Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue

Spine

Volumn 32, Issue 11, 2007, Pages

  Sairyo, Koichi ^a,b   Biyani, Ashok ^a   Goel, Vijay K ^a,d   Leaman, Douglas W ^a   Booth Jr , Robert ^c   Thomas, Jean ^c   Ebraheim, Nabil A ^a   Cowgill, Ian A ^a   Mohan, Suneeth E ^a  

^a UNIVERSITY OF TOLEDO   (United States)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c MEDICAL COLLEGE OF OHIO   (United States)

^d The University of Toledo   (United States)

Author keywords

FEM; Histology; Ligamentum flavum; Magnetic resonance imaging; Reverse transcriptase polymerase chain reaction; Spinal canal stenosis

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1; INTERLEUKIN 15; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DNA MICROARRAY; ELASTIC FIBER; FEMALE; FIBROSIS; GENE EXPRESSION; GENETIC ANALYSIS; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIGAMENT DISEASE; LIGAMENTUM FLAVUM HYPERTROPHY; LUMBAR SPINE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; SCAR FORMATION; TISSUE DISTRIBUTION; VERTEBRAL CANAL STENOSIS;

ADULT; AGED; CICATRIX; CYCLOOXYGENASE 2; FIBROSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKINS; LIGAMENTUM FLAVUM; LINEAR MODELS; LUMBAR VERTEBRAE; MEMBRANE PROTEINS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SPINAL STENOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34248332147     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000263407.25009.6e     Document Type: Article

References (29)

1. Beamer YB, Garner JT, Shelden HS. Hypertrophied ligamentum flavum. Arch Surg 1973;106:289-92.
2. Elsberg CA. Experiments in spinal surgery. Surg Gynecol Obstet 1913;16:117-32.
3. Park JB, Chang H, Lee JK. Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. Spine 2001;26:E492-5.
4. Towne EB, Reichert FL. Compression of the lumbosacral roots of the spinal cord by thickened ligamenta flava. Ann Surg 1931;94:327-36.
5. Ulrich CG, Binet EF, Sanecki MG, et al. Quantitative assessment of the spinal canal by computed tomography. Radiology 1980;134:137-43.
6. Evans JH, Nachemson AL. Biomechanical study of human ligamentum flavum. J Anat 1969;105:188-9.
7. Nachemson AL, Evans JH. Some mechanical properties of the third human lumbar interlaminar ligament (ligamentum flavum). J Biomech 1968;1:211-20.
8. Mensor MC, Fender FA. The ligamentum flavum: Its relationship to low back pain. Surg Gynecol Obstet 1941;73:822-7.
9. Naffziger HC, Inman V, Saunders JB. Lesions of the intervertebral disc and ligamentum flava. Surg Gynecol Obstet 1938;66:288-99.
10. Okuda T, Baba I, Fujimoto Y, et al. The pathology of ligamentum flavum in degenerative lumbar disease. Spine 2004;29:1689-97.
11. Postacchini F, Gumina S, Cinotti G, et al. Ligamenta flava in lumbar disc herniation and spinal stenosis. Spine 1994;8:917-22.
12. Ramsey R. The anatomy of the ligamentum flavum. Clin Orthop 1966;44:129-40.
13. Sairyo K, Biyani A, Goel VK, et al. Pathomechanism of ligamentum flavum hypertrophy: A multidisciplinary investigation based on clinical, biomechanical, histologic and biologic assessments. Spine 2005;30:2649-56.
14. Schrader P, Grob D, Rahn BA, et al. Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis. Eur Spine J 1999;8:323-8.
15. Yoshida M, Shima K, Taniguchi Y, et al. Hypertrophied ligamentum flavum in lumbar spinal canal stenosis. Spine 1992;17:1353-60.
16. Nakatani T, Marui T, Hitora T, et al. Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-beta1. J Orthop Res 2002;20:1380-6.
17. Wilgus TA, Vodovotz Y, Vittadini E, et al. Reduction of scar formation in full-thickness wounds with topical celecoxib treatment. Wound Repair Regen 2003;11:25-34.
18. Wilgus TA, Bergdall VK, Tober KL, et al. The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing. Am J Pathol 2004;165:753-61.
19. Frangogiannis NG. Chemokines in the ischemic myocardium: From inflammation to fibrosis. Inflamm Res 2004;53:585-95.
20. Polo M, Ko F, Busillo F, et al. Cytokine production in patients with hypertrophic burn scars. J Burn Care Rehabil 1997;18:477-82.
21. Kobayashi S, Baba H, Uchida K, et al. Effect of mechanical compression on the lumbar nerve root: Localization and changes of intraradicular inflammatory cytokines, nitric oxide, and cyclooxygenase. Spine 2005;30:1699-705.
22. Chen MA, Davidson TM. Scar management: Prevention and treatment strategies. Curr Opin Otolaryngol Head Neck Surg 2005;13:242-7.
23. Pohl HG, Rushton HG, Park JS, et al. Adjunctive oral corticosteroids reduce renal scarring: The piglet model of reflux and acute experimental pyelonephritis. J Urol 1999;162:815-20.
24. Leeson CR, Leeson S, Paparo AA. In: Atlas of Histology. 2nd ed. Philadelphia, PA: Saunders; 1985:249-66.
25. Leeson CR, Leeson S, Paparo AA. In: Atlas of Histology. 2nd ed. Philadelphia, PA: Saunders; 1985:113-29.
26. Majima T, Lo IK, Randle JA, et al. ACL transection influences mRNA levels for collagen type I and TNF-alpha in MCL scar. J Orthop Res 2002;20:520-5.
27. Spindler KP, Murray MM, Detwiler KB, et al. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res 2003;21:245-9.
28. Kumar V, Abbas AK, Fausto N. In: Pathologica Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Saunders; 2005:87-118.
29. Chodorowska G, Rogus-Skorupska D. Cutaneous wound healing. Ann Univ Mariae Curie Sklodowska [Med] 2004;59:403-7.