CC chemokine ligand 18 in ANCA-associated crescentic GN

Journal of the American Society of Nephrology

Volumn 26, Issue 9, 2015, Pages 2105-2117

  Brix, Silke R ^a   Stege, Gesa ^a   Disteldorf, Erik ^a   Hoxha, Elion ^a   Krebs, Christian ^a   Krohn, Sonja ^a   Otto, Benjamin ^a   Klätschke, Kristin ^a   Herden, Elisabeth ^a   Heymann, Felix ^b   Lira, Sergio A ^c   Tacke, Frank ^b   Wolf, Gunter ^d   Busch, Martin ^d   Jabs, Wolfram J ^e   Özcan, Fedai ^f   Keller, Frieder ^g   Beige, Joachim ^h   Wagner, Karl ⁱ   Helmchen, Udo ^a   Noriega, Mercedes ^a   Wiech, Thorsten ^a   Panzer, Ulf ^a   Stahl, Rolf A K ^a   more..

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d JENA UNIVERSITY HOSPITAL   (Germany)

^e VIVANTES KLINIKUM IM FRIEDRICHSHAIN   (Germany)

^f KLINIKUM DORTMUND   (Germany)

^g UNIVERSITY HOSPITAL ULM   (Germany)

^h Klinikum St Georg   (Germany)

ⁱ ASKLEPIOS HOSPITAL BARMBEK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CC CHEMOKINE LIGAND 18; CD209 ANTIGEN; CD68 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CCR8; MONOCYTE CHEMOTACTIC PROTEIN 2; UNCLASSIFIED DRUG; BETA CHEMOKINE; CCL18 PROTEIN, HUMAN; CCL8 PROTEIN, MOUSE; CCR8 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ADULT; ANCA ASSOCIATED VASCULITIS; ARTICLE; CELL DENSITY; CELL INFILTRATION; CONTROLLED STUDY; DISEASE ACTIVITY; EXPERIMENTAL DISEASE; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; INTERSTITIAL INFLAMMATION; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PARENCHYMA; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MONONUCLEAR CELL; MONONUCLEAR PHAGOCYTE; MURINE MODEL; MYELOID DENDRITIC CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; RELAPSE; REMISSION; UPREGULATION; WILD TYPE; AGED; ANIMAL; BLOOD; CHEMISTRY; COMPLICATION; DENDRITIC CELL; GENETICS; GLOMERULONEPHRITIS; METABOLISM; MIDDLE AGED; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN MICROARRAY;

AGED; ANIMALS; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; BIOMARKERS; CHEMOKINE CCL8; CHEMOKINES, CC; DENDRITIC CELLS; FEMALE; GLOMERULONEPHRITIS; HUMANS; MACROPHAGES; MALE; MICE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN ARRAY ANALYSIS; RECEPTORS, CCR8; UP-REGULATION;

EID: 84940744103     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2014040407     Document Type: Article

References (56)

1. Furuta S, Jayne DR: Antineutrophil cytoplasm antibody-associated vasculitis: Recent developments. Kidney Int 84: 244-249, 2013
2. Falk RJ, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis.NEngl JMed 318: 1651-1657, 1988
3. Falk RJ, Jennette JC: ANCA disease: Where is this field heading? J Am Soc Nephrol 21: 745-752, 2010
4. Kallenberg CG: Pathogenesis of ANCA-associated vasculitides. Ann Rheum Dis 70[Suppl 1]: i59-i63, 2011
5. Kain R, Exner M, Brandes R, Ziebermayr R, Cunningham D, Alderson CA, Davidovits A, Raab I, Jahn R, Ashour O, Spitzauer S, Sunder-Plassmann G, Fukuda M, Klemm P, Rees AJ, Kerjaschki D: Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 14: 1088-1096, 2008
6. Kain R, Tadema H, McKinney EF, Benharkou A, Brandes R, Peschel A, Hubert V, Feenstra T, Sengölge G, Stegeman C, Heeringa P, Lyons PA, Smith KG, Kallenberg C, Rees AJ: High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis. J Am Soc Nephrol 23: 556-566, 2012
7. Jennette JC, Xiao H, Falk RJ: Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 17: 1235-1242, 2006
8. Jones RB, Tervaert JW, Hauser T, Luqmani R, Morgan MD, Peh CA, Savage CO, Segelmark M, Tesar V, van Paassen P, Walsh D, Walsh M, Westman K, Jayne DR; European Vasculitis Study Group: Rituximab versus cyclophosphamide inANCA-associated renal vasculitis.NEngl J Med 363: 211-220, 2010
9. Stone JH, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, KallenbergCG, St.ClairEW, TurkiewiczA, Tchao NK,Webber L,Ding L, Sejismundo LP, Mieras K, Weitzenkamp D, Ikle D, Seyfert-Margolis V, Mueller M, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh KA, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Specks U; RAVE-ITN Research Group: Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 363: 221-232, 2010
10. Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St. Clair EW, Fessler BJ, Ding L, Viviano L, Tchao NK, Phippard DJ, Asare AL, Lim N, Ikle D, Jepson B, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, YtterbergSR,MuellerM,SejismundoLP, Mieras K, Stone JH; RAVE-ITN Research Group: Efficacy of remission-induction regimens for ANCA-associated vasculitis. N Engl J Med 369: 417-427, 2013
11. Schönermarck U, Gross WL, de Groot K: Treatment of ANCA-associated vasculitis. Nat Rev Nephrol 10: 25-36, 2014
12. Chung AC, Lan HY: Chemokines in renal injury. J Am Soc Nephrol 22: 802-809, 2011
13. Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD: Identification of human CCR8 as a CCL18 receptor. J ExpMed 210: 1889-1898, 2013
14. Kodelja V,Müller C, PolitzO,HakijN,Orfanos CE,Goerdt S: Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. J Immunol 160: 1411-1418, 1998
15. Schutyser E, Richmond A, VanDamme J: Involvement ofCC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol 78: 14-26, 2005
16. ThomasGD, Rückerl D,Maskrey BH,Whitfield PD, BlaxterML, Allen JE: The biology of nematode- and IL4Ra-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics. Blood 120: e93-e104, 2012
17. Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, Minegishi Y, Karasuyama H: Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophilderived interleukin-4. Immunity 38: 570-580, 2013
18. Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD: Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol 12: 167-177, 2011
19. Prasse A, Pechkovsky DV, Toews GB, SchferM, Eggeling S, Ludwig C, Germann M, Kollert F, Zissel G, Müller-Quernheim J: CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. Arthritis Rheum 56: 1685-1693, 2007
20. Liu T, Baek HA, Yu H, Lee HJ, Park BH, Ullenbruch M, Liu J, Nakashima T, Choi YY, Wu GD, Chung MJ, Phan SH: FIZZ2/RELM-b induction and role in pulmonary fibrosis. J Immunol 187: 450-461, 2011
21. Ribeiro-Silva A, Zhang H, Jeffrey SS: RNA extraction from ten year old formalin-fixed paraffin-embedded breast cancer samples: A comparison of column purification and magnetic bead-based technologies. BMC Mol Biol 8: 118, 2007
22. Hodgin JB, Borczuk AC, Nasr SH, Markowitz GS, Nair V, Martini S, Eichinger F, Vining C, Berthier CC, Kretzler M, D'Agati VD: Amolecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue. Am J Pathol 177: 1674-1686, 2010
23. Nelson PJ, Rees AJ, GriffinMD, Hughes J, Kurts C, Duffield J: The renal mononuclear phagocytic system. J AmSocNephrol 23: 194-203, 2012
24. Tacke F, Yoneyama H: FromNAFLDtoNASH to fibrosis to HCC: Role of dendritic cell populations in the liver. Hepatology 58: 494-496, 2013
25. Segerer S, Heller F, Lindenmeyer MT, Schmid H, Cohen CD, Draganovici D, Mandelbaum J, Nelson PJ, Gröne HJ, Gröne EF, Figel AM, Nössner E, Schlöndorff D: Compartment specific expression of dendritic cell markers in human glomerulonephritis. Kidney Int 74: 37-46, 2008
26. Kurts C, Panzer U, Anders HJ, Rees AJ: The immune system and kidney disease: Basic concepts and clinical implications. Nat Rev Immunol 13: 738-753, 2013
27. Berden AE, Jones RB, Erasmus DD, Walsh M, Nol LH, Ferrario F, Waldherr R, Bruijn JA, Jayne DR, Bajema IM; European Vasculitis Society: Tubular lesions predict renal outcome in antineutrophil cytoplasmic antibody-associated glomerulonephritis after rituximab therapy. J Am Soc Nephrol 23: 313-321, 2012
28. Weidner S, Carl M, Riess R, Rupprecht HD: Histologic analysis of renal leukocyte infiltration in antineutrophil cytoplasmic antibody-associated vasculitis: Importance of monocyte and neutrophil infiltration in tissue damage. Arthritis Rheum 50: 3651-3657, 2004
29. Aasard K, Bostad L, Hammerstrm J, Jrstad S, Iversen BM: Wegener's granulomatosis: Inflammatory cells and markers of repair and fibrosis in renal biopsies-a clinicopathological study. Scand J Urol Nephrol 35: 401-410, 2001
30. Fiore N, Castellano G, Blasi A, Capobianco C, Loverre A, Montinaro V, Netti S, Torres D, Manno C, Grandaliano G, Ranieri E, Schena FP, Gesualdo L: Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis. Mol Immunol 45: 259-265, 2008
31. Castellano G, Trouw LA, Fiore N, Daha MR, Schena FP, van Kooten C: Infiltrating dendritic cells contribute to local synthesis of C1q in murine and human lupus nephritis. Mol Immunol 47: 2129-2137, 2010
32. Steinmetz OM, Velden J, Kneissler U, Marx M, Klein A, Helmchen U, Stahl RA, Panzer U: Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis. Kidney Int 74: 448-457, 2008
33. Snelgrove SL, Kausman JY, Lo C, Lo C, Ooi JD, Coates PT, Hickey MJ, Holdsworth SR, Kurts C, Engel DR, Kitching AR: Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am J Pathol 180: 91-103, 2012
34. van der Voort R, Kramer M, Lindhout E, Torensma R, Eleveld D, van Lieshout AW, LoomanM, Ruers T, Radstake TR, Figdor CG, Adema GJ: Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions. J Leukoc Biol 77: 739-747, 2005
35. Cai M, Bonella F, He X, Sixt SU, Sarria R, Guzman J, Costabel U: CCL18 in serum, BAL fluid and alveolar macrophage culture supernatant in interstitial lung diseases. Respir Med 107: 1444-1452, 2013
36. Tsicopoulos A, Chang Y, Ait Yahia S, de Nadai P, Chenivesse C: Role of CCL18 in asthma and lung immunity. Clin Exp Allergy 43: 716-722, 2013
37. Prasse A, Probst C, Bargagli E, Zissel G, Toews GB, Flaherty KR, Olschewski M, Rottoli P, Müller-Quernheim J: Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179: 717-723, 2009
38. Günther C, Zimmermann N, Berndt N, Grosser M, Stein A, Koch A, MeurerM: Up-regulation of the chemokine CCL18 by macrophages is a potential immunomodulatory pathway in cutaneous T-cell lymphoma. Am J Pathol 179: 1434-1442, 2011
39. Miyagaki T, Sugaya M, Suga H, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S: Increased CCL18 expression in patients with cutaneous T-cell lymphoma: Association with disease severity and prognosis. J Eur Acad Dermatol Venereol 27: e60-e67, 2013
40. Chen J, Yao Y,Gong C, Yu F, Su S, Chen J, Liu B, Deng H,Wang F, Lin L, YaoH, Su F, Anderson KS, LiuQ, EwenME, Yao X, Song E:CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19: 541-555, 2011
41. Lindhout E, Vissers JL, Hartgers FC, Huijbens RJ, Scharenborg NM, Figdor CG, Adema GJ: The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes. J Immunol 166: 3284-3289, 2001
42. Hieshima K, Imai T, BabaM, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdenakker G, Van Damme J, Yoshie O, Nomiyama H: A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J Immunol 159: 1140-1149, 1997
43. Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB, Figdor CG: A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387: 713-717, 1997
44. D'Ambrosio D, Iellem A, Bonecchi R, Mazzeo D, Sozzani S, Mantovani A, Sinigaglia F: Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol 161: 5111-5115, 1998
45. Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y: Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 32: 840-851, 2010
46. Jakubzick C, Tacke F, Llodra J, van Rooijen N, Randolph GJ: Modulation of dendritic cell trafficking to and fromthe airways. J Immunol 176: 3578-3584, 2006
47. Qu C, Edwards EW, Tacke F, Angeli V, Llodrá J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N, Sanchez-Torres C, Bromberg J, Charo IF, Jung S, Lira SA, Randolph GJ: Role of CCR8 and other chemokine pathways in the migration of monocytederived dendritic cells to lymph nodes. J ExpMed 200: 1231-1241, 2004
48. Krebs CF, Kapffer S, PaustHJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR,Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U: MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN. J Am Soc Nephrol 24: 1955-1965, 2013
49. Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio F, David DS, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M: Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 8: 753-760, 2008
50. Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedrick JA, Cook DN, Zingoni A, Narula SK, Zlotnik A, Barrat FJ,O'Garra A, NapolitanoM, Lira SA: Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 193: 573-584, 2001
51. Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker HW, Tiegs G, Stahl RA, Panzer U: CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J Am Soc Nephrol 21: 974-985, 2010
52. Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix SR, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RAK, Kurts C, Kaufmann SH, Panzer U. CXCL5 drives neutrophil recruitment in TH17-mediated GN [published online ahead of print on June 5, 2014]. J Am Soc Nephrol doi.10.1681/ ASN.2013101061
53. Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I,Magnus T, Korn T, Stahl RA, Kurts C, Panzer U: IL-17A production by renal gd T cells promotes kidney injury in crescentic GN. J AmSoc Nephrol 23: 1486-1495, 2012
54. Heymann F, Hammerich L, Storch D, Bartneck M, Huss S, Rüsseler V, Gassler N, Lira SA, Luedde T, Trautwein C, Tacke F: Hepatic macrophagemigration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology 55: 898-909, 2012
55. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP: Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15, 2003
56. Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-193, 2003