Time to epinephrine and survival after pediatric in-hospital cardiac arrest

JAMA - Journal of the American Medical Association

Volumn 314, Issue 8, 2015, Pages 802-810

  Andersen, Lars W ^a,b   Berg, Katherine M ^a   Saindon, Brian Z ^a   Massaro, Joseph M ^c,d   Raymond, Tia T ^e   Berg, Robert A ^f   Nadkarni, Vinay M ^f   Donnino, Michael W ^a   Topjian, Alexis A ^g   Foglia, Elizabeth ^g   Sutton, Robert ^g   Allen, Emilie ^h   Bembea, Melania ⁱ   Fink, Ericka ^j   Gaies, Michael G ^k   Guerguerian, Anne Marie ^l   Parshuram, Chris ^l   Kleinman, Monica ^m   Knight, Lynda J ⁿ   Laussen, Peter C ^o   Sawyer, Taylor ^p   Schexnayder, Stephen M ^q   more..

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c HARVARD CLINICAL RESEARCH INSTITUTE   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e Medical City Children's Hospital   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^h PARKLAND HEALTH AND HOSPITAL SYSTEM   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF MICHIGAN   (United States)

^l Hospital for Sick Children   (United States)

^m BOSTON CHILDREN S HOSPITAL   (United States)

ⁿ STANFORD UNIVERSITY   (United States)

^o UNIVERSITY OF TORONTO   (Canada)

^p SEATTLE CHILDREN S HOSPITAL   (United States)

^q ARKANSAS CHILDREN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ARTICLE; CHILD; DOSE TIME EFFECT RELATION; FEMALE; HEART ARREST; HOSPITAL DISCHARGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETURN OF SPONTANEOUS CIRCULATION; SCORING SYSTEM; SURVIVAL RATE; THERAPY DELAY; ADOLESCENT; ALGORITHM; CIRCULATION; CLINICAL TRIAL; COHORT ANALYSIS; HOSPITALIZED CHILD; MORTALITY; MULTICENTER STUDY; NEWBORN; PRESCHOOL CHILD; REGISTER; RISK; TIME TO TREATMENT;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-AGONISTS; ALGORITHMS; BLOOD CIRCULATION; CHILD; CHILD, HOSPITALIZED; CHILD, PRESCHOOL; COHORT STUDIES; EPINEPHRINE; FEMALE; HEART ARREST; HUMANS; INFANT; INFANT, NEWBORN; MALE; REGISTRIES; RISK; TIME-TO-TREATMENT;

EID: 84940471372     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2015.9678     Document Type: Article

References (39)

1. Topjian AA, Berg RA, Nadkarni VM. Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomes. Pediatrics. 2008;122(5):1086-1098.
2. BergMD, Nadkarni VM, Zuercher M, Berg RA. In-hospital pediatric cardiac arrest. Pediatr Clin North Am. 2008;55(3):589-604.
3. Nadkarni VM, Larkin GL, Peberdy MA, et al; National Registry of Cardiopulmonary Resuscitation Investigators. First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults. JAMA. 2006;295(1):50-57.
4. Girotra S, Spertus JA, Li Y, Berg RA, Nadkarni VM, Chan PS; American Heart Association Get With the Guidelines-Resuscitation Investigators. Survival trends in pediatric in-hospital cardiac arrests: an analysis from Get With the Guidelines- Resuscitation. Circ Cardiovasc Qual Outcomes. 2013;6(1):42-49.
5. Tibballs J, Kinney S. A prospective study of outcome of in-patient paediatric cardiopulmonary arrest. Resuscitation. 2006;71(3):310-318.
6. Kleinman ME, Chameides L, Schexnayder SM, et al. Part 14: Pediatric advanced life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010;122(18)(suppl 3):S876-S908.
7. Kleinman ME, de Caen AR, Chameides L, et al; Pediatric Basic and Advanced Life Support Chapter Collaborators. Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2010;122(16)(suppl 2):S466-S515.
8. Biarent D, Bingham R, Eich C, et al. European Resuscitation Council Guidelines for Resuscitation 2010 section 6: paediatric life support. Resuscitation. 2010;81(10):1364-1388.
9. Sanders AB, Ewy GA, Taft TV. Prognostic and therapeutic importance of the aortic diastolic pressure in resuscitation from cardiac arrest. Crit Care Med. 1984;12(10):871-873.
10. Niemann JT, Criley JM, Rosborough JP, Niskanen RA, Alferness C. Predictive indices of successful cardiac resuscitation after prolonged arrest and experimental cardiopulmonary resuscitation. Ann Emerg Med. 1985;14(6):521-528.
11. Paradis NA, Martin GB, Rivers EP, et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA. 1990;263(8):1106-1113.
12. Perondi MB, Reis AG, Paiva EF, Nadkarni VM, Berg RA. A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med. 2004;350(17):1722-1730.
13. Carpenter TC, Stenmark KR. High-dose epinephrine is not superior to standard-dose epinephrine in pediatric in-hospital cardiopulmonary arrest. Pediatrics. 1997;99(3): 403-408.
14. Dieckmann RA, Vardis R. High-dose epinephrine in pediatric out-of-hospital cardiopulmonary arrest. Pediatrics. 1995;95(6): 901-913.
15. DonninoMW, Salciccioli JD, Howell MD, et al; American Heart Association's Get With the Guidelines-Resuscitation Investigators. Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry. BMJ. 2014;348:g3028.
16. Peberdy MA, KayeW, Ornato JP, et al. Cardiopulmonary resuscitation of adults in the hospital: a report of 14720 cardiac arrests from the National Registry of Cardiopulmonary Resuscitation. Resuscitation. 2003;58(3):297-308.
17. Cummins RO, Chamberlain D, Hazinski MF, et al; American Heart Association. Recommended guidelines for reviewing, reporting, and conducting research on in-hospital resuscitation: the in-hospital "Utstein style." Circulation. 1997;95(8): 2213-2239.
18. Jacobs I, Nadkarni V, Bahr J, et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Councils of Southern Africa). Circulation. 2004;110(21):3385-3397.
19. Peberdy MA, Ornato JP, Larkin GL, et al; National Registry of Cardiopulmonary Resuscitation Investigators. Survival from in-hospital cardiac arrest during nights and weekends. JAMA. 2008; 299(7):785-792.
20. Fiser DH. Assessing the outcome of pediatric intensive care. J Pediatr. 1992;121(1):68-74.
21. Matos RI,Watson RS, Nadkarni VM, et al; American Heart Association's Get With the Guidelines-Resuscitation (Formerly the National Registry of Cardiopulmonary Resuscitation) Investigators. Duration of cardiopulmonary resuscitation and illness category impact survival and neurologic outcomes for in-hospital pediatric cardiac arrests. Circulation. 2013;127(4):442-451.
22. Ortmann L, Prodhan P, Gossett J, et al; American Heart Association's Get With the Guidelines-Resuscitation Investigators. Outcomes after in-hospital cardiac arrest in children with cardiac disease: a report from Get With the Guidelines-Resuscitation. Circulation. 2011;124(21): 2329-2337.
23. Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159(7):702-706.
24. Zou GY, Donner A. Extension of the modified Poisson regression model to prospective studies with correlated binary data. Stat Methods Med Res. 2013;22(6):661-670.
25. Girotra S, Chan PS. Trends in survival after in-hospital cardiac arrest. N Engl J Med. 2013;368 (7):680-681.
26. Peng TJ, Andersen LW, Saindon BZ, et al; American Heart Association's Get With the Guidelines-Resuscitation Investigators. The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity. Crit Care. 2015;19(1):160.
27. Meaney PA, Nadkarni VM, Cook EF, et al; American Heart Association National Registry of Cardiopulmonary Resuscitation Investigators. Higher survival rates among younger patients after pediatric intensive care unit cardiac arrests. Pediatrics. 2006;118(6):2424-2433.
28. Donoghue AJ, Nadkarni VM, Elliott M, Durbin D; American Heart Association National Registry of Cardiopulmonary Resuscitation Investigators. Effect of hospital characteristics on outcomes from pediatric cardiopulmonary resuscitation: a report from the national registry of cardiopulmonary resuscitation. Pediatrics. 2006;118(3):995-1001.
29. Ornato JP, Peberdy MA, Reid RD, Feeser VR, Dhindsa HS; NRCPR Investigators. Impact of resuscitation system errors on survival from in-hospital cardiac arrest. Resuscitation. 2012;83(1): 63-69.
30. Weiner GM, Niermeyer S. Medications in neonatal resuscitation: epinephrine and the search for better alternative strategies. Clin Perinatol. 2012;39(4):843-855.
31. Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial. Resuscitation. 2011;82(9):1138-1143.
32. Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 2012;307(11):1161-1168.
33. Nakahara S, Tomio J, Takahashi H, et al. Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study. BMJ. 2013;347:f6829.
34. Goto Y, Maeda T, Goto Y. Effects of prehospital epinephrine during out-of-hospital cardiac arrest with initial non-shockable rhythm: an observational cohort study. Crit Care. 2013;17(5):R188.
35. Reynolds JC, Rittenberger JC, Menegazzi JJ. Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. Resuscitation. 2007;74(1):13-26.
36. Olasveengen TM. Adrenaline for out of hospital cardiac arrest? BMJ. 2013;347:f7268.
37. Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA,Wik L. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA. 2009;302(20):2222-2229.
38. Callaway CW. Questioning the use of epinephrine to treat cardiac arrest. JAMA. 2012;307 (11):1198-1200.
39. Chan PS, Krumholz HM, Nichol G, Nallamothu BK; American Heart Association National Registry of Cardiopulmonary Resuscitation Investigators. Delayed time to defibrillation after in-hospital cardiac arrest. N Engl J Med. 2008;358(1):9-17.