Angiopoietin-like protein 2 promotes inflammatory conditions in the ligamentum flavum in the pathogenesis of lumbar spinal canal stenosis by activating interleukin-6 expression

European Spine Journal

Volumn 24, Issue 9, 2015, Pages 2001-2009

  Nakamura, Takayuki ^a,b   Okada, Tatsuya ^a   Endo, Motoyoshi ^b   Nakamura, Takafumi ^c   Oike, Yuichi ^b,d   Mizuta, Hiroshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c Nakamura Orthopaedic Clinic ^*  (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Angiopoietin like protein 2; Fibroblasts; IL 6; Ligamentum flavum; Lumbar spinal canal stenosis

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; ANGIOPOIETIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; VERY LATE ACTIVATION ANTIGEN 5; ANGIOPOIETIN; ANGPTL2 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; MESSENGER RNA;

ADULT; AGED; ARTICLE; BINDING AFFINITY; CELL ADHESION ASSAY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HYPERTROPHY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; LIGAMENT DISEASE; LIGAMENTUM FLAVUM; LIGAMENTUM FLAVUM DEGENERATION; LIGAMENTUM FLAVUM HYPERTROPHY; LIGAMENTUM FLAVUM INFLAMMATION; LUMBAR SPINAL CANAL STENOSIS; LUMBAR SPINAL STENOSIS; MALE; MIDDLE AGED; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SECRETION; RECEPTOR BINDING; TISSUE DEGENERATION; CASE CONTROL STUDY; CELL ADHESION; FLOW CYTOMETRY; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LUMBAR VERTEBRA; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; VERTEBRAL CANAL STENOSIS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANGIOPOIETINS; CASE-CONTROL STUDIES; CELL ADHESION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTEGRIN ALPHA5BETA1; INTERLEUKIN-6; LIGAMENTUM FLAVUM; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; NF-KAPPA B; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPINAL STENOSIS;

EID: 84940453702     PISSN: 09406719     EISSN: 14320932     Source Type: Journal    
DOI: 10.1007/s00586-015-3835-z     Document Type: Article

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