A simple, high-throughput, colourimetric, field applicable loop-mediated isothermal amplification (HtLAMP) assay for malaria elimination

Malaria Journal

Volumn 14, Issue 1, 2015, Pages

  Britton, Sumudu ^a,b   Cheng, Qin ^c   Sutherland, Colin J ^d   McCarthy, James S ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Diagnosis; Elimination; High throughput; LAMP; Loop mediated isothermal amplification; Malaria

Indexed keywords

CALCIUM CHLORIDE; CHEMICAL COMPOUND; HYDROXYNAPHTHOLBLUE; MAGNESIUM SULFATE; UNCLASSIFIED DRUG; MITOCHONDRIAL DNA; NAPHTHALENESULFONIC ACID DERIVATIVE; PROTOZOAL DNA; TRISODIUM 3-HYDROXY-4-((2Z)-2-(2-OXO-4-SULFONATONAPHTHALEN-1-YLIDENE)HYDRAZINYL)NAPHTHALENE-2,7-DISULFONATE;

ARTICLE; CHILD; COLOR; COLORIMETRY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEASIBILITY STUDY; GAMBIA; GHANA; HIGH THROUGHPUT SCREENING; HUMAN; LIMIT OF DETECTION; LOOP MEDIATED ISOTHERMAL AMPLIFICATION; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALAYSIA; OPTICAL DENSITY; PAPUA NEW GUINEA; PATHOGEN CLEARANCE; PH; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY; BLOOD; GENETICS; MALARIA; NUCLEIC ACID AMPLIFICATION; PARASITEMIA; PARASITOLOGY; PROCEDURES; REPRODUCIBILITY;

CALCIUM CHLORIDE; COLORIMETRY; DNA, MITOCHONDRIAL; DNA, PROTOZOAN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIMIT OF DETECTION; MAGNESIUM SULFATE; MALARIA; NAPHTHALENESULFONATES; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PARASITEMIA; REPRODUCIBILITY OF RESULTS;

EID: 84940488194     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-015-0848-3     Document Type: Article

References (44)

1. WHO. Global malaria control and elimination: report of a technical review. Geneva: World Health Organization; 2008.
2. WHO. Disease surveillance for malaria elimination: an operational manual. Geneva: World Health Organization; 2012.
3. Okell LC, Bousema T, Griffin JT, Ouedraogo AL, Ghani AC, Drakeley CJ. Factors determining the occurrence of submicroscopic malaria infections and their relevance for control. Nat Commun. 2012;3:1237.
4. Coleman RE, Maneechai N, Rachaphaew N, Kumpitak C, Miller RS, Soyseng V, et al. Comparison of field and expert laboratory microscopy for active surveillance for asymptomatic Plasmodium falciparum and Plasmodium vivax in western Thailand. Am J Trop Med Hyg. 2002;67:141-4.
5. Okell LC, Ghani AC, Lyons E, Drakeley CJ. Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis. J Infect Dis. 2009;200:1509-17.
6. Bousema T, Drakeley C. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin Microbiol Rev. 2011;24:377-410.
7. MalERA Consultative Group on Diagnoses and Diagnostics. A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med 2011; 8:e1000396.
8. WHO. WHO evidence review group on malaria diagnosis in low transmission settings, 16-18 December 2013. Geneva: World Health Organization; 2014.
9. Mori Y, Nagamine K, Tomita N, Notomi T. Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation. Biochem Biophys Res Commun. 2001;289:150-4.
10. Tomita N, Mori Y, Kanda H, Notomi T. Loop-mediated isothermal amplification (LAMP) of gene sequences and simple visual detection of products. Nat Protoc. 2008;3:877-82.
11. Goto M, Honda E, Ogura A, Nomoto A, Hanaki K. Colorimetric detection of loop-mediated isothermal amplification reaction by using hydroxy naphthol blue. Biotechniques. 2009;46:167-72.
12. Wastling SL, Picozzi K, Kakembo ASL, Welburn SC. LAMP for Human African trypanosomiasis: a comparative study of detection formats. PLoS Negl Trop Dis. 2010;4:e865.
13. Yamamura M, Makimura K, Ota Y. Evaluation of a new rapid molecular diagnostic system for Plasmodium falciparum combined with DNA filter paper, loop-mediated isothermal amplification, and melting curve analysis. Jpn J Infect Dis. 2009;62:20-5.
14. Kiddle G, Hardinge P, Buttigieg N, Gandelman O, Pereira C, McElgunn CJ, et al. GMO detection using a bioluminescent real time reporter (BART) of loop mediated isothermal amplification (LAMP) suitable for field use. BMC Biotechnol. 2012;12:15.
15. Njiru ZK, Mikosza AS, Armstrong T, Enyaru JC, Ndung'u JM, Thompson AR. Loop-mediated isothermal amplification (LAMP) method for rapid detection of Trypanosoma brucei rhodesiense. PLoS Negl Trop Dis. 2008;2:e147.
16. Lucchi NW, Demas A, Narayanan J, Sumari D, Kabanywanyi A, Kachur SP, et al. Real-time fluorescence loop mediated isothermal amplification for the diagnosis of malaria. PLoS One. 2010;5:e13733.
17. Ou X, Li Q, Xia H, Pang Y, Wang S, Zhao B, et al. Diagnostic accuracy of the PURE-LAMP test for pulmonary tuberculosis at the county-level laboratory in China. PLoS One. 2014;9:e94544.
18. Dittrich S, Castonguay-Vanier J, Moore CE, Thongyoo N, Newton PN, Paris DH. Loop-mediated isothermal amplification for Rickettsia typhi (the causal agent of murine typhus): problems with diagnosis at the limit of detection. J Clin Microbiol. 2014;52:832-8.
19. Luo L, Nie K, Yang MJ, Wang M, Li J, Zhang C, et al. Visual detection of high-risk human papillomavirus genotypes 16, 18, 45, 52, and 58 by loop-mediated isothermal amplification with hydroxynaphthol blue dye. J Clin Microbiol. 2011;49:3545-50.
20. Scheel CM, Zhou Y, Theodoro RC, Abrams B, Balajee SA, Litvintseva AP. Development of a loop-mediated isothermal amplification method for detection of Histoplasma capsulatum DNA in clinical samples. J Clin Microbiol. 2014;52:483-8.
21. Arimatsu Y, Kaewkes S, Laha T, Sripa B. Specific diagnosis of Opisthorchis viverrini using loop-mediated isothermal amplification (LAMP) targeting parasite microsatellites. Acta Trop. 2015;141:368-71.
22. Poon LL, Wong BW, Ma EH, Chan KH, Chow LM, Abeyewickreme W, et al. Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification. Clin Chem. 2006;52:303-6.
23. Polley SD, Mori Y, Watson J, Perkins MD, Gonzalez IJ, Notomi T, et al. Mitochondrial DNA targets increase sensitivity of malaria detection using loop-mediated isothermal amplification. J Clin Microbiol. 2010;48:2866-71.
24. Han E, Watanabe R, Sattabongkot J, Khuntirat B, Sirichaisinthop J, Iriko H. Detection of four Plasmodium species by genus and species-specific loop mediated isothermal amplication for clinical diagnosis. J Clin Microbiol. 2007;45:2521-8.
25. Lau YL, Fong MY, Mahmud R, Chang PY, Palaeya V, Cheong FW, et al. Specific, sensitive and rapid detection of human Plasmodium knowlesi infection by loop-mediated isothermal amplification (LAMP) in blood samples. Malar J. 2011;10:197.
26. Iseki H, Kawai S, Takahashi N, Hirai M, Tanabe K, Yokoyama N, et al. Evaluation of a loop-mediated isothermal amplification method as a tool for diagnosis of infection by the zoonotic simian malaria parasite Plasmodium knowlesi. J Clin Microbiol. 2010;48:2509-14.
27. Polley SD, Gonzalez IJ, Mohamed D, Daly R, Bowers K, Watson J, et al. Clinical evaluation of a loop-mediated amplification kit for diagnosis of imported malaria. J Infect Dis. 2013;208:637-44.
28. Patel JC, Oberstaller J, Xayavong M, Narayanan J, Debarry JD, Srinivasamoorthy G, et al. Real-time loop-mediated isothermal amplification (ReaLamp) for the species-specific identification of Plasmodium vivax. PLoS One. 2013;8:e54986.
29. Lu F, Gao Q, Zhou H, Cao J, Wang W, Lim CS, et al. Molecular test for vivax malaria with loop-mediated isothermal amplification method in central China. Parasitol Res. 2011;110:2439-44.
30. Hopkins H, Gonzalez IJ, Polley SD, Angutoko P, Ategeka J, Asiimwe C, et al. Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J Infect Dis. 2013;208:645-52.
31. Cook J, Aydin-Schmidt B, Gonzalez IJ, Bell D, Edlund E, Nassor MH, et al. Loop-mediated isothermal amplification (LAMP) for point-of-care detection of asymptomatic low-density malaria parasite carriers in Zanzibar. Malar J. 2015;14:43.
32. Vallejo AF, Martinez NL, Gonzalez IJ, Arevalo-Herrera M, Herrera S. Evaluation of the loop mediated isothermal DNA amplification (LAMP) kit for malaria diagnosis in P. vivax endemic settings of Colombia. PLoS Negl Trop Dis. 2015;9:e3453.
33. Hsiang MS, Greenhouse B, Rosenthal PJ. Point of care testing for malaria using LAMP, loop mediated isothermal amplification. J Infect Dis. 2014;210:1167-9.
34. Dinko B, Oguike M, Larbi J, Bousema T, Sutherland C. Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children. Int J Parasitol Drugs Drug Resist. 2013;3:45-50.
35. Sutherland CJ, Ord R, Dunyo S, Jawara M, Drakeley CJ, Alexander N, et al. Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether. PLoS Med. 2005;2:e92.
36. Grigg MJ, William T, Drakeley CJ, Jelip J, von Seidlein L, Barber BE, et al. Factors that are associated with the risk of acquiring Plasmodium knowlesi malaria in Sabah, Malaysia: a case-control study protocol. BMJ Open. 2014;4:e006004.
37. Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg. 1995;52:565-8.
38. Walsh PS, Metzger DA, Higuchi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques. 1991;10:506-13.
39. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, et al. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol. 1993;61:315-20.
40. Padley D, Moody AH, Chiodini PL, Saldanha J. Use of a rapid, single-round, multiplex PCR to detect malarial parasites and identify the species present. Ann Trop Med Parasitol. 2003;97:131-7.
41. MedCalc. http://www.medcalc.org/calc/diagnostic-test.php.
42. Sema M, Alemu A, Bayih A, Getie S, Getnet G, Guelig D, et al. Evaluation of non-instrumented nucleic acid amplification by loop-mediated isothermal amplification (NINA-LAMP) for the diagnosis of malaria in Northwest Ethiopia. Malar J. 2015;14:44.
43. Yongkiettrakul S, Jaroenram W, Arunrut N, Chareanchim W, Pannengpetch S, Suebsing R, et al. Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax. Parasitol Int. 2014;63:777-84.
44. Morris U, Khamis M, Aydin-Schmidt B, Abass AK, Msellem MI, Nassor MH, et al. Field deployment of loop-mediated isothermal amplification for centralized mass-screening of asymptomatic malaria in Zanzibar: a pre-elimination setting. Malar J. 2015;14:205.