Rheumatoid cachexia: What is it and why is it important?

Journal of Rheumatology

Volumn 38, Issue 3, 2011, Pages 406-408

  Rajbhandary, Rosy ^a,b   Khezri, Azadeh ^a,b   Panush, Richard S ^a,b  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; GAMMA INTERFERON; GROWTH HORMONE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ARTHRALGIA; CACHEXIA; CALORIC INTAKE; CYTOKINE PRODUCTION; DIET RESTRICTION; DIET SUPPLEMENTATION; DIET THERAPY; EDITORIAL; ENERGY METABOLISM; ENZYME RELEASE; EXERCISE; HUMAN; IMMOBILIZATION; INSULIN RESISTANCE; JOINT DESTRUCTION; LEAN BODY WEIGHT; MALNUTRITION; MUSCLE ATROPHY; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN METABOLISM; RHEUMATOID ARTHRITIS; VEGETARIAN DIET;

ARTHRITIS, RHEUMATOID; CACHEXIA; CYTOKINES; HUMANS;

EID: 79952391735     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.101036     Document Type: Editorial

References (19)

1. Bhangle SD, Khezri A, Rajbhandary R, Sen D, Panush RS. Rheumatoid arthritis and cachexia. Arthritis Self-Management 2010 (in press).
2. Symmons DP. Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome. Best Pract Res Clin Rheumatol 2002;16:707-22.
3. Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, et al. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379-86. (Pubitemid 24177149)
4. Paget J. Nervous mimicry of organic diseases. Lancet 1873;2:727-9.
5. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 1980;69:491-7. (Pubitemid 10018703)
6. Roubenoff R, Kehayias JJ. The meaning and measurement of lean body mass. Nutr Rev 1991;46:163-75.
7. Rall LC, Roubenoff R. Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions. Rheumatology 2004;43:1219-23. (Pubitemid 39359292)
8. Walsmith J, Roubenoff R. Cachexia in rheumatoid arthritis. Intern J Cardio 2002;85:89-99.
9. Choy EHS, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001;344:907-16. (Pubitemid 32224400)
10. Koch AE, Kunkel SL, Strieter RM. Cytokines in rheumatoid arthritis. J Invest Med 1995;43:28-38.
11. Rall LC, Rosen C, Dolnikowski G, Hartman WJ, Lundgren N, Abad LW, et al. Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha. Arthritis Rheum 1996;39:1115-24.
12. Biolo G, Ciocchi B, Stulle M, Piccoli A, Lorenzon S, Dal Mas V, et al. Metabolic consequences of physical inactivity. J Ren Nutr 2005;15:49-53. (Pubitemid 40093682)
13. Lemmey A, Maddison P, Breslin A, Cassar P, Hasso N, McCann R, et al. Association between insulin-like growth factor status and physical activity levels in rheumatoid arthritis. J Rheumatol 2001;28:29-34. (Pubitemid 32062021)
14. Svenson KL, Lundqvist G, Wide L, Hallgren R. Impaired glucose handling in active rheumatoid arthritis: relationship to the secretion of insulin and counter-regulatory hormones. Metabolism 1987;36:940-3. (Pubitemid 17160510)
15. Yamaguchi K, Higashiura K, Ura N, Murakami H, Hyakukoku M, Furuhashi M, et al. The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling. Hypertens Res 2003;26:389-96. (Pubitemid 36701680)
16. Rall LC, Meydani SN, Kehayias JJ, Dawson-Hughes B, Roubenoff R. The effect of progressive resistance training in rheumatoid arthritis: increased strength without changes in energy balance or body composition. Arthritis Rheum 1996;39:415-26. (Pubitemid 26085217)
17. Bearne L, Scott D, Hurley M. Exercise can reverse quadriceps sensorimotor dysfunction that is associated with rheumatoid arthritis without exacerbating disease activity. Rheumatology 2002;41:157-66. (Pubitemid 34537892)
18. Marcora SM, Chester KR. Dietary treatment of rheumatoid cachexia. Clin Nutr 2005;24:442-54.
19. Marcora SM, Chester KR, Mittal G, Lemmey AB, Maddison PJ. Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis. Am J Clin Nutr 2006;84:1463-72. (Pubitemid 44912832)