Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells

Toxicology Letters

Volumn 222, Issue 2, 2013, Pages 117-121

  Jo, Chulman ^a   Koh, Young Ho ^a  

^a Korea National Institute of Health   (South Korea)

Author keywords

Secretase; Cadmium; ERK; JNK; N cadherin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CADMIUM; CALCIUM ION; GAMMA SECRETASE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; NICASTRIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; SIGNAL TRANSDUCTION;

Γ-SECRETASE; CADMIUM; CD; ERK; EXTRACELLULAR SIGNAL-ACTIVATED PROTEIN KINASE; JNK; JUN N-TERMINAL KINASE; N-CAD/CTF2; N-CADHERIN; N-CADHERIN C-TERMINAL FRAGMENT 2; REACTIVE OXYGEN SPECIES; ROS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIOXIDANTS; ASTROCYTES; CADHERINS; CADMIUM; CADMIUM CHLORIDE; CALCIUM CHANNEL BLOCKERS; CELL LINE; ENZYME ACTIVATION; KINETICS; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; OXIDANTS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEIN KINASE INHIBITORS; PROTEOLYSIS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84882771079     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.07.015     Document Type: Article

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