Sortase A-mediated synthesis of ligand-grafted cyclized peptides for modulating a model protein-protein interaction

Biotechnology Journal

Volumn 10, Issue 9, 2015, Pages 1499-1505

  Zhang, Jing ^a   Yamaguchi, Satoshi ^a   Nagamune, Teruyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Peptide cyclization; Peptide drugs; Protein protein interactions; Sortase A; Sunflower trypsin inhibitor 1

Indexed keywords

BIOSYNTHESIS; CHELATION; CYCLIZATION; DRUG INTERACTIONS; GRAFTING (CHEMICAL); LIGANDS; POLYPEPTIDES; PROTEINS;

N METHYL D ASPARTATE RECEPTOR; NATURALLY OCCURRING; PEPTIDE DRUGS; POSTSYNAPTIC DENSITIES; PROTEIN-PROTEIN INTERACTIONS; PROTEOLYTIC STABILITY; SORTASE A; SUNFLOWER TRYPSIN INHIBITOR-1;

PEPTIDES;

CYCLOPEPTIDE; LIGAND; MOLECULAR SCAFFOLD; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PDZ PROTEIN; PDZ2 PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SORTASE; SORTASE A; SUNFLOWER TRYPSIN INHIBITOR 1; TETRAPEPTIDE; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; AMINOACYLTRANSFERASE; BACTERIAL PROTEIN; CYSTEINE PROTEINASE; PROTEIN BINDING; SFTI-1 PEPTIDE, SUNFLOWER;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; HUMAN; MOLECULAR STABILITY; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; METABOLISM; PROTEIN STABILITY;

AMINOACYLTRANSFERASES; BACTERIAL PROTEINS; CYSTEINE ENDOPEPTIDASES; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STABILITY;

EID: 84940600691     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500013     Document Type: Article

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