Water-transporting proteins

Journal of Membrane Biology

Volumn 234, Issue 2, 2010, Pages 57-73

  Zeuthen, Thomas ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Absorption; Aquaporin; Cellular water homeostasis; Cotransporters; Epithelia; Uniporter; Water

Indexed keywords

ANION CHANNEL; AQUAPORIN; AQUAPORIN 1; AQUAPORIN 4; AQUAPORIN 5; COTRANSPORTER; CYTOCHROME C OXIDASE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; MEMBRANE PROTEIN; MONOCARBOXYLATE TRANSPORTER 1; POTASSIUM CHLORIDE COTRANSPORTER; SODIUM DICARBOXYLATE TRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM PHOSPHATE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; VOLTAGE GATED ANION CHANNEL;

ABSORPTION; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CYTOPLASM; ENERGY TRANSFER; ENZYME ACTIVITY; ENZYME STRUCTURE; EPITHELIUM; HOMEOSTASIS; HUMAN; HYDROPHILICITY; HYPEROSMOLARITY; ION TRANSPORT; MOLECULAR MECHANICS; MOLECULE; NONHUMAN; OOCYTE; ORAL REHYDRATION THERAPY; OSMOLARITY; OSMOSIS; REVIEW; SMALL INTESTINE; STOICHIOMETRY; THERMODYNAMICS; TRANSPORT KINETICS; WATER PERMEABILITY; WATER TRANSPORT; XENOPUS;

ANIMALS; AQUAPORINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DIFFUSION; EPITHELIUM; GLUCOSE TRANSPORTER TYPE 2; HUMANS; MEMBRANE TRANSPORT PROTEINS; OSMOSIS; SODIUM-GLUCOSE TRANSPORTER 1; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SYMPORTERS; WATER;

EID: 77952238315     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-009-9216-y     Document Type: Review

References (136)

1. J Abramson I Smirnova V Kasho G Verner HR Kaback S Iwata 2003 Structure and mechanism of the lactose permease of Escheria coli Science 301 610 615 1:CAS:528:DC%2BD3sXlvVKns7k%3D 12893935
2. NC Adragna M Di Fulvio PK Lauf 2004 Regulation of K-Cl cotransport: from function to genes J Membr Biol 201 109 137 1:CAS:528:DC%2BD2cXhtFShsb%2FF 15711773
3. P Agre LS King M Yasui WB Guggino OP Ottersen Y Fujiyoshi A Engel S Nielsen 2002 Aquaporin water channels-from atomic structure to clinical medicine J Physiol 542.1 3 16
4. P Agre S Nielsen OP Ottersen 2004 Towards a molecular understanding of water homeostasis in the brain Neuroscience 12 849 850
5. RJ Alpern KJ Howlin PA Preisig 1985 Active and passive components of chloride transport in the rat proximal convoluted tubule J Clin Invest 76 1360 1366 1:CAS:528:DyaL2MXlvFeks7g%3D 4056034
6. E Beitz B Wu LM Holm JE Schultz T Zeuthen 2006 Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons Proc Natl Acad Sci USA 103 269 274 1:CAS:528: DC%2BD28XpsVSguw%3D%3D 16407156
7. K Bomsztyk FS Wright 1986 Dependence of ion fluxes on fluid transport by rat proximal tubule Am J Physiol 250 F680 F689 1:CAS:528:DyaL28XitVCntrc%3D 3083697
8. M Borgnia S Nielsen A Engel P Agre 1999 Cellular and molecular biology of the aquaporin water channels Annu Rev Biochem 68 425 458 1:CAS:528: DyaK1MXlvFajsbs%3D 10872456
9. RC Boucher 1999 Molecular insights into the physiology of the "thin film" of airway surface liquid J Physiol 516 631 638 1:CAS:528: DyaK1MXjt1OrtL0%3D 10200413
10. +/glucose cotransport Biophys J 90 3546 3554 1:CAS:528:DC%2BD28Xkt1Okt7g%3D 16500986
11. PF Curran JR Macintosh 1962 A model system for biological water transport Nature 193 47 348
12. JM Diamond 1962 The mechanism of solute transport by the gallbladder J Physiol 161 474 502 1:CAS:528:DyaF2cXltFKl 13886110
13. JM Diamond 1964 Transport of salt and water in rabbit and guinea pig gall bladder J Gen Physiol 48 1 14 1:CAS:528:DyaF2cXkvVKlu70%3D 14212148
14. +/glucose cotransport Proc Natl Acad Sci USA 98 3796 3801 1:CAS:528:DC%2BD3MXis1Khsrw%3D 11274397
15. +/sugar symport Science 321 810 814 1:CAS:528:DC%2BD1cXptlyhsLs%3D 18599740
16. J Fischbarg K Kuang JC Vera S Arant SC Silverstein J Loike OM Rosen 1990 Glucose transporters serve as water channels Proc Natl Acad Sci USA 87 3244 3247 1:CAS:528:DyaK3cXitlartr4%3D 2326282
17. J Fischbarg FPJ Diecke P Iserovich A Rubashkin 2006 The role of tight junctions in paracellular fluid transportacross corneal endothelium. Electro-osmosis as a driving force J Membr Biol 210 117 130 1:CAS:528: DC%2BD28XnslSitrg%3D 16868674
18. - absorption from proximal tubules of the rat kidney Pfluegers Arch 343 189 220
19. +/glucose cotransport Biophys J 86 125 133 1:CAS:528: DC%2BD2cXlsV2gtg%3D%3D 14695256
20. G Gamba 2005 Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters Physiol Rev 85 423 493 1:CAS:528: DC%2BD2MXjt12ls7c%3D 15788703 (Pubitemid 40404634) (Pubitemid 40404634) (Pubitemid 40404634)
21. A Grandchamp EL Boulpaep 1974 Pressure control of sodium reabsorption and intercellular backflux across proximal kidney tubule J Clin Invest 54 69 82 1:CAS:528:DyaE2cXltlerurc%3D 4834883
22. R Green G Giebisch 1984 Luminal hypotonicity: a driving force for fluid absorption from the proximal tubule Am J Physiol 246 F167 F174 1:STN:280:DyaL2c7isFOgtg%3D%3D 6696118
23. R Green G Giebisch 1989 Osmotic forces driving water reabsorption in the proximal tubule of the rat kidney Am J Physiol 257 F669 F675 1:STN:280:DyaK3c%2Fitl2gtg%3D%3D 2801964
24. R Green G Giebisch R Unwin AM Weinstein 1991 Coupled water transport by rat proximal tubule Am J Physiol 261 F1046 F1054 1:CAS:528:DyaK38XotV2qug%3D%3D 1750518
25. M Haas B Forbush III 2000 The Na-K-Cl cotransporter of secretory epithelia Annu Rev Physiol 62 515 534 1:CAS:528:DC%2BD3cXltlGrsbc%3D 10845101
26. A Hakim RG Lester N Lifson 1963 Absorption by an in vitro preparation of dog intestinal mucosa J Appl Physiol 18 409 413 1:CAS:528:DyaF3sXksVertbg%3D 13952019
27. S Hamann 2002 Molecular mechanisms of water transport in the eye Int Rev Cytol 215 395 431 1:CAS:528:DC%2BD38XjsFCrt7c%3D 11952236
28. S Hamann T Zeuthen M La Cour EA Nagelhus OP Ottersen P Agre S Nielsen 1998 Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye Am J Physiol 274 C1332 C1345 1:CAS:528:DyaK1cXjsFSis7o%3D 9612221
29. 2O in porcine retinal pigment epithelial cells Exp Eye Res 76 1 12
30. - cotransporters in mammalian epithelial cells J Physiol 568 123 135 1:CAS:528:DC%2BD2MXhtFWisrnN 16020454
31. SR Heisey D Held JR Pappenheimer 1962 Bulk flow and diffusion in the cerebrospinal fluid system of the goat Am J Physiol 203 775 781 1:STN:280:DyaF387ksFahtw%3D%3D 13953498
32. PA Helliwell GL Kellett 2002 The active and passive components of glucose absorption in rat jejunum under low and high perfusion stress J Physiol 544 579 589 1:CAS:528:DC%2BD38Xos12qu7s%3D 12381828
33. AE Hill 1975 Solute-solvent coupling in epithelia: a critical examination of the standing-gradient osmotic flow theory Proc R Soc Lond B 190 99 114 1:STN:280:DyaE2M7ns12ktA%3D%3D 237290
34. AE Hill 2008 Fluid transport: a guide for the perplexed J Membr Biol 223 1 11 1:CAS:528:DC%2BD1cXoslWktb4%3D 18259799
35. AE Hill B Shachar-Hill Y Shachar-Hill 2004 What are aquaporins for? J Membr Biol 197 1 32 1:CAS:528:DC%2BD2cXhvF2mt7o%3D 15014915
36. T Hirai JAW Heymann D Shi R Sarker PC Maloney S Subramaniam 2002 Three-dimensional structure of a bacterial oxalate transporter Nat Struct Biol 9 597 600 1:CAS:528:DC%2BD38Xls1Sntb8%3D 12118242
37. House CR (1974) Water transport in cells and tissues. Edward Arnold, London
38. Y Huang MJ Lemieux J Song M Auer D-N Wang 2003 Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli Science 301 616 620 1:CAS:528:DC%2BD3sXlvVKns7Y%3D 12893936
39. CG Huang T Lamitima P Agre K Strange 2007 Functional analysis of the aquaporin gene family in Caenorhabditis elegans Am J Physiol 292 C1867 C1873 1:CAS:528:DC%2BD2sXls1yju7w%3D
40. MH Humphreys 1976 Inhibition of NaCl absorption from perfused rat ileum by furosemide Am J Physiol 230 1517 1523 1:CAS:528:DyaE1cXhtlSku7c%3D 937541
41. O Ikonomov MX Simon E Frömter 1985 Electrophysiological studies on lateral intercellular spaces of Necturus gallbladder epithelium Pfluegers Arch 403 301 307 1:STN:280:DyaL2M7ovFOhuw%3D%3D
42. Y Imai H Nishikawa K Yoshizaki H Watari 1973 Evidence for the osmotic flow across dog submaxillary gland epithelia as a cause of salivary secretion Jap J Physiol 23 635 644 1:STN:280:DyaE2c3ntlOhtQ%3D%3D
43. GL Kellett 2001 The facilitated component of intestinal glucose absorbtion J Physiol 531 585 595 1:CAS:528:DC%2BD3MXivVaksr0%3D 11251042
44. GL Kellett PA Helliwell 2000 The passive component of intestinal glucose absorption is mediated by the glucose-inducedrecruitment of GLUT2 to the brush-border membrane Biochem J 350 155 162 1:CAS:528:DC%2BD3cXmsVaqurs%3D 10926839
45. GL Kellett E Brot-Laroche OJ Mace A Leturque 2008 Sugar absorbtion in the intestine: the role of GLUT2 Annu Rev Nutr 28 8.1 8.20
46. LS King P Agre 1996 Pathophysiology of the aquaporin water channel Annu Rev Physiol 58 619 648 1:CAS:528:DyaK28XhvVaht7o%3D 8815812
47. LS King D Kozono P Agre 2004 From structure to disease: the evolving tale of aquaporin biology Nat Rev Mol Cell Biol 5 687 698 1:CAS:528: DC%2BD2cXntFCms7Y%3D 15340377
48. JA Kornblatt 1998 The water channel of cytochrome c oxidase: inferences from inhibitor studies Biophys J 75 3127 3134 1:CAS:528:DyaK1cXnslymsrs%3D 9826633
49. JA Kornblatt MJ Kornblatt 2002 Water as it applies to the function of enzymes Int Rev Cytol 215 49 73 1:CAS:528:DC%2BD38XjsFCrtrY%3D 11952237
50. TH Kwon J Nielsen HB Moller RA Fenton S Nielsen J Frokiaer 2009 Aquaporins in the kidney Handb Exp Pharmacol 190 95 132 1:CAS:528: DC%2BD1MXht1ahtLzE 19096774
51. JY Lapointe 2007 Response to Zeuthen and Zeuthen's comment to the editor: enough local hypertonicity is enough Biophys J 93 1417 1419 1:CAS:528:DC%2BD2sXosFCisrw%3D
52. DW Leung DF Loo BA Hirayama T Zeuthen EM Wright 2000 Urea transport by cotransporters J Physiol 528 251 257 1:CAS:528:DC%2BD3cXnvVShtr4%3D 11034615
53. J Loike S Hickman K Kuang M Xu L Cao JC Vera SC Silverstein J Fischbarg 1996 Sodium-glucose cotransporters display sodium- and phlorizin-dependent water permeability Am J Physiol 271 C1774 C1779 1:CAS:528:DyaK28XntFylu74%3D 8944663
54. +/glucose cotransporter Proc Natl Acad Sci USA 93 13367 13370 1:CAS:528:DyaK28XmvFSntr8%3D 8917597
55. DF Loo BA Hirayama A-K Meinild G Chandy T Zeuthen E Wright 1999 Passive water and ion transport by cotransporters J Physiol 518.1 195 202
56. DDF Loo EM Wright T Zeuthen 2002 Water pumps J Physiol 542 53 60 1:CAS:528:DC%2BD38XmtVamu7k%3D 12096049
57. Ludwig C (1861) Lehrbuch der Physiologie des Menschen, 2nd edn. C.F. Wintersche Verlagshandlung, Leipzig
58. T Ma AS Verkman 1999 Aquaporin water channels in gastrointestinal physiology J Physiol 517 317 326 1:CAS:528:DyaK1MXktVyksLc%3D 10332084
59. TH Ma BX Yang A Gillespie EJ Carlson CJ Epstein AS Verkman 1998 Severely impaired urinary concentration ability in transgenic mice lacking aquaporin-1 water channels J Biol Chem 273 4296 4299 1:CAS:528:DyaK1cXhtlSrt7w%3D 9468475 (Pubitemid 28103161) (Pubitemid 28103161) (Pubitemid 28103161)
60. T Ma Y Song A Gillespie EJ Carlson CJ Epstein AS Verkman 1999 Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels J Biol Chem 274 20071 20074 1:STN:280:DyaK1MzivFSjsQ%3D%3D 10400615
61. MacAulay N, Zeuthen T (2009) Water transport between CNS compartments: contributions of aquaporins and cotransporters. J Neurosci (in press)
62. +-coupled glutamate cotransporter J Physiol 530 367 378 1:CAS:528:DC%2BD3MXitlSgurY%3D 11158269
63. +-glutamate cotransporter expressed in Xenopus oocytes J Physiol 530 367 378
64. +-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1 J Physiol 544 447 458 1:CAS:528:DC%2BD38Xos12quro%3D 12381817
65. N MacAulay S Hamann T Zeuthen 2004 Water transport in the brain: role of cotransporters Neurosci 129 1031 1044 1:CAS:528:DC%2BD2cXhtVSlur%2FI
66. MacAulay N, Hamann S, Zeuthen T (2009) Chloride transporters as water pumps. In: Alvarez-Leefmans FJ, Delpire E (eds) Physiology and pathology of chloride transporters and channels in the nervous system: from molecules to diseases. Elsevier, New York
67. JF MacKenzie KM Cochran RI Russell 1975 The effect of frusemide on water and electrolyte absorption from the human jejunum Clin Sci Mol Med 49 519 521 1:CAS:528:DyaE28XosVeqsQ%3D%3D 1192712
68. JL Madara JR Pappenheimer 1987 Structural basis for physiological regulation of paracellular pathways in intestinal epithelia J Membr Biol 100 149 164 1:CAS:528:DyaL1cXnt1yrtw%3D%3D 3430571
69. - cotransporter (NKCC1) and epithelial chloride secretion World J Surg 26 826 830 11948363
70. A Mauro 1957 Nature of solvent transfer in osmosis Science 126 252 253 1:CAS:528:DyaG2sXps1WqsQ%3D%3D 13454805
71. +/glucose cotransporter is a molecular water pump J Physiol 508 15 21 1:CAS:528:DyaK1cXis1Cqs78%3D 9490810
72. +/dicarboxylate cotransporter Am J Physiol 278 F777 F783 1:CAS:528:DC%2BD3cXjvFahtbY%3D
73. - cotransporters KCC1 and KCC4 J Biol Chem 275 30326 30334 1:CAS:528:DC%2BD3cXnt1agsL0%3D 10913127
74. M Murakami K Murdiastuti K Hosoi AE Hill 2006 AQP and the control of fluid transport in a salivary gland J Membr Biol 210 91 103 1:CAS:528: DC%2BD28XnslSit74%3D 16868676
75. RJ Naftalin 2008 Osmotic water transport with glucose in GLUT2 and SGLT Biophys J 94 3912 3923 1:CAS:528:DC%2BD1cXlsF2hur4%3D 18234816
76. T Nakahari MC Steward H Yoshida Y Imai 1997 Osmotic flow transients during acetylcholine stimulation in the perfused rat submandibular gland Exp Physiol 82 55 70 1:CAS:528:DyaK2sXhtlWmurg%3D 9023506
77. S Nielsen BL Smith EI Christensen P Agre 1993 Distriburion of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia Proc Natl Acad Sci USA 90 7275 7279 1:STN:280:DyaK3szkvVamtA%3D%3D 8346245
78. C Olesen M Picard A-ML Winther C Gyrup JP Morth C Oxvig JV Møller P Nissen 2007 The structural basis of calcium transport by the calcium pump Nature 450 1036 1039 1:CAS:528:DC%2BD2sXhsVaqtr3O 18075584
79. JR Pappenheimer 1998 Scaling of dimensions of small intestines in non-ruminant eutherian mammals and its significance for absorptive mechanisms Comp Biochem Physiol 121 45 58 1:STN:280:DyaK1M7gtVShsw%3D%3D
80. JR Pappenheimer 2001 Intestinal absorption of hexoses and amino acids: from apical cytosol to villus capillaries J Membr Biol 184 233 239 1:CAS:528:DC%2BD38XktlGqtA%3D%3D 11891547
81. JR Pappenheimer KZ Reis 1987 Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat J Membr Biol 100 123 136 1:CAS:528:DyaL1cXpt1Srtg%3D%3D 3430569
82. VA Parsegian 2002 Protein-water interactions Int Rev Cytol 215 1 31 1:CAS:528:DC%2BD38XjsFCrtrg%3D 11952225
83. DS Parsons DL Wingate 1961 The effect of osmotic gradients on fluid transfer across rat intestine in vitro Biochim Biophys Acta 46 170 183 1:CAS:528:DyaF3MXptlygsQ%3D%3D 13733011
84. B-E Persson KR Spring 1982 Gallbladder epithelial cell hydraulic water permeability and volume regulation J Gen Physiol 79 481 505 1:STN:280: DyaL387ptFGlsQ%3D%3D 7077291
85. GM Preston BL Smith ML Zeidel JJ Moulds P Agre 1994 Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels Science 265 1585 1587 1:CAS:528:DyaK2cXmt1ensLk%3D 7521540
86. S Raina GM Preston WB Guggino P Agre 1995 Molecular cloning and characterization of an aquaporin cDNA from sallivary lacrimal, and respiratory tissues J Biol Chem 270 1908 1912 1:CAS:528:DyaK2MXjtlajs7k%3D 7530250
87. R Ramírez-Lorca ML Vizuete JL Venero M Revuelta J Cano AA Ilundáin M Echevarría 1999 Localization of aquaporin-3 mRNA and protein along the gastrointestinal tract of Wistar rats Pflug Arch 438 94 100
88. RP Rand 2002 The lipid-water interface: revelations by osmotic stress Int Rev Cytol 215 33 48 1:CAS:528:DC%2BD38XjsFCrtrk%3D 11952234
89. EW Reid 1892 Report on experiments upon "absorbtion without osmosis" BMJ 1 323 326
90. L Reuss 1985 Changes in cell volume measured with an electrophysiologic technique Proc Natl Acad Sci USA 82 6014 6018 1:STN:280:DyaL2M3pvVarug%3D%3D 3862114
91. Reuss L (2006) Mechanisms of water transport across cell membranes and epithelia. In: Alpern RJ, Hebert SC (eds) The kidney, physiology and pathophysiology. Elsevier, Amsterdam
92. JM Russell 2000 Sodium-potassium-chloride cotransport Physiol Rev 80 211 276 1:CAS:528:DC%2BD3cXmtl2jug%3D%3D 10617769
93. H Sackin EL Boulpeap 1981 Isolated perfused salamander proximal tubule: methods, electrophysiology, and transport Am J Physiol 241 F39 F52 1:STN:280:DyaL3M3ivFykug%3D%3D 7246773
94. J Schnermann C-L Chou T Ma T Traynor MA Knepper AS Verkman 1998 Defective proximal tubular fluid reabsorbtion in transgenic aquaporin-1 null mice Proc Natl Acad Sci USA 95 9660 9664 1:CAS:528:DyaK1cXltlCltrk%3D 9689137
95. B Shachar-Hill AE Hill 2002 Paracellular fluid transport by epithelia Int Rev Cytol 215 319 350 1:CAS:528:DC%2BD38XjsFCrt7k%3D 11952233
96. P Silva J Stoff M Field L Fine JN Forrest FH Epstein 1977 Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport Am J Physiol 233 F298 F306 1:CAS:528:DyaE2sXlvVWitb8%3D 143896
97. IA Simpson A Carruthers SJ Vannucci 2007 Supply and demand in cerebral energy metabolism: the role of nutrient transporters J Cereb Blood Flow Metab 27 1766 1791 1:CAS:528:DC%2BD2sXhtF2rur7J 17579656
98. V Vallon AS Verkman J Schnermann 2000 Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice Am J Physiol 278 F1030 F1033 1:CAS:528:DC%2BD3cXks1ymur8%3D
99. AS Verkman 2008 Mammalian aquaporins: diverse physiological roles and potential clinical significance Expert Rev Mol Med 10 e13 1:STN:280: DC%2BD1czitVWnsA%3D%3D 18482462
100. AS Verkman 2009 Knock-out models reveal new aquaporin functions Handb Exp Pharmacol 190 359 381 1:CAS:528:DC%2BD1MXht1ahtLrN 19096787
101. AS Verkman AK Mitra 2000 Structure and function of aquaporin water channels Am J Physiol 278 F13 F28 1:CAS:528:DC%2BD3cXht1GgtL0%3D
102. Weinstein AM, Windhager EE (1985) Sodium transport along the proximal tubule. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Sinauer Associates, Sunderland, MA, pp 1033-1062
103. G Whittembury BS Hill 1982 Fluid reabsorption by Necturus proximal tubule perfused with solutions of normal and reduced osmolarity Proc R Soc 215 411 431 1:CAS:528:DyaL38XkvV2hsrk%3D
104. 2O movement on NaCl concentration Am J Physiol 197 313 318 1:CAS:528: DyaG1MXht1Ggsbw%3D 13845186
105. B Wu C Steinbronn M Alsterfjord T Zeuthen E Beitz 2009 Concerted action of two cation filters in the aquaporin water channel EMBO J 28 2188 2194 1:CAS:528:DC%2BD1MXnslOjs7w%3D 19574955
106. - -dependent neurotransmitter transporters Nature 437 215 223 1:CAS:528:DC%2BD2MXpslekurY%3D 16041361
107. B Yang AS Verkman 1997 Water and glycerol permeabilities of aquaporin 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes J Biol Chem 272 14146 16140
108. B Yang AS Verkman 1998 Urea transporter UT3 functions as an efficient water channel J Biol Chem 273 9369 9372 1:CAS:528:DyaK1cXivVOku7s%3D 9545259
109. B Yang AS Verkman 2002 Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B J Biol Biochem 277 36782 36786 1:CAS:528:DC%2BD38XnsVCitL0%3D
110. D Yernool O Boudker Y Jin E Gouaux 2004 Structure of a glutamate transporter homologue from Pyrococcus horikoshii Nature 431 811 818 1:CAS:528:DC%2BD2cXotl2ktL4%3D 15483603
111. GA Zampighi M Kreman KJ Boorer DDF Loo F Bezanilla G Chandy JE Hall EM Wright 1995 A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes J Membr Biol 148 65 78 1:CAS:528:DyaK2MXpsVejtLc%3D 8558603
112. ML Zeidel A Albalak E Grossman A Carruthers 1992 Role of glucose carrier in human erythrocyte water permeability Biochemistry 31 589 596 1:CAS:528:DyaK38Xjs1egsg%3D%3D 1370631
113. ML Zeidel SV Ambudkar BL Smith P Agre 1992 Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein Biochemistry 31 7436 7440 1:CAS:528:DyaK38XltVKnuro%3D 1510932
114. Zeuthen T (1981) Isotonic transport and intracellular osmolarity in the Necturus gallbladder epithelium. In: Ussing HH, Bindslev N, Lassen NA, Sten-Knudsen O (eds) Water transport across epithelia. Munksgaard, Copenhagen, pp 313-331
115. T Zeuthen 1982 Relations between intracellular ion activities and extracellular osmolarity in necturus gallbladder epithelium J Membr Biol 66 109 121 1:CAS:528:DyaL38XhvFOjuro%3D 7077647
116. T Zeuthen 1983 Ion activities in the lateral intercellular spaces of gallbladder epithelium transporting at low external osmolarities J Membr Biol 76 113 122 1:STN:280:DyaL2c%2FmsVOrsQ%3D%3D 6606049
117. T Zeuthen 1991 Water permeability of ventricular cell membrane in choroid plexus epithelium from Necturus maculosus J Physiol 444 133 151 1:STN:280:DyaK38zkvFaqsQ%3D%3D 1822548
118. T Zeuthen 1991 Secondary active transport of water across ventricular cell membrane of choroid plexus epithelium of Necturus maculosus J Physiol 444 153 173 1:CAS:528:DyaK3MXmslKit7s%3D 1822549
119. 2O by membrane proteins from choroid plexus epithelium of Necturus maculosus J Physiol 478 203 219 1:CAS:528:DyaK2cXmt1Krsbg%3D 7965842
120. T Zeuthen 1995 Molecular mechanisms for passive and active transport of water Int Rev Cytol 160 99 161 1:CAS:528:DyaK2MXpsVektLs%3D 7558688
121. Zeuthen T (1996) Molecular mechanisms of water transport. Springer, Berlin
122. T Zeuthen 2002 General models for water transport across leaky epithelia Int Rev Cytol 215 285 317 1:CAS:528:DC%2BD38XjsFCrt7g%3D 11952232
123. T Zeuthen 2008 Molecular water pumps-or how water can move uphill across epithelia Physiol News 68 3 5
124. T Zeuthen N MacAulay 2002 Cotransporters as molecular water pumps Int Rev Cytol 215 259 284 1:CAS:528:DC%2BD38XjsFCrt7s%3D 11952231
125. T Zeuthen N MacAulay 2002 Passive water transport in biological pores Int Rev Cytol 215 203 230 1:CAS:528:DC%2BD38XjsFCrt70%3D 11952229
126. T Zeuthen WD Stein 1994 Co-transport of salt and water in membrane proteins: Membrane proteins as osmotic engines J Membr Biol 137 179 195 1:CAS:528:DyaK2cXitlygt7k%3D 8182729
127. +-coupled glucose transporters expressed in Xenopus oocytes Biophys J 93 1413 1416 1:CAS:528:DC%2BD2sXosFCisr8%3D 17513358
128. 2O by membrane proteins in retinal pigment epithelium of bullfrog J Physiol 497 3 17 1:CAS:528:DyaK28XnsVyruro%3D 8951707
129. +/glucose cotransporter under isotonic conditions Biol Cell 89 307 312 1:CAS:528:DyaK1cXotVequw%3D%3D 9468601
130. +-glucose cotransporter SGLT1 J Physiol 531 631 644 1:CAS:528:DC%2BD3MXivVaksrk%3D 11251046
131. +-coupled sugar transporters (SGLT1) J Physiol 542 71 87 1:CAS:528:DC%2BD38XmtValsr4%3D 12096052
132. +-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substratesize studied at high resolution J Physiol 570 485 499 1:CAS:528:DC%2BD28XisFKjtrk%3D 16322051
133. T Zeuthen E Zeuthen N MacAulay 2007 Water transport by GLUT2 expressed in Xenopus laevis oocytes J Physiol 579 345 361 1:CAS:528:DC%2BD2sXjvVSgsLY%3D 17158169
134. D Zhang L Vetrivel AS Verkman 2002 Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production J Gen Physiol 119 561 569 1:CAS:528:DC%2BD38XltVSmt7c%3D 12034763
135. + antiporter by a single point mutation EMBO J 28 175 182 1:CAS:528:DC%2BD1MXis1Onug%3D%3D 19131966
136. J Zimmerberg VA Parsegian 1986 Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel Nature 323 36 1:CAS:528:DyaL28Xls1ynsL0%3D 2427958