Medications in neonatal resuscitation: Epinephrine and the search for better alternative strategies

Clinics in Perinatology

Volumn 39, Issue 4, 2012, Pages 843-855

  Weiner, Gary M ^a,b   Niermeyer, Susan ^c  

^a ST JOSEPH MERCY HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenaline; Asphyxia neonatorum; Epinephrine; Newborn; Resuscitation; Vasopressin; Volume

Indexed keywords

ADRENALIN; VASOPRESSIN;

ALPHA ADRENERGIC STIMULATION; BETA ADRENERGIC STIMULATION; BLOOD FLOW; BRADYCARDIA; CORONARY ARTERY BLOOD FLOW; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG USE; ENDOTRACHEAL TUBE; HEART ARREST; HUMAN; LOW DRUG DOSE; NEWBORN; NEWBORN CARE; OPTIMAL DRUG DOSE; POSITIVE END EXPIRATORY PRESSURE; PRACTICE GUIDELINE; PRESSURE MEASUREMENT; PRIORITY JOURNAL; RESUSCITATION; REVIEW; RISK ASSESSMENT; THERAPY EFFECT; TREATMENT RESPONSE; VASCULAR ACCESS; VASOCONSTRICTION;

ASPHYXIA NEONATORUM; EPINEPHRINE; FEMALE; FETAL DISTRESS; HEART ARREST; HEART MASSAGE; HEMODYNAMICS; HUMANS; INFANT, NEWBORN; PRACTICE GUIDELINES AS TOPIC; PREGNANCY; RESUSCITATION; VASOCONSTRICTOR AGENTS; VASOPRESSINS;

EID: 84869854517     PISSN: 00955108     EISSN: 15579840     Source Type: Journal    
DOI: 10.1016/j.clp.2012.09.005     Document Type: Review

References (72)

1. Wyllie J., Perlman J.M., Kattwinkel J., et al. Part 11: neonatal resuscitation: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 2010, 81(Suppl 1):e260-e287.
2. Kattwinkel J., Perlman J.M., Aziz K., et al. Neonatal resuscitation: 2010 American heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Pediatrics 2010, 126(5):e1400-e1413.
3. Polin R.A., Fox W.W., Abman S.H. Fetal and neonatal physiology 2011, Elsevier/Saunders, Philadelphia. 4th edition.
4. Kuznetsov V., Pak E., Robinson R.B., et al. Beta 2-adrenergic receptor actions in neonatal and adult rat ventricular myocytes. Circ Res 1995, 76(1):40-52.
5. Devic E., Xiang Y., Gould D., et al. Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol 2001, 60(3):577-583.
6. Crile G., Dolley D.H. An experimental research into the resuscitation of dogs killed by anesthetics and asphyxia. J Exp Med 1906, 8(6):713-725.
7. Field J.M., Hazinski M.F., Sayre M.R., et al. Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010, 122(18 Suppl 3):S640-S656.
8. Redding J.S., Pearson J.W. Evaluation of drugs for cardiac resuscitation. Anesthesiology 1963, 24:203-207.
9. Otto C.W., Yakaitis R.W., Blitt C.D. Mechanism of action of epinephrine in resuscitation from asphyxial arrest. Crit Care Med 1981, 9(5):364-365.
10. Wyckoff M.H. Neonatal cardiopulmonary resuscitation: critical hemodynamics. NeoReviews 2010, 11(3):e123-e129.
11. Gao F., de Beer V.J., Hoekstra M., et al. Both beta1- and beta2-adrenoceptors contribute to feedforward coronary resistance vessel dilation during exercise. Am J Physiol Heart Circ Physiol 2010, 298(3):H921-H929.
12. Barber C.A., Garcia D., Wyckoff M.H. Neonatal cardiac compressions following asystole from asphyxia: beneficial or futile? 2007, Pediatric Academic Societies, Toronto, vol. 617932.7. E-PAS2007.
13. Kattwinkel J. Neonatal resuscitation textbook 2011, American Academy of Pediatrics and American Heart Association, Elk Grove Village (IL). 6th edition.
14. Barber C.A., Wyckoff M.H. Use and efficacy of endotracheal versus intravenous epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. Pediatrics 2006, 118(3):1028-1034.
15. Brimacombe J., Gandini D. Airway rescue and drug delivery in an 800 g neonate with the laryngeal mask airway. Paediatr Anaesth 1999, 9(2):178.
16. Greenberg M.I., Roberts J.R., Baskin S.I. Use of endotracheally administered epinephrine in a pediatric patient. Am J Dis Child 1981, 135(8):767-768.
17. Guay J., Lortie L. An evaluation of pediatric in-hospital advanced life support interventions using the pediatric Utstein guidelines: a review of 203 cardiorespiratory arrests. Can J Anaesth 2004, 51(4):373-378.
18. Jankov R.P., Asztalos E.V., Skidmore M.B. Favourable neurological outcomes following delivery room cardiopulmonary resuscitation of infants < or = 750 g at birth. J Paediatr Child Health 2000, 36(1):19-22.
19. Lindemann R. Resuscitation of the newborn. Endotracheal administration of epinephrine. Acta Paediatr Scand 1984, 73(2):210-212.
20. O'Donnell A.I., Gray P.H., Rogers Y.M. Mortality and neurodevelopmental outcome for infants receiving adrenaline in neonatal resuscitation. J Paediatr Child Health 1998, 34(6):551-556.
21. Polin K., Brown D.H., Leikin J.B. Endotracheal administration of epinephrine and atropine. Pediatr Emerg Care 1986, 2(3):168-169.
22. Schwab K.O., von Stockhausen H.B. Plasma catecholamines after endotracheal administration of adrenaline during postnatal resuscitation. Arch Dis Child Fetal Neonatal Ed 1994, 70(3):F213-F217.
23. Ziino A.J., Davies M.W., Davis P.G. Epinephrine for the resuscitation of apparently stillborn or extremely bradycardic newborn infants. Cochrane Database Syst Rev 2011, (2). CD003849.
24. Wyllie J., Niermeyer S. The role of resuscitation drugs and placental transfusion in the delivery room management of newborn infants. Semin Fetal Neonatal Med 2008, 13(6):416-423.
25. Wyckoff M.H., Perlman J., Niermeyer S. Medications during resuscitation-what is the evidence?. Semin Neonatol 2001, 6(3):251-259.
26. Perlman J.M., Risser R. Cardiopulmonary resuscitation in the delivery room. Associated clinical events. Arch Pediatr Adolesc Med 1995, 149(1):20-25.
27. Jasani M.S., Nadkarni V.M., Finkelstein M.S., et al. Effects of different techniques of endotracheal epinephrine administration in pediatric porcine hypoxic-hypercarbic cardiopulmonary arrest. Crit Care Med 1994, 22(7):1174-1180.
28. Kleinman M.E., Oh W., Stonestreet B.S. Comparison of intravenous and endotracheal epinephrine during cardiopulmonary resuscitation in newborn piglets. Crit Care Med 1999, 27(12):2748-2754.
29. Crespo S.G., Schoffstall J.M., Fuhs L.R., et al. Comparison of two doses of endotracheal epinephrine in a cardiac arrest model. Ann Emerg Med 1991, 20(3):230-234.
30. Barber C.A., Wyckoff M.H. Randomized controlled trial of endotracheal versus intravenous administration of epinephrine during neonatal cardiopulmonary resuscitation in asphyxiated piglets 2008, Pediatric Academic Societies, Honolulu (HI), vol. E-PAS2008: 4453.12.
31. Engle W.A. Intraosseous access for administration of medications in neonates. Clin Perinatol 2006, 33(1):161-168. ix.
32. Abe K.K., Blum G.T., Yamamoto L.G. Intraosseous is faster and easier than umbilical venous catheterization in newborn emergency vascular access models. Am J Emerg Med 2000, 18(2):126-129.
33. Rajani A.K., Chitkara R., Oehlert J., et al. Comparison of umbilical venous and intraosseous access during simulated neonatal resuscitation. Pediatrics 2011, 128(4):e954-e958.
34. Brown C.G., Werman H.A., Davis E.A., et al. The effects of graded doses of epinephrine on regional myocardial blood flow during cardiopulmonary resuscitation in swine. Circulation 1987, 75(2):491-497.
35. Chase P.B., Kern K.B., Sanders A.B., et al. Effects of graded doses of epinephrine on both noninvasive and invasive measures of myocardial perfusion and blood flow during cardiopulmonary resuscitation. Crit Care Med 1993, 21(3):413-419.
36. Goetting M.G., Paradis N.A. High dose epinephrine in refractory pediatric cardiac arrest. Crit Care Med 1989, 17(12):1258-1262.
37. Goetting M.G., Paradis N.A. High-dose epinephrine improves outcome from pediatric cardiac arrest. Ann Emerg Med 1991, 20(1):22-26.
38. Perondi M.B., Reis A.G., Paiva E.F., et al. A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med 2004, 350(17):1722-1730. [see comment].
39. Patterson M.D., Boenning D.A., Klein B.L., et al. The use of high-dose epinephrine for patients with out-of-hospital cardiopulmonary arrest refractory to prehospital interventions. Pediatr Emerg Care 2005, 21(4):227-237.
40. Dieckmann R.A., Vardis R. High-dose epinephrine in pediatric out-of-hospital cardiopulmonary arrest. Pediatrics 1995, 95(6):901-913.
41. Carpenter T.C., Stenmark K.R. High-dose epinephrine is not superior to standard-dose epinephrine in pediatric in-hospital cardiopulmonary arrest. Pediatrics 1997, 99(3):403-408.
42. Rodriguez Nunez A., Garcia C., Lopez-Herce Cid J., et al. An Pediatr (Barc) 2005, 62(2):113-116. [in Spanish].
43. Burchfield D.J., Preziosi M.P., Lucas V.W., et al. Effects of graded doses of epinephrine during asphxia-induced bradycardia in newborn lambs. Resuscitation 1993, 25(3):235-244.
44. Berg R.A., Otto C.W., Kern K.B., et al. A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrest. Crit Care Med 1996, 24(10):1695-1700.
45. Gedeborg R., Silander H.C., Ronne-Engstrom E., et al. Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation. Crit Care Med 2000, 28(5):1423-1430.
46. McCaul C.L., McNamara P.J., Engelberts D., et al. Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model. Anesth Analg 2006, 102(2):542-548.
47. Bada H.S. Prevention of intracranial hemorrhage. NeoReviews 2000, 1:e48-e53.
48. Ornato J.P. Optimal vasopressor drug therapy during resuscitation. Crit Care 2008, 12(2):123.
49. Treschan T.A., Peters J. The vasopressin system: physiology and clinical strategies. Anesthesiology 2006, 105(3):599-612. [quiz: 639-40].
50. Kornberger E., Prengel A.W., Krismer A., et al. Vasopressin-mediated adrenocorticotropin release increases plasma cortisol concentrations during cardiopulmonary resuscitation. Crit Care Med 2000, 28(10):3517-3521.
51. Koch L., Dabek M.T., Frommhold D., et al. Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants. Horm Res Paediatr 2011, 76(4):234-239.
52. Antonov A.G., Baibarina E.N., Volobuev A.I., et al. Pediatriia 1990, (10):8-12. [in Russian].
53. International Liaison Committee on Resuscitation 2005 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Part 4: advanced life support. Resuscitation 2005, 67(2-3):213-247.
54. Lindner K.H., Dirks B., Strohmenger H.U., et al. Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation. Lancet 1997, 349(9051):535-537.
55. Wenzel V., Krismer A.C., Arntz H.R., et al. A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med 2004, 350(2):105-113.
56. Stiell I.G., Hebert P.C., Wells G.A., et al. Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial. Lancet 2001, 358(9276):105-109.
57. Aung K., Htay T. Vasopressin for cardiac arrest: a systematic review and meta-analysis. Arch Intern Med 2005, 165(1):17-24.
58. Callaway C.W., Hostler D., Doshi A.A., et al. Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest. Am J Cardiol 2006, 98(10):1316-1321.
59. Gueugniaud P.Y., David J.S., Chanzy E., et al. Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation. N Engl J Med 2008, 359(1):21-30.
60. Morrison L.J., Deakin C.D., Morley P.T., et al. Part 8: advanced life support: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 2010, 122(16 Suppl 2):S345-S421.
61. Mann K., Berg R.A., Nadkarni V. Beneficial effects of vasopressin in prolonged pediatric cardiac arrest: a case series. Resuscitation 2002, 52(2):149-156.
62. Matok I., Vardi A., Augarten A., et al. Beneficial effects of terlipressin in prolonged pediatric cardiopulmonary resuscitation: a case series. Crit Care Med 2007, 35(4):1161-1164.
63. Gil-Anton J., Lopez-Herce J., Morteruel E., et al. Pediatric cardiac arrest refractory to advanced life support: is there a role for terlipressin?. Pediatr Crit Care Med 2010, 11(1):139-141.
64. Duncan J.M., Meaney P., Simpson P., et al. Vasopressin for in-hospital pediatric cardiac arrest: results from the American Heart Association National Registry of Cardiopulmonary Resuscitation. Pediatr Crit Care Med 2009, 10(2):191-195.
65. Kleinman M.E., de Caen A.R., Chameides L., et al. Part 10: pediatric basic and advanced life support: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 2010, 122(16 Suppl 2):S466-S515.
66. Mayr V., Luckner G., Jochberger S., et al. Arginine vasopressin in advanced cardiovascular failure during the post-resuscitation phase after cardiac arrest. Resuscitation 2007, 72(1):35-44.
67. Palmaers T., Albrecht S., Heuser F., et al. Milrinone combined with vasopressin improves cardiac index after cardiopulmonary resuscitation in a pig model of myocardial infarction. Anesthesiology 2007, 106(1):100-106.
68. Joynt C., Bigam D.L., Charrois G., et al. Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen. Intensive Care Med 2010, 36(6):1058-1066.
69. Joynt C., Bigam D.L., Charrois G., et al. Intestinal hemodynamic effects of milrinone in asphyxiated newborn pigs after reoxygenation with 100% oxygen: a dose-response study. Shock 2009, 31(3):292-299.
70. Wyckoff M.H., Salhab W.A., Heyne R.J., et al. Outcome of extremely low birth weight infants who received delivery room cardiopulmonary resuscitation. J Pediatr 2012, 160(2):239-244. e2.
71. Sawyer T., Sierocka-Castaneda A., Chan D., et al. Deliberate practice using simulation improves neonatal resuscitation performance. Simul Healthc 2011, 6(6):327-336.
72. Sood S., Giacoia G.P. Cardiopulmonary resuscitation in very low birthweight infants. Am J Perinatol 1992, 9(2):130-133.