Does rheumatoid cachexia predispose patients with rheumatoid arthritis to osteoporosis and vertebral fractures?

Journal of Rheumatology

Volumn 42, Issue 9, 2015, Pages 1556-1562

  El Maghraoui, Abdellah ^a   Sadni, Siham ^a   Rezqi, Asmaa ^a   Bezza, Ahmed ^a   Achemlal, Lahsen ^a   Mounach, Aziza ^a  

^a MILITARY HOSPITAL MOHAMMED V   (Morocco)

Author keywords

Adipose tissue; Dual energy X ray absorptiometry; Osteoporosis; Rheumatoid arthritis; Vertebral fractures

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BODY COMPOSITION; BODY MASS; BONE DENSITY; CACHEXIA; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT FREE MASS; FEMALE; FEMUR; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RHEUMATOID CACHEXIA; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SPINE FRACTURE; ARTHRITIS, RHEUMATOID; COMPLICATION; INJURIES; LUMBAR VERTEBRA; MIDDLE AGED; OSTEOPOROTIC FRACTURES; PHYSIOLOGY; PREVALENCE; RADIOGRAPHY; SPINAL FRACTURES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; BONE DENSITY; CACHEXIA; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; PREVALENCE; RISK FACTORS; SPINAL FRACTURES;

EID: 84940656374     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.141629     Document Type: Article

References (50)

1. Roubenoff R. Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century. Arthritis Res Ther 2009;11:108.
2. Lemmey AB, Jones J, Maddison PJ. Rheumatoid cachexia: what is it and why is it important? [letter]. J Rheumatol 2011;38:2074.
3. Rajbhandary R, Khezri A, Panush RS. Rheumatoid cachexia: what is it and why is it important? J Rheumatol 2011;38:406-8.
4. Summers GD, Metsios GS, Stavropoulos-Kalinoglou A, Kitas GD. Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol 2010;6:445-51.
5. El Maghraoui A. [Malnutrition, cachexia and osteoporosis]. [Article in French] Rev Rhum Monogr 2013;80:100-4.
6. Ali S, Garcia JM. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options-a mini-review. Gerontology 2014;60:294-305.
7. Evans WJ. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr 2010;91:1123S-7S.
8. Nampei A, Hashimoto J, Koyanagi J, Ono T, Hashimoto H, Tsumaki N, et al. Characteristics of fracture and related factors in patients with rheumatoid arthritis. Mod Rheumatol 2008;18:170-6.
9. Arai K, Hanyu T, Sugitani H, Murai T, Fujisawa J, Nakazono K, et al. Risk factors for vertebral fracture in menopausal or postmenopausal Japanese women with rheumatoid arthritis: a cross-sectional and longitudinal study. J Bone Miner Metab 2006;24:118-24.
10. Ørstavik RE, Haugeberg G, Uhlig T, Falch JA, Halse JI, Høiseth A, et al. Vertebral deformities in 229 female patients with rheumatoid arthritis: associations with clinical variables and bone mineral density. Arthritis Rheum 2003; 49: 355-60.
11. de Nijs RN, Jacobs JW, Bijlsma JW, Lems WF, Laan RF, Houben HH, et al; Osteoporosis Working Group, Dutch Society for Rheumatology. Prevalence of vertebral deformities and symptomatic vertebral fractures in corticosteroid treated patients with rheumatoid arthritis. Rheumatology 2001;40:1375-83.
12. Peel NF, Moore DJ, Barrington NA, Bax DE, Eastell R. Risk of vertebral fracture and relationship to bone mineral density in steroid treated rheumatoid arthritis. Ann Rheum Dis 1995;54:801-6.
13. El Maghraoui A, Rezqi A, Mounach A, Achemlal L, Bezza A, Ghozlani I. Prevalence and risk factors of vertebral fractures in women with rheumatoid arthritis using vertebral fracture assessment. Rheumatology 2010;49:1303-10.
14. Jalava T, Sarna S, Pylkkänen L, Mawer B, Kanis JA, Selby P, et al. Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res 2003;18:1254-60.
15. Naves M, Díaz-López JB, Gómez C, Rodríguez-Rebollar A, Rodríguez-García M, Cannata-Andía JB. The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population. Osteoporos Int 2003;14:520-4.
16. El Maghraoui A, Roux C. DXA scanning in clinical practice. QJM 2008;101:605-17.
17. Fuerst T, Wu C, Genant HK, von Ingersleben G, Chen Y, Johnston C, et al. Evaluation of vertebral fracture assessment by dual X-ray absorptiometry in a multicenter setting. Osteoporos Int 2009;20:1199-205.
18. Schousboe JT, Vokes T, Broy SB, Ferrar L, McKiernan F, Roux C, et al. Vertebral fracture assessment: the 2007 ISCD official positions. J Clin Densitom 2008;11:92-108.
19. El Maghraoui A, Morjane F, Nouijai A, Achemlal L, Bezza A, Ghozlani I. Vertebral fracture assessment in Moroccan women: prevalence and risk factors. Maturitas 2009;62:171-5.
20. El Maghraoui A, Mounach A, Gassim S, Ghazi M. Vertebral fracture assessment in healthy men: prevalence and risk factors. Bone 2008;43:544-8.
21. van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB. Validity of single variables and indices to measure disease activity in rheumatoid arthritis. J Rheumatol 1993;20:538-41.
22. El Maghraoui A, Do Santos Zounon AA, Jroundi I, Nouijai A, Ghazi M, Achemlal L, et al. Reproducibility of bone mineral density measurements using dual X-ray absorptiometry in daily clinical practice. Osteoporos Int 2005;16:1742-8.
23. Genant HK, Wu C Y, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 1993;8:1137-48.
24. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 1995;854:1-452.
25. Pødenphant J, Gotfredsen A, Engelhart M, Andersen V, Heitmann BL, Kondrup J. Comparison of body composition by dual energy X-ray absorptiometry to other estimates of body composition during weight loss in obese patients with rheumatoid arthritis. Scand J Clin Lab Invest 1996;56:615-25.
26. Kiebzak GM, Leamy LJ, Pierson LM, Nord RH, Zhang ZY. Measurement precision of body composition variables using the lunar DPX-L densitometer. J Clin Densitom 2000;3:35-41.
27. Abernathy RP, Black DR. Healthy body weights: an alternative perspective. Am J Clin Nutr 1996;63 Suppl:448S-51S.
28. Schutz Y, Kyle UU, Pichard C. Fat-free mass index and fat mass index percentiles in Caucasians aged 18-98 y. Int J Obes Relat Metab Disord 2002;26:953-60.
29. Engvall IL, Elkan AC, Tengstrand B, Cederholm T, Brismar K, Hafstrom I. Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor. Scand J Rheumatol 2008;37:321-8.
30. Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, et al. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999;15:116-22.
31. Stavropoulos-Kalinoglou A, Metsios GS, Koutedakis Y, Nevill AM, Douglas KM, Jamurtas A, et al. Redefining overweight and obesity in rheumatoid arthritis patients. Ann Rheum Dis 2007;66:1316-21.
32. van Bokhorst-de van der Schueren MA, Konijn NP, Bultink IE, Lems WF, Earthman CP, van Tuyl LH. Relevance of the new pre-cachexia and cachexia definitions for patients with rheumatoid arthritis. Clin Nutr 2012;31:1008-10.
33. Summers GD, Deighton CM, Rennie MJ, Booth AH. Rheumatoid cachexia: a clinical perspective. Rheumatology 2008;47:1124-31.
34. Roubenoff R, Roubenoff RA, Ward LM, Holland SM, Hellmann DB. Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol 1992;19:1505-10.
35. Helliwell M, Coombes EJ, Moody BJ, Batstone GF, Robertson JC. Nutritional status in patients with rheumatoid arthritis. Ann Rheum Dis 1984;43:386-90.
36. Fukuda W, Yamazaki T, Akaogi T, Hayashi H, Kusakabe T, Tsubouchi Y, et al. Malnutrition and disease progression in patients with rheumatoid arthritis. Mod Rheumatol 2005;15:104-7.
37. Munro R, Capell H. Prevalence of low body mass in rheumatoid arthritis: association with the acute phase response. Ann Rheum Dis 1997;56:326-9.
38. Hernandez-Beriain JA, Segura-Garcia C, Rodriguez-Lozano B, Bustabad S, Gantes M, González T. Undernutrition in rheumatoid arthritis patients with disability. Scand J Rheumatol 1996;25:383-7.
39. Elkan AC, Engvall IL, Cederholm T, Hafström I. Rheumatoid cachexia, central obesity and malnutrition in patients with low-active rheumatoid arthritis: feasibility of anthropometry, Mini Nutritional Assessment and body composition techniques. Eur J Nutr 2009;48:315-22.
40. Lombard LA, du Plessis LM, Visser J. Body composition of rheumatoid arthritis patients in the City of Cape Town, South Africa. Clin Rheumatol 2014;33:467-76.
41. Arshad A, Rashid R, Benjamin K. The effect of disease activity on fat-free mass and resting energy expenditure in patients with rheumatoid arthritis versus noninflammatory arthropathies/soft tissue rheumatism. Mod Rheumatol 2007;17:470-5.
42. Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, et al. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379-86.
43. Fukuda W, Omoto A, Ohta T, Majima S, Kimura T, Tanaka T, et al. Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis. Int J Rheum Dis 2013;16:297-302.
44. Dadoun S, Zeboulon-Ktorza N, Combescure C, Elhai M, Rozenberg S, Gossec L, et al. Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis. Joint Bone Spine 2013;80:29-33.
45. Pincus T, Sokka T, Wolfe F. Premature mortality in patients with rheumatoid arthritis: evolving concepts. Arthritis Rheum 2001;44:1234-6.
46. Kuo CF, Luo SF, See LC, Chou IJ, Chang HC, Yu KH. Rheumatoid arthritis prevalence, incidence, and mortality rates: a nationwide population study in Taiwan. Rheumatol Int 2013;33:355-60.
47. Giles JT, Allison M, Blumenthal RS, Post W, Gelber AC, Petri M, et al. Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics. Arthritis Rheum 2010;62:3173-82.
48. Inaba M, Tanaka K, Goto H, Sakai S, Yamada S, Naka H, et al. Independent association of increased trunk fat with increased arterial stiffening in postmenopausal patients with rheumatoid arthritis. J Rheumatol 2007;34:290-5.
49. Hida T, Harada A, Imagama S, Ishiguro N. Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations. Aging Dis 2014;5:226-37.
50. Hida T, Shimokata H, Sakai Y, Ito S, Matsui Y, Takemura M, et al. Sarcopenia and sarcopenic leg as potential risk factors for acute osteoporotic vertebral fracture among older women. Eur Spine J 2015 Feb 18 (E-pub ahead of print).