Preliminary genome-wide association study of bipolar disorder in the Japanese population

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 150, Issue 8, 2009, Pages 1110-1117

  Hattori, Eiji ^a   Toyota, Tomoko ^a   Ishitsuka, Yuichi ^a   Iwayama, Yoshimi ^a   Yamada, Kazuo ^a   Ujike, Hiroshi ^b   Morita, Yukitaka ^b   Kodama, Masafumi ^b   Nakata, Kenji ^b   Minabe, Yoshio ^c,d   Nakamura, Kazuhiko ^c   Iwata, Yasuhide ^c   Takei, Nori ^c   Mori, Norio ^c   Naitoh, Hiroshi ^e   Yamanouchi, Yoshio ^e   Iwata, Nakao ^e,f   Ozaki, Norio ^f,g   Kato, Tadafumi ^a   Nishikawa, Toru ^h   Kashiwa, Atsushi ^h   Suzuki, Mika ^h   Shioe, Kunihiko ⁱ   Shinohara, Manabu ⁱ   Hirano, Masami ⁱ   Nanko, Shinichiro ^j   Akahane, Akihisa ^j   Ueno, Mikako ^j   Kaneko, Naoshi ^k   Watanabe, Yuichiro ^k   Someya, Toshiyuki ^k   Hashimoto, Kenji ^l   Iyo, Masaomi ^m   Itokawa, Masanari ^f   Arai, Makoto ⁿ   Nankai, Masahiro ^o   Inada, Toshiya ^p   Yoshida, Sumiko ^q   Kunugi, Hiroshi ^r   Nakamura, Michiko ^s   Iijima, Yoshimi ^r   Okazaki, Yuji ^t   Higuchi, Teruhiko ^u   Yoshikawa, Takeo ^a,f   more..

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^e FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^g NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

ⁱ UNIVERSITY OF YAMANASHI   (Japan)

^j TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^k NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^l CHIBA UNIVERSITY   (Japan)

^m CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

ⁿ TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^o Nankai Clinic   (Japan)

^p SEIWA HOSPITAL   (Japan)

^q SAITAMA MEDICAL UNIVERSITY   (Japan)

^r NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^s TOHO UNIVERSITY   (Japan)

^t TOKYO METROPOLITAN MATSUZAWA HOSPITAL   (Japan)

^u NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

more..

Author keywords

Affymetrix 100K; Illumina Beadarray; PLXNA2; Principal components analysis; SNAP25

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; POPULATION RISK; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BIPOLAR DISORDER; CASE-CONTROL STUDIES; FEMALE; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; JAPAN; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PILOT PROJECTS; PRINCIPAL COMPONENT ANALYSIS;

EID: 72049127779     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30941     Document Type: Article

References (22)

1. Badner JA, Gershon ES. 2002. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411.
2. Baum AE, Akula N, Cabanero M, et al. 2007. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 13:197-207.
3. Baum AE, Hamshere M, Green E, et al. 2008. Meta-analysis of two genomewide association studies of bipolar disorder reveals important points of agreement. Mol Psychiatry 13:466-467. (Pubitemid 351556036)
4. Devlin B, Roeder K. 1999. Genomic control for association studies. Biometrics 55:997-1004.
5. Frayling TM. 2007. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657-662. (Pubitemid 47281993)
6. Lin PI, Vance JM, Pericak-Vance MA, Martin ER. 2007. No gene is an island: The flip-flop phenomenon. Am J Hum Genet 80:531-538.
7. Mah S, Nelson MR, Delisi LE, et al. 2006. Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mol Psychiatry 11:471-478.
8. Mathew CG. 2008.Newlinks to the pathogenesis of Crohn disease provided by genome-wide association scans. Nat Rev Genet 9:9-14.
9. McQueen MB, Devlin B, Faraone SV, et al. 2005. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet 77: 582-595. (Pubitemid 41361605)
10. Pe'er I, de Bakker PI, Maller J, Yelensky R, Altshuler D, Daly MJ. 2006. Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet 38:663-667.
11. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-909. (Pubitemid 44141658)
12. Purcell S, Cherny SS, Sham PC. 2003. Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150. (Pubitemid 36150192)
13. Scarr E, Gray L, Keriakous D, Robinson PJ, Dean B. 2006. Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder. Bipolar Disord 8:133-143. (Pubitemid 44026765)
14. Segurado R, Detera-Wadleigh SD, Levinson DF, et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet 73:49-62. (Pubitemid 36793779)
15. Sklar P, Smoller JW, Fan J, et al. 2008. Whole-genome association study of bipolar disorder. Mol Psychiatry 13:558-569. (Pubitemid 351704939)
16. Storey JD. 2002. A direct approach to false discovery rates. J R Stat Soc B 64:479-498.
17. Takeshita M, Yamada K, Hattori E, et al. 2008. Genetic examination of the PLXNA2 gene in Japanese and Chinese schizophrenics. Schizophr Res 99:359-364.
18. Thapar A,O'Donovan M, Owen MJ. 2005. The genetics of attention deficit hyperactivity disorder. Hum Mol Genet 14:R275-R282. (Pubitemid 41631896)
19. The International HapMap Project. 2003. The International HapMap Project. Nature 426:789-796.
20. The Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678.
21. Wray NR, James MR, Mah SP, et al. 2007. Anxiety and comorbid measures associated with PLXNA2. Arch Gen Psychiatry 64:318-326. (Pubitemid 46376783)
22. Yamaguchi-Kabata Y, Nakazono K, Takahashi A, et al. 2008. Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: Effects on population-based association studies. Am J Hum Genet 83:445-456.