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Volumn 6, Issue AUG, 2015, Pages

Toward a deeper understanding of the genetics of bipolar disorder

Author keywords

Bipolar disorder; Common genomic polymorphisms; Deep sequencing; Genetic models of transmission; Rare variants

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

EID: 84940485076     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2015.00105     Document Type: Review
Times cited : (33)

References (75)
  • 2
    • 79952327729 scopus 로고    scopus 로고
    • Prevalence and correlates of bipolar spectrum disorder in the World Mental Health Survey Initiative
    • Merikangas KR, Jin R, He J, Kessler RC, Lee S, Sampson NA, et al. Prevalence and correlates of bipolar spectrum disorder in the World Mental Health Survey Initiative. Arch Gen Psychiatry (2011) 68(3):241-51. doi: 10.1001/archgenpsychiatry.2011.12.
    • (2011) Arch Gen Psychiatry , vol.68 , Issue.3 , pp. 241-251
    • Merikangas, K.R.1    Jin, R.2    He, J.3    Kessler, R.C.4    Lee, S.5    Sampson, N.A.6
  • 3
    • 0003472502 scopus 로고    scopus 로고
    • 5th ed. Washington, DC: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). 5th ed. Washington, DC: American Psychiatric Association (2013). doi:10.1176/appi.books.9780890425596.
    • (2013) Diagnostic and Statistical Manual of Mental Disorders (DSM-5®)
  • 4
    • 0035719896 scopus 로고    scopus 로고
    • The significance of psychotic features in manic episodes: a report from the NIMH collaborative study
    • Coryell W, Leon AC, Turvey C, Akiskal HS, Mueller T, Endicott J. The significance of psychotic features in manic episodes: a report from the NIMH collaborative study. J Affect Disord (2001) 67(1-3):79-88. doi:10.1016/S0165-0327(99)00024-5.
    • (2001) J Affect Disord , vol.67 , Issue.1-3 , pp. 79-88
    • Coryell, W.1    Leon, A.C.2    Turvey, C.3    Akiskal, H.S.4    Mueller, T.5    Endicott, J.6
  • 5
    • 4744342062 scopus 로고    scopus 로고
    • High concordance of bipolar I disorder in a nationwide sample of twins
    • Kieseppä T, Partonen T, Haukka J, Kaprio J, Lönnqvist J. High concordance of bipolar I disorder in a nationwide sample of twins. Am J Psychiatry (2004) 161:1814-21. doi:10.1176/appi.ajp.161.10.1814.
    • (2004) Am J Psychiatry , vol.161 , pp. 1814-1821
    • Kieseppä, T.1    Partonen, T.2    Haukka, J.3    Kaprio, J.4    Lönnqvist, J.5
  • 6
    • 84924260749 scopus 로고    scopus 로고
    • Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population
    • Song J, Bergen SE, Kuja-Halkola R, Larsson H, Landén M, Lichtenstein P. Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population. Bipolar Disord (2015) 17(2):184-93. doi:10.1111/bdi.12242.
    • (2015) Bipolar Disord , vol.17 , Issue.2 , pp. 184-193
    • Song, J.1    Bergen, S.E.2    Kuja-Halkola, R.3    Larsson, H.4    Landén, M.5    Lichtenstein, P.6
  • 7
    • 84887117505 scopus 로고    scopus 로고
    • Childhood trauma is associated with severe clinical characteristics of bipolar disorders
    • Etain B, Aas M, Andreassen OA, Lorentzen S, Dieset I, Gard S, et al. Childhood trauma is associated with severe clinical characteristics of bipolar disorders. J Clin Psychiatry (2013) 74(10):991-8. doi:10.4088/JCP.13m08353.
    • (2013) J Clin Psychiatry , vol.74 , Issue.10 , pp. 991-998
    • Etain, B.1    Aas, M.2    Andreassen, O.A.3    Lorentzen, S.4    Dieset, I.5    Gard, S.6
  • 8
    • 84900353288 scopus 로고    scopus 로고
    • Environmental factors during adolescence associated with later development of psychotic disorders-a nested case-control study
    • Bratlien U, Øie M, Haug E, Møller P, Andreassen OA, Lien L, et al. Environmental factors during adolescence associated with later development of psychotic disorders-a nested case-control study. Psychiatry Res (2014) 215(3):579-85. doi:10.1016/j.psychres.2013.12.048.
    • (2014) Psychiatry Res , vol.215 , Issue.3 , pp. 579-585
    • Bratlien, U.1    Øie, M.2    Haug, E.3    Møller, P.4    Andreassen, O.A.5    Lien, L.6
  • 9
    • 84899904660 scopus 로고    scopus 로고
    • Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder
    • Severance EG, Gressitt KL, Yang S, Stallings CR, Origoni AE, Vaughan C, et al. Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder. Bipolar Disord (2014) 16(3):230-40. doi:10.1111/bdi.12159.
    • (2014) Bipolar Disord , vol.16 , Issue.3 , pp. 230-240
    • Severance, E.G.1    Gressitt, K.L.2    Yang, S.3    Stallings, C.R.4    Origoni, A.E.5    Vaughan, C.6
  • 12
    • 0023091644 scopus 로고
    • Bipolar affective disorders linked to DNA markers on chromosome 11
    • Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, et al. Bipolar affective disorders linked to DNA markers on chromosome 11. Nature (1987) 325(6107):783-7. doi:10.1038/325783a0.
    • (1987) Nature , vol.325 , Issue.6107 , pp. 783-787
    • Egeland, J.A.1    Gerhard, D.S.2    Pauls, D.L.3    Sussex, J.N.4    Kidd, K.K.5    Allen, C.R.6
  • 13
    • 0023135304 scopus 로고
    • Molecular genetic evidence for heterogeneity in manic depression
    • Hodgkinson S, Sherrington R, Gurling H, Marchbanks R, Reeders S, Mallet J, et al. Molecular genetic evidence for heterogeneity in manic depression. Nature (1987) 325(6107):805-6. doi:10.1038/325805a0.
    • (1987) Nature , vol.325 , Issue.6107 , pp. 805-806
    • Hodgkinson, S.1    Sherrington, R.2    Gurling, H.3    Marchbanks, R.4    Reeders, S.5    Mallet, J.6
  • 14
    • 0029916003 scopus 로고    scopus 로고
    • A manic depressive history. Editorial
    • Risch N, Botstein D. A manic depressive history. Editorial. Nat Genet (1996) 12:351-3. doi:10.1038/ng0496-351.
    • (1996) Nat Genet , vol.12 , pp. 351-353
    • Risch, N.1    Botstein, D.2
  • 16
    • 0001248345 scopus 로고
    • Segregation analysis of the NIMH Collaborative study. Family data on bipolar disorder
    • Sham PC, Morton NE, Rice JP. Segregation analysis of the NIMH Collaborative study. Family data on bipolar disorder. Psychiatr Genet (1991) 2:175-84. doi:10.1097/00041444-199203000-00002.
    • (1991) Psychiatr Genet , vol.2 , pp. 175-184
    • Sham, P.C.1    Morton, N.E.2    Rice, J.P.3
  • 17
    • 0019295650 scopus 로고
    • The transmission of manic depressive illness-II. Segregation analysis of three sets of family data
    • Bucher KD, Elston RC, Green R, Whybrow P, Helzer J, Reich T, et al. The transmission of manic depressive illness-II. Segregation analysis of three sets of family data. J Psychiatr Res (1981) 16(1):65-78. doi:10.1016/0022-3956(81)90014-5.
    • (1981) J Psychiatr Res , vol.16 , Issue.1 , pp. 65-78
    • Bucher, K.D.1    Elston, R.C.2    Green, R.3    Whybrow, P.4    Helzer, J.5    Reich, T.6
  • 18
    • 0020583285 scopus 로고
    • Segregation and linkage analyses in families of patients with bipolar, unipolar, and schizoaffective mood disorders
    • Goldin LR, Gershon ES, Targum SD, Sparkes RS, McGinniss M. Segregation and linkage analyses in families of patients with bipolar, unipolar, and schizoaffective mood disorders. Am J Hum Genet (1983) 35(2):274-87.
    • (1983) Am J Hum Genet , vol.35 , Issue.2 , pp. 274-287
    • Goldin, L.R.1    Gershon, E.S.2    Targum, S.D.3    Sparkes, R.S.4    McGinniss, M.5
  • 19
    • 0029612332 scopus 로고
    • The bipolar spectrum: research and clinical perspectives
    • Akiskal HS. The bipolar spectrum: research and clinical perspectives. Encephalocele (1995) 6:3-11.
    • (1995) Encephalocele , vol.6 , pp. 3-11
    • Akiskal, H.S.1
  • 20
    • 0031581780 scopus 로고    scopus 로고
    • Single major locus models for bipolar disorder are implausible
    • Craddock N, Van Eerdewegh P, Reich T. Single major locus models for bipolar disorder are implausible. Am J Med Genet (1997) 74:18. doi:10.1002/(SICI)1096-8628(19970221)74:1<18::AID-AJMG4>3.0.CO;2-R.
    • (1997) Am J Med Genet , vol.74 , pp. 18
    • Craddock, N.1    Van Eerdewegh, P.2    Reich, T.3
  • 21
    • 17944377728 scopus 로고    scopus 로고
    • Evolutionary epidemiology and manic depression
    • Wilson DR. Evolutionary epidemiology and manic depression. Br J Med Psychol (1998) 71(Pt 4):375-95. doi:10.1111/j.2044-8341.1998.tb00999.x.
    • (1998) Br J Med Psychol , vol.71 , pp. 375-395
    • Wilson, D.R.1
  • 22
    • 0026830747 scopus 로고
    • Evolutionary epidemiology
    • Wilson DR. Evolutionary epidemiology. Acta Biotheor (1992) 40:87-90. doi:10.1007/BF00046552.
    • (1992) Acta Biotheor , vol.40 , pp. 87-90
    • Wilson, D.R.1
  • 24
    • 78649232434 scopus 로고    scopus 로고
    • Extensive changes in the expression of the opioid genes between humans and chimpanzees
    • Cruz-Gordillo P, Fedrigo O, Wray GA, Babbitt CC. Extensive changes in the expression of the opioid genes between humans and chimpanzees. Brain Behav Evol (2010) 76(2):154-62. doi:10.1159/000320968.
    • (2010) Brain Behav Evol , vol.76 , Issue.2 , pp. 154-162
    • Cruz-Gordillo, P.1    Fedrigo, O.2    Wray, G.A.3    Babbitt, C.C.4
  • 25
    • 84874069538 scopus 로고    scopus 로고
    • Identifying recent adaptations in large-scale genomic data
    • Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, Yen A, et al. Identifying recent adaptations in large-scale genomic data. Cell (2013) 152(4):703-13. doi:10.1016/j.cell.2013.01.035.
    • (2013) Cell , vol.152 , Issue.4 , pp. 703-713
    • Grossman, S.R.1    Andersen, K.G.2    Shlyakhter, I.3    Tabrizi, S.4    Winnicki, S.5    Yen, A.6
  • 26
    • 84907202723 scopus 로고    scopus 로고
    • Intersection of population variation and autoimmunity genetics in human T cell activation
    • Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science (2014) 345(6202):1254665. doi:10.1126/science.1254665.
    • (2014) Science , vol.345 , Issue.6202
    • Ye, C.J.1    Feng, T.2    Kwon, H.K.3    Raj, T.4    Wilson, M.T.5    Asinovski, N.6
  • 27
    • 80655134678 scopus 로고    scopus 로고
    • Great wits and madness: more near allied?
    • Jamison KR. Great wits and madness: more near allied? Br J Psychiatry (2011) 199(5):351-2. doi:10.1192/bjp.bp.111.100586.
    • (2011) Br J Psychiatry , vol.199 , Issue.5 , pp. 351-352
    • Jamison, K.R.1
  • 28
    • 75749103383 scopus 로고    scopus 로고
    • Rate, molecular spectrum, and consequences of human mutation
    • Lynch M. Rate, molecular spectrum, and consequences of human mutation. Proc Natl Acad Sci U S A (2010) 107(3):961-8. doi:10.1073/pnas.0912629107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.3 , pp. 961-968
    • Lynch, M.1
  • 29
    • 0012744632 scopus 로고
    • The wave of advance of an advantageous gene: the sickle cell gene in Liberia
    • Livingstone FB. The wave of advance of an advantageous gene: the sickle cell gene in Liberia. Hum Biol (1960) 32:197-202.
    • (1960) Hum Biol , vol.32 , pp. 197-202
    • Livingstone, F.B.1
  • 30
    • 78650101852 scopus 로고    scopus 로고
    • Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis
    • Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Williams TN, et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat Commun (2010) 1:104. doi:10.1038/ncomms1104.
    • (2010) Nat Commun , vol.1 , pp. 104
    • Piel, F.B.1    Patil, A.P.2    Howes, R.E.3    Nyangiri, O.A.4    Gething, P.W.5    Williams, T.N.6
  • 31
    • 0026523829 scopus 로고
    • Cystic fibrosis: molecular biology and therapeutic implication
    • Collins F. Cystic fibrosis: molecular biology and therapeutic implication. Science (1992) 256:774-80. doi:10.1126/science.1375392.
    • (1992) Science , vol.256 , pp. 774-780
    • Collins, F.1
  • 32
    • 77957999545 scopus 로고    scopus 로고
    • Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population
    • Bray SM, Mulle JG, Dodd AF, Pulver AE, Wooding S, Warren ST. Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population. Proc Natl Acad Sci U S A (2010) 107(37):16222-7. doi:10.1073/pnas.1004381107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.37 , pp. 16222-16227
    • Bray, S.M.1    Mulle, J.G.2    Dodd, A.F.3    Pulver, A.E.4    Wooding, S.5    Warren, S.T.6
  • 33
    • 0029805706 scopus 로고    scopus 로고
    • The new genomics: global views of biology
    • Lander ES. The new genomics: global views of biology. Science (1996) 274(5287):536-9. doi:10.1126/science.274.5287.536.
    • (1996) Science , vol.274 , Issue.5287 , pp. 536-539
    • Lander, E.S.1
  • 34
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science (1996) 273(5281):1516-7. doi:10.1126/science.273.5281.1516.
    • (1996) Science , vol.273 , Issue.5281 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 35
    • 50449089356 scopus 로고    scopus 로고
    • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    • Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 40(9):1056-8. doi:10.1038/ng.209.
    • (2008) Nat Genet , vol.40 , Issue.9 , pp. 1056-1058
    • Ferreira, M.A.1    O'Donovan, M.C.2    Meng, Y.A.3    Jones, I.R.4    Ruderfer, D.M.5    Jones, L.6
  • 36
    • 84863470133 scopus 로고    scopus 로고
    • ANK3 and CACNA1C-missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples
    • Kloiber S, Czamara D, Karbalai N, Müller-Myhsok B, Hennings J, Holsboer F, et al. ANK3 and CACNA1C-missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. J Psychiatr Res (2012) 46(8):973-9. doi:10.1016/j.jpsychires.2012.04.017.
    • (2012) J Psychiatr Res , vol.46 , Issue.8 , pp. 973-979
    • Kloiber, S.1    Czamara, D.2    Karbalai, N.3    Müller-Myhsok, B.4    Hennings, J.5    Holsboer, F.6
  • 39
    • 84869852166 scopus 로고    scopus 로고
    • Re-sequencing of ankyrin 3 exon 48 and case-control association analysis of rare variants in bipolar disorder type I
    • Doyle GA, Lai AT, Chou AD, Wang MJ, Gai X, Rappaport EF, et al. Re-sequencing of ankyrin 3 exon 48 and case-control association analysis of rare variants in bipolar disorder type I. Bipolar Disord (2012) 14(8):809-21. doi:10.1111/bdi.12002.
    • (2012) Bipolar Disord , vol.14 , Issue.8 , pp. 809-821
    • Doyle, G.A.1    Lai, A.T.2    Chou, A.D.3    Wang, M.J.4    Gai, X.5    Rappaport, E.F.6
  • 40
    • 85027920560 scopus 로고    scopus 로고
    • Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data
    • Fiorentino A, O'Brien NL, Locke DP, McQuillin A, Jarram A, Anjorin A, et al. Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data. Bipolar Disord (2014) 16(6):583-91. doi:10.1111/bdi.12203.
    • (2014) Bipolar Disord , vol.16 , Issue.6 , pp. 583-591
    • Fiorentino, A.1    O'Brien, N.L.2    Locke, D.P.3    McQuillin, A.4    Jarram, A.5    Anjorin, A.6
  • 41
    • 79951633793 scopus 로고    scopus 로고
    • Ten questions for evolutionary studies of disease vulnerability
    • Nesse RM. Ten questions for evolutionary studies of disease vulnerability. Evol Appl (2011) 4(2):264-77. doi:10.1111/j.1752-4571.2010.00181.x.
    • (2011) Evol Appl , vol.4 , Issue.2 , pp. 264-277
    • Nesse, R.M.1
  • 42
    • 77049227329 scopus 로고
    • Stochastic processes and distribution of gene frequencies in natural selection
    • Kimura M. Stochastic processes and distribution of gene frequencies in natural selection. Cold Spring Harb Symp Quant Biol (1955) 22:33-53. doi:10.1101/SQB.1955.020.01.006.
    • (1955) Cold Spring Harb Symp Quant Biol , vol.22 , pp. 33-53
    • Kimura, M.1
  • 43
    • 0019470010 scopus 로고
    • Familial patterns and possible modes of inheritance of primary affective disorders
    • Smeraldi E, Negri F, Heimbuch RC, Kidd KK. Familial patterns and possible modes of inheritance of primary affective disorders. J Affect Disord (1981) 3(2):173-82. doi:10.1016/0165-0327(81)90042-2.
    • (1981) J Affect Disord , vol.3 , Issue.2 , pp. 173-182
    • Smeraldi, E.1    Negri, F.2    Heimbuch, R.C.3    Kidd, K.K.4
  • 44
    • 69449104975 scopus 로고    scopus 로고
    • Genetics of human iris colour and patterns
    • Sturm RA, Larsson M. Genetics of human iris colour and patterns. Pigment Cell Melanoma Res (2009) 22(5):544-62. doi:10.1111/j.1755-148X.2009.00606.x.
    • (2009) Pigment Cell Melanoma Res , vol.22 , Issue.5 , pp. 544-562
    • Sturm, R.A.1    Larsson, M.2
  • 45
    • 79251622232 scopus 로고    scopus 로고
    • Genotype-phenotype associations and human eye color
    • White D, Rabago-Smith M. Genotype-phenotype associations and human eye color. J Hum Genet (2011) 56(1):5-7. doi:10.1038/jhg.2010.126.
    • (2011) J Hum Genet , vol.56 , Issue.1 , pp. 5-7
    • White, D.1    Rabago-Smith, M.2
  • 46
    • 84856735797 scopus 로고    scopus 로고
    • Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12,000 twin pairs
    • Dubois L, Ohm Kyvik K, Girard M, Tatone-Tokuda F, Pérusse D, Hjelmborg J, et al. Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12,000 twin pairs. PLoS One (2012) 7(2):e30153. doi:10.1371/journal.pone.0030153.
    • (2012) PLoS One , vol.7 , Issue.2
    • Dubois, L.1    Ohm Kyvik, K.2    Girard, M.3    Tatone-Tokuda, F.4    Pérusse, D.5    Hjelmborg, J.6
  • 47
    • 77955058518 scopus 로고
    • The inheritance of liability to certain diseases, estimated from the incidence among relatives
    • Falconer DS. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet (1965) 29:51-76. doi:10.1111/j.1469-1809.1965.tb00500.x.
    • (1965) Ann Hum Genet , vol.29 , pp. 51-76
    • Falconer, D.S.1
  • 50
    • 0023600006 scopus 로고
    • Clinical genetics as clues to the "real" genetics of schizophrenia (a decade of modest gains while playing for time)
    • Gottesman II, McGuffin P, Farmer AE. Clinical genetics as clues to the "real" genetics of schizophrenia (a decade of modest gains while playing for time). Schizophr Bull (1987) 13(1):23-47. doi:10.1093/schbul/13.1.23.
    • (1987) Schizophr Bull , vol.13 , Issue.1 , pp. 23-47
    • Gottesman, I.I.1    McGuffin, P.2    Farmer, A.E.3
  • 51
    • 0034947459 scopus 로고    scopus 로고
    • Assortative mating in the affective disorders: a systematic review and meta-analysis
    • Mathews CA, Reus VI. Assortative mating in the affective disorders: a systematic review and meta-analysis. Compr Psychiatry (2001) 42(4):257-62. doi:10.1053/comp.2001.24575.
    • (2001) Compr Psychiatry , vol.42 , Issue.4 , pp. 257-262
    • Mathews, C.A.1    Reus, V.I.2
  • 52
    • 0019434406 scopus 로고
    • Multiple-threshold transmission of affective disorders
    • Baron M, Klotz J, Mendlewicz J, Rainer J. Multiple-threshold transmission of affective disorders. Arch Gen Psychiatry (1981) 38(1):79-84. doi:10.1001/archpsyc.1981.01780260081009.
    • (1981) Arch Gen Psychiatry , vol.38 , Issue.1 , pp. 79-84
    • Baron, M.1    Klotz, J.2    Mendlewicz, J.3    Rainer, J.4
  • 53
    • 0022393222 scopus 로고
    • Multiple threshold models for the affective disorders: the Yale-NIMH collaborative family study
    • Price RA, Kidd KK, Pauls DL, Gershon ES, Prusoff BA, Weissman MM, et al. Multiple threshold models for the affective disorders: the Yale-NIMH collaborative family study. J Psychiatr Res (1985) 19(4):533-46. doi:10.1016/0022-3956(85)90071-8.
    • (1985) J Psychiatr Res , vol.19 , Issue.4 , pp. 533-546
    • Price, R.A.1    Kidd, K.K.2    Pauls, D.L.3    Gershon, E.S.4    Prusoff, B.A.5    Weissman, M.M.6
  • 54
    • 0029168042 scopus 로고
    • Mathematical limits of multilocus models: the genetic transmission of bipolar disorder
    • Craddock N, Khodel V, Van Eerdewegh P, Reich T. Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet (1995) 57:690-702.
    • (1995) Am J Hum Genet , vol.57 , pp. 690-702
    • Craddock, N.1    Khodel, V.2    Van Eerdewegh, P.3    Reich, T.4
  • 55
    • 84897450080 scopus 로고    scopus 로고
    • Rare genomic variants link bipolar disorder with anxiety disorders to CREB-regulated intracellular signaling pathways
    • Kerner B, Rao AR, Christensen B, Dandekar S, Yourshaw M, Nelson SF. Rare genomic variants link bipolar disorder with anxiety disorders to CREB-regulated intracellular signaling pathways. Front Psychiatry (2013) 4:154. doi:10.3389/fpsyt.2013.00154.
    • (2013) Front Psychiatry , vol.4 , pp. 154
    • Kerner, B.1    Rao, A.R.2    Christensen, B.3    Dandekar, S.4    Yourshaw, M.5    Nelson, S.F.6
  • 56
    • 84897466223 scopus 로고    scopus 로고
    • Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate
    • Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, et al. Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate. PLoS Genet (2014) 10(3):e1004229. doi:10.1371/journal.pgen.1004229.
    • (2014) PLoS Genet , vol.10 , Issue.3
    • Georgi, B.1    Craig, D.2    Kember, R.L.3    Liu, W.4    Lindquist, I.5    Nasser, S.6
  • 57
    • 84922596581 scopus 로고    scopus 로고
    • A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder
    • Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, et al. A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder. Hum Mol Genet (2014) 23(23):6395-406. doi:10.1093/hmg/ddu335.
    • (2014) Hum Mol Genet , vol.23 , Issue.23 , pp. 6395-6406
    • Strauss, K.A.1    Markx, S.2    Georgi, B.3    Paul, S.M.4    Jinks, R.N.5    Hoshi, T.6
  • 58
    • 84925437395 scopus 로고    scopus 로고
    • Rare variants in neuronal excitability genes influence risk for bipolar disorder
    • Ament SA, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, et al. Rare variants in neuronal excitability genes influence risk for bipolar disorder. Proc Natl Acad Sci U S A (2015) 112(11):3576-81. doi:10.1073/pnas.1424958112.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.11 , pp. 3576-3581
    • Ament, S.A.1    Szelinger, S.2    Glusman, G.3    Ashworth, J.4    Hou, L.5    Akula, N.6
  • 59
    • 84864911042 scopus 로고    scopus 로고
    • Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia
    • Need AC, McEvoy JP, Gennarelli M, Heinzen EL, Ge D, Maia JM, et al. Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. Am J Hum Genet (2012) 91(2):303-12. doi:10.1016/j.ajhg.2012.06.018.
    • (2012) Am J Hum Genet , vol.91 , Issue.2 , pp. 303-312
    • Need, A.C.1    McEvoy, J.P.2    Gennarelli, M.3    Heinzen, E.L.4    Ge, D.5    Maia, J.M.6
  • 60
    • 80052269336 scopus 로고    scopus 로고
    • Increased exonic de novo mutation rate in individuals with schizophrenia
    • Girard SL, Gauthier J, Noreau A, Xiong L, Zhou S, Jouan L, et al. Increased exonic de novo mutation rate in individuals with schizophrenia. Nat Genet (2011) 43(9):860-3. doi:10.1038/ng.886.
    • (2011) Nat Genet , vol.43 , Issue.9 , pp. 860-863
    • Girard, S.L.1    Gauthier, J.2    Noreau, A.3    Xiong, L.4    Zhou, S.5    Jouan, L.6
  • 61
    • 80052273655 scopus 로고    scopus 로고
    • Exome sequencing supports a de novo mutational paradigm for schizophrenia
    • Xu B, Roos JL, Dexheimer P, Boone B, Plummer B, Levy S, et al. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat Genet (2011) 43(9):864-8. doi:10.1038/ng.902.
    • (2011) Nat Genet , vol.43 , Issue.9 , pp. 864-868
    • Xu, B.1    Roos, J.L.2    Dexheimer, P.3    Boone, B.4    Plummer, B.5    Levy, S.6
  • 62
    • 84870489243 scopus 로고    scopus 로고
    • De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia
    • Xu B, Ionita-Laza I, Roos JL, Boone B, Woodrick S, Sun Y, et al. De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. Nat Genet (2012) 44(12):1365-9. doi:10.1038/ng.2446.
    • (2012) Nat Genet , vol.44 , Issue.12 , pp. 1365-1369
    • Xu, B.1    Ionita-Laza, I.2    Roos, J.L.3    Boone, B.4    Woodrick, S.5    Sun, Y.6
  • 63
    • 84900986803 scopus 로고    scopus 로고
    • Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene
    • Takata A, Xu B, Ionita-Laza I, Roos JL, Gogos JA, Karayiorgou M. Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene. Neuron (2014) 82(4):773-80. doi:10.1016/j.neuron.2014.04.043.
    • (2014) Neuron , vol.82 , Issue.4 , pp. 773-780
    • Takata, A.1    Xu, B.2    Ionita-Laza, I.3    Roos, J.L.4    Gogos, J.A.5    Karayiorgou, M.6
  • 64
    • 84912544206 scopus 로고    scopus 로고
    • Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes
    • Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, et al. Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes. PLoS One (2014) 9(11):e112745. doi:10.1371/journal.pone.0112745.
    • (2014) PLoS One , vol.9 , Issue.11
    • Guipponi, M.1    Santoni, F.A.2    Setola, V.3    Gehrig, C.4    Rotharmel, M.5    Cuenca, M.6
  • 65
    • 84891945094 scopus 로고    scopus 로고
    • Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism
    • Ionita-Laza I, Xu B, Makarov V, Buxbaum JD, Roos JL, Gogos JA, et al. Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism. Proc Natl Acad Sci U S A (2014) 111(1):343-8. doi:10.1073/pnas.1309475110.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.1 , pp. 343-348
    • Ionita-Laza, I.1    Xu, B.2    Makarov, V.3    Buxbaum, J.D.4    Roos, J.L.5    Gogos, J.A.6
  • 66
    • 84901246368 scopus 로고    scopus 로고
    • De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
    • McCarthy SE, Gillis J, Kramer M, Lihm J, Yoon S, Berstein Y, et al. De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol Psychiatry (2014) 19(6):652-8. doi:10.1038/mp.2014.29.
    • (2014) Mol Psychiatry , vol.19 , Issue.6 , pp. 652-658
    • McCarthy, S.E.1    Gillis, J.2    Kramer, M.3    Lihm, J.4    Yoon, S.5    Berstein, Y.6
  • 67
    • 84881193129 scopus 로고    scopus 로고
    • Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network
    • Gulsuner S, Walsh T, Watts AC, Lee MK, Thornton AM, Casadei S, et al. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell (2013) 154(3):518-29. doi:10.1016/j.cell.2013.06.049.
    • (2013) Cell , vol.154 , Issue.3 , pp. 518-529
    • Gulsuner, S.1    Walsh, T.2    Watts, A.C.3    Lee, M.K.4    Thornton, A.M.5    Casadei, S.6
  • 68
    • 84878647965 scopus 로고    scopus 로고
    • Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families
    • Timms AE, Dorschner MO, Wechsler J, Choi KY, Kirkwood R, Girirajan S, et al. Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families. JAMA Psychiatry (2013) 70(6):582-90. doi:10.1001/jamapsychiatry.2013.1195.
    • (2013) JAMA Psychiatry , vol.70 , Issue.6 , pp. 582-590
    • Timms, A.E.1    Dorschner, M.O.2    Wechsler, J.3    Choi, K.Y.4    Kirkwood, R.5    Girirajan, S.6
  • 69
    • 84893919352 scopus 로고    scopus 로고
    • De novo mutations in schizophrenia implicate synaptic networks
    • Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, et al. De novo mutations in schizophrenia implicate synaptic networks. Nature (2014) 506(7487):179-84. doi:10.1038/nature12929.
    • (2014) Nature , vol.506 , Issue.7487 , pp. 179-184
    • Fromer, M.1    Pocklington, A.J.2    Kavanagh, D.H.3    Williams, H.J.4    Dwyer, S.5    Gormley, P.6
  • 70
    • 84893904007 scopus 로고    scopus 로고
    • A polygenic burden of rare disruptive mutations in schizophrenia
    • Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature (2014) 506(7487):185-90. doi:10.1038/nature12975.
    • (2014) Nature , vol.506 , Issue.7487 , pp. 185-190
    • Purcell, S.M.1    Moran, J.L.2    Fromer, M.3    Ruderfer, D.4    Solovieff, N.5    Roussos, P.6
  • 71
    • 84924652200 scopus 로고    scopus 로고
    • No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia
    • Ruderfer DM, Lim ET, Genovese G, Moran JL, Hultman CM, Sullivan PF, et al. No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia. Eur J Hum Genet (2015) 23(4):555-7. doi:10.1038/ejhg.2014.228.
    • (2015) Eur J Hum Genet , vol.23 , Issue.4 , pp. 555-557
    • Ruderfer, D.M.1    Lim, E.T.2    Genovese, G.3    Moran, J.L.4    Hultman, C.M.5    Sullivan, P.F.6
  • 72
    • 84922394049 scopus 로고    scopus 로고
    • A framework for the interpretation of de novo mutation in human disease
    • Samocha KE, Robinson EB, Sanders SJ, Stevens C, Sabo A, McGrath LM, et al. A framework for the interpretation of de novo mutation in human disease. Nat Genet (2014) 46(9):944-50. doi:10.1038/ng.3050.
    • (2014) Nat Genet , vol.46 , Issue.9 , pp. 944-950
    • Samocha, K.E.1    Robinson, E.B.2    Sanders, S.J.3    Stevens, C.4    Sabo, A.5    McGrath, L.M.6
  • 73
    • 84891837451 scopus 로고    scopus 로고
    • The human gene mutation database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine
    • Stenson PD, Mort M, Ball EV, Shaw K, Phillips A, Cooper DN. The human gene mutation database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine. Hum Genet (2014) 133(1):1-9. doi:10.1007/s00439-013-1358-4.
    • (2014) Hum Genet , vol.133 , Issue.1 , pp. 1-9
    • Stenson, P.D.1    Mort, M.2    Ball, E.V.3    Shaw, K.4    Phillips, A.5    Cooper, D.N.6
  • 74
    • 84937637283 scopus 로고    scopus 로고
    • MicroRNA and posttranscriptional dysregulation in psychiatry
    • Geaghan M, Cairns MJ. MicroRNA and posttranscriptional dysregulation in psychiatry. Biol Psychiatry (2015) 78(4):231-9. doi:10.1016/j.biopsych.2014.12.009.
    • (2015) Biol Psychiatry , vol.78 , Issue.4 , pp. 231-239
    • Geaghan, M.1    Cairns, M.J.2
  • 75
    • 84987623939 scopus 로고    scopus 로고
    • Grand challenges in cellular biochemistry: the "next-gen" biochemistry
    • Giulivi C. Grand challenges in cellular biochemistry: the "next-gen" biochemistry. Front Chem (2014) 2:22. doi:10.3389/fchem.2014.00022.
    • (2014) Front Chem , vol.2 , pp. 22
    • Giulivi, C.1


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