Mortality associated with withdrawal of life-sustaining therapy for patients with severe traumatic brain injury: A Canadian multicentre cohort study

CMAJ. Canadian Medical Association Journal

Volumn 183, Issue 14, 2011, Pages 1581-1588

  Turgeon, Alexis F ^a,b   Lauzier, François ^a,b   Simard, Jean Franco̧is ^a   Scales, Damon C ^c   Burns, Karen E A ^c   Moore, Lynne ^a,b   Zygun, David A ^d   Bernard, Francis ^e   Meade, Maureen O ^f   Dung, Tran Cong ^a   Ratnapalan, Mohana ^c   Todd, Stephanie ^d   Harlock, John ^f   Fergusson, Dean A ^g  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

^f MCMASTER UNIVERSITY   (Canada)

^g OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; CANADA; COHORT ANALYSIS; COMMUNITY; CONTROLLED STUDY; DEATH; EMERGENCY HEALTH SERVICE; FAMILY; FEMALE; GENDER; GLASGOW COMA SCALE; HUMAN; INJURY SEVERITY; LIFE SUSTAINING TREATMENT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY (TOPIC); MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATIENT CARE; PHYSICIAN; PROGNOSIS; PUPIL REFLEX; RANDOMIZATION; RETROSPECTIVE STUDY; TRAUMATIC BRAIN INJURY; TREATMENT WITHDRAWAL;

EID: 80053514170     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.101786     Document Type: Article

References (25)

1. Marshall LF, Becker DP, Bowers SA, et al. The National Traumatic Coma Data Bank. Part 1: Design, purpose, goals, and results. J Neurosurg 1983;59:276-84. (Pubitemid 13029207)
2. Murray GD, Teasdale GM, Braakman R, et al. The European brain injury consortium survey of head injuries. Acta Neurochir (Wien) 1999;141:223-36. (Pubitemid 29137535)
3. Myburgh JA, Cooper DJ, Finfer SR, et al.; Australasian Traumatic Brain Injury Study. (Atraumatic brain injuryS) Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group. Epidemiology and 12-Month Outcomes From Traumatic Brain Injury in Australia and New Zealand. J Trauma 2008;64:854-62.
4. Shafi S, Stewart RM, Nathens AB, et al. Significant variations in mortality occur at similarly designated trauma centres. Arch Surg 2009;144:64-8.
5. Moore L, Hanley JA, Turgeon AF, et al. A new method for evaluating trauma centre outcome performance: TRAM-adjusted mortality estimates. Ann Surg 2010;251:952-8.
6. Mayer SA, Kossoff SB. Withdrawal of life support in the neurological intensive care unit. Neurology 1999;52:1602-9. (Pubitemid 29220634)
7. Becker KJ, Baxter AB, Cohen WA, et al. Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology 2001;56:766-72.
8. Naidech AM, Bernstein RA, Bassin SL, et al. How patients die after intracerebral hemorrhage. Neurocrit Care 2009;11:45-9.
9. Blackwell T. Families of donors misled on death: MDs. National Post [Toronto] 2010 Sept. 14. Available: www.nationalpost.com/news/ Families+donors+misled+death/3525136 /story.html# ixzz16gVKC3fh (accessed 2010 Nov. 29).
10. Peduzzi P, Concato J, Kemper E. et al. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996;49:1373-9. (Pubitemid 27028925)
11. MRC CRASH Trial Collaborators. Perel P, Arango M, Clayton T, et al. Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. BMJ 2008;336:425-9.
12. Murray GD, Butcher I, McHugh GS, et al. Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study. J Neurotrauma 2007;24:329-37. (Pubitemid 46492154)
13. Steyerberg EW, Mushkudiani N, Perel P, et al. Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med. 2008;5:e165; discussion e165.
14. Cook D, Rocker G, Marshall J, et al.; Level of Care Study Investigators and the Canadian Critical Care Trials Group. Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med 2003;349:1123-32. (Pubitemid 37122324)
15. Plaisier BR, Blostein PA, Hurt KJ, et al. Withholding/withdrawal of life support in trauma patients: Is there an age bias? Am Surg 2002;68:159-62. (Pubitemid 44943219)
16. Nathens AB, Rivara FP, Wang J, et al. Variation in the rates of do not resuscitate orders after major trauma and the impact of intensive care unit environment. J Trauma 2008;64:81-8.
17. Hukkelhoven CW, Rampen AJ, Maas AI, et al. Some prognostic models for traumatic brain injury were not valid. J Clin Epidemiol 2006;59:132-43. (Pubitemid 43111617)
18. Bulger EM, Nathens AB, Rivara FP, et al.; Brain Trauma Foundation. Management of severe head injury: institutional variations in care and effect on outcome. Crit Care Med 2002; 30: 1870-6. (Pubitemid 34879606)
19. Fakhry SM, Trask AL, Waller MA, et al.; IRTC Neurotrauma Task Force. Management of brain-injured patients by an evidence-based medicine protocol improves outcomes and decreases hospital charges. J Trauma 2004;56:492-9.
20. Taylor MD, Tracy JK, Meyer W, et al. Trauma in the elderly: intensive care unit resource use and outcome. J Trauma 2002; 53: 407-14.
21. DuBose JJ, Browder T, Inaba K, et al. Effect of trauma centre designation on outcome in patients with severe traumatic brain injury. Arch Surg 2008;143:1213-7.
22. Sprung CL, Cohen SL, Sjokvist P, et al.; Ethicus Study Group. End-of-life practices in European intensive care units: the Ethicus Study. JAMA 2003;290:790-7. (Pubitemid 37432956)
23. Jennett B, Snoek J, Bond MR, et al. Disability after severe head injury: observations on the use of the Glasgow Outcome Scale. J Neurol Neurosurg Psychiatry 1981;44:285-93. (Pubitemid 11070501)
24. Thomas JW, Hofer TP. Research evidence on the validity of risk-adjusted mortality rate as a measure of hospital quality of care. Med Care Res Rev 1998;55:371-404. (Pubitemid 28535855)
25. Lilford R, Pronovost P. Using hospital mortality rates to judge hospital performance: a bad idea that just won't go away. BMJ 2010; 340:c2016.