibboel, Dick ^a   Van Dijk, Monique ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ISALA HOSPITAL   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Child development; Drug therapy; Follow up randomized controlled trial; Neonatology and infant care; Pain; Pediatrics

Indexed keywords

MORPHINE; PLACEBO;

ANALGESIA; ARTICLE; ARTIFICIAL VENTILATION; BEHAVIOR; CHILD; CHRONIC PAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG USE; FEMALE; FOLLOW UP; HUMAN; INTELLIGENCE; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PAIN; PRESCHOOL CHILD; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VISUOMOTOR COORDINATION;

ANALGESICS, OPIOID; CHILD, PRESCHOOL; CHRONIC DISEASE; CONFIDENCE INTERVALS; FEMALE; HUMANS; INFANT, NEWBORN; INTELLIGENCE; LONGITUDINAL STUDIES; MALE; MORPHINE; MOTOR ACTIVITY; NETHERLANDS; PAIN; QUALITY OF LIFE; REGRESSION ANALYSIS; RESPIRATION, ARTIFICIAL;

EID: 79956073366     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.02.017     Document Type: Article

References (55)

1. T.M. Achenbach, and L.A. Rescorla Manual for the ASEBA preschool forms & profiles 2000 University of Vermont, Research Center for Children, Youth, & Families Burlington, VT
2. K.J. Anand, R.W. Hall, N. Desai, B. Shephard, L.L. Bergqvist, T.E. Young, E.M. Boyle, R. Carbajal, V.K. Bhutani, M.B. Moore, S.S. Kronsberg, and B.A. Barton Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial Lancet 363 2004 1673 1682 (Pubitemid 38670324)
3. K.J. Anand, W.G. Sippell, and A. Aynsley-Green Randomised trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response Lancet 1 1987 62 66
4. S. Atici, L. Cinel, I. Cinel, N. Doruk, M. Aktekin, A. Akca, H. Camdeviren, and U. Oral Opioid neurotoxicity: comparison of morphine and tramadol in an experimental rat model Int J Neurosci 114 2004 1001 1011 (Pubitemid 38923893)
5. K.E. Beery, N. Buktenica, and V.M.I. Beery Administration, scoring, and teaching manual fifth ed. 2004 NCS Pearson, Inc. Minneapolis, MN
6. R. Bellu, K.A. de Waal, and R. Zanini Opioids for neonates receiving mechanical ventilation Cochrane Database Syst Rev 2008 CD004212
7. N. Bleichrodt, P.J.D. Drenth, and J.N. Zaal Intelligentie-Meting bij Kinderen. Empirische en Methodologische Verantwoording van de Gereviseerde Kinder Intelligentie Test [Intelligence-Measurement in Children. Empirical and Methodological Justification of the Revised Child Intelligence Test] 1987 Swets & Zeitlinger B.V Lisse
8. N. Bleichrodt, P.J.D. Drenth, J.N. Zaal, and W.C.M. Resing Revisie Amsterdamse Kinder Intelligentie Test [Revised Amsterdam Child Intelligence Test] 1988 Swets & Zeitlinger B.V Lisse
9. J.F. Boasen, R.J. McPherson, S.L. Hays, S.E. Juul, and C.A. Gleason Neonatal stress or morphine treatment alters adult mouse conditioned place preference Neonatology 95 2009 230 239
10. Centraal Bureau voor de Statistiek (CBS). CBS Standaard Beroepenclassificatie 1992; verbeterde editie 2001. Den Haag, Netherlands, 1992.
11. A.K. Cheng, H.R. Rubin, N.R. Powe, N.K. Mellon, H.W. Francis, and J.K. Niparko Cost-utility analysis of the cochlear implant in children JAMA 284 2000 850 856 (Pubitemid 30643612)
12. C.R.I.B. The (Clinical Risk Index for Babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. The International Neonatal Network Lancet 342 1993 193 198
13. N.F. de Keizer, G.J. Bonsel, and R.J. Gemke Health status prediction in critically ill children: a pilot study introducing standardized health ratios Qual Life Res 6 1997 192 199 (Pubitemid 27207284)
14. D. Feeny, W. Furlong, S. Saigal, and J. Sun Comparing directly measured standard gamble scores to HUI2 and HUI3 utility scores: group- and individual-level comparisons Soc Sci Med 58 2004 799 809 (Pubitemid 37524002)
15. D. Feeny, W. Furlong, G.W. Torrance, C.H. Goldsmith, Z. Zhu, S. DePauw, M. Denton, and M. Boyle Multiattribute and single-attribute utility functions for the health utilities index mark 3 system Med Care 40 2002 113 128
16. P. Goffaux, S. Lafrenaye, M. Morin, H. Patural, G. Demers, and S. Marchand Preterm births: can neonatal pain alter the development of endogenous gating systems? Eur J Pain 12 2008 945 951
17. R.E. Grunau, L. Holsti, D.W. Haley, T. Oberlander, J. Weinberg, A. Solimano, M.F. Whitfield, C. Fitzgerald, and W. Yu Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU Pain 113 2005 293 300 (Pubitemid 40127510)
18. R.E. Grunau, T.F. Oberlander, M.F. Whitfield, C. Fitzgerald, and S.K. Lee Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 weeks' postconceptional age Pediatrics 107 2001 105 112 (Pubitemid 32055423)
19. R.E. Grunau, J. Weinberg, and M.F. Whitfield Neonatal procedural pain and preterm infant cortisol response to novelty at 8 months Pediatrics 114 2004 e77 e84
20. R.E. Grunau, M.F. Whitfield, and C. Davis Pattern of learning disabilities in children with extremely low birth weight and broadly average intelligence Arch Pediatr Adolesc Med 156 2002 615 620 (Pubitemid 34596193)
21. R.E. Grunau, M.F. Whitfield, J. Petrie-Thomas, A.R. Synnes, I.L. Cepeda, A. Keidar, M. Rogers, M. Mackay, P. Hubber-Richard, and D. Johannesen Neonatal pain, parenting stress and interaction, in relation to cognitive and motor development at 8 and 18 months in preterm infants Pain 143 2009 138 146
22. R.V. Grunau, M.F. Whitfield, J.H. Petrie, and E.L. Fryer Early pain experience, child and family factors, as precursors of somatization: a prospective study of extremely premature and fullterm children Pain 56 1994 353 359 (Pubitemid 24087986)
23. G.E. Handelmann, and D. Dow-Edwards Modulation of brain development by morphine: effects on central motor systems and behavior Peptides 6 1985 29 34 (Pubitemid 16211104)
24. C. Hermann, J. Hohmeister, S. Demirakca, K. Zohsel, and H. Flor Long-term alteration of pain sensitivity in school-aged children with early pain experiences Pain 125 2006 278 285 (Pubitemid 44708471)
25. M.J. Hilz, B. Stemper, G. Schweibold, I. Neuner, F. Grahmann, and E.H. Kolodny Quantitative thermal perception testing in 225 children and juveniles J Clin Neurophysiol 15 1998 529 534 (Pubitemid 29014392)
26. S. Hu, W.S. Sheng, J.R. Lokensgard, and P.K. Peterson Morphine induces apoptosis of human microglia and neurons Neuropharmacology 42 2002 829 836 (Pubitemid 34520444)
27. C.C. Johnston, and B.J. Stevens Experience in a neonatal intensive care unit affects pain response Pediatrics 98 1996 925 930 (Pubitemid 26398777)
28. M.X. Ma, Y.M. Chen, J. He, T. Zeng, and J.H. Wang Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice Neuroscience 147 2007 1059 1065 (Pubitemid 47102553)
29. R. MacGregor, D. Evans, D. Sugden, T. Gaussen, and M. Levene Outcome at 5-6 years of prematurely born children who received morphine as neonates Arch Dis Child Fetal Neonatal Ed 79 1998 F40 F43
30. R.J. McPherson, C. Gleason, M. Mascher-Denen, M. Chan, B. Kellert, and S.E. Juul A new model of neonatal stress which produces lasting neurobehavioral effects in adult rats Neonatology 92 2007 33 41 (Pubitemid 47013395)
31. P.M. Meier, C.B. Berde, J. DiCanzio, D. Zurakowski, and N.F. Sethna Quantitative assessment of cutaneous thermal and vibration sensation and thermal pain detection thresholds in healthy children and adolescents Muscle Nerve 24 2001 1339 1345 (Pubitemid 32924053)
32. A. Narberhaus, E. Lawrence, M.P. Allin, M. Walshe, P. McGuire, L. Rifkin, R. Murray, and C. Nosarti Neural substrates of visual paired associates in young adults with a history of very preterm birth: alterations in fronto-parieto-occipital networks and caudate nucleus Neuroimage 47 2009 1884 1893
33. C.W. Perquin, A.A. Hazebroek-Kampschreur, J.A. Hunfeld, A.M. Bohnen, L.W. van Suijlekom-Smit, J. Passchier, and J.C. van der Wouden Pain in children and adolescents: a common experience Pain 87 2000 51 58 (Pubitemid 30345661)
34. M.L. Pokela Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures Pediatrics 93 1994 379 383
35. G. Purcell-Jones, F. Dormon, and E. Sumner Paediatric anaesthetists' perceptions of neonatal and infant pain Pain 33 1988 181 187
36. M.W. Quinn, F. Otoo, J.A. Rushforth, H.G. Dean, J.W. Puntis, J. Wild, and M.I. Levene Effect of morphine and pancuronium on the stress response in ventilated preterm infants Early Hum Dev 30 1992 241 248
37. M.W. Quinn, J. Wild, H.G. Dean, R. Hartley, J.A. Rushforth, J.W. Puntis, and M.I. Levene Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies Lancet 342 1993 324 327 (Pubitemid 23227560)
38. R. Rao, J.S. Sampers, S.S. Kronsberg, J.V. Brown, N.S. Desai, and K.J. Anand Neurobehavior of preterm infants at 36 weeks postconception as a function of morphine analgesia Am J Perinatol 24 2007 511 517 (Pubitemid 47623680)
39. A.L. Rickards, E.A. Kelly, L.W. Doyle, and C. Callanan Cognition, academic progress, behavior and self-concept at 14 years of very low birth weight children J Dev Behav Pediatr 22 2001 11 18 (Pubitemid 33040473)
40. M.J. Rietveld, G.C. van Baal, C.V. Dolan, and D.I. Boomsma Genetic factor analyses of specific cognitive abilities in 5-year-old Dutch children Behav Genet 30 2000 29 40 (Pubitemid 30602872)
41. S. Saigal, B. Stoskopf, J. Pinelli, D. Streiner, L. Hoult, N. Paneth, and J. Goddeeris Self-perceived health-related quality of life of former extremely low birth weight infants at young adulthood Pediatrics 118 2006 1140 1148 (Pubitemid 46090057)
42. T.J. Sargeant, J.H. Miller, and D.J. Day Opioidergic regulation of astroglial/neuronal proliferation: where are we now? J Neurochem 107 2008 883 897
43. B.M. Schmelzle-Lubiecki, K.A. Campbell, R.H. Howard, L. Franck, and M. Fitzgerald Long-term consequences of early infant injury and trauma upon somatosensory processing Eur J Pain 11 2007 799 809 (Pubitemid 47176430)
44. S.H. Simons, D.W. Roofthooft, M. van Dijk, R.A. van Lingen, H.J. Duivenvoorden, J.N. van den Anker, and D. Tibboel Morphine in ventilated neonates: its effects on arterial blood pressure Arch Dis Child Fetal Neonatal Ed 91 2006 F46 F51
45. S.H. Simons, M. van Dijk, R.A. van Lingen, D. Roofthooft, F. Boomsma, J.N. van den Anker, and D. Tibboel Randomised controlled trial evaluating effects of morphine on plasma adrenaline/noradrenaline concentrations in newborns Arch Dis Child Fetal Neonatal Ed 90 2005 F36 F40
46. S.H. Simons, M. van Dijk, R.A. van Lingen, D. Roofthooft, H.J. Duivenvoorden, N. Jongeneel, C. Bunkers, E. Smink, K.J. Anand, J.N. van den Anker, and D. Tibboel Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial JAMA 290 2003 2419 2427 (Pubitemid 37430541)
47. A. Taddio, M. Goldbach, M. Ipp, B. Stevens, and G. Koren Effect of neonatal circumcision on pain responses during vaccination in boys Lancet 345 1995 291 292
48. A. Taddio, J. Katz, A.L. Ilersich, and G. Koren Effect of neonatal circumcision on pain response during subsequent routine vaccination Lancet 349 1997 599 603 (Pubitemid 27101886)
49. A. Taylor, N.M. Fisk, and V. Glover Mode of delivery and subsequent stress response Lancet 355 2000 120 (Pubitemid 30068563)
50. H.G. Taylor, K.A. Espy, and P.J. Anderson Mathematics deficiencies in children with very low birth weight or very preterm birth Dev Disabil Res Rev 15 2009 52 59
51. S.M. Walker, L.S. Franck, M. Fitzgerald, J. Myles, J. Stocks, and N. Marlow Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm Pain 141 2009 79 87
52. N. Weisglas-Kuperus, E.E. Hille, H.H. Duivenvoorden, M.M. Finken, J.M. Wit, S. van Buuren, and J.V. Goudoever Verloove-Vanhorick PM; Dutch POPS-19 Collaborative Study Group. Intelligence of very preterm or very low birth weight infants in young adulthood Arch Dis Child Fetal Neonatal Ed 94 2009 F196 F200
53. J. Williams, K.J. Lee, and P.J. Anderson Prevalence of motor-skill impairment in preterm children who do not develop cerebral palsy: a systematic review Dev Med Child Neurol 52 2010 232 237
54. C.M. Wood, J.A. Rushforth, R. Hartley, H. Dean, J. Wild, and M.I. Levene Randomised double blind trial of morphine versus diamorphine for sedation of preterm neonates Arch Dis Child Fetal Neonatal Ed 79 1998 F34 F39
55. A.A. Wright, B. Zhang, A. Ray, J.W. Mack, E. Trice, T. Balboni, S.L. Mitchell, V.A. Jackson, S.D. Block, P.K. Maciejewski, and H.G. Prigerson Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment JAMA 300 2008 1665 1673