Effects of prehospital epinephrine during out-of-hospital cardiac arrest with initial non-shockable rhythm: An observational cohort study

Critical Care

Volumn 17, Issue 5, 2013, Pages

  Goto, Yoshikazu ^a   Maeda, Tetsuo ^a   Goto, Yumiko N ^b  

^a KANAZAWA UNIVERSITY HOSPITAL   (Japan)

^b Yawata Medical Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN;

AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; EMERGENCY CARE; EMERGENCY HEALTH SERVICE; FEMALE; HEALTH CARE PERSONNEL; HEART RHYTHM; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; OBSERVATIONAL STUDY; OUT OF HOSPITAL CARDIAC ARREST; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SURVIVAL; DRUG EFFECTS; HEART RATE; MIDDLE AGED; OUT-OF-HOSPITAL CARDIAC ARREST; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COHORT STUDIES; EMERGENCY MEDICAL SERVICES; EPINEPHRINE; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; OUT-OF-HOSPITAL CARDIAC ARREST; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84883293265     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc12872     Document Type: Article

References (34)

1. Kitamura T, Iwami T, Kawamura T, Nagao K, Tanaka H, Hiraide A, for the Implementation Working Group for the All-Japan Utstein Registry of the Fire and Disaster Management Agency Nationwide public-access defibrillation in Japan. N Engl J Med 2010, 362:994-1004. 10.1056/NEJMoa0906644, 20237345, for the Implementation Working Group for the All-Japan Utstein Registry of the Fire and Disaster Management Agency.
2. Nakahara S, Tomio J, Nishida M, Morimura N, Ichikawa M, Sakamoto T. Association between timing of epinephrine administration and intact neurologic survival following out-of-hospital cardiac arrest in Japan: a population-based prospective observational study. Acad Emerg Med 2012, 19:782-792. 10.1111/j.1553-2712.2012.01387.x, 22805628.
3. Hayashi Y, Iwami T, Kitamura T, Nishiuchi T, Kajino K, Sakai T, Nishiyama C, Nitta M, Hiraide A, Kai T. Impact of early intravenous epinephrine administration on outcomes following out-of-hospital cardiac arrest. Circ J 2012, 76:1639-1645. 10.1253/circj.CJ-11-1433, 22481099.
4. ECC Committee, Subcommittees and Task Forces of the American Heart Association 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2005, 112(24 Suppl):IV1-IV203. ECC Committee, Subcommittees and Task Forces of the American Heart Association.
5. Sasson C, Rogers MAM, Dahl J, Kellermann AL. Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 2010, 3:63-81. 10.1161/CIRCOUTCOMES.109.889576, 20123673.
6. Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA 2012, 307:1161-1168. 10.1001/jama.2012.294, 22436956.
7. Ogawa T, Akahane M, Koike S, Tanabe S, Mizoguchi T, Imamura T. Outcomes of chest compression only CPR versus conventional CPR conducted by lay people in patients with out of hospital cardiopulmonary arrest witnessed by bystanders: nationwide population based observational study. BMJ 2011, 342:c7106.
8. Kitamura T, Iwami T, Kawamura T, Nitta M, Nagao K, Nonogi H, Yonemoto N, Kimura T, for the Japanese Circulation Society Resuscitation Science Study Group Nationwide improvements in survival from out-of-hospital cardiac arrest in Japan. Circulation 2012, 126:2834-2843. 10.1161/CIRCULATIONAHA.112.109496, 23035209, for the Japanese Circulation Society Resuscitation Science Study Group.
9. Callaway CW. Questioning the use of epinephrine to treat cardiac arrest. JAMA 2012, 307:1198-1200. 10.1001/jama.2012.313, 22436961.
10. Redding JS, Pearson JW. Resuscitation from asphyxia. JAMA 1962, 182:283-286.
11. Redding JS, Pearson JW. Resuscitation from ventricular fibrillation: drug therapy. JAMA 1968, 203:255-260. 10.1001/jama.1968.03140040007002, 5694097.
12. Paradis NA, Martin GB, Rosenberg J, Rivers EP, Goetting MG, Appleton TJ, Feingold M, Cryer PE, Wortsman J, Nowak RM. The effect of standard- and high-dose epinephrine on coronary perfusion pressure during prolonged cardiopulmonary resuscitation. JAMA 1991, 265:1139-1144. 10.1001/jama.1991.03460090087038, 1996000.
13. Hazinski MF, Field JM, American Heart Association 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science. Circulation 2010, 122(Suppl):S639-S946. American Heart Association.
14. Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA, Wik L. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA 2009, 302:2222-2229. 10.1001/jama.2009.1729, 19934423.
15. Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial. Resuscitation 2011, 82:1138-1143. 10.1016/j.resuscitation.2011.06.029, 21745533.
16. Tang W, Weil MH, Sun S, Noc M, Yang L, Gazmuri RJ. Epinephrine increases the severity of postresuscitation myocardial dysfunction. Circulation 1995, 92:3089-3093. 10.1161/01.CIR.92.10.3089, 7586280.
17. Angelos MG, Butke RL, Panchal AR, Torres CAA, Blumberg A, Schneider JE, Aune SE. Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest. Resuscitation 2008, 77:101-110. 10.1016/j.resuscitation.2007.10.017, 18164797.
18. Ristagno G, Sun S, Tang W, Castillo C, Weil MH. Effect of epinephrine and vasopressin on cerebral microcirculatory flows during and after cardiopulmonary resuscitation. Crit Care Med 2007, 35:2145-2149. 10.1097/01.CCM.0000280427.76175.D2, 17855828.
19. Yasunaga H, Miyata H, Horiguchi H, Tanabe S, Akahane M, Ogawa T, Koike S, Imamura T. Population density, call-response interval, and survival of out-of-hospital cardiac arrest. Int J Health Geogr 2011, 10:26. 10.1186/1476-072X-10-26, 3100230, 21489299.
20. Akahane M, Ogawa T, Koike S, Tanabe S, Horiguchi H, Mizoguchi T, Yasunaga H, Imamura T. The effects of sex on out-of-hospital cardiac arrest outcomes. Am J Med 2011, 124:325-333. 10.1016/j.amjmed.2010.10.020, 21435423.
21. Japanese Guidelines for Emergency Care and Cardiopulmonary Resuscitation 2007, Tokyo: Health Shuppan-Sha, 3.
22. Tanigawa K, Ito Y, Kondo H, Sakamoto T, Shimizu N, Hase N, Hatanaka T, Matsumoto N, Yoshida R, Marukawa S. Emergency Care Activities by ELSTs Based on Japanese Guidelines for Emergency Care and CPR [in Japanese]. (accessed 16 November 2012)., http://kouroukaken-kyukyusosei.info/wpm/archivepdf/18-20/2_02.pdf
23. Jacobs I, Nadkarni V, Bahr J, Berg RA, Billi JE, Bossaert L, Cassan P, Coovadia A, D'Este K, Finn J, Halperin H, Handley A, Herlitz J, Hickey R, Idris A, Kloeck W, Larkin GL, Mancini ME, Mason P, Mears G, Monsieurs K, Montgomery W, Morley P, Nichol G, Nolan J, Okada K, Perlman J, Shuster M, Steen PA, Sterz F, Tibballs J, Timerman S, Truitt T, Zideman D, International Liaison Committee on Resuscitation; American Heart Association; European Resuscitation Council; Australian Resuscitation Council; New Zealand Resuscitation Council; Heart and Stroke Foundation of Canada; InterAmerican Heart Foundation; Resuscitation Councils of Southern Africa; ILCOR Task Force on Cardiac Arrest and Cardiopulmonary Resuscitation Outcomes Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Councils of Southern Africa). Circulation 2004, 110:3385-3397. 10.1161/01.CIR.0000147236.85306.15, 15557386, International Liaison Committee on Resuscitation; American Heart Association; European Resuscitation Council; Australian Resuscitation Council; New Zealand Resuscitation Council; Heart and Stroke Foundation of Canada; InterAmerican Heart Foundation; Resuscitation Councils of Southern Africa; ILCOR Task Force on Cardiac Arrest and Cardiopulmonary Resuscitation Outcomes.
24. Yakaitis RW, Otto CW, Blitt CD. Relative importance of α and β adrenergic receptors during resuscitation. Crit Care Med 1979, 7:293-296. 10.1097/00003246-197907000-00001, 222538.
25. Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol 2013, 28:36-42. 10.1097/HCO.0b013e32835b0979, 23196774.
26. Holmberg M, Holmberg S, Herlitz J. Low chance of survival among patients requiring adrenaline (epinephrine) or intubation after out-of-hospital cardiac arrest in Sweden. Resuscitation 2002, 54:37-45. 10.1016/S0300-9572(02)00048-5, 12104107.
27. Nordseth T, Olasveengen TM, Kvaløy JT, Wik L, Steen PA, Skogvoll E. Dynamic effects of adrenaline (epinephrine) in out-of-hospital cardiac arrest with initial pulseless electrical activity (PEA). Resuscitation 2012, 83:946-952. 10.1016/j.resuscitation.2012.02.031, 22429969.
28. Aufderheide TP. Etiology, electrophysiology, and myocardial mechanics of pulseless electrical activity. Cardiac Arrest: The Science and Practice of Resuscitation Medicine 2007, 426-446. Cambridge, UK: Cambridge University Press, Paradis NA, Halperin HR, Kern KB, Wenzel V, Chamberlain DA, 2.
29. Arrich J, Sterz F, Herkner H, Testori C, Behringer W. Total epinephrine dose during asystole and pulseless electrical activity cardiac arrests is associated with unfavourable functional outcome and increased in-hospital mortality. Resuscitation 2012, 83:333-337. 10.1016/j.resuscitation.2011.10.027, 22079948.
30. Kitsou V, Xanthos T, Stroumpoulis K, Rokas G, Papadimitriou D, Serpetinis I, Dontas I, Perrea D, Kouskouni E. Nitroglycerin and epinephrine improve coronary perfusion pressure in a porcine model of ventricular fibrillation arrest: a pilot study. J Emerg Med 2009, 37:369-375. 10.1016/j.jemermed.2008.07.003, 19097731.
31. Bassiakou E, Xanthos T, Koudouna E, Goulas S, Prapa V, Papadimitriou D, Rokas G, Papadimitriou L. Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation. Am J Emerg Med 2008, 26:578-584. 10.1016/j.ajem.2007.09.010, 18534288.
32. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563. 10.1056/NEJMoa003289, 11856794.
33. Kagawa E, Dote K, Kato M, Sasaki S, Nakano Y, Kajikawa M, Higashi A, Itakura K, Sera A, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Kurisu S. Should we emergently revascularize occluded coronaries for cardiac arrest? Rapid-response extracorporeal membrane oxygenation and intra-arrest percutaneous coronary intervention. Circulation 2012, 126:1605-1613. 10.1161/CIRCULATIONAHA.111.067538, 22899771.
34. Rivers EP, Wortsman J, Rady MY, Blake HC, McGeorge FT, Buderer NM. The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period. Chest 1994, 106:1499-1507. 10.1378/chest.106.5.1499, 7956410.