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Volumn 40, Issue 9, 2015, Pages 1929-1944

Calcium Signaling Involvement in Cadmium-Induced Astrocyte Cytotoxicity and Cell Death Through Activation of MAPK and PI3K/Akt Signaling Pathways

Author keywords

Astrocytes; Cadmium; Cytotoxicity; MAPK; PI3K Akt

Indexed keywords

CADMIUM; CALCIUM; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

EID: 84940722060     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1686-y     Document Type: Article
Times cited : (62)

References (48)
  • 1
    • 84893823199 scopus 로고    scopus 로고
    • Interplay of calcium and cadmium in mediating cadmium toxicity
    • COI: 1:CAS:528:DC%2BC2cXkt1WjtbY%3D, PID: 24463198
    • Choong G, Liu Y, Templeton DM (2014) Interplay of calcium and cadmium in mediating cadmium toxicity. Chem Biol Interact 211:54–65
    • (2014) Chem Biol Interact , vol.211 , pp. 54-65
    • Choong, G.1    Liu, Y.2    Templeton, D.M.3
  • 2
    • 33847201491 scopus 로고    scopus 로고
    • Cadmium neurotoxicity
    • COI: 1:CAS:528:DC%2BD2sXit1Glsbo%3D, PID: 21783780
    • Mendez-Armenta M, Rios C (2007) Cadmium neurotoxicity. Environ Toxicol Pharmacol 23:350–358
    • (2007) Environ Toxicol Pharmacol , vol.23 , pp. 350-358
    • Mendez-Armenta, M.1    Rios, C.2
  • 3
    • 84884232816 scopus 로고    scopus 로고
    • Cadmium and its neurotoxic effects
    • PID: 23997854
    • Wang B, Du Y (2013) Cadmium and its neurotoxic effects. Oxid Med Cell Longev 2013:898034
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 898034
    • Wang, B.1    Du, Y.2
  • 4
    • 0031454212 scopus 로고    scopus 로고
    • Parkinsonism after acute cadmium poisoning
    • COI: 1:STN:280:DyaK1c7lt1SjsA%3D%3D, PID: 9491302
    • Okuda B, Iwamoto Y, Tachibana H, Sugita M (1997) Parkinsonism after acute cadmium poisoning. Clin Neurol Neurosurg 99:263–265
    • (1997) Clin Neurol Neurosurg , vol.99 , pp. 263-265
    • Okuda, B.1    Iwamoto, Y.2    Tachibana, H.3    Sugita, M.4
  • 5
    • 77955065023 scopus 로고    scopus 로고
    • Review of effect on human health for environmental cadmium pollution
    • PID: 16758981
    • Du Y, Shang Q (2006) Review of effect on human health for environmental cadmium pollution. Wei Sheng Yan Jiu 35:241–243
    • (2006) Wei Sheng Yan Jiu , vol.35 , pp. 241-243
    • Du, Y.1    Shang, Q.2
  • 6
    • 0142219722 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of cadmium carcinogenesis
    • COI: 1:CAS:528:DC%2BD3sXot1Kjt7w%3D, PID: 14580780
    • Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95–117
    • (2003) Toxicology , vol.192 , pp. 95-117
    • Waisberg, M.1    Joseph, P.2    Hale, B.3    Beyersmann, D.4
  • 7
    • 84862815361 scopus 로고    scopus 로고
    • An investigation and pathological analysis of two fatal cases of cadmium poisoning
    • COI: 1:CAS:528:DC%2BC38XptFagurs%3D, PID: 22349354
    • Chang YF, Wen JF, Cai JF, Xiao-Ying W, Yang L, Guo YD (2012) An investigation and pathological analysis of two fatal cases of cadmium poisoning. Forensic Sci Int 220:e5–8
    • (2012) Forensic Sci Int , vol.220 , pp. e5-e8
    • Chang, Y.F.1    Wen, J.F.2    Cai, J.F.3    Xiao-Ying, W.4    Yang, L.5    Guo, Y.D.6
  • 8
    • 77957180502 scopus 로고
    • Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal
    • COI: 1:CAS:528:DyaK38XlvVKhsLk%3D, PID: 1516785
    • Evans J, Hastings L (1992) Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal. Fundam Appl Toxicol 19:275–278
    • (1992) Fundam Appl Toxicol , vol.19 , pp. 275-278
    • Evans, J.1    Hastings, L.2
  • 9
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood–brain barrier
    • COI: 1:CAS:528:DC%2BD2MXhtlaktbjP, PID: 16371949
    • Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood–brain barrier. Nat Rev Neurosci 7:41–53
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 12
    • 0141533210 scopus 로고    scopus 로고
    • New roles for astrocytes (stars at last)
    • COI: 1:CAS:528:DC%2BD3sXns1CgtbY%3D, PID: 14522143
    • Ransom B, Behar T, Nedergaard M (2003) New roles for astrocytes (stars at last). Trends Neurosci 26:520–522
    • (2003) Trends Neurosci , vol.26 , pp. 520-522
    • Ransom, B.1    Behar, T.2    Nedergaard, M.3
  • 13
    • 84923183501 scopus 로고    scopus 로고
    • Astrocytic exportin-7 responds to ischemia through mediating LKB1 translocation from the nucleus to the cytoplasm
    • COI: 1:CAS:528:DC%2BC2cXitV2nsr7M, PID: 25250856
    • Liang HJ, Chai RC, Li X, Kong JG, Jiang JH, Ma J, Vatcher G, Yu AC (2015) Astrocytic exportin-7 responds to ischemia through mediating LKB1 translocation from the nucleus to the cytoplasm. J Neurosci Res 93:253–267
    • (2015) J Neurosci Res , vol.93 , pp. 253-267
    • Liang, H.J.1    Chai, R.C.2    Li, X.3    Kong, J.G.4    Jiang, J.H.5    Ma, J.6    Vatcher, G.7    Yu, A.C.8
  • 14
    • 84882907087 scopus 로고    scopus 로고
    • AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries
    • PID: 23922257
    • Chai RC, Jiang JH, Kwan Wong AY, Jiang F, Gao K, Vatcher G, Hoi Yu AC (2013) AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries. Glia 61:1748–1765
    • (2013) Glia , vol.61 , pp. 1748-1765
    • Chai, R.C.1    Jiang, J.H.2    Kwan Wong, A.Y.3    Jiang, F.4    Gao, K.5    Vatcher, G.6    Hoi Yu, A.C.7
  • 15
    • 64349102366 scopus 로고    scopus 로고
    • Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte
    • COI: 1:CAS:528:DC%2BD1MXlsFyktr8%3D, PID: 19393026
    • Dong Y, Liu HD, Zhao R, Yang CZ, Chen XQ, Wang XH, Lau LT, Chen J, Yu AC (2009) Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte. J Neurochem 109(Suppl 1):182–188
    • (2009) J Neurochem , vol.109 , pp. 182-188
    • Dong, Y.1    Liu, H.D.2    Zhao, R.3    Yang, C.Z.4    Chen, X.Q.5    Wang, X.H.6    Lau, L.T.7    Chen, J.8    Yu, A.C.9
  • 16
    • 84886639648 scopus 로고    scopus 로고
    • Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression
    • PID: 24123203
    • Gao K, Wang CR, Jiang F, Wong AY, Su N, Jiang JH, Chai RC, Vatcher G, Teng J, Chen J, Jiang YW, Yu AC (2013) Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression. Glia 61:2063–2077
    • (2013) Glia , vol.61 , pp. 2063-2077
    • Gao, K.1    Wang, C.R.2    Jiang, F.3    Wong, A.Y.4    Su, N.5    Jiang, J.H.6    Chai, R.C.7    Vatcher, G.8    Teng, J.9    Chen, J.10    Jiang, Y.W.11    Yu, A.C.12
  • 18
    • 41149128223 scopus 로고    scopus 로고
    • MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis
    • COI: 1:CAS:528:DC%2BD1cXksFais7s%3D, PID: 18021293
    • Chen L, Liu L, Luo Y, Huang S (2008) MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem 105:251–261
    • (2008) J Neurochem , vol.105 , pp. 251-261
    • Chen, L.1    Liu, L.2    Luo, Y.3    Huang, S.4
  • 19
    • 36549015683 scopus 로고    scopus 로고
    • Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells
    • COI: 1:CAS:528:DC%2BD2sXhtlyrtr%2FP, PID: 17961543
    • Jung YS, Jeong EM, Park EK, Kim YM, Sohn S, Lee SH, Baik EJ, Moon CH (2008) Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells. Eur J Pharmacol 578:11–18
    • (2008) Eur J Pharmacol , vol.578 , pp. 11-18
    • Jung, Y.S.1    Jeong, E.M.2    Park, E.K.3    Kim, Y.M.4    Sohn, S.5    Lee, S.H.6    Baik, E.J.7    Moon, C.H.8
  • 20
    • 79955544309 scopus 로고    scopus 로고
    • Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network
    • COI: 1:CAS:528:DC%2BC3MXlsVantbg%3D, PID: 21544200
    • Xu B, Chen S, Luo Y, Chen Z, Liu L, Zhou H, Chen W, Shen T, Han X, Chen L, Huang S (2011) Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS ONE 6:e19052
    • (2011) PLoS ONE , vol.6 , pp. e19052
    • Xu, B.1    Chen, S.2    Luo, Y.3    Chen, Z.4    Liu, L.5    Zhou, H.6    Chen, W.7    Shen, T.8    Han, X.9    Chen, L.10    Huang, S.11
  • 21
    • 84860343561 scopus 로고    scopus 로고
    • Biochemical mechanisms of neurotoxicity caused by cadmium
    • COI: 1:CAS:528:DC%2BC38Xht1Gru7jN, PID: 22435288
    • Labudda M (2011) Biochemical mechanisms of neurotoxicity caused by cadmium. Rocz Panstw Zakl Hig 62:357–363
    • (2011) Rocz Panstw Zakl Hig , vol.62 , pp. 357-363
    • Labudda, M.1
  • 23
    • 0037349147 scopus 로고    scopus 로고
    • Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture
    • COI: 1:CAS:528:DC%2BD3sXisFegsLc%3D, PID: 12642392
    • Lopez E, Figueroa S, Oset-Gasque MJ, Gonzalez MP (2003) Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. Br J Pharmacol 138:901–911
    • (2003) Br J Pharmacol , vol.138 , pp. 901-911
    • Lopez, E.1    Figueroa, S.2    Oset-Gasque, M.J.3    Gonzalez, M.P.4
  • 24
    • 84878552275 scopus 로고    scopus 로고
    • Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway
    • COI: 1:CAS:528:DC%2BC3sXpslOhsb4%3D, PID: 23741317
    • Yuan Y, Jiang CY, Xu H, Sun Y, Hu FF, Bian JC, Liu XZ, Gu JH, Liu ZP (2013) Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway. PLoS ONE 8:e64330
    • (2013) PLoS ONE , vol.8 , pp. e64330
    • Yuan, Y.1    Jiang, C.Y.2    Xu, H.3    Sun, Y.4    Hu, F.F.5    Bian, J.C.6    Liu, X.Z.7    Gu, J.H.8    Liu, Z.P.9
  • 25
    • 84855964605 scopus 로고    scopus 로고
    • Astrocytes: multitalented stars of the central nervous system
    • COI: 1:CAS:528:DC%2BC38XhslWisrvK, PID: 22144296
    • Ransom BR, Ransom CB (2012) Astrocytes: multitalented stars of the central nervous system. Methods Mol Biol 814:3–7
    • (2012) Methods Mol Biol , vol.814 , pp. 3-7
    • Ransom, B.R.1    Ransom, C.B.2
  • 26
    • 39049149164 scopus 로고    scopus 로고
    • Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium
    • COI: 1:CAS:528:DC%2BD1cXit1Shs78%3D, PID: 17631669
    • Yang CS, Tzou BC, Liu YP, Tsai MJ, Shyue SK, Tzeng SF (2008) Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium. J Cell Biochem 103:825–834
    • (2008) J Cell Biochem , vol.103 , pp. 825-834
    • Yang, C.S.1    Tzou, B.C.2    Liu, Y.P.3    Tsai, M.J.4    Shyue, S.K.5    Tzeng, S.F.6
  • 27
    • 78549247841 scopus 로고    scopus 로고
    • Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions
    • COI: 1:CAS:528:DC%2BC3cXhsVKjsbfK, PID: 20829427
    • Rai A, Maurya SK, Khare P, Srivastava A, Bandyopadhyay S (2010) Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions. Toxicol Sci 118:586–601
    • (2010) Toxicol Sci , vol.118 , pp. 586-601
    • Rai, A.1    Maurya, S.K.2    Khare, P.3    Srivastava, A.4    Bandyopadhyay, S.5
  • 29
    • 77951622431 scopus 로고    scopus 로고
    • Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells
    • COI: 1:CAS:528:DC%2BC3cXkvFOisr8%3D, PID: 20152897
    • Liu J, Kapron CM (2010) Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells. Reprod Toxicol 29:286–291
    • (2010) Reprod Toxicol , vol.29 , pp. 286-291
    • Liu, J.1    Kapron, C.M.2
  • 31
    • 63049091896 scopus 로고    scopus 로고
    • Cadmium and cellular signaling cascades: to be or not to be?
    • COI: 1:CAS:528:DC%2BD1MXosVaqsrY%3D, PID: 19371614
    • Thevenod F (2009) Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharmacol 238:221–239
    • (2009) Toxicol Appl Pharmacol , vol.238 , pp. 221-239
    • Thevenod, F.1
  • 32
    • 84866631100 scopus 로고    scopus 로고
    • Oxidative stress and apoptotic changes of rat cerebral cortical neurons exposed to cadmium in vitro
    • PID: 22998824
    • Yan Y, Bian JC, Zhong LX, Zhang Y, Sun Y, Liu ZP (2012) Oxidative stress and apoptotic changes of rat cerebral cortical neurons exposed to cadmium in vitro. Biomed Environ Sci 25:172–181
    • (2012) Biomed Environ Sci , vol.25 , pp. 172-181
    • Yan, Y.1    Bian, J.C.2    Zhong, L.X.3    Zhang, Y.4    Sun, Y.5    Liu, Z.P.6
  • 33
    • 79551488995 scopus 로고    scopus 로고
    • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death
    • COI: 1:CAS:528:DC%2BC3MXhtlejtbs%3D, PID: 21195169
    • Chen L, Xu B, Liu L, Luo Y, Zhou H, Chen W, Shen T, Han X, Kontos CD, Huang S (2011) Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med 50:624–632
    • (2011) Free Radic Biol Med , vol.50 , pp. 624-632
    • Chen, L.1    Xu, B.2    Liu, L.3    Luo, Y.4    Zhou, H.5    Chen, W.6    Shen, T.7    Han, X.8    Kontos, C.D.9    Huang, S.10
  • 34
    • 51349166119 scopus 로고    scopus 로고
    • Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5
    • COI: 1:CAS:528:DC%2BD1cXhtFamsbbK, PID: 18703135
    • Chen L, Liu L, Huang S (2008) Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med 45:1035–1044
    • (2008) Free Radic Biol Med , vol.45 , pp. 1035-1044
    • Chen, L.1    Liu, L.2    Huang, S.3
  • 35
    • 31844446605 scopus 로고    scopus 로고
    • Cadmium-induced astroglial death proceeds via glutathione depletion
    • COI: 1:CAS:528:DC%2BD28Xhs1altbk%3D, PID: 16385582
    • Im JY, Paik SG, Han PL (2006) Cadmium-induced astroglial death proceeds via glutathione depletion. J Neurosci Res 83:301–308
    • (2006) J Neurosci Res , vol.83 , pp. 301-308
    • Im, J.Y.1    Paik, S.G.2    Han, P.L.3
  • 36
    • 84882771079 scopus 로고    scopus 로고
    • Cadmium induces N-cadherin cleavage via ERK-mediated gamma-secretase activation in C6 astroglia cells
    • COI: 1:CAS:528:DC%2BC3sXhsVWjt7jJ, PID: 23876460
    • Jo C, Koh YH (2013) Cadmium induces N-cadherin cleavage via ERK-mediated gamma-secretase activation in C6 astroglia cells. Toxicol Lett 222:117–121
    • (2013) Toxicol Lett , vol.222 , pp. 117-121
    • Jo, C.1    Koh, Y.H.2
  • 37
    • 84871410588 scopus 로고    scopus 로고
    • Primary cultures of astrocytes: their value in understanding astrocytes in health and disease
    • COI: 1:CAS:528:DC%2BC38Xht1Grt7nL, PID: 22926576
    • Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD (2012) Primary cultures of astrocytes: their value in understanding astrocytes in health and disease. Neurochem Res 37:2569–2588
    • (2012) Neurochem Res , vol.37 , pp. 2569-2588
    • Lange, S.C.1    Bak, L.K.2    Waagepetersen, H.S.3    Schousboe, A.4    Norenberg, M.D.5
  • 38
    • 33644862368 scopus 로고    scopus 로고
    • JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species
    • COI: 1:CAS:528:DC%2BD28Xis1egtL4%3D, PID: 16540388
    • Shen HM, Liu ZG (2006) JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 40:928–939
    • (2006) Free Radic Biol Med , vol.40 , pp. 928-939
    • Shen, H.M.1    Liu, Z.G.2
  • 39
    • 6344256753 scopus 로고    scopus 로고
    • mTOR: a protein kinase switching between life and death
    • COI: 1:CAS:528:DC%2BD2cXovVyqsr4%3D, PID: 15501691
    • Asnaghi L, Bruno P, Priulla M, Nicolin A (2004) mTOR: a protein kinase switching between life and death. Pharmacol Res 50:545–549
    • (2004) Pharmacol Res , vol.50 , pp. 545-549
    • Asnaghi, L.1    Bruno, P.2    Priulla, M.3    Nicolin, A.4
  • 40
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • COI: 1:CAS:528:DC%2BC3cXitlSntLY%3D, PID: 20079433
    • Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 1802:396–405
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 41
    • 81255160568 scopus 로고    scopus 로고
    • CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death
    • COI: 1:CAS:528:DC%2BC3MXhs1GqtbzM, PID: 21933187
    • Chen S, Xu Y, Xu B, Guo M, Zhang Z, Liu L, Ma H, Chen Z, Luo Y, Huang S, Chen L (2011) CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death. J Neurochem 119:1108–1118
    • (2011) J Neurochem , vol.119 , pp. 1108-1118
    • Chen, S.1    Xu, Y.2    Xu, B.3    Guo, M.4    Zhang, Z.5    Liu, L.6    Ma, H.7    Chen, Z.8    Luo, Y.9    Huang, S.10    Chen, L.11
  • 42
    • 84919598978 scopus 로고    scopus 로고
    • The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway
    • COI: 1:CAS:528:DC%2BC2cXhtFyht7%2FI, PID: 25043952
    • Yuan Y, Jiang C, Hu F, Wang Q, Zhang K, Wang Y, Gu J, Liu X, Bian J, Liu Z (2015) The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway. J Trace Elem Med Biol 29:275–283
    • (2015) J Trace Elem Med Biol , vol.29 , pp. 275-283
    • Yuan, Y.1    Jiang, C.2    Hu, F.3    Wang, Q.4    Zhang, K.5    Wang, Y.6    Gu, J.7    Liu, X.8    Bian, J.9    Liu, Z.10
  • 43
    • 84891835356 scopus 로고    scopus 로고
    • Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network
    • COI: 1:CAS:528:DC%2BC2cXjtVSrug%3D%3D, PID: 24111524
    • Chen S, Gu C, Xu C, Zhang J, Xu Y, Ren Q, Guo M, Huang S, Chen L (2014) Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. J Neurochem 128:256–266
    • (2014) J Neurochem , vol.128 , pp. 256-266
    • Chen, S.1    Gu, C.2    Xu, C.3    Zhang, J.4    Xu, Y.5    Ren, Q.6    Guo, M.7    Huang, S.8    Chen, L.9
  • 44
    • 69049105313 scopus 로고    scopus 로고
    • Dysregulation of calcium homeostasis in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXjvV2ksb8%3D, PID: 19337829
    • Small DH (2009) Dysregulation of calcium homeostasis in Alzheimer’s disease. Neurochem Res 34:1824–1829
    • (2009) Neurochem Res , vol.34 , pp. 1824-1829
    • Small, D.H.1
  • 45
    • 0031172562 scopus 로고    scopus 로고
    • Cadmium, gene regulation, and cellular signalling in mammalian cells
    • COI: 1:CAS:528:DyaK2sXjsl2jtLs%3D, PID: 9194408
    • Beyersmann D, Hechtenberg S (1997) Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol Appl Pharmacol 144:247–261
    • (1997) Toxicol Appl Pharmacol , vol.144 , pp. 247-261
    • Beyersmann, D.1    Hechtenberg, S.2
  • 48
    • 0031308219 scopus 로고    scopus 로고
    • Up-regulation of reactive astrogliosis in the rat glioma 9L cell line by combined mechanical and chemical injuries
    • COI: 1:STN:280:DyaK1c%2FjtVSksA%3D%3D, PID: 9363621
    • Malhotra SK, Luong LT, Bhatnagar R, Shnitka TK (1997) Up-regulation of reactive astrogliosis in the rat glioma 9L cell line by combined mechanical and chemical injuries. Cytobios 89:115–134
    • (1997) Cytobios , vol.89 , pp. 115-134
    • Malhotra, S.K.1    Luong, L.T.2    Bhatnagar, R.3    Shnitka, T.K.4


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