Conjugated Polymer Nanoparticles for Fluorescence Imaging and Sensing of Neurotransmitter Dopamine in Living Cells and the Brains of Zebrafish Larvae

ACS Applied Materials and Interfaces

Volumn 7, Issue 33, 2015, Pages 18581-18589

  Qian, Cheng Gen ^a   Zhu, Sha ^a   Feng, Pei Jian ^a   Chen, Yu Lei ^a   Yu, Ji Cheng ^a   Tang, Xin ^a   Liu, Yun ^a   Shen, Qun Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

bioimaging; conjugated polymers; dopamine; fluorescence sensing; nanoparticles

Indexed keywords

AMINES; DIAGNOSIS; DISEASE CONTROL; FLUORESCENCE; MEDICAL APPLICATIONS; NANOCONJUGATES; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NEUROPHYSIOLOGY;

BIO-IMAGING; BIOLOGICAL FLUORESCENCE; BIOMEDICAL APPLICATIONS; DOPAMINE; FLUORESCENCE DETECTION; FLUORESCENCE SENSING; FLUORESCENCE SIGNAL AMPLIFICATION; PHOTOPHYSICAL PROPERTIES;

CONJUGATED POLYMERS;

BENZENEBORONIC ACID; BORONIC ACID DERIVATIVE; DOPAMINE; FLUORESCENT DYE; NANOPARTICLE; POLYMER;

ANIMAL; BRAIN; CHEMISTRY; CONFOCAL MICROSCOPY; GROWTH, DEVELOPMENT AND AGING; LARVA; LIGHT; METABOLISM; PC12 CELL LINE; PHOTON CORRELATION SPECTROSCOPY; RAT; SYNTHESIS; ZEBRA FISH;

ANIMALS; BORONIC ACIDS; BRAIN; DOPAMINE; DYNAMIC LIGHT SCATTERING; FLUORESCENT DYES; LARVA; LIGHT; MICROSCOPY, CONFOCAL; NANOPARTICLES; PC12 CELLS; POLYMERS; RATS; ZEBRAFISH;

EID: 84940703230     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b04987     Document Type: Article

References (44)

1. Weissleder, R.; Nahrendorf, M.; Pittet, M. J. Imaging Macrophages with Nanoparticles Nat. Mater. 2014, 13, 125-138 10.1038/nmat3780
2. Yang, W.; Ratinac, K. R.; Ringer, S. P.; Thordarson, P.; Gooding, J. J.; Braet, F. Carbon Nanomaterials in Biosensors: Should You Use Nanotubes or Graphene? Angew. Chem., Int. Ed. 2010, 49, 2114-2138 10.1002/anie.200903463
3. Kanasty, R.; Dorkin, J. R.; Vegas, A.; Anderson, D. Delivery Materials for Sirna Therapeutics Nat. Mater. 2013, 12, 967-977 10.1038/nmat3765
4. Petros, R. A.; DeSimone, J. M. Strategies in the Design of Nanoparticles for Therapeutic Applications Nat. Rev. Drug Discovery 2010, 9, 615-627 10.1038/nrd2591
5. Giljohann, D. A.; Seferos, D. S.; Daniel, W. L.; Massich, M. D.; Patel, P. C.; Mirkin, C. A. Gold Nanoparticles for Biology and Medicine Angew. Chem., Int. Ed. 2010, 49, 3280-3294 10.1002/anie.200904359
6. Gu, Z.; Aimetti, A. A.; Wang, Q.; Dang, T. T.; Zhang, Y.; Veiseh, O.; Cheng, H.; Langer, R. S.; Anderson, D. G. Injectable Nano-Network for Glucose-Mediated Insulin Delivery ACS Nano 2013, 7, 4194-4201 10.1021/nn400630x
7. Pecher, J.; Mecking, S. Nanoparticles of Conjugated Polymers Chem. Rev. 2010, 110, 6260-6279 10.1021/cr100132y
8. Li, K.; Liu, B. Polymer-Encapsulated Organic Nanoparticles for Fluorescence and Photoacoustic Imaging Chem. Soc. Rev. 2014, 43, 6570-6597 10.1039/C4CS00014E
9. Feng, L.; Zhu, C.; Yuan, H.; Liu, L.; Lv, F.; Wang, S. Conjugated Polymer Nanoparticles: Preparation, Properties, Functionalization and Biological Applications Chem. Soc. Rev. 2013, 42, 6620-6633 10.1039/c3cs60036j
10. Koner, A. L.; Krndija, D.; Hou, Q.; Sherratt, D. J.; Howarth, M. Hydroxy-Terminated Conjugated Polymer Nanoparticles Have Near-Unity Bright Fraction and Reveal Cholesterol-Dependence of Igf1r Nanodomains ACS Nano 2013, 7, 1137-1144 10.1021/nn3042122
11. Ahmed, E.; Morton, S. W.; Hammond, P. T.; Swager, T. M. Fluorescent Multiblock Π-Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting Adv. Mater. 2013, 25, 4504-4510 10.1002/adma.201301656
12. Yuan, Y.; Liu, J.; Liu, B. Conjugated-Polyelectrolyte-Based Polyprodrug: Targeted and Image-Guided Photodynamic and Chemotherapy with On-Demand Drug Release Upon Irradiation with a Single Light Source Angew. Chem., Int. Ed. 2014, 53, 7163-7168 10.1002/anie.201402189
13. Yuan, H. X.; Liu, Z.; Liu, L. B.; Lv, F. T.; Wang, Y. L.; Wang, S. Cationic Conjugated Polymers for Discrimination of Microbial Pathogens Adv. Mater. 2014, 26, 4333-4338 10.1002/adma.201400636
14. Brouard, D.; Viger, M. L.; Bracamonte, A. G.; Boudreau, D. Label-Free Biosensing Based on Multilayer Fluorescent Nanocomposites and a Cationic Polymeric Transducer ACS Nano 2011, 5, 1888-1896 10.1021/nn102776m
15. McQuade, D. T.; Pullen, A. E.; Swager, T. M. Conjugated Polymer-Based Chemical Sensors Chem. Rev. 2000, 100, 2537-2574 10.1021/cr9801014
16. Zhu, C.; Liu, L.; Yang, Q.; Lv, F.; Wang, S. Water-Soluble Conjugated Polymers for Imaging, Diagnosis, and Therapy Chem. Rev. 2012, 112, 4687-4735 10.1021/cr200263w
17. Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J. Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging ACS Nano 2008, 2, 2415-2423 10.1021/nn800590n
18. Sun, B.; Sun, M. J.; Gu, Z.; Shen, Q. D.; Jiang, S. J.; Xu, Y.; Wang, Y. Conjugated Polymer Fluorescence Probe for Intracellular Imaging of Magnetic Nanoparticles Macromolecules 2010, 43, 10348-10354 10.1021/ma101680g
19. Pu, K.-Y.; Liu, B. Fluorescent Conjugated Polyelectrolytes for Bioimaging Adv. Funct. Mater. 2011, 21, 3408-3423 10.1002/adfm.201101153
20. Liu, Y.; Huang, J.; Sun, M.-J.; Yu, J.-C.; Chen, Y.-L.; Zhang, Y.-Q.; Jiang, S.-J.; Shen, Q.-D. A Fluorescence-Raman Dual-Imaging Platform Based on Complexes of Conjugated Polymers and Carbon Nanotubes Nanoscale 2014, 6, 1480-1489 10.1039/C3NR04430K
21. Yu, J.; Wu, C.; Sahu, S. P.; Fernando, L. P.; Szymanski, C.; McNeill, J. Nanoscale 3d Tracking with Conjugated Polymer Nanoparticles J. Am. Chem. Soc. 2009, 131, 18410-18414 10.1021/ja907228q
22. Kim, J. H.; Auerbach, J. M.; Rodríguez-Gómez, J. A.; Velasco, I.; Gavin, D.; Lumelsky, N.; Lee, S.-H.; Nguyen, J.; Sánchez-Pernaute, R.; Bankiewicz, K.; McKay, R. Dopamine Neurons Derived from Embryonic Stem Cells Function in an Animal Model of Parkinson's Disease Nature 2002, 418, 50-56 10.1038/nature00900
23. Chaudhury, D.; Walsh, J. J.; Friedman, A. K.; Juarez, B.; Ku, S. M.; Koo, J. W.; Ferguson, D.; Tsai, H. C.; Pomeranz, L.; Christoffel, D. J.; Nectow, A. R.; Ekstrand, M.; Domingos, A.; Mazei-Robison, M. S.; Mouzon, E.; Lobo, M. K.; Neve, R. L.; Friedman, J. M.; Russo, S. J.; Deisseroth, K.; Nestler, E. J.; Han, M. H. Rapid Regulation of Depression-Related Behaviours by Control of Midbrain Dopamine Neurons Nature 2013, 493, 532-536 10.1038/nature11713
24. Volkow, N. D.; Fowler, J. S.; Wang, G.-J.; Swanson, J. M. Dopamine in Drug Abuse and Addiction: Results from Imaging Studies and Treatment Implications Mol. Psychiatry 2004, 9, 557-569 10.1038/sj.mp.4001507
25. Yue, H. Y.; Huang, S.; Chang, J.; Heo, C.; Yao, F.; Adhikari, S.; Gunes, F.; Liu, L. C.; Lee, T. H.; Oh, E. S.; Li, B.; Zhang, J. J.; Huy, T. Q.; Luan, N. V.; Lee, Y. H. Zno Nanowire Arrays on 3d Hierachical Graphene Foam: Biomarker Detection of Parkinson's Disease ACS Nano 2014, 8, 1639-1646 10.1021/nn405961p
26. Schmidt, A. C.; Wang, X.; Zhu, Y.; Sombers, L. A. Carbon Nanotube Yarn Electrodes for Enhanced Detection of Neurotransmitter Dynamics in Live Brain Tissue ACS Nano 2013, 7, 7864-7873 10.1021/nn402857u
27. Li, B.-R.; Hsieh, Y.-J.; Chen, Y.-X.; Chung, Y.-T.; Pan, C.-Y.; Chen, Y.-T. An Ultrasensitive Nanowire-Transistor Biosensor for Detecting Dopamine Release from Living Pc12 Cells under Hypoxic Stimulation J. Am. Chem. Soc. 2013, 135, 16034-16037 10.1021/ja408485m
28. Zhang, M.; Liao, C.; Yao, Y.; Liu, Z.; Gong, F.; Yan, F. High-Performance Dopamine Sensors Based on Whole-Graphene Solution-Gated Transistors Adv. Funct. Mater. 2014, 24, 978-985 10.1002/adfm.201302359
29. Rodriguez, P. C.; Pereira, D. B.; Borgkvist, A.; Wong, M. Y.; Barnard, C.; Sonders, M. S.; Zhang, H.; Sames, D.; Sulzer, D. Fluorescent Dopamine Tracer Resolves Individual Dopaminergic Synapses and Their Activity in the Brain Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 870-875 10.1073/pnas.1213569110
30. Pradhan, T.; Jung, H. S.; Jang, J. H.; Kim, T. W.; Kang, C.; Kim, J. S. Chemical Sensing of Neurotransmitters Chem. Soc. Rev. 2014, 43, 4684-4713 10.1039/c3cs60477b
31. Kruss, S.; Landry, M. P.; Vander Ende, E.; Lima, B. M.; Reuel, N. F.; Zhang, J.; Nelson, J.; Mu, B.; Hilmer, A.; Strano, M. Neurotransmitter Detection Using Corona Phase Molecular Recognition on Fluorescent Single-Walled Carbon Nanotube Sensors J. Am. Chem. Soc. 2014, 136, 713-724 10.1021/ja410433b
32. Jeon, S.-J.; Kwak, S.-Y.; Yim, D.; Ju, J.-M.; Kim, J.-H. Chemically-Modulated Photoluminescence of Graphene Oxide for Selective Detection of Neurotransmitter by "Turn-on" Response J. Am. Chem. Soc. 2014, 136, 10842-10845 10.1021/ja504276z
33. Pinto, M. R.; Schanze, K. S. Amplified Fluorescence Sensing of Protease Activity with Conjugated Polyelectrolytes Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 7505-7510 10.1073/pnas.0402280101
34. Jiang, H.; Taranekar, P.; Reynolds, J. R.; Schanze, K. S. Conjugated Polyelectrolytes: Synthesis, Photophysics, and Applications Angew. Chem., Int. Ed. 2009, 48, 4300-4316 10.1002/anie.200805456
35. Feng, X. L.; Liu, L. B.; Wang, S.; Zhu, D. B. Water-Soluble Fluorescent Conjugated Polymers and Their Interactions with Biomacromolecules for Sensitive Biosensors Chem. Soc. Rev. 2010, 39, 2411-2419 10.1039/b909065g
36. Dmitriev, R. I.; Borisov, S. M.; Düssmann, H.; Sun, S.; Müller, B. J.; Prehn, J.; Baklaushev, V. P.; Klimant, I.; Papkovsky, D. B. Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3d Tissue Models ACS Nano 2015, 9, 5275-5288 10.1021/acsnano.5b00771
37. Ho, L.-C.; Wu, W.-C.; Chang, C.-Y.; Hsieh, H.-H.; Lee, C.-H.; Chang, H.-T. Aptamer-Conjugated Polymeric Nanoparticles for the Detection of Cancer Cells through "Turn-on" Retro-Self-Quenched Fluorescence Anal. Chem. 2015, 87, 4925-4932 10.1021/acs.analchem.5b00569
38. Jia, Y.; Zuo, X.; Lou, X.; Miao, M.; Cheng, Y.; Min, X.; Li, X.; Xia, F. Rational Designed Bipolar, Conjugated Polymer-DNA Composite Beacon for the Sensitive Detection of Proteins and Ions Anal. Chem. 2015, 87, 3890-3894 10.1021/ac504690y
39. Sanromán-Iglesias, M.; Zhang, K. A.; Chuvilin, A.; Lawrie, C.; Grzelczak, M.; Liz-Marzan, L. M. Conjugated Polymers as Molecular Gates for Light-Controlled Release of Gold Nanoparticles ACS Appl. Mater. Interfaces 2015, 7, 15692-15695 10.1021/acsami.5b05087
40. Wang, H.; Li, Y.; Chen, Y.; Li, L.; Fang, T.; Tang, Z. Development of a Conjugated Polymer-Based Fluorescent Probe for Selective Detection of Hocl J. Mater. Chem. C 2015, 3, 5136-5140 10.1039/C5TC00611B
41. Justice, J. B., Jr. Quantitative Microdialysis of Neurotransmitters J. Neurosci. Methods 1993, 48, 263-276 10.1016/0165-0270(93)90097-B
42. Martin, A. R.; Vasseur, J. J.; Smietana, M. Boron and Nucleic Acid Chemistries: Merging the Best of Both Worlds Chem. Soc. Rev. 2013, 42, 5684-713 10.1039/c3cs60038f
43. Borisov, S. M.; Mayr, T.; Mistlberger, G.; Waich, K.; Koren, K.; Chojnacki, P.; Klimant, I. Precipitation as a Simple and Versatile Method for Preparation of Optical Nanochemosensors Talanta 2009, 79, 1322-1330 10.1016/j.talanta.2009.05.041
44. Ahnert-Hilger, G.; Bräutigam, M.; Gratzl, M. Calcium-Stimulated Catecholamine Release From Alpha-Toxin-Permeabilized Pc12 Cells: Biochemical Evidence for Exocytosis and Its Modulation by Protein Kinase C and G Proteins Biochemistry 1987, 26, 7842-7848 10.1021/bi00398a046