Characterization of 5-fluorouracil release from hydroxypropylmethylcellulose compression-coated tablets

Pharmaceutical Development and Technology

Volumn 12, Issue 2, 2007, Pages 203-210

  Wu, Baojian ^a   Shun, Ningyun ^a   Wei, Xiuli ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Colonic delivery; Compression coated tablets; Fluorouracil; Hydroxypropylmethylcellulose (HPMC); Lag time; Zero order

Indexed keywords

FLUOROURACIL;

ARTICLE; CORRELATION ANALYSIS; DRUG FORMULATION; EVALUATION; HARDNESS; HYDROGEL; MATERIAL COATING; PRIORITY JOURNAL; SLOW DRUG RELEASE; TABLET;

ADMINISTRATION, ORAL; ANTIMETABOLITES, ANTINEOPLASTIC; COLON; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FLUOROURACIL; HARDNESS; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; KINETICS; LACTOSE; LINEAR MODELS; METHYLCELLULOSE; TABLETS, ENTERIC-COATED; VISCOSITY;

EID: 34249109783     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450601168722     Document Type: Article

References (27)

1. Friend, D.R. Colon-specific drug delivery. Adv. Drug Deliv. Rev. 1991, 7, 149-199.
2. Friend, D.R. New oral delivery systems for treatment of inflammatory bowel disease. Adv. Drug Deliv. Rev. 2005, 57, 247-265.
3. Lee, V.H.L.; Mukherjee, S.K. Drug delivery-oral colon-specific. In Encyclopedia of Pharmaceutical Technology. Marcel Dekker: New York, 2002, 871-885.
4. Krishnaiah, Y.S.R.; Satyanarayana, V.; Kumar, B.D.; Karthikeyan, R.S. In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil. Eur. J. Pharm. Sci. 2002, 16, 185-192.
5. Pozzi, F.; Furlani, P.; Gazzaniga, A.; Davis, S.S.; Wilding, I.R. The Time-Clock® system: A new oral dosage form for fast and complete release of drug after predetermined lag time. J. Control. Release 1994, 31, 99-108.
6. Tozaki, H.; Komoike, J.; Tada, C.; Maruyama, T.; Terabe, A.; Suzuki, T.; Yamamoto, A.; Muranishi, S. Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. J. Pharm. Sci. 1997, 86, 1016-1021.
7. Gupta, V.K.; Beckert, T.E.; Price, J.C. A novel pH- and time-based multi-unit potential colonic drug delivery system. I. Development. Int. J. Pharm. 2001, 213, 83-91.
8. Takaya, T.; Ikeda, C.; Imagawa, N.; Niwa, K.; Takada, K. Development of a colon delivery capsule and the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in beagle dogs. J. Pharm. Pharmacol. 1995, 47, 474-478.
9. Ashford, M.; Fell, J.; Atwood, D.; Sharma, H.; Woodhead, P. An evaluation of pectin as a carrier for targeting to the colon. J. Control. Release 1993, 26, 213-220.
10. Krishnaiah, Y.S.R.; Satyanarayana, S.; Rama Prasad, Y.V.; Narasimha Rao, S. Evaluation of guar gum as a compression coat for drug targeting to colon. Int. J. Pharm. 1998, 171, 137-146.
11. Turkoglu, M.; Ugurlu, T. In vitro evaluation of pectin-HPMC compression coated 5-aminosalicylic acid tablets for colonic delivery. Eur. J. Pharm. Biopharm. 2002, 53, 65-73.
12. Conte, U.; Magg, L.; Torre, M.L.; Giunchedi, P.; La Manna, A. Press-coated tablets for time-programmed release of drugs. Biomaterials 1993, 14, 1017-1023.
13. Gazzaniga, A.; Sangalli, M.; Giordano, F. Oral chronotopic drug delivery systems: achievement of time and/or site specificity. Eur. J. Pharm. Biopharm. 1994, 40, 246-250.
14. Matsuo, M.; Arimori, K.; Nakamura, C.; Nakano, M. Delayed-release tablets using hydroxyethycellulose as a gel-forming matrix. Int. J. Pharm. 1996, 138, 225-235.
15. Fukui, E.; Uemura, K.; Kobayashi, M. Studies on applicability of press-coated tablets using hydroxypropylcellulose (HPC) in the outer shell for timed-release preparations. J. Control. Release 2000, 68, 215-223.
16. Sawada, T.; Sako, K.; Fukui, M.; Yokohama, S.; Hayashi, M. A new index, the core erosion ratio, of compression-coated timed-release tablets predicts the bioavailability of acetaminophen. Int. J. Pharm. 2003, 265, 55-63.
17. Potter, J.D. Colorectal cancer: Molecules and populations. J. Natl. Cancer Inst. 1999, 91, 916-932.
18. Calabresi, P.; Chabner, B.A. Chemotherapy of neoplastic diseases. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th Ed.; McGraw-Hill: New Delhi, 1996, 1225-1232.
19. Hahn, R.G.; Moertel, C.G.; Schutt, A.J. A double-blind comparison of intensive course 5-fluorouracil by oral versus intravenous route in the treatment of colorectal carcinoma. Cancer 1975, 35, 1031-1035.
20. Diasio, R.B.; Harris, B.E. Clinical pharmacology of 5-fluorouracil. Clin. Pharmacokinet. 1989, 16, 215-237.
21. Ji, C.M.; Xu, H.N.; Wu, W. A novel pH-, time- and enzyme-controlled multi-unit colon-specific delivery system of 5-fluorouracil based on guar gum coating. Arch. Pharm. Res. In press.
22. Fyfe, C.A.; Grondey, H.; Blazek-Welsh, A.I.; Chopra, S.K.; Fahie, B.J. NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus. J. Control. Release 2000, 68, 73-83.
23. Gao, P.; Meury, R.H. Swelling of hydroxypropyl methylcellulose matrix tablets. 1. characterization of swelling using a novel optical imaging method. J. Pharm. Sci. 1996, 85, 725-731.
24. Colombo, P.; Bettini, R.; Peppas, N.A. Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug. J. Control. Release 1999, 61, 83-91.
25. Campos-Aldrete, M.E.; Villafuerte-Robles, L. Influence of the viscosity grade and the particle size of HPMC on metronidazole release from matrix tablets. Eur. J. Pharm. Biopharm. 1997, 43, 173-178.
26. Gao, P.; Skoug, J.W.; Nixon, P.R.; Ju, T.R.; Stemm, N.L.; Sung, K.C. Swelling of hydroxypropyl methylcellulose matrix tablets. 2. Mechanistic study of the influence of formulation variables on matrix performance and drug release. J. Pharm. Sci. 1996, 85, 732-740.
27. Sako, K.; Sawada, T.; Nakashima, H.; Yokohama, S.; Sonobe, T. Influence of water soluble fillers in hydroxypro-pylmethylcellulose matrices on in vitro and in vivo drug release. J. Control. Release 2002, 81, 165-172.