Pharmacokinetics of colon-specific pH and time-dependent flurbiprofen tablets

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 40, Issue 3, 2015, Pages 301-311

  Vemula, Sateesh Kumar ^a,b   Veerareddy, Prabhakar Reddy ^a,c   Devadasu, Venkat Ratnam ^a  

^a Chaitanya College of Pharmacy Education and Research   (India)

^b ST PETER'S INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^c PALAMURU UNIVERSITY   (India)

Author keywords

Direct compression; In vitro drug release; Lag period; pH sensitive; Time dependent; X ray imaging

Indexed keywords

ALGINIC ACID; EUDRAGIT; FLURBIPROFEN; EXCIPIENT; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; POLYMETHACRYLIC ACID DERIVATIVE; TABLET;

AREA UNDER THE CURVE; AREA UNDER THE MOMENT CURVE; ARTICLE; COLON SPECIFIC PH; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELAYED RELEASE FORMULATION; DRUG BIOAVAILABILITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SCREENING; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; INTESTINE PARAMETERS; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHARMACOKINETICS; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUNTEER; ADULT; CHEMISTRY; COLON; DRUG EFFECTS; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PH; PROCEDURES; SOLUBILITY; TABLET; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; CHEMISTRY, PHARMACEUTICAL; COLON; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FLURBIPROFEN; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; POLYMETHACRYLIC ACIDS; SOLUBILITY; TABLETS; YOUNG ADULT;

EID: 84940607848     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-014-0210-0     Document Type: Article

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