Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection

Clinical Infectious Diseases

Volumn 61, Issue 6, 2015, Pages 1013-1021

  Braun, Dominique L ^a,b   Kouyos, Roger D ^a,b   Balmer, Belinda ^a   Grube, Christina ^a   Weber, Rainer ^a   Günthard, Huldrych F ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

acute HIV infection; acute retroviral syndrome; ARS; atypical clinical presentation; primary HIV 1 infection

Indexed keywords

ACALCULOUS CHOLECYSTITIS; ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; CLINICAL FEATURE; COLITIS; COUGHING; DIARRHEA; DISTAL PARESTHESIA; ENCEPHALITIS; ENTEROCOCCUS FAECIUM; EPIDIDYMITIS; ESOPHAGITIS; FATIGUE; FEMALE; FEVER; GASTRITIS; GASTROINTESTINAL TRACT; GENITAL ULCER; HEADACHE; HEALTH CARE PERSONNEL; HEPATITIS; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; HIGH RISK POPULATION; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMPETIGO; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; MENINGITIS; MENTAL DISEASE; MORBIDITY; MOUTH ULCER; MYALGIA; NAUSEA; NEURITIS; NEUROLOGIC DISEASE; NEW-ONSET ATRIAL FIBRILLATION; NIGHT SWEAT; OPPORTUNISTIC INFECTION; ORGAN; PANCYTOPENIA; PARESIS; PHARYNGITIS; PNEUMONIA; PRIMARY INFECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RASH; SEROCONVERSION; SOFT TISSUE INFECTION; STOMATITIS; THROMBOCYTOPENIA; THROMBOPHLEBITIS; TONSILLITIS; UPPER RESPIRATORY TRACT INFECTION; VERTIGO; VOMITING; WEIGHT REDUCTION; ADOLESCENT; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; MIDDLE AGED; PATHOLOGY; SWITZERLAND; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SWITZERLAND; YOUNG ADULT;

EID: 84940640736     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ398     Document Type: Article

References (22)

1. Kinloch-de Loes S, de Saussure P, Saurat JH, Stalder H, Hirschel B, Perrin LH. Symptomatic primary infection due to human immunodeficiency virus type 1: review of 31 cases. Clin Infect Dis 1993; 17:59-65.
2. Schacker T, Collier AC, Hughes J, Shea T, Corey L. Clinical and epidemiologic features of primary HIV infection. Ann Intern Med 1996; 125:257-64.
3. Fox R, Eldred LJ, Fuchs EJ, et al. Clinical manifestations of acute infection with human immunodeficiency virus in a cohort of gay men. AIDS 1987; 1:35-8.
4. Tindall B, Barker S, Donovan B, et al. Characterization of the acute clinical illness associated with human immunodeficiency virus infection. Arch Intern Med 1988; 148:945-9.
5. Hofer CB, Harrison LH, Struchiner CJ, et al. Acute retrovirus syndrome among prospectively identified homosexual men with incident HIV infection in Brazil. Projecto Praca Onze Study Group. J Acquir Immune Defic Syndr 2000; 25:188-91.
6. Bollinger RC, Brookmeyer RS, Mehendale SM, et al. Risk factors and clinical presentation of acute primary HIV infection in India. JAMA 1997; 278:2085-9.
7. Vanhems P, Routy JP, Hirschel B, et al. Clinical features of acute retroviral syndrome differ by route of infection but not by gender and age. J Acquir Immune Defic Syndr 2002; 31:318-21.
8. Daar ES, Pilcher CD, Hecht FM. Clinical presentation and diagnosis of primary HIV-1 infection. Curr Opin HIV AIDS 2008; 3:10-5.
9. Dorrucci M, Rezza G, Vlahov D, et al. Clinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users. Italian Seroconversion Study. AIDS 1995; 9:597-604.
10. Lavreys L, Thompson ML, Martin HL Jr, et al. Primary human immunodeficiency virus type 1 infection: clinical manifestations among women in Mombasa, Kenya. Clin Infect Dis 2000; 30:486-90.
11. Cooper DA, Gold J, Maclean P, et al. Acute AIDS retrovirus infection. Definition of a clinical illness associated with seroconversion. Lancet 1985; 1:537-40.
12. Gaines H, von Sydow M, Pehrson PO, Lundbegh P. Clinical picture of primary HIV infection presenting as a glandular-fever-like illness. BMJ 1988; 297:1363-8.
13. Quinn TC. Acute primary HIV infection. JAMA 1997; 278:58-62.
14. Brenner BG, Roger M, Routy JP, et al. High rates of forward transmission events after acute/early HIV-1 infection. J Infect Dis 2007; 195:951-9.
15. Gunthard HF, Aberg JA, Eron JJ, et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA 2014; 312:410-25.
16. Gianella S, von Wyl V, Fischer M, et al. Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA. Antivir Ther 2011; 16:535-45.
17. Rieder P, Joos B, von Wyl V, et al. HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men. AIDS 2010; 24:1177-83.
18. Rieder P, Joos B, Scherrer AU, et al. Characterization of human immunodeficiency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection. Clin Infect Dis 2011; 53:1271-9.
19. Cohen MS, Shaw GM, McMichael AJ, Haynes BF. Acute HIV-1 infection. N Engl J Med 2011; 364:1943-54.
20. Valcour V, Chalermchai T, Sailasuta N, et al. Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis 2012; 206:275-82.
21. Wood E, Kerr T, Rowell G, et al. Does this adult patient have early HIV infection?: The Rational Clinical Examination systematic review. JAMA 2014; 312:278-85.
22. O'Connell R, Rono K, Kunz A, et al. Prospectively ascertained clinical manifestations of very early acute HIV-1 infection among Early Capture HIV Cohort (ECHO) participants in East Africa and Thailand [abstract 60LB]. In: 19th Conference on Retroviruses and Opportunistic Infections, Seattle, March 5-8, 2012.