YAP is closely correlated with castration-resistant prostate cancer, and downregulation of YAP reduces proliferation and induces apoptosis of PC-3 cells

Molecular Medicine Reports

Volumn 12, Issue 4, 2015, Pages 4867-4876

  Sheng, Xia ^a   Li, Wen Bin ^a   Wang, De Lin ^a   Chen, Ke Hong ^a   Cao, Jian Jia ^a   Luo, Zhao ^a   He, Jiang ^b   Li, Mei Cai ^a   Liu, Wu Jiang ^c   Yu, Chao ^b  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

PC 3 cell; Prostate cancer; RNA interference; TEA domain family member 1; Yes associated protein

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE YES; GENETIC MARKER; MESSENGER RNA; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER STAGING; CASTRATION RESISTANT PROSTATE CANCER; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE SYNTHESIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GLEASON SCORE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INVESTIGATIVE PROCEDURES; MAJOR CLINICAL STUDY; MALE; MTT ASSAY; PLASMID; PROSTATE CANCER CELL LINE; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; QUANTITATIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING; CANCER GRADING; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROSTATE; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; TUMOR CELL LINE; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; NEOPLASM GRADING; PHOSPHOPROTEINS; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RNA INTERFERENCE; RNA, MESSENGER; TRANSFECTION;

EID: 84940472347     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4005     Document Type: Article

References (40)

1. Conlon I and Raff M: Size control in animal development. Cell 96: 235-244, 1999.
2. Wu S, Huang J, Dong J and Pan D: Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with Salvador and warts. Cell 114: 445-456, 2003.
3. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, et al: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21: 2747-2761, 2007.
4. Chen L, Chan SW, Zhang X, Walsh M, Lim CJ, Hong W and Song H: Structural basis of YAP recognition by TEAD4 in the hippo pathway. Genes Dev 24: 290-300, 2010.
5. Huang J, Wu S, Barrera J, Matthews K and Pan D: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating yorkie, the Drosophila Homolog of YAP. Cell 122: 421-434, 2005.
6. Nolo R, Morrison CM, Tao C, Zhang X and Halder G: The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol 16: 1895-1904, 2006.
7. Thompson BJ and Cohen SM: The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell 126: 767-774, 2006.
8. Bertini E, Oka T, Sudol M, Strano S and Blandino G: YAP: At the crossroad between transformation and tumor suppression. Cell Cycle 8: 49-57, 2009.
9. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS and Haber DA: Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 103: 12405-12410, 2006.
10. Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, et al: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125: 1253-1267, 2006.
11. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y and Sasaki H: Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol 28: 3177-3189, 2008.
12. Zhang L, Ren F, Zhang Q, Chen Y, Wang B and Jiang J: The TEAD/TEF family of transcription factor Scalloped mediates hippo signaling in organ size control. Dev Cell 14: 377-387, 2008.
13. Ota M and Sasaki H: Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of hippo signaling. Development 135: 4059-4069, 2008.
14. Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, et al: TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22: 1962-1971, 2008.
15. Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, et al: Role of YAP TAZ in mechanotransduction. Nature 474: 179-183, 2011.
16. Chan SW, Lim CJ, Loo LS, Chong YF, Huang C and Hong W: TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J Bio Chem 284: 14347-14358, 2009.
17. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global Cancer Statistics. Ca Cancer J Clin 61: 69-90, 2011.
18. Katoh M: Function and cancer genomics of FAT family genes (review). Int J Oncol 41: 1913-1918, 2012.
19. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, et al: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 107: 1437-1442, 2010.
20. Zhou Z, Zhu JS, Xu ZP and Zhang Q: Lentiviral vector-mediated siRNA knockdown of the YAP gene inhibits growth and induces aoptosis in the SGC7901 gastric cancer cell line. Mol Med Rep 4: 1075-1082, 2011.
21. Li W, Wang L, Katoh H, Liu R, Zheng P and Liu Y: Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res 71: 2162-2171, 2011.
22. Zagurovskaya M, Shareef MM, Das A, Reeves A, Gupta S, Sudol M, Bedford MT, Prichard J, Mohiuddin M and Ahmed MM: EGR-1 forms a complex with YAP-1 and up regulates Bax expression in irradiated prostate carcinoma cells. Oncogene 28: 1121-1131, 2009.
23. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber D and Hariharan IK: Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467-478, 2002.
24. Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, et al: The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell 16: 398-410, 2009.
25. Berney DM: Low Gleason score prostatic adenocarcinomas are no longer viable entities. Histopathology 50: 683-690, 2007.
26. Na Y, Ye Z and Sun G: Diagnosis and Treatment Guideline of Chinese Urology Diseases. People's Medical Publishing House, Beijing, p52-53, 2011 (In Chinese).
27. Hudson TS, Perkins SN, Hursting SD, Young HA, Kim YS, Wang TC and Wang TT: Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. Int J Oncol 40: 1113-1121, 2012.
28. Sheng X, Li Z, Wang DL, Li WB, Luo Z, Chen KH, Cao JJ, Yu C and Liu WJ: Isolation and enrichment of PC-3 prostate cancer stem-like cells using MACS and serum-free medium. Oncol Lett 5: 787-792, 2013.
29. Wang DL, Lan JH, Chen L, Huang B, Li Z, Zhao XM, Ma Q, Sheng X, Li WB and Tang WX: Integrin-linked kinase functions as a tumor promoter in bladder transitional cell carcinoma. Asian Pac J Cancer Prev 13: 2799-2806, 2012.
30. Okamoto Y, Ohkubo T, Ikebe T and Yamazaki J: Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol 40: 1431-1440, 2012.
31. De Ganck A, De Corte V, Bruyneel E, Bracke M, Vandekerckhove J and Gettemans J: Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. Int J Oncol 34: 1403-1409, 2009.
32. Lamar JM, Stern P, Liu H, Schindler JW, Jiang ZG and Hynes RO: The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Natl Acad Sci USA 109: E2441-E2450, 2012.
33. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A and Pan D: Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130: 1120-1133, 2007.
34. Zhao B, Li L, Wang L, Wang CY, Yu J and Guan KL: Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev 26: 54-68, 2012.
35. Yamazaki H, Nishiyama K, Tanaka E, Maeda O, Meguro N, Kinouchi T, Usami M, Kakimoto K, Ono Y and Nishimura T: Reduction of irradiation volume and toxicities with 3-D radiotherapy planning over conventional radiotherapy for prostate cancer treated with long-term hormonal therapy. Anticancer Res 28: 3913-3920, 2008.
36. Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, et al: YAP induces malignant mesothelioma cell proliferation by up regulating transcription of cell cycle-promoting genes. Oncogene 31: 5117-5122, 2012.
37. Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, et al: The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147: 759-772, 2011.
38. Rick FG, Schally AV, Szalontay L, Block NL, Szepeshazi K, Nadji M, Zarandi M, Hohla F, Buchholz S and Seitz S: Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inac-tivation of ERK and Akt kinases. Proc Natl Acad Sci USA 109: 1655-1660, 2012.
39. Zhang X, Grusche FA and Harvey KF: Control of tissue growth and cell transformation by the Salvador/Warts/Hippo pathway. PLoS One 7: e31994, 2012.
40. Xu MZ, Yao TJ, Lee N P, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT and Luk JM: Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer 115: 4576-4585, 2009.