Global variability in withholding and withdrawal of life-sustaining treatment in the intensive care unit: a systematic review

Intensive Care Medicine

Volumn 41, Issue 9, 2015, Pages 1572-1585

  Mark, N M ^a   Rayner, S G ^a   Lee, N J ^a   Curtis, J R ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Critical care; Intensive care; Medical decision making; Withdrawal of life support; Withholding of life support

Indexed keywords

ARTIFICIAL VENTILATION; BRAIN DEATH; CANCER PATIENT; ELECTRONIC MEDICAL RECORD; HOSPITAL POLICY; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; INTENSIVIST; LIFE SUSTAINING TREATMENT; MEDICAL DECISION MAKING; METHODOLOGY; QUALITY CONTROL; REVIEW; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TERMINAL CARE; TREATMENT WITHDRAWAL; VENTILATED PATIENT; ADULT; COMPARATIVE STUDY; INTERNATIONAL COOPERATION; LONG TERM CARE; PROCEDURES;

ADULT; HUMANS; INTENSIVE CARE UNITS; INTERNATIONALITY; LIFE SUPPORT CARE; WITHHOLDING TREATMENT;

EID: 84940449422     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-3810-5     Document Type: Review

References (75)

1. Angus DC, Barnato AE, Linde-Zwirble WT et al (2004) Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med 32:638–643. doi:10.1097/01.CCM.0000114816.62331.08
2. Curtis JR, Vincent J-L (2010) Ethics and end-of-life care for adults in the intensive care unit. Lancet 376:1347–1353. doi:10.1016/S0140-6736(10)60143-2
3. Sprung CL, Cohen SL, Sjokvist P et al (2003) End-of-life practices in European intensive care units: the ethicus study. JAMA 290:790–797
4. Eidelman LA, Jakobson DJ, Pizov R et al (1998) Forgoing life-sustaining treatment in an Israeli ICU. Intensive Care Med 24:162–166
5. Aldawood AS, Alsultan M, Arabi YM et al (2012) End-of-life practices in a tertiary intensive care unit in Saudi Arabia. Anaesth Intensive Care 40:137–141
6. Yazigi A, Riachi M, Dabbar G (2005) Withholding and withdrawal of life-sustaining treatment in a Lebanese intensive care unit: a prospective observational study. Intensive Care Med 31:562–567. doi:10.1007/s00134-005-2578-4
7. Mani RK, Mandal AK, Bal S et al (2009) End-of-life decisions in an Indian intensive care unit. Intensive Care Med 35:1713–1719. doi:10.1007/s00134-009-1561-x
8. Esteban A, Gordo F, Solsona JF et al (2001) Withdrawing and withholding life support in the intensive care unit: a Spanish prospective multi-centre observational study. Intensive Care Med 27:1744–1749. doi:10.1007/s00134-001-1111-7
9. Kapadia F, Singh M, Divatia J et al (2005) Limitation and withdrawal of intensive therapy at the end of life: practices in intensive care units in Mumbai, India. Crit Care Med 33:1272–1275. doi:10.1097/01.CCM.0000165557.02879.29
10. Keenan SP, Busche KD, Chen LM et al (1997) A retrospective review of a large cohort of patients undergoing the process of withholding or withdrawal of life support. Crit Care Med 25:1324–1331
11. Keenan S, Busche K, Chen L et al (1998) Withdrawal and withholding of life support in the intensive care unit: a comparison of teaching and community hospitals. Crit Care Med 26:245–251
12. McLean RF, Tarshis J, Mazer CD, Szalai JP (2000) Death in two Canadian intensive care units: institutional difference and changes over time. Crit Care Med 28:100–103
13. Ouanes I, Stambouli N, Dachraoui F et al (2012) Pattern of end-of-life decisions in two Tunisian intensive care units: the role of culture and intensivists’ training. Intensive Care Med 38:710–717. doi:10.1007/s00134-012-2500-9
14. Prendergast TJ, Claessens MT, Luce JM (1998) A national survey of end-of-life care for critically ill patients. Am J Respir Crit Care Med 158:1163–1167. doi:10.1164/ajrccm.158.4.9801108
15. Prendergast TJ, Luce JM (1997) Increasing incidence of withholding and withdrawal of life support from the critically ill. Am J Respir Crit Care Med 155:15–20. doi:10.1164/ajrccm.155.1.9001282
16. Turgeon AF, Lauzier F, Simard J-F et al (2011) Mortality associated with withdrawal of life-sustaining therapy for patients with severe traumatic brain injury: a Canadian multicentre cohort study. Can Med Assoc J 183:1581–1588. doi:10.1503/cmaj.110974
17. Wunsch H, Harrison DA, Harvey S, Rowan K (2005) End-of-life decisions: a cohort study of the withdrawal of all active treatment in intensive care units in the United Kingdom. Intensive Care Med 31:823–831. doi:10.1007/s00134-005-2644-y
18. Mercer M, Winter R, Dennis S, Smith C (1998) An audit of treatment withdrawal in one hundred patients on a general ICU. Nurs Crit Care 3:63–66
19. Garland A, Connors AF (2007) Physicians’ influence over decisions to forego life support. J Palliat Med 10:1298–1305. doi:10.1089/jpm.2007.0061
20. Rayner SG, Mark NM, Lee NJ, Curtis JR (2014) Variability in the withdrawal of life-sustaining treatment in the intensive care unit: a systematic review, [Publication Number: A1138]. Poster Presenation, Am Thorac Soc Int Conf, San Diego, CA
21. Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6:e1000100. doi:10.1371/journal.pmed.1000100
22. Lorenz KA, Lynn J, Morton SC et al (2005) Methodological approaches for a systematic review of end-of-life care. J Palliat Med 8:S4–S11
23. Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology. JAMA 283:2008–2012
24. Higgins JPT, Altman DG, Gøtzsche PC et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928. doi:10.1136/bmj.d5928
25. Bertolini G, Boffelli S, Malacarne P et al (2010) End-of-life decision-making and quality of ICU performance: an observational study in 84 Italian units. Intensive Care Med 36:1495–1504. doi:10.1007/s00134-010-1910-9
26. Brieva JL, Cooray P, Rowley M (2009) Withholding and withdrawal of life-sustaining therapies in intensive care: an Australian experience. Crit Care Resusc 11:266–268
27. Cesta MA, Cardenas-Turanzas M, Wakefield C et al (2009) Life-supportive therapy withdrawal and length of stay in a large oncologic intensive care unit at the end of life. J Palliat Med 12:713–718. doi:10.1089/jpm.2009.0045
28. Collins N, Phelan D, Carton E (2006) End of life in ICU: care of the dying or “pulling the plug”. Ir Med J 99:112–114
29. Collins N, Phelan D, Marsh B, Sprung CL (2006) End-of-life care in the intensive care unit: the Irish Ethicus data. Crit Care Resusc 8:315–320
30. Cook D, Rocker G, Marshall J et al (2003) Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med 349:1123–1132. doi:10.1056/NEJMoa030083
31. Cooper Z, Rivara FP, Wang J et al (2009) Withdrawal of life-sustaining therapy in injured patients: variations between trauma centers and nontrauma centers. J Trauma 66:1327–1335. doi:10.1097/TA.0b013e31819ea047
32. Côte N, Turgeon AF, Lauzier F et al (2013) Factors associated with the withdrawal of life-sustaining therapies in patients with severe traumatic brain injury: a multicenter cohort study. Neurocrit Care 18:154–160. doi:10.1007/s12028-012-9787-9
33. Diringer MN, Edwards DF, Aiyagari V, Hollingsworth H (2001) Factors associated with withdrawal of mechanical ventilation in a neurology/neurosurgery intensive care unit. Crit Care Med 29:1792–1797
34. Eidelman LA, Jakobson DJ, Worner TM et al (2003) End-of-life intensive care unit decisions, communication, and documentation: an evaluation of physician training. J Crit Care 18:11–16. doi:10.1053/jcrc.2003.YJCRC3
35. Gajewska K, Schroeder M, De Marre F, Vincent J-L (2004) Analysis of terminal events in 109 successive deaths in a Belgian intensive care unit. Intensive Care Med 30:1224–1227. doi:10.1007/s00134-004-2308-3
36. Jakobson DJ, Eidelman LA, Worner TM et al (2004) Evaluation of changes in forgoing life-sustaining treatment in Israeli ICU patients. Chest 126:1969–1973
37. Jensen HI, Ammentorp J, Ørding H (2011) Withholding or withdrawing therapy in Danish regional ICUs: frequency, patient characteristics and decision process. Acta Anaesthesiol Scand 55:344–351. doi:10.1111/j.1399-6576.2010.02375.x
38. Kranidiotis G, Gerovasili V, Tasoulis A et al (2010) End-of-life decisions in Greek intensive care units: a multicenter cohort study. Crit Care 14:R228. doi:10.1186/cc9380
39. Meissner A, Genga KR, Studart FS et al (2010) Epidemiology of and factors associated with end-of-life decisions in a surgical intensive care unit. Crit Care Med 38:1060–1068. doi:10.1097/CCM.0b013e3181cd1110
40. Mosenthal AC, Murphy PA, Barker LK et al (2008) Changing the culture around end-of-life care in the trauma intensive care unit. J Trauma 64:1587–1593. doi:10.1097/TA.0b013e318174f112
41. Pham TN, Otto A, Young SR et al (2012) Early withdrawal of life support in severe burn injury. J Burn Care Res 33:130–135. doi:10.1097/BCR.0b013e31823e598d
42. Quenot JP, Rigaud JP, Prin S et al (2012) Impact of an intensive communication strategy on end-of-life practices in the intensive care unit. Intensive Care Med 38:145–152. doi:10.1007/s00134-011-2405-z
43. Sprung CL, Maia P, Bulow H-H et al (2007) The importance of religious affiliation and culture on end-of-life decisions in European intensive care units. Intensive Care Med 33:1732–1739. doi:10.1007/s00134-007-0693-0
44. Sprung CL, Ledoux D, Bulow H-H et al (2008) Relieving suffering or intentionally hastening death: where do you draw the line? Crit Care Med 36:8–13
45. Verkade MA, Epker JL, Nieuwenhoff MD et al (2012) Withdrawal of life-sustaining treatment in a mixed intensive care unit: most common in patients with catastropic brain injury. Neurocrit Care 16:130–135. doi:10.1007/s12028-011-9567-y
46. Watch LS, Saxton-Daniels S, Schermer CR (2005) Who Has Life-Sustaining Therapy Withdrawn After Injury? J Trauma Inj Infect Crit Care 59:1320–1327. doi:10.1097/01.ta.0000196003.41799.41
47. White AC, Joseph B, Gireesh A et al (2009) Terminal withdrawal of mechanical ventilation at a long-term acute care hospital: comparison with a medical ICU. Chest 136:465–470. doi:10.1378/chest.09-0085
48. White DB, Curtis JR, Lo B, Luce JM (2006) Decisions to limit life-sustaining treatment for critically ill patients who lack both decision-making capacity and surrogate decision-makers. Crit Care Med 34:2053–2059
49. White DB, Curtis JR, Wolf LE et al (2007) Life support for patients without a surrogate decision maker: who decides? Ann Intern Med 147:34–40
50. Wilson ME, Samirat R, Yilmaz M et al (2013) Physician staffing models impact the timing of decisions to limit life support in the ICU. Chest 143:656–663. doi:10.1378/chest.12-1173
51. Wood GG, Martin E (1995) Withholding and withdrawing life-sustaining therapy in a Canadian intensive care unit. Can J Anaesth 42:186–191
52. Zib M, Saul P (2007) A pilot audit of the process of end-of-life decision-making in the intensive care unit. Crit Care Resusc 9:213–218
53. Azoulay E, Metnitz B, Sprung CL et al (2009) End-of-life practices in 282 intensive care units: data from the SAPS 3 database. Intensive Care Med 35:623–630. doi:10.1007/s00134-008-1310-6
54. Buckley TA, Joynt GM, Tan PYH et al (2004) Limitation of life support: frequency and practice in a Hong Kong intensive care unit. Crit Care Med 32:415–420. doi:10.1097/01.CCM.0000110675.34569.A9
55. Ferrand E, Robert R, Ingrand P, Lemaire F (2001) Withholding and withdrawal of life support in intensive-care units in France: a prospective survey. French LATAREA Group. Lancet 357:9–14
56. Ganz FD, Benbenishty J, Hersch M et al (2006) The impact of regional culture on intensive care end of life decision making: an Israeli perspective from the ETHICUS study. J Med Ethics 32:196–199. doi:10.1136/jme.2005.012542
57. Ismail A, Long J, Moiemen N, Wilson Y (2011) End of life decisions and care of the adult burn patient. Burns 37:288–293. doi:10.1016/j.burns.2010.08.009
58. Knaus WA, Rauss A, Alperovitch A et al (1990) Do objectiue estimates of chances for survival influence decisions to withhold or withdraw treatment? Med Decis Mak 10:163–171
59. Kollef MH (1996) Private attending physician status and the withdrawal of life-sustaining interventions in a medical intensive care unit population. Crit Care Med 24:968–975
60. Kollef MH, Ward S (1999) The influence of access to a private attending physician on the withdrawal of life-sustaining therapies in the intensive care unit. Crit Care Med 27:2125–2132
61. Lee DKP, Swinburne AJ, Fedullo AJ, Wahl GW (1994) Withdrawing care: experience in a medical intensive care unit. JAMA 271:1358–1361
62. Manara AR, Pittman JA, Braddon FE (1998) Reasons for withdrawing treatment in patients receiving intensive care. Anaesthesia 53:523–528
63. Mayer SA, Kossoff SB (1999) Withdrawal of life support in the neurological intensive care unit. Neurology 52:1602–1609
64. Miguel N, León M, Ibáñez J et al (1998) Sepsis-related organ failure assessment and withholding or withdrawing life support from critically ill patients. Crit Care 2:61–66. doi:10.1186/cc127
65. Nolin T, Andersson R (2003) Withdrawal of medical treatment in the ICU. A cohort study of 318 cases during 1994-2000. Acta Anaesthesiol Scand 47:501–507
66. Sjökvist P, Sundin P, Berggren L (1998) Limiting life support: experiences with a special protocol. Acta Anaesthesiol Scand 42:232–237
67. Spronk PE, Kuiper AV, Rommes JH et al (2009) The practice of and documentation on withholding and withdrawing life support: a retrospective study in two Dutch intensive care units. Anesth Analg 109:841–846. doi:10.1213/ane.0b013e3181acc64a
68. Sprung CL, Woodcock T, Sjokvist P et al (2008) Reasons, considerations, difficulties and documentation of end-of-life decisions in European intensive care units: the ETHICUS Study. Intensive Care Med 34:271–277. doi:10.1007/s00134-007-0927-1
69. Trunkey DD, Cahn RM, Lenfesty B, Mullins R (2000) Management of the geriatric trauma patient at risk of death: therapy withdrawal decision making. Arch Surg 135:34–38
70. Turner J, Michell W, Morgan C, Benatar S (1996) Limitation of life support: frequency and practice in a London and a Cape Town intensive care unit. Intensive Care Med 22:1020–1025
71. Sprung CL, Paruk F, Sa F et al (2014) The Durban World Congress Ethics Round Table Conference Report: i. Differences between withholding and withdrawing life-sustaining treatments. J Crit Care 29:890–895. doi:10.1016/j.jcrc.2014.06.022
72. Kirchoff KT, Anumandla PR, Foth KT et al (2004) Documentation on withdrawal of life support in adult patients in the intensive care unit. Am J Crit Care 13:328–334
73. Quill CM, Ratcliffe SJ, Harhay MO, Halpern SD (2014) Variation in decisions to forgo life-sustaining therapies in US ICUs. Chest 146:573–582. doi:10.1378/chest.13-2529
74. Cook D, Guyatt G, Jaeschke R et al (1995) Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. JAMA 273:703–708
75. Sprung CL, Truog RD, Curtis JR et al (2014) Seeking worldwide professional consensus on the principles of end-of-life care for the critically ill. The Consensus for Worldwide End-of-Life Practice for Patients in Intensive Care Units (WELPICUS) study. Am J Respir Crit Care Med 190:855–866. doi:10.1164/rccm.201403-0593CC