Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

Journal of Controlled Release

Volumn 217, Issue , 2015, Pages 53-63

  De Backer, Lynn ^a   Naessens, Thomas ^a   De Koker, Stefaan ^a   Zagato, Elisa ^a   Demeester, Jo ^a   Grooten, Johan ^a   De Smedt, Stefaan C ^a   Raemdonck, Koen ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Dextran nanogel; In vivo test; Macrophage; Pulmonary delivery; Pulmonary surfactant; siRNA

Indexed keywords

BIOLOGICAL ORGANS; DEXTRAN; GENE EXPRESSION; GENES; MACROPHAGES; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NUCLEIC ACIDS; PHOSPHOLIPIDS; RNA;

IN-VIVO TESTS; NANOGELS; PULMONARY DELIVERY; PULMONARY SURFACTANTS; SIRNA;

SURFACE ACTIVE AGENTS;

CXCL1 CHEMOKINE; DEXTRAN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NANOGEL; NANOPARTICLE; PORACTANT; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CD45 ANTIGEN; CYTOKINE; GEL; LUNG SURFACTANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; GENE EXPRESSION; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CHEMISTRY; CYTOLOGY; GEL; GENETICS; METABOLISM;

ANIMALS; ANTIGENS, CD45; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CYTOKINES; DEXTRANS; FEMALE; GELS; GENE SILENCING; MACROPHAGES, ALVEOLAR; MICE, INBRED BALB C; NANOPARTICLES; PULMONARY SURFACTANTS; RNA, SMALL INTERFERING;

EID: 84940660227     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.08.030     Document Type: Article

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