The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization

PLoS Computational Biology

Volumn 11, Issue 8, 2015, Pages

  Ullah, Ghanim ^a   Wei, Yina ^b   Dahlem, Markus A ^c   Wechselberger, Martin ^d   Schiff, Steven J ^e  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

^d UNIVERSITY OF SYDNEY   (Australia)

^e The Pennsylvania State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; CYTOLOGY; DYNAMICS; NEURONS; OSMOSIS; OXYGEN SUPPLY; PHYSIOLOGICAL MODELS; SWELLING;

CELL SWELLING; CELL VOLUME; EPILEPTIC SEIZURES; ION CONCENTRATIONS; ISCHAEMIA; NEURONAL DYNAMICS; ORDER PARAMETER; SPONTANEOUS TRANSITION; SPREADING DEPRESSION; VOLUME CHANGE;

DEPOLARIZATION;

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); POTASSIUM ION; SODIUM ION;

ANOXIC DEPOLARIZATION; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN HYPOXIA; CELL SIZE; CELL SWELLING; CELL VOLUME; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXTRACELLULAR SPACE; FEASIBILITY STUDY; GLIA; HODGKIN HUXLEY TYPE EQUATION; HOMEOSTASIS; INTRACELLULAR SPACE; ION CONCENTRATION; ISCHEMIA; MATHEMATICAL MODEL; MATHEMATICAL PHENOMENA; MEMBRANE STEADY POTENTIAL; MICROENVIRONMENT; MOLECULAR DYNAMICS; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEURONAL MICROENVIRONMENT; NEUROPROTECTION; OSMOTIC PRESSURE; OXYGEN HOMEOSTASIS; OXYGEN SUPPLY; POTASSIUM TRANSPORT; PREDICTIVE VALUE; SEIZURE; SODIUM TRANSPORT; SPREADING CORTICAL DEPRESSION; STEADY STATE; BIOLOGICAL MODEL; BIOLOGY; BRAIN; CYTOLOGY; DEPRESSION; HUMAN; HYPOXIA; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR MICROENVIRONMENT;

BRAIN; CELL SIZE; CELLULAR MICROENVIRONMENT; COMPUTATIONAL BIOLOGY; DEPRESSION; HUMANS; HYPOXIA; MODELS, NEUROLOGICAL; NEURONS; SEIZURES;

EID: 84940784788     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004414     Document Type: Article

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