Induction of regulatory B-cells by mesenchymal stem cells is affected by SDF-1α-CXCR7

Cellular Physiology and Biochemistry

Volumn 37, Issue 1, 2015, Pages 117-130

  Qin, Yan ^a   Zhou, Zhihua ^a   Zhang, Fang ^a   Wang, Yong ^a   Shen, Bing ^a   Liu, Yong ^a   Guo, Yifeng ^a   Fan, Yu ^a   Qiu, Jianxin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

CXCL12 SDF 1 ; Immunomodulatory; Mesenchymal stem cells (MSCs); Regulatory B cells (Breg)

Indexed keywords

CD1D ANTIGEN; CD5 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 6; MEMBRANE ANTIGEN; STROMAL CELL DERIVED FACTOR 1ALPHA; CHEMOKINE RECEPTOR CXCR; CMKOR1 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL CONTACT; CELL CULTURE; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOREGULATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINEAGE; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES, REGULATORY; BONE MARROW; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CHEMOKINE CXCL12; COCULTURE TECHNIQUES; INTERLEUKINS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; RECEPTORS, CXCR; SIGNAL TRANSDUCTION;

EID: 84940665386     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430338     Document Type: Article

References (40)

1. Bruder SP, Fink DJ, Caplan AI: Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994;56:283-294
2. Zhao S, Wehner R, Bornhauser M, Wassmuth R, Bachmann M, Schmitz M: Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev 2009;19:607-614
3. Franquesa M, Herrero E, Torras J, Ripoll E, Flaquer M, Goma M, Lloberas N, Anegon I, Cruzado JM, Grinyo JM, Herrero-Fresneda I: Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model. Stem Cells Dev 2012;21:3125-3135
4. Nauta AJ, Fibbe WE: Immunomodulatory properties of mesenchymal stromal cells. Blood 2007;110:3499-3506
5. Rasmusson I, Le Blanc K, Sundberg B, Ringden O: Mesenchymal stem cells stimulate antibody secretion in human b cells. Scand J Immunol 2007;65:336-343
6. Rasmusson I, Uhlin M, Le Blanc K, Levitsky V: Mesenchymal stem cells fail to trigger effector functions of cytotoxic t lymphocytes. J Leukoc Biol 2007;82:887-893
7. Bassi EJ, Aita CA, Camara NO: Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand? World J Stem Cells 2011;3:1-8
8. Franquesa M, Hoogduijn MJ, Bestard O, Grinyo JM: Immunomodulatory effect of mesenchymal stem cells on b cells. Front Immunol 2012;3:212
9. Traggiai E, Volpi S, Schena F, Gattorno M, Ferlito F, Moretta L, Martini A: Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of b cells isolated from healthy donors and systemic lupus erythematosus patients. Stem Cells 2008;26:562-569
10. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A: Human mesenchymal stem cells modulate b-cell functions. Blood 2006;107:367-372
11. Krampera M, Cosmi L, Angeli R, Pasini A, Liotta F, Andreini A, Santarlasci V, Mazzinghi B, Pizzolo G, Vinante F, Romagnani P, Maggi E, Romagnani S, Annunziato F: Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006;24:386-398
12. Mauri C, Bosma A: Immune regulatory function of b cells. Annu Rev Immunol 2012;30:221-241
13. Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C: Novel suppressive function of transitional 2 b cells in experimental arthritis. J Immunol 2007;178:7868-7878
14. DiLillo DJ, Matsushita T, Tedder TF: B10 cells and regulatory b cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci 2010;1183:38-57
15. Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF: A regulatory b cell subset with a unique cd1dhicd5+ phenotype controls t cell-dependent inflammatory responses. Immunity 2008;28:639-650
16. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF: The development and function of regulatory b cells expressing il-10 (b10 cells) requires antigen receptor diversity and tlr signals. J Immunol 2009;182:7459-7472
17. Mizoguchi A, Bhan AK: A case for regulatory b cells. J Immunol 2006;176:705-710
18. Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML: Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant 2010;19:667-679
19. Uccelli A, Pistoia V, Moretta L: Mesenchymal stem cells: A new strategy for immunosuppression? Trends Immunol 2007;28:219-226
20. Miller RJ, Banisadr G, Bhattacharyya BJ: Cxcr4 signaling in the regulation of stem cell migration and development. J Neuroimmunol 2008;198:31-38
21. Vandercappellen J, Van Damme J, Struyf S: The role of cxc chemokines and their receptors in cancer. Cancer Lett 2008;267:226-244
22. Vinader V, Afarinkia K: The emerging role of cxc chemokines and their receptors in cancer. Future Med Chem 2012;4:853-867
23. Brunn A, Utermohlen O, Mihelcic M, Sanchez-Ruiz M, Carstov M, Blau T, Ustinova I, Penfold M, Montesinos-Rongen M, Deckert M: Differential effects of cxcr4-cxcl12-and cxcr7-cxcl12-mediated immune reactions on murine p0106-125-induced experimental autoimmune neuritis. Neuropathol Appl Neurobiol 2013;39:772-787
24. Busillo JM, Benovic JL: Regulation of cxcr4 signaling. Biochim Biophys Acta 2007;1768:952-963
25. Lagane B, Chow KY, Balabanian K, Levoye A, Harriague J, Planchenault T, Baleux F, Gunera-Saad N, Arenzana-Seisdedos F, Bachelerie F: Cxcr4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to cxcl12 in whim syndrome. Blood 2008;112:34-44
26. Xu FT, Li HM, Yin QS, Liu DL, Nan H, Zhao PR, Liang SW: Human breast adipose-derived stem cells transfected with the stromal cell-derived factor-1 receptor cxcr4 exhibit enhanced viability in human autologous free fat grafts. Cell Physiol Biochem 2014;34:2091-2104
27. Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes HG, Rot A, Thelen M: Cxcr7 functions as a scavenger for cxcl12 and cxcl11. PLoS One 2010;5:e9175
28. Humpert ML, Pinto D, Jarrossay D, Thelen M: Cxcr7 influences the migration of b cells during maturation. Eur J Immunol 2013;44:694-705
29. Luz-Crawford P, Kurte M, Bravo-Alegria J, Contreras R, Nova-Lamperti E, Tejedor G, Noel D, Jorgensen C, Figueroa F, Djouad F, Carrion F: Mesenchymal stem cells generate a cd4+cd25+foxp3+ regulatory t cell population during the differentiation process of th1 and th17 cells. Stem Cell Res Ther 2013;4:65
30. Carrion F, Nova E, Luz P, Apablaza F, Figueroa F: Opposing effect of mesenchymal stem cells on th1 and th17 cell polarization according to the state of cd4+ t cell activation. Immunol Lett 2010;135:10-16
31. Kuan YC, Wu YJ, Hung CL, Sheu F: Trametes versicolor protein yzp activates regulatory b lymphocytes-gene identification through de novo assembly and function analysis in a murine acute colitis model. PLoS One 2013;8:e72422
32. Calpe E, Purroy N, Carpio C, Abrisqueta P, Carabia J, Palacio C, Castellvi J, Crespo M, Bosch F: Zap-70 promotes the infiltration of malignant b-lymphocytes into the bone marrow by enhancing signaling and migration after cxcr4 stimulation. PLoS One 2013;8:e81221
33. Spaggiari GM, Abdelrazik H, Becchetti F, Moretta L: Mscs inhibit monocyte-derived dc maturation and function by selectively interfering with the generation of immature dcs: Central role of msc-derived prostaglandin e2. Blood 2009;113:6576-6583
34. Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L: Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: Role of indoleamine 2,3-dioxygenase and prostaglandin e2. Blood 2008;111:1327-1333
35. Barr TA, Brown S, Ryan G, Zhao J, Gray D: Tlr-mediated stimulation of apc: Distinct cytokine responses of b cells and dendritic cells. Eur J Immunol 2007;37:3040-3053
36. Colgan SP, Hershberg RM, Furuta GT, Blumberg RS: Ligation of intestinal epithelial cd1d induces bioactive il-10: Critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci U S A 1999;96:13938-13943
37. Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK: Chronic intestinal inflammatory condition generates il-10-producing regulatory b cell subset characterized by cd1d upregulation. Immunity 2002;16:219-230
38. Locatelli F, Maccario R, Frassoni F: Mesenchymal stromal cells, from indifferent spectators to principal actors. Are we going to witness a revolution in the scenario of allograft and immune-mediated disorders? Haematologica 2007;92:872-877
39. Berahovich RD, Zabel BA, Lewen S, Walters MJ, Ebsworth K, Wang Y, Jaen JC, Schall TJ: Endothelial expression of cxcr7 and the regulation of systemic cxcl12 levels. Immunology 2013;141:111-122
40. Ryan JM, Barry F, Murphy JM, Mahon BP: Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol 2007;149:353-363